Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DRD4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed, PubMed, PubMed, PubMed). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed, PubMed, PubMed, PubMed, PubMed). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DRD4_HUMAN
GO:0043169 cation binding 33.3333 4 yes
GO:0004930 G protein-coupled receptor activity 27.7778 4 yes
GO:0001664 G protein-coupled receptor binding 27.7778 4 no
GO:0008227 G protein-coupled amine receptor activity 22.2222 5 yes
GO:0015459 potassium channel regulator activity 22.2222 5 yes
GO:0046872 metal ion binding 22.2222 5 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 22.2222 4 yes
GO:0099106 ion channel regulator activity 22.2222 4 yes
GO:0019900 kinase binding 22.2222 4 no
GO:0031625 ubiquitin protein ligase binding 22.2222 5 no
GO:0044389 ubiquitin-like protein ligase binding 22.2222 4 no
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go 16.6667 6 yes
GO:0004952 dopamine neurotransmitter receptor activity 16.6667 5 yes
GO:0017124 SH3 domain binding 16.6667 4 yes
GO:0035240 dopamine binding 16.6667 4 yes
GO:0051380 norepinephrine binding 16.6667 4 yes
GO:0004993 G protein-coupled serotonin receptor activity 11.1111 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DRD4_HUMAN
GO:0048522 positive regulation of cellular process 77.7778 4 yes
GO:0051128 regulation of cellular component organization 77.7778 4 yes
GO:0010646 regulation of cell communication 72.2222 4 yes
GO:0048523 negative regulation of cellular process 72.2222 4 yes
GO:0009893 positive regulation of metabolic process 66.6667 4 yes
GO:0009966 regulation of signal transduction 66.6667 4 yes
GO:0031323 regulation of cellular metabolic process 66.6667 4 yes
GO:0031399 regulation of protein modification process 61.1111 6 yes
GO:0048584 positive regulation of response to stimulus 61.1111 4 yes
GO:0051246 regulation of protein metabolic process 61.1111 5 yes
GO:0060255 regulation of macromolecule metabolic process 61.1111 4 yes
GO:0080090 regulation of primary metabolic process 61.1111 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 55.5556 5 yes
GO:1902531 regulation of intracellular signal transduction 55.5556 5 yes
GO:0001932 regulation of protein phosphorylation 50.0000 7 yes
GO:0010647 positive regulation of cell communication 50.0000 5 yes
GO:0019220 regulation of phosphate metabolic process 50.0000 6 yes
GO:0023056 positive regulation of signaling 50.0000 4 yes
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 yes
GO:0042325 regulation of phosphorylation 50.0000 7 yes
GO:0051049 regulation of transport 50.0000 4 yes
GO:0051174 regulation of phosphorus metabolic process 50.0000 5 yes
GO:0051247 positive regulation of protein metabolic process 50.0000 6 yes
GO:0010648 negative regulation of cell communication 44.4444 5 no
GO:0023057 negative regulation of signaling 44.4444 4 no
GO:0009967 positive regulation of signal transduction 44.4444 5 yes
GO:0031401 positive regulation of protein modification process 44.4444 7 yes
GO:0043408 regulation of MAPK cascade 44.4444 6 yes
GO:1902533 positive regulation of intracellular signal transduction 44.4444 6 yes
GO:0009889 regulation of biosynthetic process 44.4444 4 no
GO:0010468 regulation of gene expression 44.4444 6 no
GO:0010556 regulation of macromolecule biosynthetic process 44.4444 5 no
GO:0031326 regulation of cellular biosynthetic process 44.4444 5 no
GO:0051130 positive regulation of cellular component organization 44.4444 5 no
GO:0009968 negative regulation of signal transduction 38.8889 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 38.8889 5 no
GO:0022607 cellular component assembly 38.8889 4 no
GO:0048585 negative regulation of response to stimulus 38.8889 4 no
GO:0051252 regulation of RNA metabolic process 38.8889 5 no
GO:2001141 regulation of RNA biosynthetic process 38.8889 6 no
GO:0010243 response to organonitrogen compound 38.8889 4 yes
GO:0043410 positive regulation of MAPK cascade 38.8889 7 yes
GO:0051050 positive regulation of transport 38.8889 4 yes
GO:0060627 regulation of vesicle-mediated transport 38.8889 4 yes
GO:0009892 negative regulation of metabolic process 38.8889 4 no
GO:0010605 negative regulation of macromolecule metabolic process 38.8889 5 no
GO:0031324 negative regulation of cellular metabolic process 38.8889 5 no
GO:0043933 protein-containing complex organization 38.8889 4 no
GO:0006355 regulation of DNA-templated transcription 38.8889 7 no
GO:0036211 protein modification process 33.3333 4 no
GO:0043412 macromolecule modification 33.3333 4 no
GO:0051241 negative regulation of multicellular organismal process 33.3333 4 no
GO:0009891 positive regulation of biosynthetic process 33.3333 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 33.3333 6 no
GO:0031328 positive regulation of cellular biosynthetic process 33.3333 6 no
GO:0051240 positive regulation of multicellular organismal process 33.3333 4 no
GO:0001934 positive regulation of protein phosphorylation 33.3333 8 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 33.3333 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 yes
GO:0030100 regulation of endocytosis 33.3333 5 yes
GO:0042327 positive regulation of phosphorylation 33.3333 8 yes
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 yes
GO:0048259 regulation of receptor-mediated endocytosis 33.3333 6 yes
GO:0071702 organic substance transport 33.3333 4 yes
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0098657 import into cell 33.3333 4 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:0006357 regulation of transcription by RNA polymerase II 33.3333 8 no
GO:0080134 regulation of response to stress 27.7778 4 no
GO:0090304 nucleic acid metabolic process 27.7778 4 no
GO:0045893 positive regulation of DNA-templated transcription 27.7778 8 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 27.7778 5 no
GO:0045944 positive regulation of transcription by RNA polymerase II 27.7778 9 no
GO:0051254 positive regulation of RNA metabolic process 27.7778 6 no
GO:1902680 positive regulation of RNA biosynthetic process 27.7778 7 no
GO:0050804 modulation of chemical synaptic transmission 27.7778 5 no
GO:0051094 positive regulation of developmental process 27.7778 4 no
GO:0099177 regulation of trans-synaptic signaling 27.7778 4 no
GO:0045595 regulation of cell differentiation 27.7778 4 no
GO:0002090 regulation of receptor internalization 27.7778 7 yes
GO:0008344 adult locomotory behavior 27.7778 4 yes
GO:0014070 response to organic cyclic compound 27.7778 4 yes
GO:0022898 regulation of transmembrane transporter activity 27.7778 4 yes
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 27.7778 5 yes
GO:0034762 regulation of transmembrane transport 27.7778 4 yes
GO:0009890 negative regulation of biosynthetic process 27.7778 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 27.7778 6 no
GO:0010629 negative regulation of gene expression 27.7778 7 no
GO:0030030 cell projection organization 27.7778 4 no
GO:0031327 negative regulation of cellular biosynthetic process 27.7778 6 no
GO:0031400 negative regulation of protein modification process 27.7778 7 no
GO:0051248 negative regulation of protein metabolic process 27.7778 6 no
GO:0006898 receptor-mediated endocytosis 27.7778 4 no
GO:0006996 organelle organization 27.7778 4 no
GO:0044087 regulation of cellular component biogenesis 27.7778 4 no
GO:0010564 regulation of cell cycle process 27.7778 5 no
GO:0051726 regulation of cell cycle 27.7778 4 no
GO:0001817 regulation of cytokine production 27.7778 4 no
GO:0009894 regulation of catabolic process 22.2222 4 no
GO:0010498 proteasomal protein catabolic process 22.2222 5 no
GO:0016567 protein ubiquitination 22.2222 8 no
GO:0019941 modification-dependent protein catabolic process 22.2222 6 no
GO:0030163 protein catabolic process 22.2222 4 no
GO:0031396 regulation of protein ubiquitination 22.2222 9 no
GO:0032446 protein modification by small protein conjugation 22.2222 7 no
GO:0042127 regulation of cell population proliferation 22.2222 4 no
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 22.2222 6 no
GO:0043632 modification-dependent macromolecule catabolic process 22.2222 5 no
GO:0043687 post-translational protein modification 22.2222 5 no
GO:0051603 proteolysis involved in protein catabolic process 22.2222 5 no
GO:0065003 protein-containing complex assembly 22.2222 5 no
GO:0070647 protein modification by small protein conjugation or removal 22.2222 6 no
GO:1901565 organonitrogen compound catabolic process 22.2222 4 no
GO:1901873 regulation of post-translational protein modification 22.2222 7 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 22.2222 8 no
GO:0008104 protein localization 22.2222 4 no
GO:0070372 regulation of ERK1 and ERK2 cascade 22.2222 7 no
GO:0070374 positive regulation of ERK1 and ERK2 cascade 22.2222 8 no
GO:0071705 nitrogen compound transport 22.2222 4 no
GO:0016070 RNA metabolic process 22.2222 5 no
GO:0040014 regulation of multicellular organism growth 22.2222 4 no
GO:0044057 regulation of system process 22.2222 4 no
GO:0048638 regulation of developmental growth 22.2222 4 no
GO:0045597 positive regulation of cell differentiation 22.2222 5 no
GO:0010628 positive regulation of gene expression 22.2222 7 no
GO:0031347 regulation of defense response 22.2222 5 no
GO:0032101 regulation of response to external stimulus 22.2222 4 no
GO:0050806 positive regulation of synaptic transmission 22.2222 5 no
GO:0002028 regulation of sodium ion transport 22.2222 7 yes
GO:0006873 intracellular monoatomic ion homeostasis 22.2222 4 yes
GO:0006874 intracellular calcium ion homeostasis 22.2222 5 yes
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 22.2222 5 yes
GO:0007268 chemical synaptic transmission 22.2222 7 yes
GO:0010959 regulation of metal ion transport 22.2222 6 yes
GO:0030003 intracellular monoatomic cation homeostasis 22.2222 5 yes
GO:0032880 regulation of protein localization 22.2222 5 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 22.2222 5 yes
GO:0043085 positive regulation of catalytic activity 22.2222 4 yes
GO:0043269 regulation of monoatomic ion transport 22.2222 5 yes
GO:0043549 regulation of kinase activity 22.2222 5 yes
GO:0045859 regulation of protein kinase activity 22.2222 6 yes
GO:0046903 secretion 22.2222 4 yes
GO:0051046 regulation of secretion 22.2222 5 yes
GO:0051051 negative regulation of transport 22.2222 4 yes
GO:0051338 regulation of transferase activity 22.2222 4 yes
GO:0051588 regulation of neurotransmitter transport 22.2222 5 yes
GO:0051590 positive regulation of neurotransmitter transport 22.2222 5 yes
GO:0051952 regulation of amine transport 22.2222 5 yes
GO:0051954 positive regulation of amine transport 22.2222 5 yes
GO:0055074 calcium ion homeostasis 22.2222 4 yes
GO:0055080 monoatomic cation homeostasis 22.2222 4 yes
GO:0060078 regulation of postsynaptic membrane potential 22.2222 4 yes
GO:0060341 regulation of cellular localization 22.2222 4 yes
GO:0098916 anterograde trans-synaptic signaling 22.2222 6 yes
GO:0099536 synaptic signaling 22.2222 4 yes
GO:0099537 trans-synaptic signaling 22.2222 5 yes
GO:1903530 regulation of secretion by cell 22.2222 4 yes
GO:0001933 negative regulation of protein phosphorylation 22.2222 8 no
GO:0007417 central nervous system development 22.2222 4 no
GO:0010563 negative regulation of phosphorus metabolic process 22.2222 6 no
GO:0042326 negative regulation of phosphorylation 22.2222 8 no
GO:0045936 negative regulation of phosphate metabolic process 22.2222 7 no
GO:0002684 positive regulation of immune system process 22.2222 4 no
GO:0031623 receptor internalization 22.2222 5 no
GO:0050776 regulation of immune response 22.2222 4 no
GO:1901701 cellular response to oxygen-containing compound 22.2222 4 no
GO:0006508 proteolysis 22.2222 4 no
GO:0006511 ubiquitin-dependent protein catabolic process 22.2222 7 no
GO:0009057 macromolecule catabolic process 22.2222 4 no
GO:0001975 response to amphetamine 16.6667 6 yes
GO:0006576 biogenic amine metabolic process 16.6667 5 yes
GO:0006584 catecholamine metabolic process 16.6667 6 yes
GO:0006869 lipid transport 16.6667 5 yes
GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway 16.6667 4 yes
GO:0009308 amine metabolic process 16.6667 4 yes
GO:0009712 catechol-containing compound metabolic process 16.6667 5 yes
GO:0014075 response to amine 16.6667 5 yes
GO:0015711 organic anion transport 16.6667 5 yes
GO:0015718 monocarboxylic acid transport 16.6667 7 yes
GO:0015849 organic acid transport 16.6667 5 yes
GO:0015908 fatty acid transport 16.6667 6 yes
GO:0015909 long-chain fatty acid transport 16.6667 7 yes
GO:0018958 phenol-containing compound metabolic process 16.6667 4 yes
GO:0032309 icosanoid secretion 16.6667 5 yes
GO:0032410 negative regulation of transporter activity 16.6667 4 yes
GO:0032411 positive regulation of transporter activity 16.6667 4 yes
GO:0032413 negative regulation of ion transmembrane transporter activity 16.6667 5 yes
GO:0032414 positive regulation of ion transmembrane transporter activity 16.6667 5 yes
GO:0033674 positive regulation of kinase activity 16.6667 6 yes
GO:0034763 negative regulation of transmembrane transport 16.6667 5 yes
GO:0034764 positive regulation of transmembrane transport 16.6667 5 yes
GO:0034766 negative regulation of monoatomic ion transmembrane transport 16.6667 6 yes
GO:0034767 positive regulation of monoatomic ion transmembrane transport 16.6667 6 yes
GO:0034776 response to histamine 16.6667 5 yes
GO:0042417 dopamine metabolic process 16.6667 7 yes
GO:0043270 positive regulation of monoatomic ion transport 16.6667 5 yes
GO:0043271 negative regulation of monoatomic ion transport 16.6667 5 yes
GO:0045860 positive regulation of protein kinase activity 16.6667 7 yes
GO:0046942 carboxylic acid transport 16.6667 6 yes
GO:0048148 behavioral response to cocaine 16.6667 4 yes
GO:0048149 behavioral response to ethanol 16.6667 4 yes
GO:0050482 arachidonic acid secretion 16.6667 6 yes
GO:0050708 regulation of protein secretion 16.6667 5 yes
GO:0050709 negative regulation of protein secretion 16.6667 6 yes
GO:0051048 negative regulation of secretion 16.6667 5 yes
GO:0051223 regulation of protein transport 16.6667 5 yes
GO:0051224 negative regulation of protein transport 16.6667 5 yes
GO:0051347 positive regulation of transferase activity 16.6667 5 yes
GO:0051580 regulation of neurotransmitter uptake 16.6667 6 yes
GO:0051582 positive regulation of neurotransmitter uptake 16.6667 6 yes
GO:0051584 regulation of dopamine uptake involved in synaptic transmission 16.6667 7 yes
GO:0051586 positive regulation of dopamine uptake involved in synaptic transmission 16.6667 7 yes
GO:0051924 regulation of calcium ion transport 16.6667 7 yes
GO:0051926 negative regulation of calcium ion transport 16.6667 6 yes
GO:0051940 regulation of catecholamine uptake involved in synaptic transmission 16.6667 6 yes
GO:0051944 positive regulation of catecholamine uptake involved in synaptic transmission 16.6667 6 yes
GO:0070201 regulation of establishment of protein localization 16.6667 6 yes
GO:0071715 icosanoid transport 16.6667 7 yes
GO:0071900 regulation of protein serine/threonine kinase activity 16.6667 7 yes
GO:0071902 positive regulation of protein serine/threonine kinase activity 16.6667 8 yes
GO:1901019 regulation of calcium ion transmembrane transporter activity 16.6667 6 yes
GO:1901020 negative regulation of calcium ion transmembrane transporter activity 16.6667 6 yes
GO:1901385 regulation of voltage-gated calcium channel activity 16.6667 7 yes
GO:1901386 negative regulation of voltage-gated calcium channel activity 16.6667 7 yes
GO:1903169 regulation of calcium ion transmembrane transport 16.6667 7 yes
GO:1903170 negative regulation of calcium ion transmembrane transport 16.6667 7 yes
GO:1903531 negative regulation of secretion by cell 16.6667 5 yes
GO:1903828 negative regulation of protein localization 16.6667 5 yes
GO:1903963 arachidonate transport 16.6667 8 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 16.6667 6 yes
GO:1904063 negative regulation of cation transmembrane transport 16.6667 7 yes
GO:1904950 negative regulation of establishment of protein localization 16.6667 6 yes
GO:2001257 regulation of cation channel activity 16.6667 6 yes
GO:2001258 negative regulation of cation channel activity 16.6667 6 yes
GO:0001662 behavioral fear response 11.1111 4 yes
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 11.1111 4 yes
GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway 11.1111 5 yes
GO:0010155 regulation of proton transport 11.1111 7 yes
GO:0010765 positive regulation of sodium ion transport 11.1111 6 yes
GO:0032415 regulation of sodium:proton antiporter activity 11.1111 7 yes
GO:0032417 positive regulation of sodium:proton antiporter activity 11.1111 7 yes
GO:0033238 regulation of amine metabolic process 11.1111 4 yes
GO:0042053 regulation of dopamine metabolic process 11.1111 6 yes
GO:0042069 regulation of catecholamine metabolic process 11.1111 5 yes
GO:0043405 regulation of MAP kinase activity 11.1111 8 yes
GO:0043406 positive regulation of MAP kinase activity 11.1111 8 yes
GO:0060080 inhibitory postsynaptic potential 11.1111 5 yes
GO:0098664 G protein-coupled serotonin receptor signaling pathway 11.1111 4 yes
GO:1902305 regulation of sodium ion transmembrane transport 11.1111 7 yes
GO:1902307 positive regulation of sodium ion transmembrane transport 11.1111 7 yes
GO:1904064 positive regulation of cation transmembrane transport 11.1111 7 yes
GO:2000649 regulation of sodium ion transmembrane transporter activity 11.1111 6 yes
GO:2000651 positive regulation of sodium ion transmembrane transporter activity 11.1111 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DRD4_HUMAN [view entry] [view interactions] Low throughput yes no
ADA1B_HUMAN [view interactions] Low throughput no no
ADRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
DRD2_HUMAN [view entry] [view interactions] Low throughput yes no
CLIC6_HUMAN [view interactions] Low throughput no no
KCNJ3_HUMAN [view interactions] Low throughput no yes
KCNJ9_HUMAN [view interactions] Low throughput no yes
KCNJ5_HUMAN [view interactions] Low throughput no yes
CUL3_HUMAN [view entry] [view interactions] Low throughput yes yes
KLH12_HUMAN [view interactions] Low throughput no no
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
CHIP_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
ADRB2_HUMAN [view entry] [view interactions] Low throughput yes no
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
NCK1_HUMAN [view interactions] Low throughput no yes
ADCY2_HUMAN [view interactions] Low throughput no yes
GNAI1_HUMAN [view entry] [view interactions] Low throughput yes yes
SH3G2_HUMAN [view entry] [view interactions] High throughput yes yes
SH3G3_HUMAN [view entry] [view interactions] High throughput yes no
SH3G1_HUMAN [view entry] [view interactions] High throughput yes no
NEUM_HUMAN [view entry] [view interactions] High throughput yes yes
STXB1_HUMAN [view entry] [view interactions] High throughput yes yes
MAP2_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
ATM_HUMAN [view interactions] High throughput no yes
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
INT1_HUMAN [view interactions] High throughput no yes
MRS2_HUMAN [view interactions] High throughput no no
CTR3_HUMAN [view interactions] High throughput no no
ARL10_HUMAN [view interactions] High throughput no yes
D19L3_HUMAN [view interactions] High throughput no yes
PIGM_HUMAN [view interactions] High throughput no no
TNPO2_HUMAN [view interactions] High throughput no yes