SYNEM_HUMAN
Evidence for PS localization
Functions
Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
No data found.
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SYNEM_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 60.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 60.0000 | 4 | no |
| GO:0006996 | organelle organization | 56.0000 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 56.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 56.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 56.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 52.0000 | 5 | no |
| GO:0007010 | cytoskeleton organization | 44.0000 | 5 | yes |
| GO:0048522 | positive regulation of cellular process | 44.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 44.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 36.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 36.0000 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 36.0000 | 5 | no |
| GO:0010646 | regulation of cell communication | 36.0000 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 36.0000 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 36.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 32.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 32.0000 | 4 | no |
| GO:0031399 | regulation of protein modification process | 32.0000 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 32.0000 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 28.0000 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 28.0000 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 28.0000 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 28.0000 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 28.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 28.0000 | 5 | no |
| GO:0036211 | protein modification process | 28.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 28.0000 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 28.0000 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 24.0000 | 6 | no |
| GO:0030030 | cell projection organization | 24.0000 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 24.0000 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 24.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 24.0000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 24.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 24.0000 | 4 | no |
| GO:0031400 | negative regulation of protein modification process | 24.0000 | 7 | no |
| GO:0006355 | regulation of DNA-templated transcription | 24.0000 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 24.0000 | 7 | no |
| GO:0006936 | muscle contraction | 12.0000 | 4 | yes |
| GO:0006941 | striated muscle contraction | 8.0000 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SYNEM_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 12.0000 | 3 | no |
| DOID:0080000 | muscular disease | 12.0000 | 3 | no |
| DOID:423 | myopathy | 12.0000 | 5 | no |
| DOID:66 | muscle tissue disease | 12.0000 | 4 | no |
| DOID:0050700 | cardiomyopathy | 8.0000 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 8.0000 | 5 | no |
| DOID:114 | heart disease | 8.0000 | 3 | no |
| DOID:9884 | muscular dystrophy | 8.0000 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DTNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TITIN_HUMAN | [view interactions] | Low throughput | no | no |
| FLNC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DISC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PACN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SH3G2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AMPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| P85A_HUMAN | [view interactions] | Low throughput | no | yes |
| CBL_HUMAN | [view interactions] | Low throughput | no | yes |
| 2ABB_HUMAN | [view interactions] | Low throughput | no | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DESM_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| HLAA_HUMAN | [view interactions] | Low throughput | no | no |
| B2MG_HUMAN | [view interactions] | Low throughput | no | yes |
| LIRB1_HUMAN | [view interactions] | Low throughput | no | no |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA3C_HUMAN | [view interactions] | High throughput | no | no |
| TBA3D_HUMAN | [view interactions] | High throughput | no | no |
| SKA1_HUMAN | [view interactions] | High throughput | no | yes |
| CEP43_HUMAN | [view interactions] | High throughput | no | no |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BACH1_HUMAN | [view interactions] | High throughput | no | no |
| WRP73_HUMAN | [view interactions] | High throughput | no | no |
| CT55_HUMAN | [view interactions] | High throughput | no | no |
| DNJB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
| ERBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| CSN6_HUMAN | [view interactions] | High throughput | no | yes |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| SYNCI_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEST_HUMAN | [view interactions] | High throughput | no | no |
| SLN11_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| BIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| TNR6A_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6C_HUMAN | [view interactions] | High throughput | no | no |
| GRRE1_HUMAN | [view interactions] | High throughput | no | no |
| FKBP8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| GFAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K1C19_HUMAN | [view interactions] | High throughput | no | no |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| PERI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| PLEC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| VINC_HUMAN | [view entry] [view interactions] | Computational | yes | no |