SAC1_HUMAN
Evidence for PS localization
Functions
Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P) (PubMed, PubMed, PubMed, PubMed). Can also catalyze the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) . Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a cis configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in trans configuration (PubMed, PubMed, PubMed). PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in trans configuration) is enhanced in the presence of PLEKHA3 (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SAC1_HUMAN |
|---|---|---|---|---|
| GO:0016791 | phosphatase activity | 17.1429 | 5 | yes |
| GO:0042578 | phosphoric ester hydrolase activity | 17.1429 | 4 | yes |
| GO:0052866 | phosphatidylinositol phosphate phosphatase activity | 17.1429 | 6 | yes |
| GO:0004438 | phosphatidylinositol-3-phosphatase activity | 14.2857 | 8 | yes |
| GO:0052744 | phosphatidylinositol monophosphate phosphatase activity | 14.2857 | 7 | yes |
| GO:0034596 | phosphatidylinositol phosphate 4-phosphatase activity | 11.4286 | 7 | yes |
| GO:0043812 | phosphatidylinositol-4-phosphate phosphatase activity | 5.7143 | 8 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SAC1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 48.5714 | 4 | no |
| GO:0010646 | regulation of cell communication | 42.8571 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 37.1429 | 4 | yes |
| GO:0008104 | protein localization | 37.1429 | 4 | no |
| GO:0009966 | regulation of signal transduction | 37.1429 | 4 | no |
| GO:0006644 | phospholipid metabolic process | 34.2857 | 4 | yes |
| GO:0008610 | lipid biosynthetic process | 34.2857 | 4 | yes |
| GO:0008654 | phospholipid biosynthetic process | 34.2857 | 4 | yes |
| GO:0090407 | organophosphate biosynthetic process | 34.2857 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 34.2857 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 34.2857 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 34.2857 | 4 | no |
| GO:0006650 | glycerophospholipid metabolic process | 31.4286 | 5 | yes |
| GO:0006661 | phosphatidylinositol biosynthetic process | 31.4286 | 6 | yes |
| GO:0045017 | glycerolipid biosynthetic process | 31.4286 | 4 | yes |
| GO:0046474 | glycerophospholipid biosynthetic process | 31.4286 | 5 | yes |
| GO:0046486 | glycerolipid metabolic process | 31.4286 | 4 | yes |
| GO:0046488 | phosphatidylinositol metabolic process | 31.4286 | 6 | yes |
| GO:0080090 | regulation of primary metabolic process | 31.4286 | 4 | no |
| GO:0006996 | organelle organization | 31.4286 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 28.5714 | 4 | no |
| GO:0010468 | regulation of gene expression | 28.5714 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 28.5714 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 25.7143 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.7143 | 4 | no |
| GO:0051049 | regulation of transport | 22.8571 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 22.8571 | 4 | no |
| GO:0071702 | organic substance transport | 22.8571 | 4 | no |
| GO:0071705 | nitrogen compound transport | 22.8571 | 4 | no |
| GO:0036211 | protein modification process | 22.8571 | 4 | no |
| GO:0043412 | macromolecule modification | 22.8571 | 4 | no |
| GO:0061024 | membrane organization | 22.8571 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.8571 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.8571 | 5 | no |
| GO:0016311 | dephosphorylation | 14.2857 | 5 | yes |
| GO:0030258 | lipid modification | 14.2857 | 4 | yes |
| GO:0046839 | phospholipid dephosphorylation | 14.2857 | 5 | yes |
| GO:0046856 | phosphatidylinositol dephosphorylation | 14.2857 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SAC1_HUMAN |
|---|---|---|---|---|
| DOID:10595 | Charcot-Marie-Tooth disease | 5.7143 | 6 | no |
| DOID:440 | neuromuscular disease | 5.7143 | 5 | no |
| DOID:574 | peripheral nervous system disease | 5.7143 | 3 | no |
| DOID:870 | neuropathy | 5.7143 | 4 | no |
| DOID:331 | central nervous system disease | 5.7143 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COPG1_HUMAN | [view interactions] | Low throughput | no | yes |
| COPB_HUMAN | [view interactions] | Low throughput | no | yes |
| COPD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COPA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| COPE_HUMAN | [view interactions] | Low throughput | no | yes |
| P2RY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FFAR1_HUMAN | [view interactions] | High throughput | no | no |
| CC107_HUMAN | [view interactions] | High throughput | no | no |
| S1PR1_HUMAN | [view interactions] | High throughput | no | no |
| CD70_HUMAN | [view interactions] | High throughput | no | no |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEDD1_HUMAN | [view interactions] | High throughput | no | yes |
| NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
| AL3A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| BRD8_HUMAN | [view interactions] | High throughput | no | yes |
| OSBL9_HUMAN | [view interactions] | High throughput | no | yes |
| UFD1_HUMAN | [view interactions] | High throughput | no | no |
| SCFD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM115_HUMAN | [view interactions] | High throughput | no | yes |
| CISD2_HUMAN | [view interactions] | High throughput | no | yes |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| TM9S3_HUMAN | [view interactions] | High throughput | no | yes |
| CCD47_HUMAN | [view interactions] | High throughput | no | yes |
| LDLR_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| CAH9_HUMAN | [view interactions] | High throughput | no | no |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| MK11_HUMAN | [view interactions] | High throughput | no | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| CREB3_HUMAN | [view interactions] | High throughput | no | no |
| COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPZ1_HUMAN | [view interactions] | High throughput | no | no |
| EFR3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| CLPX_HUMAN | [view interactions] | High throughput | no | yes |
| SMC4_HUMAN | [view interactions] | High throughput | no | yes |
| OST48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPG2_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| KLDC2_HUMAN | [view interactions] | High throughput | no | yes |
| TM9S4_HUMAN | [view interactions] | High throughput | no | yes |
| LPAR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EVA1C_HUMAN | [view interactions] | High throughput | no | yes |
| S22A9_HUMAN | [view interactions] | High throughput | no | no |
| P2Y12_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CR3L1_HUMAN | [view interactions] | High throughput | no | yes |
| FMO3_HUMAN | [view interactions] | High throughput | no | no |
| FFAR2_HUMAN | [view interactions] | High throughput | no | yes |
| GP152_HUMAN | [view interactions] | High throughput | no | no |
| RN19B_HUMAN | [view interactions] | High throughput | no | yes |
| JAGN1_HUMAN | [view interactions] | High throughput | no | no |
| MTEF2_HUMAN | [view interactions] | High throughput | no | yes |
| ZFY27_HUMAN | [view interactions] | High throughput | no | yes |
| ACKR2_HUMAN | [view interactions] | High throughput | no | no |
| GP151_HUMAN | [view interactions] | High throughput | no | no |
| DHRS7_HUMAN | [view interactions] | High throughput | no | yes |
| AR13B_HUMAN | [view interactions] | High throughput | no | yes |
| SL7A1_HUMAN | [view interactions] | High throughput | no | no |
| CD79A_HUMAN | [view interactions] | High throughput | no | no |
| AQP6_HUMAN | [view interactions] | High throughput | no | no |
| NTCP_HUMAN | [view interactions] | High throughput | no | no |
| SOAT_HUMAN | [view interactions] | High throughput | no | no |
| SCN3B_HUMAN | [view interactions] | High throughput | no | no |
| TMX2_HUMAN | [view interactions] | High throughput | no | yes |
| EBP_HUMAN | [view interactions] | High throughput | no | no |
| S35A5_HUMAN | [view interactions] | High throughput | no | no |
| ODFP4_HUMAN | [view interactions] | High throughput | no | no |
| DHB13_HUMAN | [view interactions] | High throughput | no | yes |
| KISHB_HUMAN | [view interactions] | High throughput | no | no |
| MF14B_HUMAN | [view interactions] | High throughput | no | no |
| TRPV2_HUMAN | [view interactions] | High throughput | no | yes |
| FOXB1_HUMAN | [view interactions] | High throughput | no | no |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VEZA_HUMAN | [view interactions] | High throughput | no | yes |
| S35C2_HUMAN | [view interactions] | High throughput | no | yes |
| RTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MFF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPIT2_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| LCOR_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S15A3_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| FA20C_HUMAN | [view interactions] | High throughput | no | no |
| RN185_HUMAN | [view interactions] | High throughput | no | no |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OSBP1_HUMAN | [view interactions] | High throughput | no | yes |
| SCAP_HUMAN | [view interactions] | High throughput | no | yes |
| SRBP1_HUMAN | [view interactions] | High throughput | no | yes |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| IL2RA_HUMAN | [view interactions] | High throughput | no | no |
| K2C80_HUMAN | [view interactions] | High throughput | no | no |
| EVA1B_HUMAN | [view interactions] | High throughput | no | yes |
| COX42_HUMAN | [view interactions] | High throughput | no | no |
| SMIM5_HUMAN | [view interactions] | High throughput | no | yes |
| JTB_HUMAN | [view interactions] | High throughput | no | yes |
| CD226_HUMAN | [view interactions] | High throughput | no | yes |
| CSPG5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PBIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CML1_HUMAN | [view interactions] | High throughput | no | yes |
| PACC1_HUMAN | [view interactions] | High throughput | no | no |
| IPPK_HUMAN | [view interactions] | High throughput | no | yes |
| CCR6_HUMAN | [view interactions] | High throughput | no | no |
| ICAM2_HUMAN | [view interactions] | High throughput | no | no |
| P2RY2_HUMAN | [view interactions] | High throughput | no | no |
| LPAR2_HUMAN | [view interactions] | High throughput | no | yes |
| CCG4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MANS1_HUMAN | [view interactions] | High throughput | no | yes |
| VIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| P2RY8_HUMAN | [view interactions] | High throughput | no | no |
| GPR35_HUMAN | [view interactions] | High throughput | no | no |
| PIGH_HUMAN | [view interactions] | High throughput | no | yes |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| MFD4A_HUMAN | [view interactions] | High throughput | no | yes |
| TMEM9_HUMAN | [view interactions] | High throughput | no | no |
| VSIG4_HUMAN | [view interactions] | High throughput | no | no |
| GPR45_HUMAN | [view interactions] | High throughput | no | no |
| P3C2A_HUMAN | [view interactions] | Computational | no | yes |
| P3C2B_HUMAN | [view interactions] | Computational | no | no |
| PI5L1_HUMAN | [view interactions] | Computational | no | no |
| PTEN_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| OSBL8_HUMAN | [view interactions] | Computational | no | yes |
| DPM1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TPTE2_HUMAN | [view interactions] | Computational | no | no |
| PI4KA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| P4K2A_HUMAN | [view interactions] | Computational | no | yes |
| PK3C3_HUMAN | [view interactions] | Computational | no | yes |
| MTMR7_HUMAN | [view interactions] | Computational | no | no |
| P55G_HUMAN | [view interactions] | Computational | no | yes |
| GOLP3_HUMAN | [view interactions] | Computational | no | no |
| MTMR2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| P85A_HUMAN | [view interactions] | Computational | no | yes |
| P4K2B_HUMAN | [view interactions] | Computational | no | yes |
| GLP3L_HUMAN | [view interactions] | Computational | no | no |
| PI51B_HUMAN | [view interactions] | Computational | no | yes |
| PI5PA_HUMAN | [view interactions] | Computational | no | no |
| FYV1_HUMAN | [view interactions] | Computational | no | no |
| SYNJ2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| P85B_HUMAN | [view interactions] | Computational | no | yes |
| CDIPT_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| INP5K_HUMAN | [view interactions] | Computational | no | no |
| INP4A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| INP4B_HUMAN | [view interactions] | Computational | no | no |
| MTMR6_HUMAN | [view interactions] | Computational | no | no |
| I5P2_HUMAN | [view interactions] | Computational | no | yes |
| OCRL_HUMAN | [view interactions] | Computational | no | yes |
| INP5E_HUMAN | [view interactions] | Computational | no | yes |
| PI51C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PI51A_HUMAN | [view interactions] | Computational | no | yes |