Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ADRB1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ADRB1_HUMAN
GO:0001664 G protein-coupled receptor binding 44.4444 4 yes
GO:0099106 ion channel regulator activity 27.7778 4 no
GO:0004930 G protein-coupled receptor activity 22.2222 4 yes
GO:0031690 adrenergic receptor binding 22.2222 5 yes
GO:0019900 kinase binding 22.2222 4 no
GO:0043169 cation binding 22.2222 4 no
GO:0008227 G protein-coupled amine receptor activity 16.6667 5 yes
GO:0030165 PDZ domain binding 16.6667 4 yes
GO:0004935 adrenergic receptor activity 11.1111 6 yes
GO:0004939 beta-adrenergic receptor activity 11.1111 7 yes
GO:0046982 protein heterodimerization activity 11.1111 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 11.1111 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ADRB1_HUMAN
GO:0060255 regulation of macromolecule metabolic process 72.2222 4 no
GO:0080090 regulation of primary metabolic process 72.2222 4 no
GO:0048523 negative regulation of cellular process 72.2222 4 no
GO:0051049 regulation of transport 72.2222 4 no
GO:0048522 positive regulation of cellular process 66.6667 4 no
GO:0051246 regulation of protein metabolic process 66.6667 5 no
GO:0009893 positive regulation of metabolic process 61.1111 4 yes
GO:0009966 regulation of signal transduction 61.1111 4 no
GO:0010646 regulation of cell communication 61.1111 4 no
GO:0031323 regulation of cellular metabolic process 61.1111 4 no
GO:0019220 regulation of phosphate metabolic process 55.5556 6 no
GO:0031399 regulation of protein modification process 55.5556 6 no
GO:0051174 regulation of phosphorus metabolic process 55.5556 5 no
GO:0008104 protein localization 50.0000 4 no
GO:0009892 negative regulation of metabolic process 50.0000 4 no
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:1902531 regulation of intracellular signal transduction 50.0000 5 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0044057 regulation of system process 44.4444 4 yes
GO:0009889 regulation of biosynthetic process 44.4444 4 no
GO:0010647 positive regulation of cell communication 44.4444 5 no
GO:0023056 positive regulation of signaling 44.4444 4 no
GO:0048584 positive regulation of response to stimulus 44.4444 4 no
GO:0010648 negative regulation of cell communication 44.4444 5 no
GO:0023057 negative regulation of signaling 44.4444 4 no
GO:0034762 regulation of transmembrane transport 44.4444 4 no
GO:0043269 regulation of monoatomic ion transport 44.4444 5 no
GO:0048585 negative regulation of response to stimulus 44.4444 4 no
GO:0051050 positive regulation of transport 44.4444 4 no
GO:0010604 positive regulation of macromolecule metabolic process 44.4444 5 no
GO:0051241 negative regulation of multicellular organismal process 38.8889 4 yes
GO:0009967 positive regulation of signal transduction 38.8889 5 no
GO:0010605 negative regulation of macromolecule metabolic process 38.8889 5 no
GO:0001932 regulation of protein phosphorylation 38.8889 7 no
GO:0010468 regulation of gene expression 38.8889 6 no
GO:0010556 regulation of macromolecule biosynthetic process 38.8889 5 no
GO:0031326 regulation of cellular biosynthetic process 38.8889 5 no
GO:0042325 regulation of phosphorylation 38.8889 7 no
GO:0043933 protein-containing complex organization 38.8889 4 no
GO:0009968 negative regulation of signal transduction 38.8889 5 no
GO:0010959 regulation of metal ion transport 38.8889 6 no
GO:0034765 regulation of monoatomic ion transmembrane transport 38.8889 5 no
GO:0010562 positive regulation of phosphorus metabolic process 38.8889 6 no
GO:0031401 positive regulation of protein modification process 38.8889 7 no
GO:0045937 positive regulation of phosphate metabolic process 38.8889 7 no
GO:0051247 positive regulation of protein metabolic process 38.8889 6 no
GO:0008016 regulation of heart contraction 33.3333 6 yes
GO:1903522 regulation of blood circulation 33.3333 5 yes
GO:0009891 positive regulation of biosynthetic process 33.3333 5 no
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 no
GO:0051248 negative regulation of protein metabolic process 33.3333 6 no
GO:0071702 organic substance transport 33.3333 4 no
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0022898 regulation of transmembrane transporter activity 33.3333 4 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 33.3333 5 no
GO:0043408 regulation of MAPK cascade 33.3333 6 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0030100 regulation of endocytosis 33.3333 5 no
GO:0048259 regulation of receptor-mediated endocytosis 33.3333 6 no
GO:0060627 regulation of vesicle-mediated transport 33.3333 4 no
GO:0003018 vascular process in circulatory system 27.7778 4 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 27.7778 4 yes
GO:0043085 positive regulation of catalytic activity 27.7778 4 yes
GO:0071705 nitrogen compound transport 27.7778 4 no
GO:0031400 negative regulation of protein modification process 27.7778 7 no
GO:0006937 regulation of muscle contraction 27.7778 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 27.7778 5 no
GO:0022607 cellular component assembly 27.7778 4 no
GO:0090257 regulation of muscle system process 27.7778 5 no
GO:1902532 negative regulation of intracellular signal transduction 27.7778 6 no
GO:1904062 regulation of monoatomic cation transmembrane transport 27.7778 6 no
GO:0001934 positive regulation of protein phosphorylation 27.7778 8 no
GO:0002090 regulation of receptor internalization 27.7778 7 no
GO:0042327 positive regulation of phosphorylation 27.7778 8 no
GO:0051051 negative regulation of transport 27.7778 4 no
GO:0031328 positive regulation of cellular biosynthetic process 27.7778 6 no
GO:0043410 positive regulation of MAPK cascade 27.7778 7 no
GO:0098657 import into cell 27.7778 4 no
GO:1902533 positive regulation of intracellular signal transduction 27.7778 6 no
GO:0010243 response to organonitrogen compound 27.7778 4 no
GO:0035150 regulation of tube size 22.2222 4 yes
GO:0035296 regulation of tube diameter 22.2222 5 yes
GO:0051240 positive regulation of multicellular organismal process 22.2222 4 yes
GO:0097746 blood vessel diameter maintenance 22.2222 5 yes
GO:0007268 chemical synaptic transmission 22.2222 7 no
GO:0009894 regulation of catabolic process 22.2222 4 no
GO:0071310 cellular response to organic substance 22.2222 4 no
GO:0098916 anterograde trans-synaptic signaling 22.2222 6 no
GO:0099536 synaptic signaling 22.2222 4 no
GO:0099537 trans-synaptic signaling 22.2222 5 no
GO:0009890 negative regulation of biosynthetic process 22.2222 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0010563 negative regulation of phosphorus metabolic process 22.2222 6 no
GO:0031327 negative regulation of cellular biosynthetic process 22.2222 6 no
GO:0045936 negative regulation of phosphate metabolic process 22.2222 7 no
GO:0002028 regulation of sodium ion transport 22.2222 7 no
GO:0006355 regulation of DNA-templated transcription 22.2222 7 no
GO:0006942 regulation of striated muscle contraction 22.2222 7 no
GO:0032880 regulation of protein localization 22.2222 5 no
GO:0043270 positive regulation of monoatomic ion transport 22.2222 5 no
GO:0051252 regulation of RNA metabolic process 22.2222 5 no
GO:0055117 regulation of cardiac muscle contraction 22.2222 7 no
GO:0060341 regulation of cellular localization 22.2222 4 no
GO:0065003 protein-containing complex assembly 22.2222 5 no
GO:0072657 protein localization to membrane 22.2222 4 no
GO:0141124 intracellular signaling cassette 22.2222 4 no
GO:2001141 regulation of RNA biosynthetic process 22.2222 6 no
GO:0051094 positive regulation of developmental process 22.2222 4 no
GO:0006898 receptor-mediated endocytosis 22.2222 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0015031 protein transport 22.2222 4 no
GO:0003085 negative regulation of systemic arterial blood pressure 16.6667 5 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 16.6667 5 yes
GO:0042311 vasodilation 16.6667 6 yes
GO:0045776 negative regulation of blood pressure 16.6667 4 yes
GO:0050795 regulation of behavior 16.6667 4 yes
GO:0071875 adrenergic receptor signaling pathway 16.6667 4 yes
GO:0002025 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure 11.1111 6 yes
GO:0010460 positive regulation of heart rate 11.1111 4 yes
GO:0031649 heat generation 11.1111 4 yes
GO:0040014 regulation of multicellular organism growth 11.1111 4 yes
GO:0040015 negative regulation of multicellular organism growth 11.1111 5 yes
GO:0042749 regulation of circadian sleep/wake cycle 11.1111 4 yes
GO:0045187 regulation of circadian sleep/wake cycle, sleep 11.1111 5 yes
GO:0045444 fat cell differentiation 11.1111 4 yes
GO:0045823 positive regulation of heart contraction 11.1111 6 yes
GO:0045926 negative regulation of growth 11.1111 4 yes
GO:0048638 regulation of developmental growth 11.1111 4 yes
GO:0048640 negative regulation of developmental growth 11.1111 5 yes
GO:0050873 brown fat cell differentiation 11.1111 5 yes
GO:0051093 negative regulation of developmental process 11.1111 4 yes
GO:0051336 regulation of hydrolase activity 11.1111 4 yes
GO:0051345 positive regulation of hydrolase activity 11.1111 5 yes
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 11.1111 5 yes
GO:0120161 regulation of cold-induced thermogenesis 11.1111 4 yes
GO:0120162 positive regulation of cold-induced thermogenesis 11.1111 5 yes
GO:1903524 positive regulation of blood circulation 11.1111 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MAGI1_HUMAN [view interactions] Low throughput no no
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGI3_HUMAN [view interactions] Low throughput no no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
GOPC_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
GIPC1_HUMAN [view entry] [view interactions] Low throughput yes yes
PDE4D_HUMAN [view entry] [view interactions] Low throughput yes yes
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
AA1R_HUMAN [view entry] [view interactions] Low throughput yes no
DRD4_HUMAN [view entry] [view interactions] Low throughput yes no
ADRB2_HUMAN [view entry] [view interactions] Low throughput yes no
UBP20_HUMAN [view interactions] Low throughput no yes
GASP1_HUMAN [view interactions] High throughput no yes
GASP2_HUMAN [view entry] [view interactions] High throughput yes yes
SH3G2_HUMAN [view entry] [view interactions] High throughput yes yes
SH3G1_HUMAN [view entry] [view interactions] High throughput yes no
SH3G3_HUMAN [view entry] [view interactions] High throughput yes no
SNTA1_HUMAN [view entry] [view interactions] High throughput yes no