ARF5_HUMAN
Evidence for PS localization
Functions
(Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ARF5_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 34.2466 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 31.5068 | 5 | yes |
| GO:0043168 | anion binding | 30.1370 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 28.7671 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.7671 | 4 | yes |
| GO:0043169 | cation binding | 24.6575 | 4 | no |
| GO:0046872 | metal ion binding | 23.2877 | 5 | no |
| GO:0005525 | GTP binding | 15.0685 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 15.0685 | 6 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 15.0685 | 5 | yes |
| GO:0003924 | GTPase activity | 12.3288 | 7 | yes |
| GO:0016462 | pyrophosphatase activity | 12.3288 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 12.3288 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 12.3288 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ARF5_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 50.6849 | 4 | yes |
| GO:0006996 | organelle organization | 38.3562 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 36.9863 | 4 | no |
| GO:0071702 | organic substance transport | 35.6164 | 4 | yes |
| GO:0022607 | cellular component assembly | 35.6164 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 35.6164 | 4 | no |
| GO:0071705 | nitrogen compound transport | 34.2466 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 34.2466 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 34.2466 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 34.2466 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 32.8767 | 4 | no |
| GO:0010646 | regulation of cell communication | 32.8767 | 4 | no |
| GO:0010468 | regulation of gene expression | 31.5068 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 31.5068 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 31.5068 | 5 | no |
| GO:0015031 | protein transport | 30.1370 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 28.7671 | 4 | no |
| GO:0006886 | intracellular protein transport | 27.3973 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 24.6575 | 4 | no |
| GO:0009966 | regulation of signal transduction | 24.6575 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 24.6575 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.6575 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 23.2877 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.2877 | 5 | no |
| GO:0033365 | protein localization to organelle | 23.2877 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.9178 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.9178 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 21.9178 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.9178 | 5 | no |
| GO:0051049 | regulation of transport | 21.9178 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.5479 | 5 | no |
| GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum | 8.2192 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| STX6_HUMAN | [view interactions] | Low throughput | no | yes |
| ARFP2_HUMAN | [view interactions] | Low throughput | no | no |
| AP3B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARFP1_HUMAN | [view interactions] | Low throughput | no | no |
| GGA1_HUMAN | [view interactions] | Low throughput | no | yes |
| NEMO_HUMAN | [view interactions] | Low throughput | no | yes |
| DEN1A_HUMAN | [view interactions] | Low throughput | no | no |
| DEN1B_HUMAN | [view interactions] | Low throughput | no | yes |
| CAPS2_HUMAN | [view interactions] | Low throughput | no | no |
| RFIP4_HUMAN | [view interactions] | Low throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RFIP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| PGFRB_HUMAN | [view interactions] | High throughput | no | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| ACY3_HUMAN | [view interactions] | High throughput | no | no |
| DTX3_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CBX7_HUMAN | [view interactions] | High throughput | no | yes |
| TECT2_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| CLN3_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLK8_HUMAN | [view interactions] | High throughput | no | no |
| BIEA_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNR6_HUMAN | [view interactions] | High throughput | no | no |
| SLAF1_HUMAN | [view interactions] | High throughput | no | no |
| TMPS5_HUMAN | [view interactions] | High throughput | no | no |
| RNF26_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNDP1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| DUS12_HUMAN | [view interactions] | High throughput | no | no |
| DUS16_HUMAN | [view interactions] | High throughput | no | yes |
| DUS19_HUMAN | [view interactions] | High throughput | no | yes |
| DUS21_HUMAN | [view interactions] | High throughput | no | no |
| DUS22_HUMAN | [view interactions] | High throughput | no | yes |
| DUS28_HUMAN | [view interactions] | High throughput | no | yes |
| DUS6_HUMAN | [view interactions] | High throughput | no | yes |
| DUS9_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WWP1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| F16P1_HUMAN | [view interactions] | High throughput | no | no |
| MAGA8_HUMAN | [view interactions] | High throughput | no | no |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADA11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARF4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARF3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCYOX_HUMAN | [view interactions] | High throughput | no | yes |
| PCD20_HUMAN | [view interactions] | High throughput | no | no |
| COPT1_HUMAN | [view interactions] | High throughput | no | no |
| EPDR1_HUMAN | [view interactions] | High throughput | no | yes |
| MARH4_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VMA21_HUMAN | [view interactions] | High throughput | no | no |
| ARL5B_HUMAN | [view interactions] | High throughput | no | yes |
| UQCC1_HUMAN | [view interactions] | High throughput | no | yes |
| NIP7_HUMAN | [view interactions] | High throughput | no | yes |
| VMAT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAL4C_HUMAN | [view interactions] | High throughput | no | no |
| PAL4G_HUMAN | [view interactions] | High throughput | no | no |
| GHITM_HUMAN | [view interactions] | High throughput | no | yes |
| GTR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| ENTP2_HUMAN | [view interactions] | High throughput | no | yes |
| TIDC1_HUMAN | [view interactions] | High throughput | no | yes |
| F174A_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SERPH_HUMAN | [view interactions] | High throughput | no | no |
| LMAN2_HUMAN | [view interactions] | High throughput | no | yes |
| ERP44_HUMAN | [view interactions] | High throughput | no | yes |
| RRP36_HUMAN | [view interactions] | High throughput | no | yes |
| COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPE_HUMAN | [view interactions] | High throughput | no | yes |
| COPZ1_HUMAN | [view interactions] | High throughput | no | no |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| MYO10_HUMAN | [view interactions] | High throughput | no | no |
| UBE2O_HUMAN | [view interactions] | High throughput | no | yes |
| ARAF_HUMAN | [view interactions] | High throughput | no | yes |
| BRAF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| GOLI_HUMAN | [view interactions] | High throughput | no | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| GORAB_HUMAN | [view interactions] | High throughput | no | yes |
| ACADM_HUMAN | [view interactions] | High throughput | no | yes |
| SSDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAZP1_HUMAN | [view interactions] | High throughput | no | yes |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDH6A_HUMAN | [view interactions] | High throughput | no | no |
| LDH6B_HUMAN | [view interactions] | High throughput | no | no |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LDHC_HUMAN | [view interactions] | High throughput | no | no |
| PCBP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SERC_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PI51A_HUMAN | [view interactions] | High throughput | no | yes |
| ASAP2_HUMAN | [view interactions] | High throughput | no | yes |
| TYPH_HUMAN | [view interactions] | High throughput | no | no |
| CTBP2_HUMAN | [view interactions] | High throughput | no | no |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTNA_HUMAN | [view interactions] | High throughput | no | yes |
| DPCD_HUMAN | [view interactions] | High throughput | no | yes |
| PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| EPN4_HUMAN | [view interactions] | High throughput | no | yes |
| COPB_HUMAN | [view interactions] | High throughput | no | yes |
| SYDE2_HUMAN | [view interactions] | High throughput | no | no |
| ARFG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARFG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDXD1_HUMAN | [view interactions] | High throughput | no | no |
| K1C10_HUMAN | [view interactions] | High throughput | no | no |
| AP4M1_HUMAN | [view interactions] | High throughput | no | yes |
| GOGB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K2C1_HUMAN | [view interactions] | High throughput | no | no |
| AP3D1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COPG2_HUMAN | [view interactions] | High throughput | no | yes |
| AP4E1_HUMAN | [view interactions] | High throughput | no | no |
| MCM3_HUMAN | [view interactions] | High throughput | no | no |
| TRIPB_HUMAN | [view interactions] | High throughput | no | yes |
| AP3S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FILA2_HUMAN | [view interactions] | High throughput | no | no |
| TB22B_HUMAN | [view interactions] | High throughput | no | no |
| K319L_HUMAN | [view interactions] | High throughput | no | yes |
| K1C9_HUMAN | [view interactions] | High throughput | no | no |
| K1C16_HUMAN | [view interactions] | High throughput | no | no |
| K2C5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SH3B4_HUMAN | [view interactions] | High throughput | no | yes |
| 4F2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S38A1_HUMAN | [view interactions] | High throughput | no | yes |
| PRPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GOGA5_HUMAN | [view interactions] | High throughput | no | yes |
| STX5_HUMAN | [view interactions] | High throughput | no | yes |
| K22E_HUMAN | [view interactions] | High throughput | no | no |
| K1C14_HUMAN | [view interactions] | High throughput | no | no |
| COPG1_HUMAN | [view interactions] | High throughput | no | yes |
| HORN_HUMAN | [view interactions] | High throughput | no | no |
| SCAM1_HUMAN | [view interactions] | High throughput | no | no |
| MPRI_HUMAN | [view interactions] | High throughput | no | yes |
| SYNEM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI33_HUMAN | [view interactions] | High throughput | no | yes |
| RL11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSG2_HUMAN | [view interactions] | High throughput | no | no |
| PCCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA2_HUMAN | [view interactions] | High throughput | no | no |
| ZCC17_HUMAN | [view interactions] | High throughput | no | yes |
| SCYL1_HUMAN | [view interactions] | High throughput | no | yes |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| PYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2R3A_HUMAN | [view interactions] | High throughput | no | yes |
| LSR_HUMAN | [view interactions] | High throughput | no | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| GORS2_HUMAN | [view interactions] | High throughput | no | yes |
| NECP2_HUMAN | [view interactions] | High throughput | no | yes |
| TM263_HUMAN | [view interactions] | High throughput | no | yes |
| CNTP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GEPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNR27_HUMAN | [view interactions] | High throughput | no | yes |
| A4GCT_HUMAN | [view interactions] | High throughput | no | no |
| APJ_HUMAN | [view interactions] | High throughput | no | yes |
| S15A1_HUMAN | [view interactions] | High throughput | no | no |
| I20RA_HUMAN | [view interactions] | High throughput | no | no |
| VMAT1_HUMAN | [view interactions] | High throughput | no | no |
| GRPR_HUMAN | [view interactions] | High throughput | no | no |
| SRPRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GINM1_HUMAN | [view interactions] | High throughput | no | yes |
| ARL4C_HUMAN | [view interactions] | High throughput | no | yes |
| 5NTD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAD13_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLPR2_HUMAN | [view interactions] | High throughput | no | yes |
| PPBI_HUMAN | [view interactions] | High throughput | no | no |
| RHBT3_HUMAN | [view interactions] | High throughput | no | no |
| CX6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDKM_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| MED20_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |