Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

P2RY1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Receptor for extracellular adenine nucleotides such as ADP (PubMed, PubMed, PubMed). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in P2RY1_HUMAN
GO:0001664 G protein-coupled receptor binding 45.4545 4 yes
GO:0017076 purine nucleotide binding 45.4545 4 yes
GO:0032555 purine ribonucleotide binding 45.4545 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 45.4545 4 yes
GO:0005216 ion channel activity 36.3636 4 no
GO:0005261 cation channel activity 36.3636 5 no
GO:0008324 cation transmembrane transporter activity 36.3636 4 no
GO:0015267 channel activity 36.3636 4 no
GO:0022890 inorganic cation transmembrane transporter activity 36.3636 4 no
GO:0046872 metal ion binding 36.3636 4 no
GO:0001614 purinergic nucleotide receptor activity 27.2727 5 yes
GO:0005524 ATP binding 27.2727 5 yes
GO:0016502 nucleotide receptor activity 27.2727 4 yes
GO:0030554 adenyl nucleotide binding 27.2727 5 yes
GO:0032559 adenyl ribonucleotide binding 27.2727 5 yes
GO:0005230 extracellular ligand-gated ion channel activity 27.2727 6 no
GO:0015276 ligand-gated ion channel activity 27.2727 5 no
GO:0022834 ligand-gated channel activity 27.2727 6 no
GO:0022836 gated channel activity 27.2727 5 no
GO:0099094 ligand-gated cation channel activity 27.2727 6 no
GO:0005262 calcium channel activity 27.2727 6 no
GO:0015085 calcium ion transmembrane transporter activity 27.2727 6 no
GO:0046873 metal ion transmembrane transporter activity 27.2727 5 no
GO:0004930 G protein-coupled receptor activity 18.1818 4 yes
GO:0046982 protein heterodimerization activity 18.1818 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in P2RY1_HUMAN
GO:0051171 regulation of nitrogen compound metabolic process 63.6364 4 yes
GO:0010646 regulation of cell communication 63.6364 4 yes
GO:0048522 positive regulation of cellular process 63.6364 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 54.5455 5 yes
GO:0051246 regulation of protein metabolic process 54.5455 5 yes
GO:0060255 regulation of macromolecule metabolic process 54.5455 4 yes
GO:0080090 regulation of primary metabolic process 54.5455 4 yes
GO:0009893 positive regulation of metabolic process 54.5455 4 yes
GO:0031323 regulation of cellular metabolic process 54.5455 4 yes
GO:0051049 regulation of transport 45.4545 4 yes
GO:0051247 positive regulation of protein metabolic process 45.4545 6 yes
GO:0099177 regulation of trans-synaptic signaling 45.4545 4 yes
GO:0043085 positive regulation of catalytic activity 45.4545 4 no
GO:0008104 protein localization 45.4545 4 yes
GO:0009966 regulation of signal transduction 45.4545 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 45.4545 5 yes
GO:0010647 positive regulation of cell communication 45.4545 5 yes
GO:0023056 positive regulation of signaling 45.4545 4 yes
GO:0043269 regulation of ion transport 45.4545 5 yes
GO:0050804 modulation of chemical synaptic transmission 45.4545 5 yes
GO:0051050 positive regulation of transport 36.3636 4 yes
GO:0051174 regulation of phosphorus metabolic process 36.3636 5 yes
GO:0072657 protein localization to membrane 36.3636 4 yes
GO:1903530 regulation of secretion by cell 36.3636 4 yes
GO:0001508 action potential 36.3636 4 no
GO:0044057 regulation of system process 36.3636 4 no
GO:0001932 regulation of protein phosphorylation 36.3636 7 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 36.3636 4 yes
GO:0009967 positive regulation of signal transduction 36.3636 5 yes
GO:0010243 response to organonitrogen compound 36.3636 4 yes
GO:0019220 regulation of phosphate metabolic process 36.3636 6 yes
GO:0031325 positive regulation of cellular metabolic process 36.3636 5 yes
GO:0031399 regulation of protein modification process 36.3636 6 yes
GO:0042325 regulation of phosphorylation 36.3636 7 yes
GO:0043270 positive regulation of ion transport 36.3636 5 yes
GO:0048523 negative regulation of cellular process 36.3636 4 yes
GO:0048584 positive regulation of response to stimulus 36.3636 4 yes
GO:0051046 regulation of secretion 36.3636 5 yes
GO:0051051 negative regulation of transport 27.2727 4 yes
GO:0060249 anatomical structure homeostasis 27.2727 4 yes
GO:0060627 regulation of vesicle-mediated transport 27.2727 4 yes
GO:0090075 relaxation of muscle 27.2727 4 yes
GO:1902531 regulation of intracellular signal transduction 27.2727 5 yes
GO:1902533 positive regulation of intracellular signal transduction 27.2727 6 yes
GO:1990778 protein localization to cell periphery 27.2727 5 yes
GO:0006811 ion transport 27.2727 4 no
GO:0006812 cation transport 27.2727 5 no
GO:0006937 regulation of muscle contraction 27.2727 6 no
GO:0007268 chemical synaptic transmission 27.2727 6 no
GO:0010959 regulation of metal ion transport 27.2727 6 no
GO:0034762 regulation of transmembrane transport 27.2727 4 no
GO:0034765 regulation of ion transmembrane transport 27.2727 5 no
GO:0051336 regulation of hydrolase activity 27.2727 4 no
GO:0051345 positive regulation of hydrolase activity 27.2727 5 no
GO:0071702 organic substance transport 27.2727 4 no
GO:0071705 nitrogen compound transport 27.2727 4 no
GO:0090257 regulation of muscle system process 27.2727 5 no
GO:0098916 anterograde trans-synaptic signaling 27.2727 5 no
GO:0099537 trans-synaptic signaling 27.2727 4 no
GO:1903522 regulation of blood circulation 27.2727 5 no
GO:1904062 regulation of cation transmembrane transport 27.2727 6 no
GO:0043549 regulation of kinase activity 27.2727 5 no
GO:0045859 regulation of protein kinase activity 27.2727 6 no
GO:0050806 positive regulation of synaptic transmission 27.2727 5 no
GO:0050890 cognition 27.2727 4 no
GO:0051338 regulation of transferase activity 27.2727 4 no
GO:0009894 regulation of catabolic process 27.2727 4 no
GO:0009416 response to light stimulus 27.2727 4 no
GO:0009892 negative regulation of metabolic process 27.2727 4 no
GO:0001934 positive regulation of protein phosphorylation 27.2727 8 yes
GO:0007600 sensory perception 27.2727 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 27.2727 6 yes
GO:0014070 response to organic cyclic compound 27.2727 4 yes
GO:0014074 response to purine-containing compound 27.2727 5 yes
GO:0019233 sensory perception of pain 27.2727 5 yes
GO:0031401 positive regulation of protein modification process 27.2727 7 yes
GO:0033198 response to ATP 27.2727 4 yes
GO:0042327 positive regulation of phosphorylation 27.2727 8 yes
GO:0045937 positive regulation of phosphate metabolic process 27.2727 7 yes
GO:0046683 response to organophosphorus 27.2727 4 yes
GO:0048878 chemical homeostasis 27.2727 4 yes
GO:0051047 positive regulation of secretion 27.2727 5 yes
GO:0051480 regulation of cytosolic calcium ion concentration 18.1818 8 yes
GO:0051588 regulation of neurotransmitter transport 18.1818 5 yes
GO:0051952 regulation of amine transport 18.1818 5 yes
GO:0051953 negative regulation of amine transport 18.1818 5 yes
GO:0055065 metal ion homeostasis 18.1818 7 yes
GO:0055074 calcium ion homeostasis 18.1818 8 yes
GO:0055080 cation homeostasis 18.1818 6 yes
GO:0071310 cellular response to organic substance 18.1818 4 yes
GO:0071318 cellular response to ATP 18.1818 5 yes
GO:0071407 cellular response to organic cyclic compound 18.1818 5 yes
GO:0071417 cellular response to organonitrogen compound 18.1818 4 yes
GO:0072503 cellular divalent inorganic cation homeostasis 18.1818 6 yes
GO:0072507 divalent inorganic cation homeostasis 18.1818 7 yes
GO:0097746 blood vessel diameter maintenance 18.1818 5 yes
GO:0098771 inorganic ion homeostasis 18.1818 6 yes
GO:0099509 regulation of presynaptic cytosolic calcium ion concentration 18.1818 4 yes
GO:1901699 cellular response to nitrogen compound 18.1818 4 yes
GO:1901701 cellular response to oxygen-containing compound 18.1818 4 yes
GO:1903305 regulation of regulated secretory pathway 18.1818 6 yes
GO:1903531 negative regulation of secretion by cell 18.1818 5 yes
GO:1903532 positive regulation of secretion by cell 18.1818 5 yes
GO:2000300 regulation of synaptic vesicle exocytosis 18.1818 5 yes
GO:0003018 vascular process in circulatory system 18.1818 4 yes
GO:0006873 cellular ion homeostasis 18.1818 4 yes
GO:0006874 cellular calcium ion homeostasis 18.1818 7 yes
GO:0006875 cellular metal ion homeostasis 18.1818 6 yes
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 18.1818 5 yes
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 18.1818 4 yes
GO:0008347 glial cell migration 18.1818 4 yes
GO:0009889 regulation of biosynthetic process 18.1818 4 yes
GO:0009891 positive regulation of biosynthetic process 18.1818 5 yes
GO:0017157 regulation of exocytosis 18.1818 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 18.1818 4 yes
GO:0022604 regulation of cell morphogenesis 18.1818 5 yes
GO:0030003 cellular cation homeostasis 18.1818 5 yes
GO:0031326 regulation of cellular biosynthetic process 18.1818 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 18.1818 6 yes
GO:0035150 regulation of tube size 18.1818 4 yes
GO:0035296 regulation of tube diameter 18.1818 5 yes
GO:0035590 purinergic nucleotide receptor signaling pathway 18.1818 4 yes
GO:0043271 negative regulation of ion transport 18.1818 5 yes
GO:0043408 regulation of MAPK cascade 18.1818 6 yes
GO:0043410 positive regulation of MAPK cascade 18.1818 7 yes
GO:0046883 regulation of hormone secretion 18.1818 4 yes
GO:0046928 regulation of neurotransmitter secretion 18.1818 4 yes
GO:0050801 ion homeostasis 18.1818 5 yes
GO:0051048 negative regulation of secretion 18.1818 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AA1R_HUMAN [view entry] [view interactions] Low throughput yes no
NHRF1_HUMAN [view interactions] Low throughput no no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
MIB2_HUMAN [view interactions] High throughput no yes
S19A2_HUMAN [view interactions] High throughput no yes
GPHRB_HUMAN [view interactions] High throughput no no
AT11C_HUMAN [view interactions] High throughput no no
GPHRA_HUMAN [view interactions] High throughput no no
CMIP_HUMAN [view interactions] High throughput no yes
OSBL8_HUMAN [view interactions] High throughput no yes
SC5D_HUMAN [view interactions] High throughput no yes
OSBL5_HUMAN [view interactions] High throughput no yes
S12A9_HUMAN [view interactions] High throughput no yes
FZD2_HUMAN [view interactions] High throughput no no
AGRE5_HUMAN [view interactions] High throughput no no
VP26A_HUMAN [view entry] [view interactions] High throughput yes no
MSMO1_HUMAN [view interactions] High throughput no yes
GP180_HUMAN [view interactions] High throughput no yes
UN93B_HUMAN [view interactions] High throughput no yes
DERL2_HUMAN [view interactions] High throughput no yes
TM87A_HUMAN [view interactions] High throughput no yes
EI24_HUMAN [view interactions] High throughput no yes
SERC3_HUMAN [view interactions] High throughput no yes
YIPF3_HUMAN [view interactions] High throughput no yes
ATPB_HUMAN [view interactions] High throughput no yes
ATPG_HUMAN [view interactions] High throughput no yes
T161A_HUMAN [view interactions] High throughput no yes
GPC5C_HUMAN [view interactions] High throughput no no
PTSS2_HUMAN [view interactions] High throughput no yes
DHC24_HUMAN [view interactions] High throughput no yes
TM9S3_HUMAN [view interactions] High throughput no yes
ATPO_HUMAN [view interactions] High throughput no yes
VKORL_HUMAN [view interactions] High throughput no yes
CERS2_HUMAN [view interactions] High throughput no no
ATPA_HUMAN [view interactions] High throughput no yes
YIF1B_HUMAN [view interactions] High throughput no yes
RETR3_HUMAN [view interactions] High throughput no yes
AT5F1_HUMAN [view interactions] High throughput no yes
SAC1_HUMAN [view entry] [view interactions] High throughput yes yes
CERS6_HUMAN [view interactions] High throughput no yes
GNA11_HUMAN [view entry] [view interactions] High throughput yes yes
ATP5H_HUMAN [view interactions] High throughput no yes
B3A2_HUMAN [view interactions] High throughput no yes
SCAM2_HUMAN [view interactions] High throughput no no
P2RX1_HUMAN [view entry] [view interactions] Computational yes no
P2RX4_HUMAN [view entry] [view interactions] Computational yes yes
GNAQ_HUMAN [view entry] [view interactions] Computational yes yes
P2RX2_HUMAN [view interactions] Computational no no