Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AA1R_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AA1R_HUMAN
GO:0004930 G protein-coupled receptor activity 53.3333 4 yes
GO:0001664 G protein-coupled receptor binding 46.6667 4 yes
GO:0046872 metal ion binding 26.6667 4 no
GO:0003924 GTPase activity 26.6667 7 no
GO:0016462 pyrophosphatase activity 26.6667 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 26.6667 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 26.6667 6 no
GO:0017076 purine nucleotide binding 26.6667 4 no
GO:0032555 purine ribonucleotide binding 26.6667 4 no
GO:0035639 purine ribonucleoside triphosphate binding 26.6667 4 no
GO:0046982 protein heterodimerization activity 20.0000 4 yes
GO:0001609 G protein-coupled adenosine receptor activity 13.3333 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AA1R_HUMAN
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 80.0000 4 yes
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0010646 regulation of cell communication 60.0000 4 yes
GO:0031323 regulation of cellular metabolic process 60.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 53.3333 4 yes
GO:0080090 regulation of primary metabolic process 53.3333 4 yes
GO:0009893 positive regulation of metabolic process 53.3333 4 yes
GO:0009966 regulation of signal transduction 53.3333 4 yes
GO:0048523 negative regulation of cellular process 53.3333 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 53.3333 4 yes
GO:0099177 regulation of trans-synaptic signaling 46.6667 4 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 46.6667 5 no
GO:0010243 response to organonitrogen compound 46.6667 4 no
GO:0071310 cellular response to organic substance 46.6667 4 no
GO:0010647 positive regulation of cell communication 46.6667 5 yes
GO:0019220 regulation of phosphate metabolic process 46.6667 6 yes
GO:0023056 positive regulation of signaling 46.6667 4 yes
GO:0031399 regulation of protein modification process 46.6667 6 yes
GO:0043269 regulation of ion transport 46.6667 5 yes
GO:0044057 regulation of system process 46.6667 4 yes
GO:0048585 negative regulation of response to stimulus 46.6667 4 yes
GO:0050804 modulation of chemical synaptic transmission 46.6667 5 yes
GO:0051049 regulation of transport 46.6667 4 yes
GO:0051174 regulation of phosphorus metabolic process 46.6667 5 yes
GO:0051246 regulation of protein metabolic process 46.6667 5 yes
GO:1902531 regulation of intracellular signal transduction 40.0000 5 yes
GO:0010468 regulation of gene expression 40.0000 5 no
GO:0014070 response to organic cyclic compound 40.0000 4 no
GO:1901701 cellular response to oxygen-containing compound 40.0000 4 no
GO:0001932 regulation of protein phosphorylation 40.0000 7 yes
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 40.0000 5 yes
GO:0009967 positive regulation of signal transduction 40.0000 5 yes
GO:0010959 regulation of metal ion transport 40.0000 6 yes
GO:0031325 positive regulation of cellular metabolic process 40.0000 5 yes
GO:0042325 regulation of phosphorylation 40.0000 7 yes
GO:0043085 positive regulation of catalytic activity 40.0000 4 yes
GO:0048584 positive regulation of response to stimulus 40.0000 4 yes
GO:0051050 positive regulation of transport 40.0000 4 yes
GO:1902533 positive regulation of intracellular signal transduction 33.3333 6 yes
GO:1903530 regulation of secretion by cell 33.3333 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 no
GO:0051252 regulation of RNA metabolic process 33.3333 5 no
GO:0003018 vascular process in circulatory system 33.3333 4 no
GO:0035150 regulation of tube size 33.3333 4 no
GO:0035296 regulation of tube diameter 33.3333 5 no
GO:0051240 positive regulation of multicellular organismal process 33.3333 4 no
GO:0097746 blood vessel diameter maintenance 33.3333 5 no
GO:0071407 cellular response to organic cyclic compound 33.3333 5 no
GO:0071417 cellular response to organonitrogen compound 33.3333 4 no
GO:1901699 cellular response to nitrogen compound 33.3333 4 no
GO:0031279 regulation of cyclase activity 33.3333 4 no
GO:0045761 regulation of adenylate cyclase activity 33.3333 5 no
GO:0051339 regulation of lyase activity 33.3333 4 no
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 yes
GO:0010648 negative regulation of cell communication 33.3333 5 yes
GO:0023057 negative regulation of signaling 33.3333 4 yes
GO:0043270 positive regulation of ion transport 33.3333 5 yes
GO:0043408 regulation of MAPK cascade 33.3333 6 yes
GO:0043410 positive regulation of MAPK cascade 33.3333 7 yes
GO:0051046 regulation of secretion 33.3333 5 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 26.6667 6 yes
GO:0060548 negative regulation of cell death 26.6667 5 yes
GO:0006355 regulation of DNA-templated transcription 26.6667 6 no
GO:0007600 sensory perception 26.6667 4 no
GO:0009889 regulation of biosynthetic process 26.6667 4 no
GO:0010556 regulation of macromolecule biosynthetic process 26.6667 5 no
GO:0017157 regulation of exocytosis 26.6667 5 no
GO:0031326 regulation of cellular biosynthetic process 26.6667 5 no
GO:0042311 vasodilation 26.6667 6 no
GO:0051924 regulation of calcium ion transport 26.6667 7 no
GO:0060627 regulation of vesicle-mediated transport 26.6667 4 no
GO:1903305 regulation of regulated secretory pathway 26.6667 6 no
GO:1903506 regulation of nucleic acid-templated transcription 26.6667 7 no
GO:2001141 regulation of RNA biosynthetic process 26.6667 6 no
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 26.6667 4 no
GO:0001934 positive regulation of protein phosphorylation 26.6667 8 yes
GO:0009892 negative regulation of metabolic process 26.6667 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 26.6667 6 yes
GO:0010941 regulation of cell death 26.6667 4 yes
GO:0031401 positive regulation of protein modification process 26.6667 7 yes
GO:0031644 regulation of nervous system process 26.6667 5 yes
GO:0032101 regulation of response to external stimulus 26.6667 4 yes
GO:0032102 negative regulation of response to external stimulus 26.6667 5 yes
GO:0042127 regulation of cell population proliferation 26.6667 4 yes
GO:0042327 positive regulation of phosphorylation 26.6667 8 yes
GO:0042981 regulation of apoptotic process 26.6667 6 yes
GO:0043066 negative regulation of apoptotic process 26.6667 7 yes
GO:0043067 regulation of programmed cell death 26.6667 5 yes
GO:0043069 negative regulation of programmed cell death 26.6667 6 yes
GO:0045937 positive regulation of phosphate metabolic process 26.6667 7 yes
GO:0051047 positive regulation of secretion 26.6667 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 26.6667 5 yes
GO:0051241 negative regulation of multicellular organismal process 26.6667 4 yes
GO:0051247 positive regulation of protein metabolic process 26.6667 6 yes
GO:0051952 regulation of amine transport 26.6667 5 yes
GO:0071702 organic substance transport 20.0000 4 yes
GO:0071705 nitrogen compound transport 20.0000 4 yes
GO:0080134 regulation of response to stress 20.0000 4 yes
GO:0098801 regulation of renal system process 20.0000 5 yes
GO:1903531 negative regulation of secretion by cell 20.0000 5 yes
GO:2000145 regulation of cell motility 20.0000 4 yes
GO:0003085 negative regulation of systemic arterial blood pressure 20.0000 5 yes
GO:0008104 protein localization 20.0000 4 yes
GO:0009894 regulation of catabolic process 20.0000 4 yes
GO:0009896 positive regulation of catabolic process 20.0000 5 yes
GO:0016192 vesicle-mediated transport 20.0000 4 yes
GO:0030334 regulation of cell migration 20.0000 5 yes
GO:0031347 regulation of defense response 20.0000 5 yes
GO:0031348 negative regulation of defense response 20.0000 5 yes
GO:0035813 regulation of renal sodium excretion 20.0000 6 yes
GO:0042749 regulation of circadian sleep/wake cycle 20.0000 4 yes
GO:0043549 regulation of kinase activity 20.0000 5 yes
GO:0044062 regulation of excretion 20.0000 5 yes
GO:0045187 regulation of circadian sleep/wake cycle, sleep 20.0000 5 yes
GO:0045776 negative regulation of blood pressure 20.0000 4 yes
GO:0045859 regulation of protein kinase activity 20.0000 6 yes
GO:0050727 regulation of inflammatory response 20.0000 5 yes
GO:0050728 negative regulation of inflammatory response 20.0000 6 yes
GO:0050795 regulation of behavior 20.0000 4 yes
GO:0050805 negative regulation of synaptic transmission 20.0000 5 yes
GO:0050806 positive regulation of synaptic transmission 20.0000 5 yes
GO:0051048 negative regulation of secretion 20.0000 5 yes
GO:0051051 negative regulation of transport 20.0000 4 yes
GO:0051338 regulation of transferase activity 20.0000 4 yes
GO:0051930 regulation of sensory perception of pain 20.0000 7 yes
GO:0051931 regulation of sensory perception 20.0000 6 yes
GO:0051955 regulation of amino acid transport 13.3333 6 yes
GO:0060078 regulation of postsynaptic membrane potential 13.3333 4 yes
GO:0060079 excitatory postsynaptic potential 13.3333 5 yes
GO:0072657 protein localization to membrane 13.3333 4 yes
GO:0090075 relaxation of muscle 13.3333 4 yes
GO:0090257 regulation of muscle system process 13.3333 5 yes
GO:1900271 regulation of long-term synaptic potentiation 13.3333 4 yes
GO:1901214 regulation of neuron death 13.3333 5 yes
GO:1903522 regulation of blood circulation 13.3333 5 yes
GO:2000273 positive regulation of signaling receptor activity 13.3333 4 yes
GO:0002683 negative regulation of immune system process 13.3333 4 yes
GO:0006886 intracellular protein transport 13.3333 4 yes
GO:0006909 phagocytosis 13.3333 5 yes
GO:0006937 regulation of muscle contraction 13.3333 6 yes
GO:0006940 regulation of smooth muscle contraction 13.3333 7 yes
GO:0006954 inflammatory response 13.3333 4 yes
GO:0008016 regulation of heart contraction 13.3333 6 yes
GO:0008285 negative regulation of cell population proliferation 13.3333 5 yes
GO:0010942 positive regulation of cell death 13.3333 5 yes
GO:0014048 regulation of glutamate secretion 13.3333 5 yes
GO:0015031 protein transport 13.3333 4 yes
GO:0032228 regulation of synaptic transmission, GABAergic 13.3333 6 yes
GO:0032890 regulation of organic acid transport 13.3333 5 yes
GO:0033674 positive regulation of kinase activity 13.3333 6 yes
GO:0035303 regulation of dephosphorylation 13.3333 7 yes
GO:0035304 regulation of protein dephosphorylation 13.3333 7 yes
GO:0036293 response to decreased oxygen levels 13.3333 4 yes
GO:0040013 negative regulation of locomotion 13.3333 4 yes
GO:0043266 regulation of potassium ion transport 13.3333 7 yes
GO:0043268 positive regulation of potassium ion transport 13.3333 6 yes
GO:0043271 negative regulation of ion transport 13.3333 5 yes
GO:0044070 regulation of anion transport 13.3333 6 yes
GO:0045860 positive regulation of protein kinase activity 13.3333 7 yes
GO:0045932 negative regulation of muscle contraction 13.3333 5 yes
GO:0045986 negative regulation of smooth muscle contraction 13.3333 6 yes
GO:0046883 regulation of hormone secretion 13.3333 4 yes
GO:0048878 chemical homeostasis 13.3333 4 yes
GO:0050890 cognition 13.3333 4 yes
GO:0051347 positive regulation of transferase activity 13.3333 5 yes
GO:0051953 negative regulation of amine transport 13.3333 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AA2AR_HUMAN [view entry] [view interactions] Low throughput yes yes
ADRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
ADRB2_HUMAN [view entry] [view interactions] Low throughput yes no
P2RY1_HUMAN [view entry] [view interactions] Low throughput yes yes
DRD1_HUMAN [view entry] [view interactions] Low throughput yes no
GNAI2_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM1_HUMAN [view entry] [view interactions] Low throughput yes yes
EGFR_HUMAN [view interactions] Low throughput no no
ADA_HUMAN [view interactions] Low throughput no no
TSHR_HUMAN [view interactions] High throughput no no
SNF8_HUMAN [view interactions] High throughput no yes
ATX1L_HUMAN [view interactions] High throughput no no
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
UBAC2_HUMAN [view interactions] High throughput no yes
PELI3_HUMAN [view interactions] High throughput no yes
VINEX_HUMAN [view interactions] High throughput no no
BRI3B_HUMAN [view interactions] High throughput no yes
UFD1_HUMAN [view interactions] High throughput no no
NPL4_HUMAN [view interactions] High throughput no yes
GBB1_HUMAN [view entry] [view interactions] Computational yes yes
GBG2_HUMAN [view entry] [view interactions] Computational yes yes
BKRB2_HUMAN [view interactions] Computational no yes
GNAI3_HUMAN [view entry] [view interactions] Computational yes yes
GNAI1_HUMAN [view entry] [view interactions] Computational yes yes
OPRD_HUMAN [view entry] [view interactions] Computational yes no
5NTD_HUMAN [view entry] [view interactions] Computational yes yes
AA2BR_HUMAN [view interactions] Computational no no