RTN3_HUMAN
Evidence for PS localization
Functions
May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. Induces the formation of endoplasmic reticulum tubules (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI004447 | LIG_LIR_Gen_1 | LIG | 246 | 256 | - |
| ELMI004447 | LIG_LIR_Gen_1 | LIG | 246 | 256 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RTN3_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 30.6452 | 4 | no |
| GO:0046872 | metal ion binding | 29.0323 | 5 | no |
| GO:0043168 | anion binding | 20.9677 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RTN3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 48.3871 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 46.7742 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 45.1613 | 4 | yes |
| GO:0006996 | organelle organization | 43.5484 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 40.3226 | 5 | yes |
| GO:0008104 | protein localization | 40.3226 | 4 | no |
| GO:0010646 | regulation of cell communication | 38.7097 | 4 | no |
| GO:0022607 | cellular component assembly | 37.0968 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 37.0968 | 4 | no |
| GO:0009966 | regulation of signal transduction | 35.4839 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.4839 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 33.8710 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.8710 | 5 | no |
| GO:0051049 | regulation of transport | 33.8710 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 32.2581 | 4 | no |
| GO:0071702 | organic substance transport | 32.2581 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 30.6452 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.4194 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 27.4194 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.8065 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.8065 | 6 | no |
| GO:0141124 | intracellular signaling cassette | 25.8065 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.8065 | 5 | no |
| GO:0030030 | cell projection organization | 25.8065 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.8065 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 24.1935 | 6 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 24.1935 | 6 | no |
| GO:0051050 | positive regulation of transport | 24.1935 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 24.1935 | 5 | no |
| GO:0071705 | nitrogen compound transport | 24.1935 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 22.5806 | 7 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.5806 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 22.5806 | 7 | no |
| GO:0060341 | regulation of cellular localization | 22.5806 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.5806 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 22.5806 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.5806 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 20.9677 | 7 | no |
| GO:0009889 | regulation of biosynthetic process | 20.9677 | 4 | no |
| GO:0010468 | regulation of gene expression | 20.9677 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 20.9677 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 20.9677 | 5 | no |
| GO:0031175 | neuron projection development | 20.9677 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 20.9677 | 5 | no |
| GO:0007029 | endoplasmic reticulum organization | 9.6774 | 5 | yes |
| GO:0030182 | neuron differentiation | 9.6774 | 4 | yes |
| GO:0006915 | apoptotic process | 8.0645 | 4 | yes |
| GO:0007420 | brain development | 6.4516 | 4 | yes |
| GO:0034248 | regulation of amide metabolic process | 6.4516 | 4 | yes |
| GO:0034249 | negative regulation of amide metabolic process | 6.4516 | 5 | yes |
| GO:0071786 | endoplasmic reticulum tubular network organization | 6.4516 | 6 | yes |
| GO:0071787 | endoplasmic reticulum tubular network formation | 6.4516 | 5 | yes |
| GO:1902003 | regulation of amyloid-beta formation | 6.4516 | 5 | yes |
| GO:1902430 | negative regulation of amyloid-beta formation | 6.4516 | 6 | yes |
| GO:1902991 | regulation of amyloid precursor protein catabolic process | 6.4516 | 6 | yes |
| GO:1902992 | negative regulation of amyloid precursor protein catabolic process | 6.4516 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| BACE1_HUMAN | [view interactions] | Low throughput | no | yes |
| RTN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CEGT_HUMAN | [view interactions] | Low throughput | no | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BCL2_HUMAN | [view interactions] | Low throughput | no | no |
| TRI25_HUMAN | [view interactions] | Low throughput | no | yes |
| GBRAP_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RIGI_HUMAN | [view interactions] | Low throughput | no | yes |
| ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| S38A1_HUMAN | [view interactions] | High throughput | no | yes |
| ATLA3_HUMAN | [view interactions] | High throughput | no | no |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SG196_HUMAN | [view interactions] | High throughput | no | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR3_HUMAN | [view interactions] | High throughput | no | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDIPT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN9_HUMAN | [view interactions] | High throughput | no | yes |
| SNX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2R3C_HUMAN | [view interactions] | High throughput | no | yes |
| CERT_HUMAN | [view interactions] | High throughput | no | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHF2_HUMAN | [view interactions] | High throughput | no | yes |
| RB33A_HUMAN | [view interactions] | High throughput | no | no |
| SPOP_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGTR1_HUMAN | [view interactions] | High throughput | no | no |
| CCR2_HUMAN | [view interactions] | High throughput | no | yes |
| CCR8_HUMAN | [view interactions] | High throughput | no | no |
| DRD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GPR35_HUMAN | [view interactions] | High throughput | no | no |
| S15A4_HUMAN | [view interactions] | High throughput | no | yes |
| PARP2_HUMAN | [view interactions] | High throughput | no | yes |
| MEF2C_HUMAN | [view interactions] | High throughput | no | yes |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| TECT3_HUMAN | [view interactions] | High throughput | no | yes |
| TECT2_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| ZN391_HUMAN | [view interactions] | High throughput | no | no |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDRG4_HUMAN | [view interactions] | High throughput | no | no |
| ZNT3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMD2_HUMAN | [view interactions] | High throughput | no | yes |
| MITD1_HUMAN | [view interactions] | High throughput | no | no |
| ZNT8_HUMAN | [view interactions] | High throughput | no | no |
| GP152_HUMAN | [view interactions] | High throughput | no | no |
| PPLA_HUMAN | [view interactions] | High throughput | no | no |
| SAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| TRIM9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| F241A_HUMAN | [view interactions] | High throughput | no | yes |
| TMM70_HUMAN | [view interactions] | High throughput | no | yes |
| ESYT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F241B_HUMAN | [view interactions] | High throughput | no | yes |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| SNX19_HUMAN | [view interactions] | High throughput | no | yes |
| SCAM2_HUMAN | [view interactions] | High throughput | no | no |
| NSMA_HUMAN | [view interactions] | High throughput | no | yes |
| RETR3_HUMAN | [view interactions] | High throughput | no | yes |
| SCAM3_HUMAN | [view interactions] | High throughput | no | no |
| ESYT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TEX2_HUMAN | [view interactions] | High throughput | no | yes |
| MSMO1_HUMAN | [view interactions] | High throughput | no | yes |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| TSN15_HUMAN | [view interactions] | High throughput | no | yes |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM9S1_HUMAN | [view interactions] | High throughput | no | yes |
| PGAP4_HUMAN | [view interactions] | High throughput | no | no |
| RTN2_HUMAN | [view interactions] | High throughput | no | no |
| YIPF5_HUMAN | [view interactions] | High throughput | no | yes |
| TM208_HUMAN | [view interactions] | High throughput | no | yes |
| DERL2_HUMAN | [view interactions] | High throughput | no | yes |
| NAGPA_HUMAN | [view interactions] | High throughput | no | no |
| LTMD1_HUMAN | [view interactions] | High throughput | no | no |
| DHC24_HUMAN | [view interactions] | High throughput | no | yes |
| PRAF3_HUMAN | [view interactions] | High throughput | no | yes |
| RTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KDSR_HUMAN | [view interactions] | High throughput | no | yes |
| EMC7_HUMAN | [view interactions] | High throughput | no | yes |
| DIESL_HUMAN | [view interactions] | High throughput | no | yes |
| PTH2_HUMAN | [view interactions] | High throughput | no | yes |
| PRAF1_HUMAN | [view interactions] | High throughput | no | yes |
| TBL2_HUMAN | [view interactions] | High throughput | no | no |
| MMP15_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AR6P1_HUMAN | [view interactions] | High throughput | no | yes |
| COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPE_HUMAN | [view interactions] | High throughput | no | yes |
| COPG2_HUMAN | [view interactions] | High throughput | no | yes |
| COPZ1_HUMAN | [view interactions] | High throughput | no | no |
| DOCK7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REEP4_HUMAN | [view interactions] | High throughput | no | no |
| REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| REEP6_HUMAN | [view interactions] | High throughput | no | no |
| STK26_HUMAN | [view interactions] | High throughput | no | no |
| VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VAPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| CBL_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| PRDC1_HUMAN | [view interactions] | High throughput | no | yes |
| AT1B3_HUMAN | [view interactions] | High throughput | no | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANR28_HUMAN | [view interactions] | High throughput | no | no |
| PA24A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| SYVN1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| TMT1A_HUMAN | [view interactions] | High throughput | no | no |
| NU155_HUMAN | [view interactions] | High throughput | no | yes |
| PANX1_HUMAN | [view interactions] | High throughput | no | no |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3B_HUMAN | [view interactions] | High throughput | no | no |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |