Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DRD4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed, PubMed, PubMed, PubMed). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed, PubMed, PubMed, PubMed, PubMed). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in DRD4_HUMAN
GO:0046872 metal ion binding 30.4348 4 yes
GO:0001664 G protein-coupled receptor binding 30.4348 4 no
GO:0004930 G protein-coupled receptor activity 26.0870 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 21.7391 4 yes
GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go 17.3913 6 yes
GO:0004952 dopamine neurotransmitter receptor activity 17.3913 5 yes
GO:0008227 G protein-coupled amine receptor activity 17.3913 5 yes
GO:0015459 potassium channel regulator activity 17.3913 4 yes
GO:0035240 dopamine binding 17.3913 4 yes
GO:0017124 SH3 domain binding 13.0435 4 yes
GO:0051380 norepinephrine binding 13.0435 4 yes
GO:0004993 G protein-coupled serotonin receptor activity 8.6957 5 yes
GO:0051379 epinephrine binding 8.6957 4 yes
GO:0099589 serotonin receptor activity 8.6957 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DRD4_HUMAN
GO:0048522 positive regulation of cellular process 73.9130 4 yes
GO:0010646 regulation of cell communication 65.2174 4 yes
GO:0048523 negative regulation of cellular process 65.2174 4 yes
GO:0051128 regulation of cellular component organization 65.2174 4 yes
GO:0009893 positive regulation of metabolic process 60.8696 4 yes
GO:0031323 regulation of cellular metabolic process 60.8696 4 yes
GO:0009966 regulation of signal transduction 56.5217 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 56.5217 4 yes
GO:0060255 regulation of macromolecule metabolic process 56.5217 4 yes
GO:0080090 regulation of primary metabolic process 56.5217 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 52.1739 5 yes
GO:0010243 response to organonitrogen compound 47.8261 4 yes
GO:0031325 positive regulation of cellular metabolic process 47.8261 5 yes
GO:0031399 regulation of protein modification process 47.8261 6 yes
GO:0048584 positive regulation of response to stimulus 47.8261 4 yes
GO:0051049 regulation of transport 47.8261 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 47.8261 5 yes
GO:0051246 regulation of protein metabolic process 47.8261 5 yes
GO:1902531 regulation of intracellular signal transduction 47.8261 5 yes
GO:0010468 regulation of gene expression 43.4783 5 no
GO:0010648 negative regulation of cell communication 43.4783 5 no
GO:0023057 negative regulation of signaling 43.4783 4 no
GO:0010647 positive regulation of cell communication 43.4783 5 yes
GO:0023056 positive regulation of signaling 43.4783 4 yes
GO:0051050 positive regulation of transport 43.4783 4 yes
GO:0051247 positive regulation of protein metabolic process 43.4783 6 yes
GO:0016192 vesicle-mediated transport 39.1304 4 no
GO:0033043 regulation of organelle organization 39.1304 5 no
GO:0048585 negative regulation of response to stimulus 39.1304 4 no
GO:0051130 positive regulation of cellular component organization 39.1304 5 no
GO:0001932 regulation of protein phosphorylation 39.1304 7 yes
GO:0009967 positive regulation of signal transduction 39.1304 5 yes
GO:0014070 response to organic cyclic compound 39.1304 4 yes
GO:0019220 regulation of phosphate metabolic process 39.1304 6 yes
GO:0031401 positive regulation of protein modification process 39.1304 7 yes
GO:0042325 regulation of phosphorylation 39.1304 7 yes
GO:0043269 regulation of ion transport 39.1304 5 yes
GO:0051174 regulation of phosphorus metabolic process 39.1304 5 yes
GO:0060627 regulation of vesicle-mediated transport 39.1304 4 yes
GO:0071702 organic substance transport 39.1304 4 yes
GO:0006355 regulation of DNA-templated transcription 34.7826 6 no
GO:0009889 regulation of biosynthetic process 34.7826 4 no
GO:0009968 negative regulation of signal transduction 34.7826 5 no
GO:0010556 regulation of macromolecule biosynthetic process 34.7826 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 34.7826 5 no
GO:0031326 regulation of cellular biosynthetic process 34.7826 5 no
GO:0043933 protein-containing complex organization 34.7826 4 no
GO:0051240 positive regulation of multicellular organismal process 34.7826 4 no
GO:0051241 negative regulation of multicellular organismal process 34.7826 4 no
GO:0051252 regulation of RNA metabolic process 34.7826 5 no
GO:0071310 cellular response to organic substance 34.7826 4 no
GO:1903506 regulation of nucleic acid-templated transcription 34.7826 7 no
GO:2001141 regulation of RNA biosynthetic process 34.7826 6 no
GO:0009892 negative regulation of metabolic process 34.7826 4 no
GO:0010605 negative regulation of macromolecule metabolic process 34.7826 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 34.7826 5 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 34.7826 4 yes
GO:0030100 regulation of endocytosis 34.7826 5 yes
GO:0043408 regulation of MAPK cascade 34.7826 6 yes
GO:0048259 regulation of receptor-mediated endocytosis 34.7826 6 yes
GO:1901565 organonitrogen compound catabolic process 30.4348 4 no
GO:0006357 regulation of transcription by RNA polymerase II 30.4348 7 no
GO:0006897 endocytosis 30.4348 5 no
GO:0009891 positive regulation of biosynthetic process 30.4348 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 30.4348 6 no
GO:0022607 cellular component assembly 30.4348 4 no
GO:0031328 positive regulation of cellular biosynthetic process 30.4348 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 30.4348 6 no
GO:0050804 modulation of chemical synaptic transmission 30.4348 5 no
GO:0051094 positive regulation of developmental process 30.4348 4 no
GO:0099177 regulation of trans-synaptic signaling 30.4348 4 no
GO:0051726 regulation of cell cycle 30.4348 4 no
GO:0045595 regulation of cell differentiation 30.4348 4 no
GO:0031324 negative regulation of cellular metabolic process 30.4348 5 no
GO:0001934 positive regulation of protein phosphorylation 30.4348 8 yes
GO:0002090 regulation of receptor internalization 30.4348 7 yes
GO:0006576 cellular biogenic amine metabolic process 30.4348 5 yes
GO:0006584 catecholamine metabolic process 30.4348 6 yes
GO:0009308 amine metabolic process 30.4348 4 yes
GO:0009712 catechol-containing compound metabolic process 30.4348 5 yes
GO:0010562 positive regulation of phosphorus metabolic process 30.4348 6 yes
GO:0018958 phenol-containing compound metabolic process 30.4348 4 yes
GO:0042327 positive regulation of phosphorylation 30.4348 8 yes
GO:0042417 dopamine metabolic process 30.4348 7 yes
GO:0043085 positive regulation of catalytic activity 30.4348 4 yes
GO:0043270 positive regulation of ion transport 30.4348 5 yes
GO:0043410 positive regulation of MAPK cascade 30.4348 7 yes
GO:0044106 cellular amine metabolic process 30.4348 4 yes
GO:0045937 positive regulation of phosphate metabolic process 30.4348 7 yes
GO:1902533 positive regulation of intracellular signal transduction 30.4348 6 yes
GO:2001257 regulation of cation channel activity 26.0870 6 yes
GO:0006898 receptor-mediated endocytosis 26.0870 6 no
GO:0045893 positive regulation of DNA-templated transcription 26.0870 7 no
GO:0045944 positive regulation of transcription by RNA polymerase II 26.0870 8 no
GO:0048638 regulation of developmental growth 26.0870 4 no
GO:0051254 positive regulation of RNA metabolic process 26.0870 6 no
GO:1902680 positive regulation of RNA biosynthetic process 26.0870 7 no
GO:1903508 positive regulation of nucleic acid-templated transcription 26.0870 8 no
GO:0010941 regulation of cell death 26.0870 4 no
GO:0060548 negative regulation of cell death 26.0870 5 no
GO:0010564 regulation of cell cycle process 26.0870 5 no
GO:0042127 regulation of cell population proliferation 26.0870 4 no
GO:0032101 regulation of response to external stimulus 26.0870 4 no
GO:0036211 protein modification process 26.0870 4 no
GO:0043412 macromolecule modification 26.0870 4 no
GO:0006811 ion transport 26.0870 4 yes
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 26.0870 5 yes
GO:0010959 regulation of metal ion transport 26.0870 6 yes
GO:0022898 regulation of transmembrane transporter activity 26.0870 4 yes
GO:0032412 regulation of ion transmembrane transporter activity 26.0870 5 yes
GO:0032880 regulation of protein localization 26.0870 5 yes
GO:0034762 regulation of transmembrane transport 26.0870 4 yes
GO:0034765 regulation of ion transmembrane transport 26.0870 5 yes
GO:0046903 secretion 26.0870 4 yes
GO:0051046 regulation of secretion 26.0870 5 yes
GO:0051338 regulation of transferase activity 26.0870 4 yes
GO:0051347 positive regulation of transferase activity 26.0870 5 yes
GO:0060341 regulation of cellular localization 26.0870 4 yes
GO:1903530 regulation of secretion by cell 26.0870 4 yes
GO:1904062 regulation of cation transmembrane transport 26.0870 6 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 21.7391 5 no
GO:0040014 regulation of multicellular organism growth 21.7391 4 no
GO:0044057 regulation of system process 21.7391 4 no
GO:0051093 negative regulation of developmental process 21.7391 4 no
GO:0065003 protein-containing complex assembly 21.7391 5 no
GO:1901701 cellular response to oxygen-containing compound 21.7391 4 no
GO:0006996 organelle organization 21.7391 4 no
GO:0042981 regulation of apoptotic process 21.7391 6 no
GO:0043067 regulation of programmed cell death 21.7391 5 no
GO:0044087 regulation of cellular component biogenesis 21.7391 4 no
GO:0050776 regulation of immune response 21.7391 4 no
GO:0071705 nitrogen compound transport 21.7391 4 no
GO:0010628 positive regulation of gene expression 21.7391 6 no
GO:0045787 positive regulation of cell cycle 21.7391 5 no
GO:0031623 receptor internalization 21.7391 7 no
GO:0030030 cell projection organization 21.7391 4 no
GO:0031400 negative regulation of protein modification process 21.7391 7 no
GO:0051248 negative regulation of protein metabolic process 21.7391 6 no
GO:0045597 positive regulation of cell differentiation 21.7391 5 no
GO:0002028 regulation of sodium ion transport 21.7391 7 yes
GO:0006873 cellular ion homeostasis 21.7391 4 yes
GO:0006874 cellular calcium ion homeostasis 21.7391 7 yes
GO:0006875 cellular metal ion homeostasis 21.7391 6 yes
GO:0008344 adult locomotory behavior 21.7391 4 yes
GO:0030003 cellular cation homeostasis 21.7391 5 yes
GO:0033674 positive regulation of kinase activity 21.7391 6 yes
GO:0043549 regulation of kinase activity 21.7391 5 yes
GO:0045859 regulation of protein kinase activity 21.7391 6 yes
GO:0045860 positive regulation of protein kinase activity 21.7391 7 yes
GO:0048878 chemical homeostasis 21.7391 4 yes
GO:0050801 ion homeostasis 21.7391 5 yes
GO:0051051 negative regulation of transport 21.7391 4 yes
GO:0051223 regulation of protein transport 21.7391 5 yes
GO:0051588 regulation of neurotransmitter transport 21.7391 5 yes
GO:0051924 regulation of calcium ion transport 21.7391 7 yes
GO:0051952 regulation of amine transport 21.7391 5 yes
GO:0055065 metal ion homeostasis 21.7391 7 yes
GO:0055074 calcium ion homeostasis 21.7391 8 yes
GO:0055080 cation homeostasis 21.7391 6 yes
GO:0070201 regulation of establishment of protein localization 21.7391 6 yes
GO:0072503 cellular divalent inorganic cation homeostasis 21.7391 6 yes
GO:0072507 divalent inorganic cation homeostasis 21.7391 7 yes
GO:0098771 inorganic ion homeostasis 21.7391 6 yes
GO:1903828 negative regulation of protein localization 21.7391 5 yes
GO:1904063 negative regulation of cation transmembrane transport 17.3913 7 yes
GO:1904950 negative regulation of establishment of protein localization 17.3913 6 yes
GO:2001258 negative regulation of cation channel activity 17.3913 6 yes
GO:0006820 anion transport 17.3913 5 yes
GO:0006869 lipid transport 17.3913 5 yes
GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway 17.3913 4 yes
GO:0007268 chemical synaptic transmission 17.3913 6 yes
GO:0015711 organic anion transport 17.3913 5 yes
GO:0015718 monocarboxylic acid transport 17.3913 7 yes
GO:0015849 organic acid transport 17.3913 5 yes
GO:0015908 fatty acid transport 17.3913 6 yes
GO:0015909 long-chain fatty acid transport 17.3913 7 yes
GO:0032309 icosanoid secretion 17.3913 5 yes
GO:0032410 negative regulation of transporter activity 17.3913 4 yes
GO:0032413 negative regulation of ion transmembrane transporter activity 17.3913 5 yes
GO:0034763 negative regulation of transmembrane transport 17.3913 5 yes
GO:0034766 negative regulation of ion transmembrane transport 17.3913 6 yes
GO:0034776 response to histamine 17.3913 5 yes
GO:0043271 negative regulation of ion transport 17.3913 5 yes
GO:0046942 carboxylic acid transport 17.3913 6 yes
GO:0048148 behavioral response to cocaine 17.3913 4 yes
GO:0050482 arachidonic acid secretion 17.3913 6 yes
GO:0050708 regulation of protein secretion 17.3913 5 yes
GO:0050709 negative regulation of protein secretion 17.3913 6 yes
GO:0051048 negative regulation of secretion 17.3913 5 yes
GO:0051224 negative regulation of protein transport 17.3913 5 yes
GO:0051580 regulation of neurotransmitter uptake 17.3913 4 yes
GO:0051584 regulation of dopamine uptake involved in synaptic transmission 17.3913 6 yes
GO:0051590 positive regulation of neurotransmitter transport 17.3913 5 yes
GO:0051926 negative regulation of calcium ion transport 17.3913 6 yes
GO:0051940 regulation of catecholamine uptake involved in synaptic transmission 17.3913 5 yes
GO:0051954 positive regulation of amine transport 17.3913 5 yes
GO:0060078 regulation of postsynaptic membrane potential 17.3913 4 yes
GO:0071715 icosanoid transport 17.3913 7 yes
GO:0071900 regulation of protein serine/threonine kinase activity 17.3913 7 yes
GO:0071902 positive regulation of protein serine/threonine kinase activity 17.3913 8 yes
GO:0098916 anterograde trans-synaptic signaling 17.3913 5 yes
GO:0099537 trans-synaptic signaling 17.3913 4 yes
GO:1901019 regulation of calcium ion transmembrane transporter activity 17.3913 6 yes
GO:1901020 negative regulation of calcium ion transmembrane transporter activity 17.3913 6 yes
GO:1901385 regulation of voltage-gated calcium channel activity 17.3913 7 yes
GO:1901386 negative regulation of voltage-gated calcium channel activity 17.3913 7 yes
GO:1903169 regulation of calcium ion transmembrane transport 17.3913 7 yes
GO:1903170 negative regulation of calcium ion transmembrane transport 17.3913 7 yes
GO:1903531 negative regulation of secretion by cell 17.3913 5 yes
GO:1903963 arachidonate transport 17.3913 8 yes
GO:1904064 positive regulation of cation transmembrane transport 13.0435 7 yes
GO:2000649 regulation of sodium ion transmembrane transporter activity 13.0435 6 yes
GO:0001975 response to amphetamine 13.0435 6 yes
GO:0010155 regulation of proton transport 13.0435 7 yes
GO:0014075 response to amine 13.0435 5 yes
GO:0032411 positive regulation of transporter activity 13.0435 4 yes
GO:0032414 positive regulation of ion transmembrane transporter activity 13.0435 5 yes
GO:0032415 regulation of sodium:proton antiporter activity 13.0435 7 yes
GO:0033238 regulation of cellular amine metabolic process 13.0435 5 yes
GO:0034764 positive regulation of transmembrane transport 13.0435 5 yes
GO:0034767 positive regulation of ion transmembrane transport 13.0435 6 yes
GO:0042053 regulation of dopamine metabolic process 13.0435 6 yes
GO:0042069 regulation of catecholamine metabolic process 13.0435 5 yes
GO:0043405 regulation of MAP kinase activity 13.0435 8 yes
GO:0043406 positive regulation of MAP kinase activity 13.0435 8 yes
GO:0048149 behavioral response to ethanol 13.0435 4 yes
GO:0051582 positive regulation of neurotransmitter uptake 13.0435 5 yes
GO:0051586 positive regulation of dopamine uptake involved in synaptic transmission 13.0435 6 yes
GO:0051944 positive regulation of catecholamine uptake involved in synaptic transmission 13.0435 6 yes
GO:1902305 regulation of sodium ion transmembrane transport 13.0435 7 yes
GO:2000651 positive regulation of sodium ion transmembrane transporter activity 8.6957 6 yes
GO:0001662 behavioral fear response 8.6957 4 yes
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 8.6957 4 yes
GO:0010765 positive regulation of sodium ion transport 8.6957 6 yes
GO:0032417 positive regulation of sodium:proton antiporter activity 8.6957 7 yes
GO:0060080 inhibitory postsynaptic potential 8.6957 5 yes
GO:1902307 positive regulation of sodium ion transmembrane transport 8.6957 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
NCK1_HUMAN [view interactions] Low throughput no yes
ADCY2_HUMAN [view interactions] Low throughput no yes
GNAI1_HUMAN [view entry] [view interactions] Low throughput yes yes
DRD4_HUMAN [view entry] [view interactions] Low throughput yes no
ADA1B_HUMAN [view interactions] Low throughput no no
ADRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
DRD2_HUMAN [view entry] [view interactions] Low throughput yes no
CLIC6_HUMAN [view interactions] Low throughput no no
KCNJ3_HUMAN [view interactions] Low throughput no yes
KCNJ9_HUMAN [view interactions] Low throughput no yes
KCNJ5_HUMAN [view interactions] Low throughput no yes
CUL3_HUMAN [view entry] [view interactions] Low throughput yes yes
KLH12_HUMAN [view interactions] Low throughput no no
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
CHIP_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
ADRB2_HUMAN [view entry] [view interactions] Low throughput yes no
PRKDC_HUMAN [view entry] [view interactions] High throughput yes yes
INT1_HUMAN [view interactions] High throughput no yes
MRS2_HUMAN [view interactions] High throughput no no
CTR3_HUMAN [view interactions] High throughput no no
ARL10_HUMAN [view interactions] High throughput no yes
D19L3_HUMAN [view interactions] High throughput no yes
PIGM_HUMAN [view interactions] High throughput no no
TNPO2_HUMAN [view interactions] High throughput no yes
SH3G2_HUMAN [view entry] [view interactions] High throughput yes yes
SH3G3_HUMAN [view entry] [view interactions] High throughput yes no
SH3G1_HUMAN [view entry] [view interactions] High throughput yes no
MAP2_HUMAN [view interactions] High throughput no yes
STXB1_HUMAN [view entry] [view interactions] High throughput yes yes
NEUM_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
ATM_HUMAN [view interactions] High throughput no yes
DRD3_HUMAN [view entry] [view interactions] Computational yes no
SC6A3_HUMAN [view entry] [view interactions] Computational yes yes
COMT_HUMAN [view entry] [view interactions] Computational yes yes
SC6A4_HUMAN [view entry] [view interactions] Computational yes no
AOFA_HUMAN [view entry] [view interactions] Computational yes yes