Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SYNEM_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SYNEM_HUMAN
GO:0000166 nucleotide binding 25.0000 4 no
GO:0017076 purine nucleotide binding 25.0000 5 no
GO:0030554 adenyl nucleotide binding 20.8333 6 no
GO:0032555 purine ribonucleotide binding 20.8333 4 no
GO:0043168 anion binding 20.8333 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in SYNEM_HUMAN
GO:0031323 regulation of cellular metabolic process 58.3333 4 no
GO:0048523 negative regulation of cellular process 58.3333 4 no
GO:0060255 regulation of macromolecule metabolic process 58.3333 4 no
GO:0080090 regulation of primary metabolic process 58.3333 4 no
GO:0006996 organelle organization 50.0000 4 yes
GO:0048522 positive regulation of cellular process 45.8333 4 no
GO:0051128 regulation of cellular component organization 45.8333 4 no
GO:0051246 regulation of protein metabolic process 45.8333 5 no
GO:0009889 regulation of biosynthetic process 41.6667 4 no
GO:0010468 regulation of gene expression 41.6667 6 no
GO:0010556 regulation of macromolecule biosynthetic process 41.6667 5 no
GO:0031326 regulation of cellular biosynthetic process 41.6667 5 no
GO:0009892 negative regulation of metabolic process 37.5000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 37.5000 5 no
GO:0010646 regulation of cell communication 37.5000 4 no
GO:0008104 protein localization 37.5000 4 no
GO:0007010 cytoskeleton organization 37.5000 5 yes
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0051252 regulation of RNA metabolic process 33.3333 5 no
GO:0036211 protein modification process 29.1667 4 no
GO:0043412 macromolecule modification 29.1667 4 no
GO:0006355 regulation of DNA-templated transcription 29.1667 7 no
GO:2001141 regulation of RNA biosynthetic process 29.1667 6 no
GO:0009894 regulation of catabolic process 25.0000 4 no
GO:0042981 regulation of apoptotic process 25.0000 5 no
GO:0043067 regulation of programmed cell death 25.0000 4 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0048584 positive regulation of response to stimulus 25.0000 4 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0030030 cell projection organization 25.0000 4 no
GO:0098657 import into cell 25.0000 4 no
GO:0006796 phosphate-containing compound metabolic process 20.8333 4 no
GO:0033043 regulation of organelle organization 20.8333 5 no
GO:0051726 regulation of cell cycle 20.8333 4 no
GO:0009890 negative regulation of biosynthetic process 20.8333 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 20.8333 6 no
GO:0031327 negative regulation of cellular biosynthetic process 20.8333 6 no
GO:0042127 regulation of cell population proliferation 20.8333 4 no
GO:0009967 positive regulation of signal transduction 20.8333 5 no
GO:0043408 regulation of MAPK cascade 20.8333 6 no
GO:0043933 protein-containing complex organization 20.8333 4 no
GO:0045595 regulation of cell differentiation 20.8333 4 no
GO:1902531 regulation of intracellular signal transduction 20.8333 5 no
GO:0009893 positive regulation of metabolic process 20.8333 4 no
GO:0033365 protein localization to organelle 20.8333 5 no
GO:0051094 positive regulation of developmental process 20.8333 4 no
GO:0120036 plasma membrane bounded cell projection organization 20.8333 5 no
GO:2000026 regulation of multicellular organismal development 20.8333 4 no
GO:0006936 muscle contraction 12.5000 4 yes
GO:0006941 striated muscle contraction 8.3333 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DTNA_HUMAN [view entry] [view interactions] Low throughput yes yes
TITIN_HUMAN [view interactions] Low throughput no no
FLNC_HUMAN [view entry] [view interactions] Low throughput yes no
DISC1_HUMAN [view entry] [view interactions] Low throughput yes no
PACN1_HUMAN [view entry] [view interactions] Low throughput yes yes
SH3G2_HUMAN [view entry] [view interactions] Low throughput yes yes
AMPH_HUMAN [view entry] [view interactions] Low throughput yes yes
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
P85A_HUMAN [view interactions] Low throughput no yes
CBL_HUMAN [view interactions] Low throughput no yes
2ABB_HUMAN [view interactions] Low throughput no yes
2AAA_HUMAN [view entry] [view interactions] Low throughput yes no
DESM_HUMAN [view entry] [view interactions] Low throughput yes no
HLAA_HUMAN [view interactions] Low throughput no no
LIRB1_HUMAN [view interactions] Low throughput no no
B2MG_HUMAN [view interactions] Low throughput no yes
TBA3C_HUMAN [view interactions] High throughput no no
TBA3D_HUMAN [view interactions] High throughput no no
SKA1_HUMAN [view interactions] High throughput no yes
CEP43_HUMAN [view interactions] High throughput no no
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
BACH1_HUMAN [view interactions] High throughput no no
WRP73_HUMAN [view interactions] High throughput no no
CT55_HUMAN [view interactions] High throughput no no
DNJB4_HUMAN [view entry] [view interactions] High throughput yes yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
ZBT18_HUMAN [view interactions] High throughput no yes
HMGA2_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
BMI1_HUMAN [view interactions] High throughput no yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CP135_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
ERBB3_HUMAN [view interactions] High throughput no yes
ERBB4_HUMAN [view entry] [view interactions] High throughput yes yes
CUL4A_HUMAN [view interactions] High throughput no no
CSN6_HUMAN [view interactions] High throughput no yes
PKNX1_HUMAN [view interactions] High throughput no yes
SYNCI_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
UCHL1_HUMAN [view entry] [view interactions] High throughput yes yes
NEST_HUMAN [view interactions] High throughput no no
SLN11_HUMAN [view interactions] High throughput no yes
EP300_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
ANLN_HUMAN [view interactions] High throughput no yes
B3GN2_HUMAN [view interactions] High throughput no yes
BIN1_HUMAN [view entry] [view interactions] High throughput yes yes
LZTS2_HUMAN [view interactions] High throughput no no
TNR6A_HUMAN [view interactions] High throughput no yes
TNR6C_HUMAN [view interactions] High throughput no no
GRRE1_HUMAN [view interactions] High throughput no no
FKBP8_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC1_HUMAN [view interactions] High throughput no yes
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
EMD_HUMAN [view interactions] High throughput no yes
GFAP_HUMAN [view entry] [view interactions] High throughput yes no
K1C19_HUMAN [view interactions] High throughput no no
K2C8_HUMAN [view interactions] High throughput no no
PERI_HUMAN [view entry] [view interactions] High throughput yes no
STIM1_HUMAN [view interactions] High throughput no yes
SYNE3_HUMAN [view interactions] High throughput no no
VIME_HUMAN [view entry] [view interactions] High throughput yes no
ZYX_HUMAN [view interactions] High throughput no no
RNF43_HUMAN [view interactions] High throughput no yes
PHLP1_HUMAN [view interactions] High throughput no yes
ARF5_HUMAN [view entry] [view interactions] High throughput yes no
FOXO1_HUMAN [view interactions] High throughput no yes