SH3G2_HUMAN
Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in SH3G2_HUMAN |
---|---|---|---|---|
GO:0046872 | metal ion binding | 25.3968 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in SH3G2_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 58.7302 | 4 | no |
GO:0051128 | regulation of cellular component organization | 57.1429 | 4 | no |
GO:0048523 | negative regulation of cellular process | 49.2063 | 4 | yes |
GO:0010646 | regulation of cell communication | 49.2063 | 4 | no |
GO:0051049 | regulation of transport | 49.2063 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 42.8571 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 41.2698 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 41.2698 | 4 | yes |
GO:0009966 | regulation of signal transduction | 41.2698 | 4 | no |
GO:0016192 | vesicle-mediated transport | 39.6825 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 39.6825 | 4 | yes |
GO:0051246 | regulation of protein metabolic process | 36.5079 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 36.5079 | 4 | no |
GO:0060627 | regulation of vesicle-mediated transport | 36.5079 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 34.9206 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 34.9206 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 34.9206 | 5 | no |
GO:0030030 | cell projection organization | 34.9206 | 4 | yes |
GO:0042325 | regulation of phosphorylation | 31.7460 | 7 | yes |
GO:0051174 | regulation of phosphorus metabolic process | 31.7460 | 5 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 31.7460 | 5 | no |
GO:0006897 | endocytosis | 31.7460 | 5 | no |
GO:0006996 | organelle organization | 31.7460 | 4 | no |
GO:0022607 | cellular component assembly | 31.7460 | 4 | no |
GO:0051050 | positive regulation of transport | 31.7460 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 31.7460 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 31.7460 | 4 | yes |
GO:0019220 | regulation of phosphate metabolic process | 31.7460 | 6 | yes |
GO:0031399 | regulation of protein modification process | 31.7460 | 6 | yes |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 30.1587 | 5 | yes |
GO:0120036 | plasma membrane bounded cell projection organization | 30.1587 | 5 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 30.1587 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 30.1587 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 30.1587 | 7 | yes |
GO:0010468 | regulation of gene expression | 30.1587 | 5 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 30.1587 | 5 | yes |
GO:0010647 | positive regulation of cell communication | 28.5714 | 5 | no |
GO:0023056 | positive regulation of signaling | 28.5714 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 28.5714 | 4 | no |
GO:0043085 | positive regulation of catalytic activity | 28.5714 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 28.5714 | 5 | yes |
GO:0051247 | positive regulation of protein metabolic process | 26.9841 | 6 | no |
GO:0008104 | protein localization | 26.9841 | 4 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 26.9841 | 6 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 26.9841 | 7 | no |
GO:0043269 | regulation of ion transport | 26.9841 | 5 | no |
GO:0033043 | regulation of organelle organization | 25.3968 | 5 | no |
GO:0031401 | positive regulation of protein modification process | 25.3968 | 7 | no |
GO:0042327 | positive regulation of phosphorylation | 25.3968 | 8 | no |
GO:0044057 | regulation of system process | 25.3968 | 4 | no |
GO:0030100 | regulation of endocytosis | 25.3968 | 5 | no |
GO:0051248 | negative regulation of protein metabolic process | 23.8095 | 6 | yes |
GO:0022603 | regulation of anatomical structure morphogenesis | 23.8095 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 23.8095 | 4 | no |
GO:0051129 | negative regulation of cellular component organization | 23.8095 | 5 | no |
GO:0001934 | positive regulation of protein phosphorylation | 23.8095 | 8 | no |
GO:0034762 | regulation of transmembrane transport | 23.8095 | 4 | no |
GO:0034765 | regulation of ion transmembrane transport | 23.8095 | 5 | no |
GO:1904062 | regulation of cation transmembrane transport | 23.8095 | 6 | no |
GO:0043933 | protein-containing complex organization | 22.2222 | 4 | yes |
GO:0009889 | regulation of biosynthetic process | 22.2222 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 22.2222 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 22.2222 | 5 | no |
GO:0045595 | regulation of cell differentiation | 22.2222 | 4 | no |
GO:0071310 | cellular response to organic substance | 20.6349 | 4 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 20.6349 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.6349 | 5 | no |
GO:0099537 | trans-synaptic signaling | 20.6349 | 4 | no |
GO:0031344 | regulation of cell projection organization | 20.6349 | 5 | no |
GO:0022898 | regulation of transmembrane transporter activity | 20.6349 | 4 | no |
GO:0032412 | regulation of ion transmembrane transporter activity | 20.6349 | 5 | no |
GO:0051051 | negative regulation of transport | 20.6349 | 4 | no |
GO:0051338 | regulation of transferase activity | 20.6349 | 4 | no |
GO:0010243 | response to organonitrogen compound | 20.6349 | 4 | no |
GO:0051094 | positive regulation of developmental process | 20.6349 | 4 | no |
GO:0060341 | regulation of cellular localization | 20.6349 | 4 | no |
GO:0031175 | neuron projection development | 20.6349 | 6 | yes |
GO:0031400 | negative regulation of protein modification process | 19.0476 | 7 | yes |
GO:0045936 | negative regulation of phosphate metabolic process | 17.4603 | 7 | yes |
GO:0010563 | negative regulation of phosphorus metabolic process | 17.4603 | 6 | yes |
GO:0042326 | negative regulation of phosphorylation | 15.8730 | 8 | yes |
GO:0010629 | negative regulation of gene expression | 15.8730 | 6 | yes |
GO:0001933 | negative regulation of protein phosphorylation | 14.2857 | 8 | yes |
GO:0070848 | response to growth factor | 12.6984 | 4 | yes |
GO:0022411 | cellular component disassembly | 11.1111 | 4 | yes |
GO:0051261 | protein depolymerization | 9.5238 | 6 | yes |
GO:0072318 | clathrin coat disassembly | 9.5238 | 8 | yes |
GO:0072319 | vesicle uncoating | 9.5238 | 7 | yes |
GO:0003018 | vascular process in circulatory system | 9.5238 | 4 | yes |
GO:0016191 | synaptic vesicle uncoating | 9.5238 | 9 | yes |
GO:0032984 | protein-containing complex disassembly | 9.5238 | 5 | yes |
GO:0071363 | cellular response to growth factor stimulus | 7.9365 | 5 | yes |
GO:0007417 | central nervous system development | 7.9365 | 4 | yes |
GO:1990090 | cellular response to nerve growth factor stimulus | 6.3492 | 4 | yes |
GO:1990138 | neuron projection extension | 6.3492 | 4 | yes |
GO:0097484 | dendrite extension | 4.7619 | 5 | yes |
GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus | 4.7619 | 5 | yes |
GO:0043116 | negative regulation of vascular permeability | 3.1746 | 4 | yes |
GO:1905603 | regulation of blood-brain barrier permeability | 3.1746 | 4 | yes |
GO:1905604 | negative regulation of blood-brain barrier permeability | 3.1746 | 5 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in SH3G2_HUMAN |
---|---|---|---|---|
DOID:331 | central nervous system disease | 4.7619 | 3 | no |
DOID:0050700 | cardiomyopathy | 3.1746 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 3.1746 | 5 | no |
DOID:114 | heart disease | 3.1746 | 3 | no |
DOID:2843 | long QT syndrome | 3.1746 | 6 | no |
DOID:0050890 | synucleinopathy | 3.1746 | 5 | no |
DOID:0060894 | early-onset Parkinsons disease | 3.1746 | 7 | no |
DOID:1289 | neurodegenerative disease | 3.1746 | 4 | no |
DOID:14330 | Parkinsons disease | 3.1746 | 6 | no |
DOID:936 | brain disease | 3.1746 | 4 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
SH3K1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PTN23_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ITCH_HUMAN | [view interactions] | Low throughput | no | yes |
PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SRGP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RAPH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
M4K3_HUMAN | [view interactions] | Low throughput | no | no |
AMPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EMD_HUMAN | [view interactions] | Low throughput | no | yes |
DYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
DEN1A_HUMAN | [view interactions] | Low throughput | no | no |
LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
PACN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AGRB2_HUMAN | [view interactions] | Low throughput | no | no |
CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EGFR_HUMAN | [view interactions] | Low throughput | no | no |
CBL_HUMAN | [view interactions] | Low throughput | no | yes |
CD2AP_HUMAN | [view interactions] | Low throughput | no | no |
ADA19_HUMAN | [view interactions] | Low throughput | no | no |
DYR1A_HUMAN | [view interactions] | Low throughput | no | yes |
SYNEM_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
DRD2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
FBX32_HUMAN | [view interactions] | Low throughput | no | no |
SYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SYNJ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ADA15_HUMAN | [view interactions] | Low throughput | no | yes |
ADAM9_HUMAN | [view interactions] | Low throughput | no | no |
PDC6I_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ATX2_HUMAN | [view interactions] | Low throughput | no | yes |
SH3G3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SH3G2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
VGLU1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
RASD1_HUMAN | [view interactions] | Low throughput | no | yes |
MAST2_HUMAN | [view interactions] | High throughput | no | yes |
PP6R1_HUMAN | [view interactions] | High throughput | no | no |
TIAM2_HUMAN | [view interactions] | High throughput | no | yes |
TM108_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TYSY_HUMAN | [view interactions] | High throughput | no | yes |
ZN219_HUMAN | [view interactions] | High throughput | no | yes |
ZN580_HUMAN | [view interactions] | High throughput | no | yes |
ZXDC_HUMAN | [view interactions] | High throughput | no | no |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAP7_HUMAN | [view interactions] | High throughput | no | no |
TNG2_HUMAN | [view interactions] | High throughput | no | yes |
FL2D_HUMAN | [view interactions] | High throughput | no | yes |
RHG08_HUMAN | [view interactions] | High throughput | no | yes |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ADRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ADRB3_HUMAN | [view interactions] | High throughput | no | no |
ADA2A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HRH1_HUMAN | [view interactions] | High throughput | no | no |
ADA2B_HUMAN | [view interactions] | High throughput | no | no |
HRH3_HUMAN | [view interactions] | High throughput | no | no |
DRD3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DRD4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ASAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARNT2_HUMAN | [view interactions] | High throughput | no | yes |
ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ERH_HUMAN | [view interactions] | High throughput | no | yes |
DQA1_HUMAN | [view interactions] | High throughput | no | yes |
IL6_HUMAN | [view interactions] | High throughput | no | no |
TCEA2_HUMAN | [view interactions] | High throughput | no | yes |
FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TERF1_HUMAN | [view interactions] | High throughput | no | no |
RET_HUMAN | [view interactions] | High throughput | no | yes |
DYN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
P4K2A_HUMAN | [view interactions] | High throughput | no | yes |
PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RBM39_HUMAN | [view interactions] | High throughput | no | yes |
NCALD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IPO11_HUMAN | [view interactions] | High throughput | no | yes |
STAM2_HUMAN | [view interactions] | High throughput | no | yes |
SYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SYNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PAXI1_HUMAN | [view interactions] | High throughput | no | no |
TETN_HUMAN | [view interactions] | High throughput | no | no |
DACT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DLGP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DPPA4_HUMAN | [view interactions] | High throughput | no | no |
DPYL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
F13A_HUMAN | [view interactions] | High throughput | no | no |
EGFL6_HUMAN | [view interactions] | High throughput | no | no |
GSTM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GCH1_HUMAN | [view interactions] | High throughput | no | no |
ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IGHM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LCP2_HUMAN | [view interactions] | High throughput | no | yes |
PPR21_HUMAN | [view interactions] | High throughput | no | yes |
PRR14_HUMAN | [view interactions] | High throughput | no | no |
PTN3_HUMAN | [view interactions] | Computational | no | yes |
EGF_HUMAN | [view interactions] | Computational | no | no |
ROCK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ROCK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ARF1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EFNB1_HUMAN | [view interactions] | Computational | no | yes |
L1CAM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
DNAL4_HUMAN | [view interactions] | Computational | no | yes |
OPHN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
EPHB2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MET_HUMAN | [view interactions] | Computational | no | yes |
EFNB3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SNX9_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
HGF_HUMAN | [view interactions] | Computational | no | yes |
AUXI_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MK01_HUMAN | [view entry] [view interactions] | Computational | yes | yes |