Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ADRB1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ADRB1_HUMAN
GO:0001664 G protein-coupled receptor binding 54.5455 4 yes
GO:0046872 metal ion binding 31.8182 4 no
GO:0031690 adrenergic receptor binding 27.2727 5 yes
GO:0017076 purine nucleotide binding 27.2727 4 no
GO:0032555 purine ribonucleotide binding 27.2727 4 no
GO:0035639 purine ribonucleoside triphosphate binding 22.7273 4 no
GO:0004930 G protein-coupled receptor activity 18.1818 4 yes
GO:0008227 G protein-coupled amine receptor activity 13.6364 5 yes
GO:0030165 PDZ domain binding 13.6364 4 yes
GO:0004935 adrenergic receptor activity 9.0909 6 yes
GO:0004939 beta-adrenergic receptor activity 9.0909 7 yes
GO:0030695 GTPase regulator activity 9.0909 4 yes
GO:0046982 protein heterodimerization activity 9.0909 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 9.0909 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ADRB1_HUMAN
GO:0048523 negative regulation of cellular process 72.7273 4 no
GO:0051049 regulation of transport 68.1818 4 no
GO:0009893 positive regulation of metabolic process 63.6364 4 yes
GO:0009966 regulation of signal transduction 63.6364 4 no
GO:0010646 regulation of cell communication 63.6364 4 no
GO:0031323 regulation of cellular metabolic process 63.6364 4 no
GO:0048522 positive regulation of cellular process 63.6364 4 no
GO:0051171 regulation of nitrogen compound metabolic process 63.6364 4 no
GO:0051246 regulation of protein metabolic process 63.6364 5 no
GO:0060255 regulation of macromolecule metabolic process 63.6364 4 no
GO:0080090 regulation of primary metabolic process 63.6364 4 no
GO:0031399 regulation of protein modification process 54.5455 6 no
GO:0019220 regulation of phosphate metabolic process 50.0000 6 no
GO:0031325 positive regulation of cellular metabolic process 50.0000 5 no
GO:0043269 regulation of ion transport 50.0000 5 no
GO:0051174 regulation of phosphorus metabolic process 50.0000 5 no
GO:0010648 negative regulation of cell communication 45.4545 5 no
GO:0023057 negative regulation of signaling 45.4545 4 no
GO:0048585 negative regulation of response to stimulus 45.4545 4 no
GO:0051128 regulation of cellular component organization 45.4545 4 no
GO:1902531 regulation of intracellular signal transduction 45.4545 5 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 40.9091 4 yes
GO:0043085 positive regulation of catalytic activity 40.9091 4 yes
GO:0044057 regulation of system process 40.9091 4 yes
GO:0001932 regulation of protein phosphorylation 40.9091 7 no
GO:0008104 protein localization 40.9091 4 no
GO:0009892 negative regulation of metabolic process 40.9091 4 no
GO:0009968 negative regulation of signal transduction 40.9091 5 no
GO:0010604 positive regulation of macromolecule metabolic process 40.9091 5 no
GO:0010959 regulation of metal ion transport 40.9091 6 no
GO:0042325 regulation of phosphorylation 40.9091 7 no
GO:0048584 positive regulation of response to stimulus 40.9091 4 no
GO:0051050 positive regulation of transport 40.9091 4 no
GO:0060627 regulation of vesicle-mediated transport 40.9091 4 no
GO:0009967 positive regulation of signal transduction 36.3636 5 no
GO:0010562 positive regulation of phosphorus metabolic process 36.3636 6 no
GO:0010605 negative regulation of macromolecule metabolic process 36.3636 5 no
GO:0010647 positive regulation of cell communication 36.3636 5 no
GO:0023056 positive regulation of signaling 36.3636 4 no
GO:0031401 positive regulation of protein modification process 36.3636 7 no
GO:0045937 positive regulation of phosphate metabolic process 36.3636 7 no
GO:0051172 negative regulation of nitrogen compound metabolic process 36.3636 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 36.3636 5 no
GO:0051247 positive regulation of protein metabolic process 36.3636 6 no
GO:0034762 regulation of transmembrane transport 36.3636 4 no
GO:0034765 regulation of ion transmembrane transport 36.3636 5 no
GO:0051241 negative regulation of multicellular organismal process 31.8182 4 yes
GO:0001934 positive regulation of protein phosphorylation 31.8182 8 no
GO:0010468 regulation of gene expression 31.8182 5 no
GO:0042327 positive regulation of phosphorylation 31.8182 8 no
GO:0043408 regulation of MAPK cascade 31.8182 6 no
GO:0050804 modulation of chemical synaptic transmission 31.8182 5 no
GO:0051248 negative regulation of protein metabolic process 31.8182 6 no
GO:0099177 regulation of trans-synaptic signaling 31.8182 4 no
GO:0022898 regulation of transmembrane transporter activity 31.8182 4 no
GO:0032412 regulation of ion transmembrane transporter activity 31.8182 5 no
GO:0071310 cellular response to organic substance 31.8182 4 no
GO:1904062 regulation of cation transmembrane transport 31.8182 6 no
GO:0008016 regulation of heart contraction 27.2727 6 yes
GO:0051240 positive regulation of multicellular organismal process 27.2727 4 yes
GO:1903522 regulation of blood circulation 27.2727 5 yes
GO:0030100 regulation of endocytosis 27.2727 5 no
GO:0031324 negative regulation of cellular metabolic process 27.2727 5 no
GO:0031400 negative regulation of protein modification process 27.2727 7 no
GO:0043410 positive regulation of MAPK cascade 27.2727 7 no
GO:0048259 regulation of receptor-mediated endocytosis 27.2727 6 no
GO:0051130 positive regulation of cellular component organization 27.2727 5 no
GO:0071702 organic substance transport 27.2727 4 no
GO:1902533 positive regulation of intracellular signal transduction 27.2727 6 no
GO:0032880 regulation of protein localization 27.2727 5 no
GO:0051051 negative regulation of transport 27.2727 4 no
GO:0060341 regulation of cellular localization 27.2727 4 no
GO:0043933 protein-containing complex organization 27.2727 4 no
GO:2001257 regulation of cation channel activity 27.2727 6 no
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 22.7273 5 yes
GO:0002090 regulation of receptor internalization 22.7273 7 no
GO:0009889 regulation of biosynthetic process 22.7273 4 no
GO:0015031 protein transport 22.7273 4 no
GO:0016192 vesicle-mediated transport 22.7273 4 no
GO:0031326 regulation of cellular biosynthetic process 22.7273 5 no
GO:0043270 positive regulation of ion transport 22.7273 5 no
GO:0051924 regulation of calcium ion transport 22.7273 7 no
GO:0071705 nitrogen compound transport 22.7273 4 no
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 22.7273 5 no
GO:0009894 regulation of catabolic process 22.7273 4 no
GO:0042127 regulation of cell population proliferation 22.7273 4 no
GO:0006937 regulation of muscle contraction 22.7273 6 no
GO:0010243 response to organonitrogen compound 22.7273 4 no
GO:0022607 cellular component assembly 22.7273 4 no
GO:0090257 regulation of muscle system process 22.7273 5 no
GO:0033674 positive regulation of kinase activity 22.7273 6 no
GO:0043549 regulation of kinase activity 22.7273 5 no
GO:0045859 regulation of protein kinase activity 22.7273 6 no
GO:0045860 positive regulation of protein kinase activity 22.7273 7 no
GO:0051338 regulation of transferase activity 22.7273 4 no
GO:0051347 positive regulation of transferase activity 22.7273 5 no
GO:0003018 vascular process in circulatory system 18.1818 4 yes
GO:0031279 regulation of cyclase activity 18.1818 4 yes
GO:0045761 regulation of adenylate cyclase activity 18.1818 5 yes
GO:0051336 regulation of hydrolase activity 18.1818 4 yes
GO:0051339 regulation of lyase activity 18.1818 4 yes
GO:0003085 negative regulation of systemic arterial blood pressure 13.6364 5 yes
GO:0035150 regulation of tube size 13.6364 4 yes
GO:0035296 regulation of tube diameter 13.6364 5 yes
GO:0045776 negative regulation of blood pressure 13.6364 4 yes
GO:0050795 regulation of behavior 13.6364 4 yes
GO:0071875 adrenergic receptor signaling pathway 13.6364 4 yes
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 13.6364 5 yes
GO:0097746 blood vessel diameter maintenance 13.6364 5 yes
GO:0120162 positive regulation of cold-induced thermogenesis 13.6364 4 yes
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine 9.0909 5 yes
GO:0002025 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure 9.0909 6 yes
GO:0007190 activation of adenylate cyclase activity 9.0909 7 yes
GO:0010460 positive regulation of heart rate 9.0909 4 yes
GO:0031281 positive regulation of cyclase activity 9.0909 5 yes
GO:0031649 heat generation 9.0909 4 yes
GO:0040014 regulation of multicellular organism growth 9.0909 4 yes
GO:0040015 negative regulation of multicellular organism growth 9.0909 5 yes
GO:0042311 vasodilation 9.0909 6 yes
GO:0042749 regulation of circadian sleep/wake cycle 9.0909 4 yes
GO:0043087 regulation of GTPase activity 9.0909 5 yes
GO:0045187 regulation of circadian sleep/wake cycle, sleep 9.0909 5 yes
GO:0045444 fat cell differentiation 9.0909 4 yes
GO:0045762 positive regulation of adenylate cyclase activity 9.0909 6 yes
GO:0045823 positive regulation of heart contraction 9.0909 6 yes
GO:0045926 negative regulation of growth 9.0909 4 yes
GO:0048638 regulation of developmental growth 9.0909 4 yes
GO:0048640 negative regulation of developmental growth 9.0909 5 yes
GO:0050873 brown fat cell differentiation 9.0909 5 yes
GO:0051093 negative regulation of developmental process 9.0909 4 yes
GO:0051345 positive regulation of hydrolase activity 9.0909 5 yes
GO:0051349 positive regulation of lyase activity 9.0909 5 yes
GO:1903524 positive regulation of blood circulation 9.0909 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MAGI1_HUMAN [view interactions] Low throughput no no
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
MAGI3_HUMAN [view interactions] Low throughput no no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
GOPC_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG1_HUMAN [view entry] [view interactions] Low throughput yes yes
GIPC1_HUMAN [view entry] [view interactions] Low throughput yes yes
PDE4D_HUMAN [view entry] [view interactions] Low throughput yes yes
KAPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
ARRB2_HUMAN [view entry] [view interactions] Low throughput yes no
AA1R_HUMAN [view entry] [view interactions] Low throughput yes no
DRD4_HUMAN [view entry] [view interactions] Low throughput yes no
ADRB2_HUMAN [view entry] [view interactions] Low throughput yes no
UBP20_HUMAN [view interactions] Low throughput no yes
GASP1_HUMAN [view interactions] High throughput no yes
GASP2_HUMAN [view entry] [view interactions] High throughput yes yes
SH3G2_HUMAN [view entry] [view interactions] High throughput yes yes
SH3G1_HUMAN [view entry] [view interactions] High throughput yes no
SH3G3_HUMAN [view entry] [view interactions] High throughput yes no
SNTA1_HUMAN [view entry] [view interactions] High throughput yes no
GNAI3_HUMAN [view entry] [view interactions] Computational yes yes
GNAI1_HUMAN [view entry] [view interactions] Computational yes yes
GNAS1_HUMAN [view entry] [view interactions] Computational yes yes
ADCY5_HUMAN [view interactions] Computational no no
ADRB3_HUMAN [view interactions] Computational no no
ARRS_HUMAN [view interactions] Computational no no
GNAI2_HUMAN [view entry] [view interactions] Computational yes yes