SH3G2_HUMAN
Evidence for PS localization
Functions
Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SH3G2_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 28.3019 | 4 | no |
| GO:0046872 | metal ion binding | 24.5283 | 5 | no |
| GO:0019900 | kinase binding | 24.5283 | 4 | no |
| GO:0019901 | protein kinase binding | 22.6415 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SH3G2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 54.7170 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 47.1698 | 4 | yes |
| GO:0010646 | regulation of cell communication | 47.1698 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 47.1698 | 4 | no |
| GO:0051049 | regulation of transport | 43.3962 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 41.5094 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 41.5094 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 35.8491 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 35.8491 | 4 | no |
| GO:0022607 | cellular component assembly | 33.9623 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 32.0755 | 5 | yes |
| GO:0006996 | organelle organization | 32.0755 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 32.0755 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 30.1887 | 4 | yes |
| GO:0010468 | regulation of gene expression | 30.1887 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.1887 | 5 | yes |
| GO:0030030 | cell projection organization | 30.1887 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 30.1887 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.1887 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.1887 | 5 | no |
| GO:0098657 | import into cell | 30.1887 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 28.3019 | 7 | yes |
| GO:0009892 | negative regulation of metabolic process | 28.3019 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 28.3019 | 6 | yes |
| GO:0031399 | regulation of protein modification process | 28.3019 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 28.3019 | 7 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 28.3019 | 5 | yes |
| GO:0010647 | positive regulation of cell communication | 28.3019 | 5 | no |
| GO:0023056 | positive regulation of signaling | 28.3019 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.3019 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.3019 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 28.3019 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.3019 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 28.3019 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.4151 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 26.4151 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 26.4151 | 4 | no |
| GO:0043933 | protein-containing complex organization | 24.5283 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 24.5283 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.5283 | 6 | no |
| GO:0051050 | positive regulation of transport | 24.5283 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.6415 | 5 | yes |
| GO:0008104 | protein localization | 22.6415 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 22.6415 | 7 | no |
| GO:0034762 | regulation of transmembrane transport | 22.6415 | 4 | no |
| GO:0051051 | negative regulation of transport | 22.6415 | 4 | no |
| GO:0044057 | regulation of system process | 22.6415 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 20.7547 | 6 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 20.7547 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 20.7547 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 20.7547 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 20.7547 | 7 | no |
| GO:0043269 | regulation of monoatomic ion transport | 20.7547 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 18.8679 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 18.8679 | 6 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 18.8679 | 6 | yes |
| GO:0031400 | negative regulation of protein modification process | 16.9811 | 7 | yes |
| GO:0001933 | negative regulation of protein phosphorylation | 15.0943 | 8 | yes |
| GO:0010563 | negative regulation of phosphorus metabolic process | 15.0943 | 6 | yes |
| GO:0042326 | negative regulation of phosphorylation | 15.0943 | 8 | yes |
| GO:0045936 | negative regulation of phosphate metabolic process | 15.0943 | 7 | yes |
| GO:0010629 | negative regulation of gene expression | 13.2075 | 7 | yes |
| GO:0031175 | neuron projection development | 13.2075 | 6 | yes |
| GO:0007417 | central nervous system development | 11.3208 | 4 | yes |
| GO:0022411 | cellular component disassembly | 11.3208 | 4 | yes |
| GO:0016191 | synaptic vesicle uncoating | 9.4340 | 9 | yes |
| GO:0032984 | protein-containing complex disassembly | 9.4340 | 5 | yes |
| GO:0051261 | protein depolymerization | 9.4340 | 6 | yes |
| GO:0072318 | clathrin coat disassembly | 9.4340 | 8 | yes |
| GO:0072319 | vesicle uncoating | 9.4340 | 7 | yes |
| GO:0003018 | vascular process in circulatory system | 7.5472 | 4 | yes |
| GO:0071363 | cellular response to growth factor stimulus | 7.5472 | 4 | yes |
| GO:1990138 | neuron projection extension | 7.5472 | 4 | yes |
| GO:0097484 | dendrite extension | 5.6604 | 5 | yes |
| GO:1990089 | response to nerve growth factor | 5.6604 | 4 | yes |
| GO:1990090 | cellular response to nerve growth factor stimulus | 5.6604 | 5 | yes |
| GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus | 5.6604 | 6 | yes |
| GO:0043116 | negative regulation of vascular permeability | 3.7736 | 4 | yes |
| GO:1905603 | regulation of blood-brain barrier permeability | 3.7736 | 4 | yes |
| GO:1905604 | negative regulation of blood-brain barrier permeability | 3.7736 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SYNJ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ADA15_HUMAN | [view interactions] | Low throughput | no | yes |
| ADAM9_HUMAN | [view interactions] | Low throughput | no | no |
| PDC6I_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ATX2_HUMAN | [view interactions] | Low throughput | no | yes |
| SH3G3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SH3G2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VGLU1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RASD1_HUMAN | [view interactions] | Low throughput | no | yes |
| SH3K1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTN23_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ITCH_HUMAN | [view interactions] | Low throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRGP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAPH1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| M4K3_HUMAN | [view interactions] | Low throughput | no | no |
| AMPH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EMD_HUMAN | [view interactions] | Low throughput | no | yes |
| DYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DEN1A_HUMAN | [view interactions] | Low throughput | no | no |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| PACN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AGRB2_HUMAN | [view interactions] | Low throughput | no | no |
| CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CBL_HUMAN | [view interactions] | Low throughput | no | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| CD2AP_HUMAN | [view interactions] | Low throughput | no | no |
| ADA19_HUMAN | [view interactions] | Low throughput | no | no |
| DYR1A_HUMAN | [view interactions] | Low throughput | no | yes |
| SYNEM_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DRD2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FBX32_HUMAN | [view interactions] | Low throughput | no | no |
| SYN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAXI1_HUMAN | [view interactions] | High throughput | no | no |
| TETN_HUMAN | [view interactions] | High throughput | no | no |
| DACT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPPA4_HUMAN | [view interactions] | High throughput | no | no |
| DPYL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFL6_HUMAN | [view interactions] | High throughput | no | no |
| F13A_HUMAN | [view interactions] | High throughput | no | no |
| GCH1_HUMAN | [view interactions] | High throughput | no | no |
| GSTM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IGHM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPR21_HUMAN | [view interactions] | High throughput | no | yes |
| LCP2_HUMAN | [view interactions] | High throughput | no | yes |
| MAST2_HUMAN | [view interactions] | High throughput | no | yes |
| PRR14_HUMAN | [view interactions] | High throughput | no | no |
| PP6R1_HUMAN | [view interactions] | High throughput | no | no |
| TIAM2_HUMAN | [view interactions] | High throughput | no | yes |
| TM108_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TYSY_HUMAN | [view interactions] | High throughput | no | yes |
| ZN219_HUMAN | [view interactions] | High throughput | no | yes |
| ZN580_HUMAN | [view interactions] | High throughput | no | yes |
| ZXDC_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAP7_HUMAN | [view interactions] | High throughput | no | no |
| TNG2_HUMAN | [view interactions] | High throughput | no | yes |
| FL2D_HUMAN | [view interactions] | High throughput | no | yes |
| RHG08_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADRB3_HUMAN | [view interactions] | High throughput | no | no |
| ADA2A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HRH1_HUMAN | [view interactions] | High throughput | no | no |
| HRH3_HUMAN | [view interactions] | High throughput | no | no |
| ADA2B_HUMAN | [view interactions] | High throughput | no | no |
| DRD3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DRD4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARNT2_HUMAN | [view interactions] | High throughput | no | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERH_HUMAN | [view interactions] | High throughput | no | yes |
| DQA1_HUMAN | [view interactions] | High throughput | no | yes |
| IL6_HUMAN | [view interactions] | High throughput | no | no |
| TCEA2_HUMAN | [view interactions] | High throughput | no | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
| FYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX4_HUMAN | [view interactions] | High throughput | no | yes |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| DYN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| P4K2A_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| NCALD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| MET14_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPO11_HUMAN | [view interactions] | High throughput | no | yes |
| STAM2_HUMAN | [view interactions] | High throughput | no | yes |
| SYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |