Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

P2RY1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Receptor for extracellular adenine nucleotides such as ADP (PubMed, PubMed, PubMed). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

No data found.

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in P2RY1_HUMAN
GO:0001664 G protein-coupled receptor binding 44.4444 4 yes
GO:0043169 cation binding 33.3333 4 no
GO:0046872 metal ion binding 33.3333 5 no
GO:0000166 nucleotide binding 22.2222 4 yes
GO:0004930 G protein-coupled receptor activity 22.2222 4 yes
GO:0017076 purine nucleotide binding 22.2222 5 yes
GO:0032555 purine ribonucleotide binding 22.2222 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 22.2222 4 yes
GO:0043168 anion binding 22.2222 4 yes
GO:0046982 protein heterodimerization activity 22.2222 4 yes
GO:0008270 zinc ion binding 22.2222 7 no
GO:0046914 transition metal ion binding 22.2222 6 no
GO:0005216 monoatomic ion channel activity 22.2222 4 no
GO:0005261 monoatomic cation channel activity 22.2222 5 no
GO:0005262 calcium channel activity 22.2222 6 no
GO:0008324 monoatomic cation transmembrane transporter activity 22.2222 4 no
GO:0015085 calcium ion transmembrane transporter activity 22.2222 6 no
GO:0015267 channel activity 22.2222 4 no
GO:0022890 inorganic cation transmembrane transporter activity 22.2222 4 no
GO:0046873 metal ion transmembrane transporter activity 22.2222 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in P2RY1_HUMAN
GO:0048522 positive regulation of cellular process 77.7778 4 yes
GO:0023056 positive regulation of signaling 66.6667 4 yes
GO:0010646 regulation of cell communication 66.6667 4 yes
GO:0010647 positive regulation of cell communication 66.6667 5 yes
GO:0048584 positive regulation of response to stimulus 55.5556 4 yes
GO:0051049 regulation of transport 55.5556 4 yes
GO:0008104 protein localization 55.5556 4 yes
GO:0009966 regulation of signal transduction 55.5556 4 yes
GO:0009967 positive regulation of signal transduction 55.5556 5 yes
GO:0031323 regulation of cellular metabolic process 44.4444 4 yes
GO:0050804 modulation of chemical synaptic transmission 44.4444 5 yes
GO:0051246 regulation of protein metabolic process 44.4444 5 yes
GO:0051247 positive regulation of protein metabolic process 44.4444 6 yes
GO:0060255 regulation of macromolecule metabolic process 44.4444 4 yes
GO:0072657 protein localization to membrane 44.4444 4 yes
GO:0080090 regulation of primary metabolic process 44.4444 4 yes
GO:0099177 regulation of trans-synaptic signaling 44.4444 4 yes
GO:0009893 positive regulation of metabolic process 44.4444 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 44.4444 5 yes
GO:0019220 regulation of phosphate metabolic process 33.3333 6 yes
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 yes
GO:0031399 regulation of protein modification process 33.3333 6 yes
GO:0031401 positive regulation of protein modification process 33.3333 7 yes
GO:0043269 regulation of monoatomic ion transport 33.3333 5 yes
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 yes
GO:0046883 regulation of hormone secretion 33.3333 4 yes
GO:0048523 negative regulation of cellular process 33.3333 4 yes
GO:0051046 regulation of secretion 33.3333 5 yes
GO:0051047 positive regulation of secretion 33.3333 5 yes
GO:0051050 positive regulation of transport 33.3333 4 yes
GO:0051051 negative regulation of transport 33.3333 4 yes
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 yes
GO:1902531 regulation of intracellular signal transduction 33.3333 5 yes
GO:1902533 positive regulation of intracellular signal transduction 33.3333 6 yes
GO:1903530 regulation of secretion by cell 33.3333 4 yes
GO:1990778 protein localization to cell periphery 33.3333 5 yes
GO:0031644 regulation of nervous system process 33.3333 5 no
GO:0044057 regulation of system process 33.3333 4 no
GO:0050806 positive regulation of synaptic transmission 33.3333 5 no
GO:0050890 cognition 33.3333 4 no
GO:0009894 regulation of catabolic process 33.3333 4 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 33.3333 4 yes
GO:0010243 response to organonitrogen compound 33.3333 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 yes
GO:0014070 response to organic cyclic compound 22.2222 4 yes
GO:0014074 response to purine-containing compound 22.2222 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 22.2222 4 yes
GO:0022604 regulation of cell morphogenesis 22.2222 5 yes
GO:0030003 intracellular monoatomic cation homeostasis 22.2222 5 yes
GO:0035150 regulation of tube size 22.2222 4 yes
GO:0035296 regulation of tube diameter 22.2222 5 yes
GO:0042325 regulation of phosphorylation 22.2222 7 yes
GO:0042327 positive regulation of phosphorylation 22.2222 8 yes
GO:0043270 positive regulation of monoatomic ion transport 22.2222 5 yes
GO:0043408 regulation of MAPK cascade 22.2222 6 yes
GO:0043410 positive regulation of MAPK cascade 22.2222 7 yes
GO:0046887 positive regulation of hormone secretion 22.2222 5 yes
GO:0051048 negative regulation of secretion 22.2222 5 yes
GO:0051480 regulation of cytosolic calcium ion concentration 22.2222 6 yes
GO:0051952 regulation of amine transport 22.2222 5 yes
GO:0051953 negative regulation of amine transport 22.2222 5 yes
GO:0055074 calcium ion homeostasis 22.2222 4 yes
GO:0055080 monoatomic cation homeostasis 22.2222 4 yes
GO:0060627 regulation of vesicle-mediated transport 22.2222 4 yes
GO:0097746 blood vessel diameter maintenance 22.2222 5 yes
GO:0099509 regulation of presynaptic cytosolic calcium ion concentration 22.2222 4 yes
GO:1903531 negative regulation of secretion by cell 22.2222 5 yes
GO:1903532 positive regulation of secretion by cell 22.2222 5 yes
GO:0007268 chemical synaptic transmission 22.2222 7 no
GO:0007399 nervous system development 22.2222 4 no
GO:0007612 learning 22.2222 4 no
GO:0022607 cellular component assembly 22.2222 4 no
GO:0030030 cell projection organization 22.2222 4 no
GO:0031175 neuron projection development 22.2222 6 no
GO:0031344 regulation of cell projection organization 22.2222 5 no
GO:0031346 positive regulation of cell projection organization 22.2222 6 no
GO:0034762 regulation of transmembrane transport 22.2222 4 no
GO:0035418 protein localization to synapse 22.2222 6 no
GO:0043085 positive regulation of catalytic activity 22.2222 4 no
GO:0048168 regulation of neuronal synaptic plasticity 22.2222 4 no
GO:0048812 neuron projection morphogenesis 22.2222 5 no
GO:0050795 regulation of behavior 22.2222 4 no
GO:0050905 neuromuscular process 22.2222 4 no
GO:0051128 regulation of cellular component organization 22.2222 4 no
GO:0051130 positive regulation of cellular component organization 22.2222 5 no
GO:0062237 protein localization to postsynapse 22.2222 7 no
GO:0098815 modulation of excitatory postsynaptic potential 22.2222 4 no
GO:0098916 anterograde trans-synaptic signaling 22.2222 6 no
GO:0099536 synaptic signaling 22.2222 4 no
GO:0099537 trans-synaptic signaling 22.2222 5 no
GO:0120036 plasma membrane bounded cell projection organization 22.2222 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 22.2222 4 no
GO:1902414 protein localization to cell junction 22.2222 5 no
GO:1903539 protein localization to postsynaptic membrane 22.2222 5 no
GO:2000463 positive regulation of excitatory postsynaptic potential 22.2222 5 no
GO:0002791 regulation of peptide secretion 22.2222 6 no
GO:0002793 positive regulation of peptide secretion 22.2222 6 no
GO:0009416 response to light stimulus 22.2222 4 no
GO:0090087 regulation of peptide transport 22.2222 5 no
GO:0009892 negative regulation of metabolic process 22.2222 4 no
GO:0009895 negative regulation of catabolic process 22.2222 5 no
GO:0042981 regulation of apoptotic process 22.2222 5 no
GO:0043067 regulation of programmed cell death 22.2222 4 no
GO:0051966 regulation of synaptic transmission, glutamatergic 22.2222 6 no
GO:0060078 regulation of postsynaptic membrane potential 22.2222 4 no
GO:0060079 excitatory postsynaptic potential 22.2222 5 no
GO:0001932 regulation of protein phosphorylation 22.2222 7 yes
GO:0001934 positive regulation of protein phosphorylation 22.2222 8 yes
GO:0003018 vascular process in circulatory system 22.2222 4 yes
GO:0006811 monoatomic ion transport 22.2222 4 yes
GO:0006873 intracellular monoatomic ion homeostasis 22.2222 4 yes
GO:0006874 intracellular calcium ion homeostasis 22.2222 5 yes
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 22.2222 5 yes
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 22.2222 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
AA1R_HUMAN [view entry] [view interactions] Low throughput yes no
NHRF1_HUMAN [view interactions] Low throughput no no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
GPHRB_HUMAN [view interactions] High throughput no no
S19A2_HUMAN [view interactions] High throughput no yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
MIB2_HUMAN [view entry] [view interactions] High throughput yes yes
AT11C_HUMAN [view interactions] High throughput no no
GPHRA_HUMAN [view interactions] High throughput no no
CMIP_HUMAN [view interactions] High throughput no yes
OSBL8_HUMAN [view interactions] High throughput no yes
SC5D_HUMAN [view interactions] High throughput no yes
OSBL5_HUMAN [view interactions] High throughput no yes
S12A9_HUMAN [view interactions] High throughput no yes
FZD2_HUMAN [view interactions] High throughput no no
AGRE5_HUMAN [view interactions] High throughput no no
VP26A_HUMAN [view entry] [view interactions] High throughput yes no
MSMO1_HUMAN [view interactions] High throughput no yes
GP180_HUMAN [view interactions] High throughput no yes
UN93B_HUMAN [view interactions] High throughput no yes
DERL2_HUMAN [view interactions] High throughput no yes
TM87A_HUMAN [view interactions] High throughput no yes
EI24_HUMAN [view interactions] High throughput no yes
SERC3_HUMAN [view interactions] High throughput no yes
YIPF3_HUMAN [view interactions] High throughput no yes
ATPB_HUMAN [view interactions] High throughput no yes
ATPG_HUMAN [view interactions] High throughput no yes
T161A_HUMAN [view interactions] High throughput no yes
GPC5C_HUMAN [view interactions] High throughput no no
PTSS2_HUMAN [view interactions] High throughput no yes
DHC24_HUMAN [view interactions] High throughput no yes
TM9S3_HUMAN [view interactions] High throughput no yes
ATPO_HUMAN [view interactions] High throughput no yes
VKORL_HUMAN [view interactions] High throughput no yes
CERS2_HUMAN [view interactions] High throughput no no
ATPA_HUMAN [view interactions] High throughput no yes
YIF1B_HUMAN [view interactions] High throughput no yes
RETR3_HUMAN [view interactions] High throughput no yes
AT5F1_HUMAN [view interactions] High throughput no yes
SAC1_HUMAN [view entry] [view interactions] High throughput yes yes
CERS6_HUMAN [view interactions] High throughput no yes
GNA11_HUMAN [view entry] [view interactions] High throughput yes yes
ATP5H_HUMAN [view interactions] High throughput no yes
B3A2_HUMAN [view interactions] High throughput no yes
SCAM2_HUMAN [view interactions] High throughput no no