SAC1_HUMAN
Evidence for PS localization
Functions
Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P) (PubMed, PubMed, PubMed, PubMed). Can also catalyze the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) . Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a cis configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in trans configuration (PubMed, PubMed, PubMed). PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in trans configuration) is enhanced in the presence of PLEKHA3 (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SAC1_HUMAN |
|---|---|---|---|---|
| GO:0004438 | phosphatidylinositol-3-phosphate phosphatase activity | 5.7143 | 8 | yes |
| GO:0016791 | phosphatase activity | 5.7143 | 5 | yes |
| GO:0034596 | phosphatidylinositol phosphate 4-phosphatase activity | 5.7143 | 7 | yes |
| GO:0042578 | phosphoric ester hydrolase activity | 5.7143 | 4 | yes |
| GO:0043812 | phosphatidylinositol-4-phosphate phosphatase activity | 5.7143 | 8 | yes |
| GO:0052744 | phosphatidylinositol monophosphate phosphatase activity | 5.7143 | 7 | yes |
| GO:0052866 | phosphatidylinositol phosphate phosphatase activity | 5.7143 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SAC1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 57.1429 | 4 | no |
| GO:0008104 | protein localization | 51.4286 | 4 | no |
| GO:0010646 | regulation of cell communication | 48.5714 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 48.5714 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 45.7143 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 42.8571 | 4 | no |
| GO:0010468 | regulation of gene expression | 42.8571 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 42.8571 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 42.8571 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 42.8571 | 4 | no |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 40.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 40.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
| GO:0006996 | organelle organization | 34.2857 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 31.4286 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.4286 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 31.4286 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 31.4286 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 31.4286 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.4286 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 28.5714 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 28.5714 | 5 | no |
| GO:0071702 | organic substance transport | 28.5714 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 25.7143 | 7 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.7143 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.7143 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 25.7143 | 6 | no |
| GO:0071705 | nitrogen compound transport | 25.7143 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.7143 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 25.7143 | 6 | no |
| GO:0032880 | regulation of protein localization | 25.7143 | 5 | no |
| GO:0033043 | regulation of organelle organization | 25.7143 | 5 | no |
| GO:0060341 | regulation of cellular localization | 25.7143 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.7143 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.7143 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.7143 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.7143 | 6 | no |
| GO:0009890 | negative regulation of biosynthetic process | 22.8571 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 22.8571 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 22.8571 | 6 | no |
| GO:0033365 | protein localization to organelle | 22.8571 | 5 | no |
| GO:0051049 | regulation of transport | 22.8571 | 4 | no |
| GO:0022607 | cellular component assembly | 22.8571 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 20.0000 | 4 | yes |
| GO:0006644 | phospholipid metabolic process | 11.4286 | 4 | yes |
| GO:0008610 | lipid biosynthetic process | 11.4286 | 4 | yes |
| GO:0008654 | phospholipid biosynthetic process | 11.4286 | 5 | yes |
| GO:0090407 | organophosphate biosynthetic process | 11.4286 | 4 | yes |
| GO:0006650 | glycerophospholipid metabolic process | 8.5714 | 5 | yes |
| GO:0006661 | phosphatidylinositol biosynthetic process | 8.5714 | 6 | yes |
| GO:0045017 | glycerolipid biosynthetic process | 8.5714 | 4 | yes |
| GO:0046474 | glycerophospholipid biosynthetic process | 8.5714 | 5 | yes |
| GO:0046486 | glycerolipid metabolic process | 8.5714 | 4 | yes |
| GO:0046488 | phosphatidylinositol metabolic process | 8.5714 | 6 | yes |
| GO:0016311 | dephosphorylation | 5.7143 | 5 | yes |
| GO:0030258 | lipid modification | 5.7143 | 4 | yes |
| GO:0046839 | phospholipid dephosphorylation | 5.7143 | 5 | yes |
| GO:0046856 | phosphatidylinositol dephosphorylation | 5.7143 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COPE_HUMAN | [view interactions] | Low throughput | no | yes |
| COPA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COPD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COPB_HUMAN | [view interactions] | Low throughput | no | yes |
| COPG1_HUMAN | [view interactions] | Low throughput | no | yes |
| PBIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CML1_HUMAN | [view interactions] | High throughput | no | yes |
| PACC1_HUMAN | [view interactions] | High throughput | no | no |
| IPPK_HUMAN | [view interactions] | High throughput | no | yes |
| CCR6_HUMAN | [view interactions] | High throughput | no | no |
| ICAM2_HUMAN | [view interactions] | High throughput | no | no |
| P2RY2_HUMAN | [view interactions] | High throughput | no | no |
| LPAR2_HUMAN | [view interactions] | High throughput | no | yes |
| CCG4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MANS1_HUMAN | [view interactions] | High throughput | no | yes |
| VIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| P2RY8_HUMAN | [view interactions] | High throughput | no | no |
| GPR35_HUMAN | [view interactions] | High throughput | no | no |
| PIGH_HUMAN | [view interactions] | High throughput | no | yes |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
| TMEM9_HUMAN | [view interactions] | High throughput | no | no |
| VSIG4_HUMAN | [view interactions] | High throughput | no | no |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| P2RY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FFAR1_HUMAN | [view interactions] | High throughput | no | no |
| CC107_HUMAN | [view interactions] | High throughput | no | no |
| S1PR1_HUMAN | [view interactions] | High throughput | no | no |
| CD70_HUMAN | [view interactions] | High throughput | no | no |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEDD1_HUMAN | [view interactions] | High throughput | no | yes |
| NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
| AL3A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| BRD8_HUMAN | [view interactions] | High throughput | no | yes |
| OSBL9_HUMAN | [view interactions] | High throughput | no | yes |
| UFD1_HUMAN | [view interactions] | High throughput | no | no |
| SCFD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM115_HUMAN | [view interactions] | High throughput | no | yes |
| CISD2_HUMAN | [view interactions] | High throughput | no | yes |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| TM9S3_HUMAN | [view interactions] | High throughput | no | yes |
| CCD47_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| GOLI_HUMAN | [view interactions] | High throughput | no | yes |
| LDLR_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| SAC2_HUMAN | [view interactions] | High throughput | no | no |
| CAH9_HUMAN | [view interactions] | High throughput | no | no |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| MK11_HUMAN | [view interactions] | High throughput | no | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| CREB3_HUMAN | [view interactions] | High throughput | no | no |
| KLDC2_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| COPG2_HUMAN | [view interactions] | High throughput | no | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OST48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMC4_HUMAN | [view interactions] | High throughput | no | yes |
| CLPX_HUMAN | [view interactions] | High throughput | no | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| EFR3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPZ1_HUMAN | [view interactions] | High throughput | no | no |
| COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM9S4_HUMAN | [view interactions] | High throughput | no | yes |
| LPAR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EVA1C_HUMAN | [view interactions] | High throughput | no | yes |
| S22A9_HUMAN | [view interactions] | High throughput | no | no |
| P2Y12_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CR3L1_HUMAN | [view interactions] | High throughput | no | yes |
| FMO3_HUMAN | [view interactions] | High throughput | no | no |
| FFAR2_HUMAN | [view interactions] | High throughput | no | yes |
| GP152_HUMAN | [view interactions] | High throughput | no | no |
| RN19B_HUMAN | [view interactions] | High throughput | no | yes |
| JAGN1_HUMAN | [view interactions] | High throughput | no | no |
| MTEF2_HUMAN | [view interactions] | High throughput | no | yes |
| ZFY27_HUMAN | [view interactions] | High throughput | no | yes |
| ACKR2_HUMAN | [view interactions] | High throughput | no | no |
| GP151_HUMAN | [view interactions] | High throughput | no | no |
| DHRS7_HUMAN | [view interactions] | High throughput | no | yes |
| AR13B_HUMAN | [view interactions] | High throughput | no | yes |
| CTR1_HUMAN | [view interactions] | High throughput | no | no |
| CD79A_HUMAN | [view interactions] | High throughput | no | no |
| AQP6_HUMAN | [view interactions] | High throughput | no | no |
| NTCP_HUMAN | [view interactions] | High throughput | no | no |
| SOAT_HUMAN | [view interactions] | High throughput | no | no |
| SCN3B_HUMAN | [view interactions] | High throughput | no | no |
| TMX2_HUMAN | [view interactions] | High throughput | no | yes |
| EBP_HUMAN | [view interactions] | High throughput | no | no |
| S35A5_HUMAN | [view interactions] | High throughput | no | no |
| ODFP4_HUMAN | [view interactions] | High throughput | no | no |
| DHB13_HUMAN | [view interactions] | High throughput | no | yes |
| KISHB_HUMAN | [view interactions] | High throughput | no | no |
| MF14B_HUMAN | [view interactions] | High throughput | no | no |
| TRPV2_HUMAN | [view interactions] | High throughput | no | yes |
| FOXB1_HUMAN | [view interactions] | High throughput | no | no |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VEZA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S35C2_HUMAN | [view interactions] | High throughput | no | yes |
| RTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MFF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPIT2_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| LCOR_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S15A3_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| FA20C_HUMAN | [view interactions] | High throughput | no | no |
| RN185_HUMAN | [view interactions] | High throughput | no | no |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSBP1_HUMAN | [view interactions] | High throughput | no | yes |
| SCAP_HUMAN | [view interactions] | High throughput | no | yes |
| SRBP1_HUMAN | [view interactions] | High throughput | no | yes |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| IL2RA_HUMAN | [view interactions] | High throughput | no | no |
| K2C80_HUMAN | [view interactions] | High throughput | no | no |
| EVA1B_HUMAN | [view interactions] | High throughput | no | yes |
| COX42_HUMAN | [view interactions] | High throughput | no | no |
| SMIM5_HUMAN | [view interactions] | High throughput | no | yes |
| JTB_HUMAN | [view interactions] | High throughput | no | yes |
| CD226_HUMAN | [view interactions] | High throughput | no | yes |
| CSPG5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |