Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AA1R_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AA1R_HUMAN
GO:0004930 G protein-coupled receptor activity 77.7778 4 yes
GO:0001664 G protein-coupled receptor binding 55.5556 4 yes
GO:0046982 protein heterodimerization activity 33.3333 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 33.3333 4 no
GO:0043169 cation binding 33.3333 4 no
GO:0099528 G protein-coupled neurotransmitter receptor activity 22.2222 4 no
GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential 22.2222 5 no
GO:0004935 adrenergic receptor activity 22.2222 6 no
GO:0004939 beta-adrenergic receptor activity 22.2222 7 no
GO:0008227 G protein-coupled amine receptor activity 22.2222 5 no
GO:0000166 nucleotide binding 22.2222 4 no
GO:0017076 purine nucleotide binding 22.2222 5 no
GO:0032555 purine ribonucleotide binding 22.2222 4 no
GO:0035639 purine ribonucleoside triphosphate binding 22.2222 4 no
GO:0043168 anion binding 22.2222 4 no
GO:0001609 G protein-coupled adenosine receptor activity 22.2222 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AA1R_HUMAN
GO:0048522 positive regulation of cellular process 77.7778 4 yes
GO:0050804 modulation of chemical synaptic transmission 77.7778 5 yes
GO:0099177 regulation of trans-synaptic signaling 77.7778 4 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 77.7778 4 yes
GO:0010646 regulation of cell communication 77.7778 4 yes
GO:0010647 positive regulation of cell communication 77.7778 5 yes
GO:0023056 positive regulation of signaling 77.7778 4 yes
GO:0031323 regulation of cellular metabolic process 77.7778 4 yes
GO:0048523 negative regulation of cellular process 66.6667 4 yes
GO:0048584 positive regulation of response to stimulus 66.6667 4 yes
GO:0051049 regulation of transport 66.6667 4 yes
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 yes
GO:0080090 regulation of primary metabolic process 66.6667 4 yes
GO:0097746 blood vessel diameter maintenance 66.6667 5 yes
GO:0003018 vascular process in circulatory system 66.6667 4 yes
GO:0009966 regulation of signal transduction 66.6667 4 yes
GO:0009967 positive regulation of signal transduction 66.6667 5 yes
GO:0035150 regulation of tube size 66.6667 4 yes
GO:0035296 regulation of tube diameter 66.6667 5 yes
GO:0043269 regulation of monoatomic ion transport 66.6667 5 yes
GO:0048585 negative regulation of response to stimulus 55.5556 4 yes
GO:0051050 positive regulation of transport 55.5556 4 yes
GO:0051241 negative regulation of multicellular organismal process 55.5556 4 yes
GO:1902531 regulation of intracellular signal transduction 55.5556 5 yes
GO:1902533 positive regulation of intracellular signal transduction 55.5556 6 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 55.5556 5 no
GO:0009893 positive regulation of metabolic process 55.5556 4 yes
GO:0010243 response to organonitrogen compound 55.5556 4 yes
GO:0010959 regulation of metal ion transport 55.5556 6 yes
GO:0042311 vasodilation 55.5556 6 yes
GO:0043408 regulation of MAPK cascade 55.5556 6 yes
GO:0043410 positive regulation of MAPK cascade 55.5556 7 yes
GO:0051046 regulation of secretion 44.4444 5 yes
GO:0051174 regulation of phosphorus metabolic process 44.4444 5 yes
GO:0051246 regulation of protein metabolic process 44.4444 5 yes
GO:0051952 regulation of amine transport 44.4444 5 yes
GO:0051966 regulation of synaptic transmission, glutamatergic 44.4444 6 yes
GO:0098657 import into cell 44.4444 4 yes
GO:1903530 regulation of secretion by cell 44.4444 4 yes
GO:0009889 regulation of biosynthetic process 44.4444 4 no
GO:0010468 regulation of gene expression 44.4444 6 no
GO:0010556 regulation of macromolecule biosynthetic process 44.4444 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 44.4444 5 no
GO:0031326 regulation of cellular biosynthetic process 44.4444 5 no
GO:0051252 regulation of RNA metabolic process 44.4444 5 no
GO:0051240 positive regulation of multicellular organismal process 44.4444 4 no
GO:0010648 negative regulation of cell communication 44.4444 5 yes
GO:0014070 response to organic cyclic compound 44.4444 4 yes
GO:0019220 regulation of phosphate metabolic process 44.4444 6 yes
GO:0023057 negative regulation of signaling 44.4444 4 yes
GO:0031325 positive regulation of cellular metabolic process 44.4444 5 yes
GO:0031399 regulation of protein modification process 44.4444 6 yes
GO:0043270 positive regulation of monoatomic ion transport 44.4444 5 yes
GO:0044057 regulation of system process 44.4444 4 yes
GO:0050795 regulation of behavior 33.3333 4 yes
GO:0050805 negative regulation of synaptic transmission 33.3333 5 yes
GO:0050806 positive regulation of synaptic transmission 33.3333 5 yes
GO:0051047 positive regulation of secretion 33.3333 5 yes
GO:0051048 negative regulation of secretion 33.3333 5 yes
GO:0051051 negative regulation of transport 33.3333 4 yes
GO:0051247 positive regulation of protein metabolic process 33.3333 6 yes
GO:1903531 negative regulation of secretion by cell 33.3333 5 yes
GO:2000145 regulation of cell motility 33.3333 4 yes
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 33.3333 4 no
GO:0007268 chemical synaptic transmission 33.3333 7 no
GO:0098916 anterograde trans-synaptic signaling 33.3333 6 no
GO:0099536 synaptic signaling 33.3333 4 no
GO:0099537 trans-synaptic signaling 33.3333 5 no
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0006355 regulation of DNA-templated transcription 33.3333 7 no
GO:0031279 regulation of cyclase activity 33.3333 4 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0043085 positive regulation of catalytic activity 33.3333 4 no
GO:0045761 regulation of adenylate cyclase activity 33.3333 5 no
GO:0051339 regulation of lyase activity 33.3333 4 no
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:0071417 cellular response to organonitrogen compound 33.3333 4 no
GO:0071875 adrenergic receptor signaling pathway 33.3333 4 no
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 33.3333 5 no
GO:1901699 cellular response to nitrogen compound 33.3333 4 no
GO:1901701 cellular response to oxygen-containing compound 33.3333 4 no
GO:2001141 regulation of RNA biosynthetic process 33.3333 6 no
GO:0001973 G protein-coupled adenosine receptor signaling pathway 33.3333 5 no
GO:0035588 G protein-coupled purinergic receptor signaling pathway 33.3333 4 no
GO:0035590 purinergic nucleotide receptor signaling pathway 33.3333 4 no
GO:0051924 regulation of calcium ion transport 33.3333 7 no
GO:0003085 negative regulation of systemic arterial blood pressure 33.3333 5 yes
GO:0051588 regulation of neurotransmitter transport 33.3333 5 no
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 33.3333 5 yes
GO:0008104 protein localization 33.3333 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 yes
GO:0010604 positive regulation of macromolecule metabolic process 33.3333 5 yes
GO:0014074 response to purine-containing compound 33.3333 5 yes
GO:0030334 regulation of cell migration 33.3333 5 yes
GO:0031401 positive regulation of protein modification process 33.3333 7 yes
GO:0031644 regulation of nervous system process 33.3333 5 yes
GO:0032101 regulation of response to external stimulus 33.3333 4 yes
GO:0032102 negative regulation of response to external stimulus 33.3333 5 yes
GO:0042127 regulation of cell population proliferation 33.3333 4 yes
GO:0042749 regulation of circadian sleep/wake cycle 33.3333 4 yes
GO:0042981 regulation of apoptotic process 33.3333 5 yes
GO:0043066 negative regulation of apoptotic process 33.3333 6 yes
GO:0043067 regulation of programmed cell death 33.3333 4 yes
GO:0043069 negative regulation of programmed cell death 33.3333 5 yes
GO:0045187 regulation of circadian sleep/wake cycle, sleep 33.3333 5 yes
GO:0045776 negative regulation of blood pressure 33.3333 4 yes
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 yes
GO:0050727 regulation of inflammatory response 22.2222 5 yes
GO:0050728 negative regulation of inflammatory response 22.2222 6 yes
GO:0050890 cognition 22.2222 4 yes
GO:0051480 regulation of cytosolic calcium ion concentration 22.2222 6 yes
GO:0051930 regulation of sensory perception of pain 22.2222 7 yes
GO:0051931 regulation of sensory perception 22.2222 6 yes
GO:0051953 negative regulation of amine transport 22.2222 5 yes
GO:0051955 regulation of amino acid transport 22.2222 6 yes
GO:0055074 calcium ion homeostasis 22.2222 4 yes
GO:0055080 monoatomic cation homeostasis 22.2222 4 yes
GO:0060078 regulation of postsynaptic membrane potential 22.2222 4 yes
GO:0060079 excitatory postsynaptic potential 22.2222 5 yes
GO:0060292 long-term synaptic depression 22.2222 4 yes
GO:0072657 protein localization to membrane 22.2222 4 yes
GO:0080134 regulation of response to stress 22.2222 4 yes
GO:0090257 regulation of muscle system process 22.2222 5 yes
GO:0099509 regulation of presynaptic cytosolic calcium ion concentration 22.2222 4 yes
GO:1900271 regulation of long-term synaptic potentiation 22.2222 4 yes
GO:1903522 regulation of blood circulation 22.2222 5 yes
GO:0016070 RNA metabolic process 22.2222 5 no
GO:0090304 nucleic acid metabolic process 22.2222 4 no
GO:0007600 sensory perception 22.2222 4 no
GO:0071702 organic substance transport 22.2222 4 no
GO:0071705 nitrogen compound transport 22.2222 4 no
GO:0001934 positive regulation of protein phosphorylation 22.2222 8 no
GO:0002025 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure 22.2222 6 no
GO:0006357 regulation of transcription by RNA polymerase II 22.2222 8 no
GO:0006936 muscle contraction 22.2222 4 no
GO:0006939 smooth muscle contraction 22.2222 5 no
GO:0007190 activation of adenylate cyclase activity 22.2222 7 no
GO:0008277 regulation of G protein-coupled receptor signaling pathway 22.2222 5 no
GO:0009891 positive regulation of biosynthetic process 22.2222 5 no
GO:0009968 negative regulation of signal transduction 22.2222 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.2222 6 no
GO:0022607 cellular component assembly 22.2222 4 no
GO:0031281 positive regulation of cyclase activity 22.2222 5 no
GO:0031328 positive regulation of cellular biosynthetic process 22.2222 6 no
GO:0031649 heat generation 22.2222 4 no
GO:0034762 regulation of transmembrane transport 22.2222 4 no
GO:0034764 positive regulation of transmembrane transport 22.2222 5 no
GO:0034765 regulation of monoatomic ion transmembrane transport 22.2222 5 no
GO:0034767 positive regulation of monoatomic ion transmembrane transport 22.2222 6 no
GO:0040014 regulation of multicellular organism growth 22.2222 4 no
GO:0040015 negative regulation of multicellular organism growth 22.2222 5 no
GO:0042327 positive regulation of phosphorylation 22.2222 8 no
GO:0045444 fat cell differentiation 22.2222 4 no
GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 22.2222 6 no
GO:0045762 positive regulation of adenylate cyclase activity 22.2222 6 no
GO:0045893 positive regulation of DNA-templated transcription 22.2222 8 no
GO:0045926 negative regulation of growth 22.2222 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 22.2222 5 no
GO:0045944 positive regulation of transcription by RNA polymerase II 22.2222 9 no
GO:0048638 regulation of developmental growth 22.2222 4 no
GO:0048640 negative regulation of developmental growth 22.2222 5 no
GO:0050873 brown fat cell differentiation 22.2222 5 no
GO:0051093 negative regulation of developmental process 22.2222 4 no
GO:0051254 positive regulation of RNA metabolic process 22.2222 6 no
GO:0051349 positive regulation of lyase activity 22.2222 5 no
GO:0120161 regulation of cold-induced thermogenesis 22.2222 4 no
GO:0120162 positive regulation of cold-induced thermogenesis 22.2222 5 no
GO:1902680 positive regulation of RNA biosynthetic process 22.2222 7 no
GO:0017157 regulation of exocytosis 22.2222 5 no
GO:0030335 positive regulation of cell migration 22.2222 6 no
GO:0002683 negative regulation of immune system process 22.2222 4 yes
GO:0035809 regulation of urine volume 22.2222 4 no
GO:0035810 positive regulation of urine volume 22.2222 5 no
GO:0040017 positive regulation of locomotion 22.2222 4 no
GO:0060627 regulation of vesicle-mediated transport 22.2222 4 no
GO:0070372 regulation of ERK1 and ERK2 cascade 22.2222 7 no
GO:0070374 positive regulation of ERK1 and ERK2 cascade 22.2222 8 no
GO:1903305 regulation of regulated secretory pathway 22.2222 6 no
GO:2000147 positive regulation of cell motility 22.2222 5 no
GO:2001233 regulation of apoptotic signaling pathway 22.2222 5 no
GO:0014061 regulation of norepinephrine secretion 22.2222 6 no
GO:0042755 eating behavior 22.2222 4 no
GO:0006873 intracellular monoatomic ion homeostasis 22.2222 4 yes
GO:0046928 regulation of neurotransmitter secretion 22.2222 5 no
GO:0006874 intracellular calcium ion homeostasis 22.2222 5 yes
GO:0050433 regulation of catecholamine secretion 22.2222 5 no
GO:0006909 phagocytosis 22.2222 4 yes
GO:0006937 regulation of muscle contraction 22.2222 6 yes
GO:0071407 cellular response to organic cyclic compound 22.2222 5 no
GO:1903532 positive regulation of secretion by cell 22.2222 5 no
GO:0006954 inflammatory response 22.2222 4 yes
GO:0001975 response to amphetamine 22.2222 6 no
GO:0014075 response to amine 22.2222 5 no
GO:0035249 synaptic transmission, glutamatergic 22.2222 8 no
GO:0051968 positive regulation of synaptic transmission, glutamatergic 22.2222 6 no
GO:0060134 prepulse inhibition 22.2222 6 no
GO:0008016 regulation of heart contraction 22.2222 6 yes
GO:0099171 presynaptic modulation of chemical synaptic transmission 22.2222 6 no
GO:0008285 negative regulation of cell population proliferation 22.2222 5 yes
GO:0009894 regulation of catabolic process 22.2222 4 yes
GO:0009896 positive regulation of catabolic process 22.2222 5 yes
GO:0014048 regulation of glutamate secretion 22.2222 5 yes
GO:0030003 intracellular monoatomic cation homeostasis 22.2222 5 yes
GO:0031347 regulation of defense response 22.2222 5 yes
GO:0031348 negative regulation of defense response 22.2222 5 yes
GO:0032228 regulation of synaptic transmission, GABAergic 22.2222 6 yes
GO:0032890 regulation of organic acid transport 22.2222 5 yes
GO:0043266 regulation of potassium ion transport 22.2222 7 yes
GO:0043268 positive regulation of potassium ion transport 22.2222 6 yes
GO:0046883 regulation of hormone secretion 22.2222 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AA2AR_HUMAN [view entry] [view interactions] Low throughput yes yes
ADRB1_HUMAN [view entry] [view interactions] Low throughput yes yes
ADRB2_HUMAN [view entry] [view interactions] Low throughput yes no
P2RY1_HUMAN [view entry] [view interactions] Low throughput yes yes
DRD1_HUMAN [view entry] [view interactions] Low throughput yes no
GNAI2_HUMAN [view entry] [view interactions] Low throughput yes yes
GRM1_HUMAN [view entry] [view interactions] Low throughput yes yes
EGFR_HUMAN [view interactions] Low throughput no no
ADA_HUMAN [view interactions] Low throughput no no
TSHR_HUMAN [view interactions] High throughput no no
SNF8_HUMAN [view interactions] High throughput no yes
ATX1L_HUMAN [view interactions] High throughput no no
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
UBAC2_HUMAN [view interactions] High throughput no yes
PELI3_HUMAN [view interactions] High throughput no yes
VINEX_HUMAN [view interactions] High throughput no no
BRI3B_HUMAN [view interactions] High throughput no yes
UFD1_HUMAN [view interactions] High throughput no no
NPL4_HUMAN [view interactions] High throughput no yes