TOLIP_HUMAN
Evidence for PS localization
Functions
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TOLIP_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 27.9279 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 27.0270 | 4 | no |
| GO:0046872 | metal ion binding | 26.1261 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.1261 | 4 | no |
| GO:0003723 | RNA binding | 23.4234 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 22.5225 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 21.6216 | 5 | no |
| GO:0005524 | ATP binding | 20.7207 | 5 | no |
| GO:0019900 | kinase binding | 15.3153 | 4 | yes |
| GO:0044389 | ubiquitin-like protein ligase binding | 15.3153 | 4 | yes |
| GO:0031625 | ubiquitin protein ligase binding | 14.4144 | 5 | yes |
| GO:0043130 | ubiquitin binding | 6.3063 | 4 | yes |
| GO:0005126 | cytokine receptor binding | 5.4054 | 4 | yes |
| GO:0070851 | growth factor receptor binding | 5.4054 | 4 | yes |
| GO:0005149 | interleukin-1 receptor binding | 3.6036 | 5 | yes |
| GO:0044390 | ubiquitin-like protein conjugating enzyme binding | 3.6036 | 4 | yes |
| GO:0031624 | ubiquitin conjugating enzyme binding | 2.7027 | 5 | yes |
| GO:0035325 | Toll-like receptor binding | 2.7027 | 4 | yes |
| GO:0005150 | interleukin-1, type I receptor binding | 1.8018 | 6 | yes |
| GO:0032183 | SUMO binding | 1.8018 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TOLIP_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 51.3514 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 51.3514 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.4505 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 47.7477 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 46.8468 | 4 | yes |
| GO:0022607 | cellular component assembly | 43.2432 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 42.3423 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 39.6396 | 4 | no |
| GO:0008104 | protein localization | 36.0360 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 36.0360 | 4 | yes |
| GO:0010468 | regulation of gene expression | 35.1351 | 5 | no |
| GO:0071702 | organic substance transport | 35.1351 | 4 | no |
| GO:0006996 | organelle organization | 34.2342 | 4 | no |
| GO:0051049 | regulation of transport | 34.2342 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | yes |
| GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
| GO:0071705 | nitrogen compound transport | 33.3333 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 32.4324 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 32.4324 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 30.6306 | 4 | no |
| GO:0043933 | protein-containing complex organization | 29.7297 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.7297 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.7297 | 5 | no |
| GO:0009966 | regulation of signal transduction | 29.7297 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.8288 | 5 | no |
| GO:0015031 | protein transport | 28.8288 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 28.8288 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 28.8288 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.0270 | 5 | no |
| GO:0033043 | regulation of organelle organization | 27.0270 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.1261 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.2252 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 25.2252 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.2252 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 25.2252 | 5 | no |
| GO:0010941 | regulation of cell death | 25.2252 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.3243 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 24.3243 | 4 | no |
| GO:0031399 | regulation of protein modification process | 23.4234 | 6 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 23.4234 | 5 | no |
| GO:0071310 | cellular response to organic substance | 23.4234 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 23.4234 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.4234 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 22.5225 | 4 | no |
| GO:0060341 | regulation of cellular localization | 22.5225 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 22.5225 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 22.5225 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.6216 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 21.6216 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.6216 | 6 | no |
| GO:0051248 | negative regulation of protein metabolic process | 21.6216 | 6 | no |
| GO:0006886 | intracellular protein transport | 20.7207 | 4 | no |
| GO:0032880 | regulation of protein localization | 20.7207 | 5 | no |
| GO:0051050 | positive regulation of transport | 20.7207 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 20.7207 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 19.8198 | 6 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 18.9189 | 4 | yes |
| GO:0009057 | macromolecule catabolic process | 15.3153 | 4 | yes |
| GO:0044265 | cellular macromolecule catabolic process | 14.4144 | 4 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 13.5135 | 5 | yes |
| GO:0006508 | proteolysis | 13.5135 | 4 | yes |
| GO:0019941 | modification-dependent protein catabolic process | 12.6126 | 6 | yes |
| GO:0031401 | positive regulation of protein modification process | 12.6126 | 7 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 12.6126 | 5 | yes |
| GO:0033365 | protein localization to organelle | 10.8108 | 5 | yes |
| GO:0016310 | phosphorylation | 9.0090 | 5 | yes |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 9.0090 | 7 | yes |
| GO:1903320 | regulation of protein modification by small protein conjugation or removal | 7.2072 | 7 | yes |
| GO:0006954 | inflammatory response | 5.4054 | 4 | yes |
| GO:0030855 | epithelial cell differentiation | 4.5045 | 4 | yes |
| GO:0019221 | cytokine-mediated signaling pathway | 3.6036 | 4 | yes |
| GO:1903322 | positive regulation of protein modification by small protein conjugation or removal | 3.6036 | 8 | yes |
| GO:0033233 | regulation of protein sumoylation | 2.7027 | 8 | yes |
| GO:0036010 | protein localization to endosome | 2.7027 | 6 | yes |
| GO:0070498 | interleukin-1-mediated signaling pathway | 2.7027 | 5 | yes |
| GO:0033235 | positive regulation of protein sumoylation | 1.8018 | 9 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in TOLIP_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 2.7027 | 4 | no |
| DOID:331 | central nervous system disease | 2.7027 | 3 | no |
| DOID:0060038 | specific developmental disorder | 1.8018 | 3 | no |
| DOID:0060307 | autosomal dominant intellectual developmental disorder | 1.8018 | 5 | no |
| DOID:1059 | intellectual disability | 1.8018 | 4 | no |
| DOID:0050700 | cardiomyopathy | 1.8018 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 1.8018 | 5 | no |
| DOID:114 | heart disease | 1.8018 | 3 | no |
| DOID:12930 | dilated cardiomyopathy | 1.8018 | 6 | no |
| DOID:0050890 | synucleinopathy | 1.8018 | 5 | no |
| DOID:0060892 | late onset Parkinsons disease | 1.8018 | 7 | no |
| DOID:14330 | Parkinsons disease | 1.8018 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TLR2_HUMAN | [view interactions] | Low throughput | no | no |
| TLR4_HUMAN | [view interactions] | Low throughput | no | yes |
| RCAN1_HUMAN | [view interactions] | Low throughput | no | yes |
| TRAF6_HUMAN | [view interactions] | Low throughput | no | yes |
| MK14_HUMAN | [view interactions] | Low throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CAV1_HUMAN | [view interactions] | Low throughput | no | no |
| SMAD7_HUMAN | [view interactions] | Low throughput | no | yes |
| TGFR1_HUMAN | [view interactions] | Low throughput | no | no |
| PINK1_HUMAN | [view interactions] | Low throughput | no | yes |
| DRA_HUMAN | [view interactions] | Low throughput | no | no |
| ILRL2_HUMAN | [view interactions] | Low throughput | no | no |
| RNF26_HUMAN | [view interactions] | Low throughput | no | yes |
| M3K5_HUMAN | [view interactions] | Low throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RN186_HUMAN | [view interactions] | Low throughput | no | no |
| GGA1_HUMAN | [view interactions] | Low throughput | no | yes |
| GGA2_HUMAN | [view interactions] | Low throughput | no | yes |
| GGA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TOM1_HUMAN | [view interactions] | Low throughput | no | yes |
| IL1AP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TM1L1_HUMAN | [view interactions] | Low throughput | no | yes |
| IRAK1_HUMAN | [view interactions] | Low throughput | no | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IL1R1_HUMAN | [view interactions] | Low throughput | no | no |
| TM1L2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC9_HUMAN | [view interactions] | Low throughput | no | yes |
| PIAS2_HUMAN | [view interactions] | Low throughput | no | yes |
| SUMO1_HUMAN | [view interactions] | Low throughput | no | yes |
| TOLIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RFOX1_HUMAN | [view interactions] | High throughput | no | yes |
| NRF1_HUMAN | [view interactions] | High throughput | no | yes |
| TET5A_HUMAN | [view interactions] | High throughput | no | yes |
| GUCD1_HUMAN | [view interactions] | High throughput | no | no |
| UBP54_HUMAN | [view interactions] | High throughput | no | yes |
| CS054_HUMAN | [view interactions] | High throughput | no | no |
| F166B_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| IKKB_HUMAN | [view interactions] | High throughput | no | yes |
| SKP2_HUMAN | [view interactions] | High throughput | no | yes |
| AKT3_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| RN19B_HUMAN | [view interactions] | High throughput | no | yes |
| TRIPC_HUMAN | [view interactions] | High throughput | no | yes |
| HABP4_HUMAN | [view interactions] | High throughput | no | yes |
| PDIP3_HUMAN | [view interactions] | High throughput | no | no |
| RRP5_HUMAN | [view interactions] | High throughput | no | yes |
| RAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RPA34_HUMAN | [view interactions] | High throughput | no | yes |
| UBF1_HUMAN | [view interactions] | High throughput | no | yes |
| KDM3B_HUMAN | [view interactions] | High throughput | no | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDGR2_HUMAN | [view interactions] | High throughput | no | yes |
| CREB1_HUMAN | [view interactions] | High throughput | no | yes |
| YTHD1_HUMAN | [view interactions] | High throughput | no | no |
| RED_HUMAN | [view interactions] | High throughput | no | yes |
| ZGPAT_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECM29_HUMAN | [view interactions] | High throughput | no | no |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEDD8_HUMAN | [view interactions] | High throughput | no | yes |
| TRIP6_HUMAN | [view interactions] | High throughput | no | yes |
| SNX8_HUMAN | [view interactions] | High throughput | no | yes |
| ACPH_HUMAN | [view interactions] | High throughput | no | yes |
| NMI_HUMAN | [view interactions] | High throughput | no | yes |
| OXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYHR1_HUMAN | [view interactions] | High throughput | no | yes |
| VPS29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UGGG1_HUMAN | [view interactions] | High throughput | no | yes |
| GIPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| ACLY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANTR1_HUMAN | [view interactions] | High throughput | no | no |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATPO_HUMAN | [view interactions] | High throughput | no | yes |
| BST2_HUMAN | [view interactions] | High throughput | no | yes |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GT251_HUMAN | [view interactions] | High throughput | no | no |
| CSRP2_HUMAN | [view interactions] | High throughput | no | yes |
| DYHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNA13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HLAA_HUMAN | [view interactions] | High throughput | no | no |
| ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIPL_HUMAN | [view interactions] | High throughput | no | no |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MCCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPZL1_HUMAN | [view interactions] | High throughput | no | yes |
| MYL6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NFIP1_HUMAN | [view interactions] | High throughput | no | yes |
| PDCD6_HUMAN | [view interactions] | High throughput | no | no |
| PDC6I_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFKAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS6B_HUMAN | [view interactions] | High throughput | no | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROBO1_HUMAN | [view interactions] | High throughput | no | yes |
| SCAM3_HUMAN | [view interactions] | High throughput | no | no |
| SDC4_HUMAN | [view interactions] | High throughput | no | yes |
| SDCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GTR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNP23_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STAM1_HUMAN | [view interactions] | High throughput | no | yes |
| STOM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFR1_HUMAN | [view interactions] | High throughput | no | yes |
| THOP1_HUMAN | [view interactions] | High throughput | no | yes |
| TMM59_HUMAN | [view interactions] | High throughput | no | yes |
| PSD11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MISP_HUMAN | [view interactions] | High throughput | no | no |
| PALLD_HUMAN | [view interactions] | High throughput | no | yes |
| SRS11_HUMAN | [view interactions] | High throughput | no | yes |
| RANG_HUMAN | [view interactions] | High throughput | no | no |
| RM49_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF5_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
| FADS1_HUMAN | [view interactions] | High throughput | no | yes |
| ALG1_HUMAN | [view interactions] | High throughput | no | yes |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| RTRAF_HUMAN | [view interactions] | High throughput | no | yes |
| RP9_HUMAN | [view interactions] | High throughput | no | yes |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHSO_HUMAN | [view interactions] | High throughput | no | no |
| PRKDC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AHNK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMHD1_HUMAN | [view interactions] | High throughput | no | yes |
| VRK2_HUMAN | [view interactions] | High throughput | no | no |
| VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| ARK72_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIR2_HUMAN | [view interactions] | High throughput | no | no |
| NU160_HUMAN | [view interactions] | High throughput | no | no |
| DMAP1_HUMAN | [view interactions] | High throughput | no | yes |
| NS1BP_HUMAN | [view interactions] | High throughput | no | yes |
| PAPS1_HUMAN | [view interactions] | High throughput | no | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| TECR_HUMAN | [view interactions] | High throughput | no | yes |
| CLPX_HUMAN | [view interactions] | High throughput | no | yes |
| XRN2_HUMAN | [view interactions] | High throughput | no | yes |
| SCRN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBCP1_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX55_HUMAN | [view interactions] | High throughput | no | yes |
| ODAM_HUMAN | [view interactions] | High throughput | no | no |
| MAP1S_HUMAN | [view interactions] | High throughput | no | no |
| E2AK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPCS2_HUMAN | [view interactions] | High throughput | no | yes |
| TLR3_HUMAN | [view interactions] | High throughput | no | yes |
| PP2BA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLR9_HUMAN | [view interactions] | High throughput | no | no |
| L2HDH_HUMAN | [view interactions] | High throughput | no | yes |
| CSTF1_HUMAN | [view interactions] | High throughput | no | yes |
| DSRAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AN13A_HUMAN | [view interactions] | High throughput | no | yes |
| CA2D1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XIAP_HUMAN | [view interactions] | High throughput | no | yes |
| NOP53_HUMAN | [view interactions] | High throughput | no | yes |
| WRIP1_HUMAN | [view interactions] | High throughput | no | yes |
| LIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC2_HUMAN | [view interactions] | High throughput | no | yes |
| CCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RING1_HUMAN | [view interactions] | High throughput | no | yes |
| NT5D2_HUMAN | [view interactions] | High throughput | no | yes |
| KBL_HUMAN | [view interactions] | High throughput | no | yes |
| PEG10_HUMAN | [view interactions] | High throughput | no | no |
| MLH1_HUMAN | [view interactions] | High throughput | no | yes |
| DZIP3_HUMAN | [view interactions] | High throughput | no | yes |
| ZN787_HUMAN | [view interactions] | High throughput | no | yes |
| RNF12_HUMAN | [view interactions] | High throughput | no | yes |
| PTN12_HUMAN | [view interactions] | High throughput | no | yes |
| ABCB6_HUMAN | [view interactions] | High throughput | no | yes |
| MLEC_HUMAN | [view interactions] | High throughput | no | no |
| IRAK2_HUMAN | [view interactions] | High throughput | no | yes |
| PNPO_HUMAN | [view interactions] | High throughput | no | yes |
| RBM34_HUMAN | [view interactions] | High throughput | no | yes |
| NED4L_HUMAN | [view interactions] | High throughput | no | yes |
| PNCB_HUMAN | [view interactions] | High throughput | no | no |
| TCAF1_HUMAN | [view interactions] | High throughput | no | no |
| GTPB6_HUMAN | [view interactions] | High throughput | no | no |
| MAGD1_HUMAN | [view interactions] | High throughput | no | no |
| UBR5_HUMAN | [view interactions] | High throughput | no | no |
| ITCH_HUMAN | [view interactions] | High throughput | no | yes |
| S38A2_HUMAN | [view interactions] | High throughput | no | yes |
| PCID2_HUMAN | [view interactions] | High throughput | no | yes |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| KEAP1_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| ADAM9_HUMAN | [view interactions] | High throughput | no | no |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DRG2_HUMAN | [view interactions] | High throughput | no | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNX6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NOC4L_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RTF2_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN4_HUMAN | [view interactions] | High throughput | no | yes |
| DAZP2_HUMAN | [view interactions] | High throughput | no | no |
| S39A7_HUMAN | [view interactions] | High throughput | no | yes |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DAB1_HUMAN | [view interactions] | High throughput | no | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| RBPMS_HUMAN | [view interactions] | High throughput | no | no |
| MAZ_HUMAN | [view interactions] | High throughput | no | yes |
| PR20D_HUMAN | [view interactions] | High throughput | no | no |
| CIR1_HUMAN | [view interactions] | High throughput | no | yes |
| DCDC2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN106_HUMAN | [view interactions] | High throughput | no | no |
| PRP39_HUMAN | [view interactions] | High throughput | no | yes |
| PHF5A_HUMAN | [view interactions] | High throughput | no | yes |
| RHXF2_HUMAN | [view interactions] | High throughput | no | no |
| STK25_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| LIPA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MSX2_HUMAN | [view interactions] | High throughput | no | no |
| EEA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KR133_HUMAN | [view interactions] | High throughput | no | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KR151_HUMAN | [view interactions] | High throughput | no | no |
| ZFR_HUMAN | [view interactions] | High throughput | no | yes |
| MSS51_HUMAN | [view interactions] | High throughput | no | no |
| PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDIP1_HUMAN | [view interactions] | High throughput | no | yes |
| GOPC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STN1_HUMAN | [view interactions] | High throughput | no | no |
| MTCL1_HUMAN | [view interactions] | High throughput | no | yes |
| DDT4L_HUMAN | [view interactions] | High throughput | no | no |
| HMGN2_HUMAN | [view interactions] | High throughput | no | no |
| ZMY19_HUMAN | [view interactions] | High throughput | no | yes |
| INCE_HUMAN | [view interactions] | High throughput | no | no |
| KRA61_HUMAN | [view interactions] | High throughput | no | no |
| MAGA1_HUMAN | [view interactions] | High throughput | no | no |
| MEDAG_HUMAN | [view interactions] | High throughput | no | no |
| EIF3L_HUMAN | [view interactions] | High throughput | no | yes |
| KRA62_HUMAN | [view interactions] | High throughput | no | no |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHAF1_HUMAN | [view interactions] | High throughput | no | yes |
| WNK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSB1_HUMAN | [view interactions] | High throughput | no | yes |
| CNOT1_HUMAN | [view interactions] | High throughput | no | yes |
| KRA71_HUMAN | [view interactions] | High throughput | no | no |
| TRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC9C_HUMAN | [view interactions] | High throughput | no | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARRD3_HUMAN | [view interactions] | High throughput | no | no |
| ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KR197_HUMAN | [view interactions] | High throughput | no | no |
| RTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MVP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BD1L1_HUMAN | [view interactions] | High throughput | no | yes |
| RNF11_HUMAN | [view interactions] | High throughput | no | yes |
| CHERP_HUMAN | [view interactions] | High throughput | no | no |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIF11_HUMAN | [view interactions] | High throughput | no | yes |
| SETB1_HUMAN | [view interactions] | High throughput | no | yes |
| E41L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZHX1_HUMAN | [view interactions] | High throughput | no | no |
| TPX2_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT16_HUMAN | [view interactions] | High throughput | no | yes |
| TS101_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEPT1_HUMAN | [view interactions] | High throughput | no | no |
| TB182_HUMAN | [view interactions] | High throughput | no | yes |
| LDB1_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| BHE40_HUMAN | [view interactions] | High throughput | no | yes |
| SPTC1_HUMAN | [view interactions] | High throughput | no | yes |
| CHD6_HUMAN | [view interactions] | High throughput | no | no |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CASA1_HUMAN | [view interactions] | High throughput | no | no |
| TP53B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CASB_HUMAN | [view interactions] | High throughput | no | no |
| ZFY16_HUMAN | [view interactions] | High throughput | no | yes |
| FRIH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAGL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HERP1_HUMAN | [view interactions] | High throughput | no | yes |
| RETST_HUMAN | [view interactions] | High throughput | no | yes |
| N4BP2_HUMAN | [view interactions] | High throughput | no | yes |
| CEP72_HUMAN | [view interactions] | High throughput | no | yes |
| RFOX2_HUMAN | [view interactions] | High throughput | no | yes |
| LIPB1_HUMAN | [view interactions] | High throughput | no | yes |
| TBX3_HUMAN | [view interactions] | High throughput | no | no |
| IF4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| AKA12_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| PP6R3_HUMAN | [view interactions] | High throughput | no | yes |
| SORCN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI67_HUMAN | [view interactions] | High throughput | no | no |
| SPF45_HUMAN | [view interactions] | High throughput | no | yes |
| FHL2_HUMAN | [view interactions] | High throughput | no | yes |
| BEX1_HUMAN | [view interactions] | High throughput | no | yes |
| AFAP1_HUMAN | [view interactions] | High throughput | no | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| HECD1_HUMAN | [view interactions] | High throughput | no | yes |
| RS27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBC15_HUMAN | [view interactions] | High throughput | no | yes |
| RS27L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DIAP3_HUMAN | [view interactions] | High throughput | no | no |
| SIAH1_HUMAN | [view interactions] | High throughput | no | yes |
| LUZP1_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF6_HUMAN | [view interactions] | High throughput | no | yes |
| TFG_HUMAN | [view interactions] | High throughput | no | yes |
| PR20E_HUMAN | [view interactions] | High throughput | no | no |
| TBCD4_HUMAN | [view interactions] | High throughput | no | yes |
| WBP2_HUMAN | [view interactions] | High throughput | no | yes |
| F168A_HUMAN | [view interactions] | High throughput | no | yes |
| IL1B_HUMAN | [view interactions] | Computational | no | no |
| ECHP_HUMAN | [view interactions] | Computational | no | no |
| IL1A_HUMAN | [view interactions] | Computational | no | no |
| IL1RA_HUMAN | [view interactions] | Computational | no | no |
| TIRAP_HUMAN | [view interactions] | Computational | no | no |
| LY96_HUMAN | [view interactions] | Computational | no | no |
| IRAK3_HUMAN | [view interactions] | Computational | no | yes |
| UBB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS27A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL40_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MYD88_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CD14_HUMAN | [view interactions] | Computational | no | no |