RTN3_HUMAN
Evidence for PS localization
Functions
May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. Induces the formation of endoplasmic reticulum tubules (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI004447 | LIG_LIR_Gen_1 | LIG | 246 | 256 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RTN3_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 21.1538 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RTN3_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 48.0769 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 48.0769 | 4 | no |
| GO:0006996 | organelle organization | 46.1538 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 46.1538 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 46.1538 | 4 | yes |
| GO:0008104 | protein localization | 44.2308 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 42.3077 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 42.3077 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 40.3846 | 4 | yes |
| GO:0071702 | organic substance transport | 36.5385 | 4 | no |
| GO:0022607 | cellular component assembly | 32.6923 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 32.6923 | 4 | no |
| GO:0010646 | regulation of cell communication | 32.6923 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 32.6923 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 32.6923 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 32.6923 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 30.7692 | 4 | yes |
| GO:0051049 | regulation of transport | 30.7692 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 28.8462 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 28.8462 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 28.8462 | 5 | no |
| GO:0015031 | protein transport | 26.9231 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 26.9231 | 6 | no |
| GO:0030030 | cell projection organization | 26.9231 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.0000 | 5 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 25.0000 | 6 | yes |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
| GO:0006886 | intracellular protein transport | 23.0769 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.0769 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.0769 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.0769 | 5 | no |
| GO:0051050 | positive regulation of transport | 23.0769 | 4 | no |
| GO:0061024 | membrane organization | 23.0769 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 23.0769 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 21.1538 | 7 | no |
| GO:0033365 | protein localization to organelle | 21.1538 | 5 | no |
| GO:0060341 | regulation of cellular localization | 21.1538 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.1538 | 4 | no |
| GO:0031175 | neuron projection development | 21.1538 | 6 | no |
| GO:0034248 | regulation of cellular amide metabolic process | 13.4615 | 5 | yes |
| GO:0007029 | endoplasmic reticulum organization | 9.6154 | 5 | yes |
| GO:0034249 | negative regulation of cellular amide metabolic process | 9.6154 | 6 | yes |
| GO:1902003 | regulation of amyloid-beta formation | 7.6923 | 6 | yes |
| GO:1902430 | negative regulation of amyloid-beta formation | 7.6923 | 7 | yes |
| GO:1902991 | regulation of amyloid precursor protein catabolic process | 7.6923 | 6 | yes |
| GO:1902992 | negative regulation of amyloid precursor protein catabolic process | 7.6923 | 7 | yes |
| GO:0006915 | apoptotic process | 5.7692 | 4 | yes |
| GO:0071786 | endoplasmic reticulum tubular network organization | 5.7692 | 6 | yes |
| GO:0071787 | endoplasmic reticulum tubular network formation | 5.7692 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in RTN3_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 5.7692 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 5.7692 | 5 | no |
| DOID:114 | heart disease | 5.7692 | 3 | no |
| DOID:2843 | long QT syndrome | 3.8462 | 6 | no |
| DOID:0050539 | Charcot-Marie-Tooth disease type 2 | 3.8462 | 7 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 3.8462 | 6 | no |
| DOID:440 | neuromuscular disease | 3.8462 | 5 | no |
| DOID:574 | peripheral nervous system disease | 3.8462 | 3 | no |
| DOID:870 | neuropathy | 3.8462 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DDX58_HUMAN | [view interactions] | Low throughput | no | yes |
| BACE1_HUMAN | [view interactions] | Low throughput | no | yes |
| RTN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CEGT_HUMAN | [view interactions] | Low throughput | no | yes |
| FGFR1_HUMAN | [view interactions] | Low throughput | no | yes |
| BCL2_HUMAN | [view interactions] | Low throughput | no | no |
| TRI25_HUMAN | [view interactions] | Low throughput | no | yes |
| GBRAP_HUMAN | [view interactions] | Low throughput | no | no |
| SCAM3_HUMAN | [view interactions] | High throughput | no | no |
| ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEX2_HUMAN | [view interactions] | High throughput | no | yes |
| MSMO1_HUMAN | [view interactions] | High throughput | no | yes |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| TSN15_HUMAN | [view interactions] | High throughput | no | yes |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM9S1_HUMAN | [view interactions] | High throughput | no | yes |
| PGAP4_HUMAN | [view interactions] | High throughput | no | no |
| RTN2_HUMAN | [view interactions] | High throughput | no | no |
| YIPF5_HUMAN | [view interactions] | High throughput | no | yes |
| TM208_HUMAN | [view interactions] | High throughput | no | yes |
| DERL2_HUMAN | [view interactions] | High throughput | no | yes |
| NAGPA_HUMAN | [view interactions] | High throughput | no | no |
| LTMD1_HUMAN | [view interactions] | High throughput | no | no |
| DHC24_HUMAN | [view interactions] | High throughput | no | yes |
| PRAF3_HUMAN | [view interactions] | High throughput | no | yes |
| RTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KDSR_HUMAN | [view interactions] | High throughput | no | yes |
| EMC7_HUMAN | [view interactions] | High throughput | no | yes |
| TMM68_HUMAN | [view interactions] | High throughput | no | yes |
| PTH2_HUMAN | [view interactions] | High throughput | no | yes |
| PRAF1_HUMAN | [view interactions] | High throughput | no | yes |
| TBL2_HUMAN | [view interactions] | High throughput | no | no |
| MMP15_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AR6P1_HUMAN | [view interactions] | High throughput | no | yes |
| COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPE_HUMAN | [view interactions] | High throughput | no | yes |
| COPG2_HUMAN | [view interactions] | High throughput | no | yes |
| COPZ1_HUMAN | [view interactions] | High throughput | no | no |
| DOCK7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REEP4_HUMAN | [view interactions] | High throughput | no | no |
| REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REEP6_HUMAN | [view interactions] | High throughput | no | no |
| STK26_HUMAN | [view interactions] | High throughput | no | no |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| PRDC1_HUMAN | [view interactions] | High throughput | no | yes |
| AT1B3_HUMAN | [view interactions] | High throughput | no | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| SYVN1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| MET7A_HUMAN | [view interactions] | High throughput | no | no |
| NU155_HUMAN | [view interactions] | High throughput | no | yes |
| PANX1_HUMAN | [view interactions] | High throughput | no | no |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3B_HUMAN | [view interactions] | High throughput | no | no |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| S38A1_HUMAN | [view interactions] | High throughput | no | yes |
| ATLA3_HUMAN | [view interactions] | High throughput | no | no |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SG196_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR3_HUMAN | [view interactions] | High throughput | no | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| CDIPT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN9_HUMAN | [view interactions] | High throughput | no | yes |
| SNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2R3C_HUMAN | [view interactions] | High throughput | no | yes |
| CERT_HUMAN | [view interactions] | High throughput | no | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHF2_HUMAN | [view interactions] | High throughput | no | yes |
| RB33A_HUMAN | [view interactions] | High throughput | no | no |
| SPOP_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGTR1_HUMAN | [view interactions] | High throughput | no | no |
| CCR2_HUMAN | [view interactions] | High throughput | no | yes |
| CCR8_HUMAN | [view interactions] | High throughput | no | no |
| DRD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GPR35_HUMAN | [view interactions] | High throughput | no | no |
| S15A4_HUMAN | [view interactions] | High throughput | no | yes |
| PARP2_HUMAN | [view interactions] | High throughput | no | yes |
| MEF2C_HUMAN | [view interactions] | High throughput | no | yes |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| TECT3_HUMAN | [view interactions] | High throughput | no | yes |
| TECT2_HUMAN | [view interactions] | High throughput | no | yes |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| ZN391_HUMAN | [view interactions] | High throughput | no | no |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDRG4_HUMAN | [view interactions] | High throughput | no | no |
| ZNT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMD2_HUMAN | [view interactions] | High throughput | no | yes |
| MITD1_HUMAN | [view interactions] | High throughput | no | no |
| ZNT8_HUMAN | [view interactions] | High throughput | no | no |
| GP152_HUMAN | [view interactions] | High throughput | no | no |
| PPLA_HUMAN | [view interactions] | High throughput | no | no |
| SAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| F241A_HUMAN | [view interactions] | High throughput | no | yes |
| TMM70_HUMAN | [view interactions] | High throughput | no | yes |
| ESYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F241B_HUMAN | [view interactions] | High throughput | no | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| SNX19_HUMAN | [view interactions] | High throughput | no | yes |
| SCAM2_HUMAN | [view interactions] | High throughput | no | no |
| NSMA_HUMAN | [view interactions] | High throughput | no | yes |
| RETR3_HUMAN | [view interactions] | High throughput | no | yes |
| BACE2_HUMAN | [view interactions] | Computational | no | yes |