Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IL1AP_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Unable to mediate canonical IL-1 signaling (PubMed). Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in IL1AP_HUMAN
GO:0000166 nucleotide binding 36.8421 4 no
GO:0017076 purine nucleotide binding 36.8421 5 no
GO:0032555 purine ribonucleotide binding 36.8421 4 no
GO:0043168 anion binding 36.8421 4 no
GO:0035639 purine ribonucleoside triphosphate binding 31.5789 4 no
GO:0019900 kinase binding 26.3158 4 no
GO:0005126 cytokine receptor binding 21.0526 4 yes
GO:0043169 cation binding 21.0526 4 no
GO:0046872 metal ion binding 21.0526 5 no
GO:0019901 protein kinase binding 21.0526 5 no
GO:0031625 ubiquitin protein ligase binding 21.0526 5 no
GO:0044389 ubiquitin-like protein ligase binding 21.0526 4 no
GO:0030554 adenyl nucleotide binding 21.0526 6 no
GO:0032559 adenyl ribonucleotide binding 21.0526 5 no
GO:0005149 interleukin-1 receptor binding 10.5263 5 yes
GO:0070851 growth factor receptor binding 10.5263 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in IL1AP_HUMAN
GO:0060255 regulation of macromolecule metabolic process 63.1579 4 yes
GO:0048522 positive regulation of cellular process 57.8947 4 yes
GO:0009966 regulation of signal transduction 57.8947 4 no
GO:0010646 regulation of cell communication 57.8947 4 no
GO:0009889 regulation of biosynthetic process 52.6316 4 yes
GO:0010468 regulation of gene expression 52.6316 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 52.6316 5 yes
GO:0031323 regulation of cellular metabolic process 52.6316 4 yes
GO:0031326 regulation of cellular biosynthetic process 52.6316 5 yes
GO:0048523 negative regulation of cellular process 52.6316 4 no
GO:0080090 regulation of primary metabolic process 52.6316 4 no
GO:0051128 regulation of cellular component organization 47.3684 4 yes
GO:0051240 positive regulation of multicellular organismal process 47.3684 4 yes
GO:0009893 positive regulation of metabolic process 42.1053 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 42.1053 5 yes
GO:2000026 regulation of multicellular organismal development 42.1053 4 yes
GO:0141124 intracellular signaling cassette 42.1053 4 no
GO:0006796 phosphate-containing compound metabolic process 42.1053 4 no
GO:0036211 protein modification process 42.1053 4 no
GO:0043412 macromolecule modification 42.1053 4 no
GO:0048584 positive regulation of response to stimulus 42.1053 4 no
GO:0031325 positive regulation of cellular metabolic process 36.8421 5 yes
GO:0051094 positive regulation of developmental process 36.8421 4 yes
GO:0032101 regulation of response to external stimulus 36.8421 4 no
GO:0042981 regulation of apoptotic process 36.8421 5 no
GO:0043067 regulation of programmed cell death 36.8421 4 no
GO:0051246 regulation of protein metabolic process 36.8421 5 no
GO:0009967 positive regulation of signal transduction 36.8421 5 no
GO:0010647 positive regulation of cell communication 36.8421 5 no
GO:0023056 positive regulation of signaling 36.8421 4 no
GO:0001817 regulation of cytokine production 31.5789 4 yes
GO:0009891 positive regulation of biosynthetic process 31.5789 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 31.5789 6 yes
GO:0019221 cytokine-mediated signaling pathway 31.5789 4 yes
GO:0031328 positive regulation of cellular biosynthetic process 31.5789 6 yes
GO:0033043 regulation of organelle organization 31.5789 5 yes
GO:0051130 positive regulation of cellular component organization 31.5789 5 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 31.5789 4 no
GO:0031344 regulation of cell projection organization 31.5789 5 no
GO:0045595 regulation of cell differentiation 31.5789 4 no
GO:0060284 regulation of cell development 31.5789 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 31.5789 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 31.5789 5 no
GO:0080134 regulation of response to stress 31.5789 4 no
GO:1902531 regulation of intracellular signal transduction 31.5789 5 no
GO:0008104 protein localization 31.5789 4 no
GO:0008284 positive regulation of cell population proliferation 31.5789 5 no
GO:0042127 regulation of cell population proliferation 31.5789 4 no
GO:0071310 cellular response to organic substance 31.5789 4 no
GO:1901701 cellular response to oxygen-containing compound 31.5789 4 no
GO:0010628 positive regulation of gene expression 26.3158 7 yes
GO:0022607 cellular component assembly 26.3158 4 yes
GO:0044087 regulation of cellular component biogenesis 26.3158 4 yes
GO:0051960 regulation of nervous system development 26.3158 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 26.3158 4 no
GO:0045597 positive regulation of cell differentiation 26.3158 5 no
GO:0050776 regulation of immune response 26.3158 4 no
GO:0002684 positive regulation of immune system process 26.3158 4 no
GO:0006355 regulation of DNA-templated transcription 26.3158 7 no
GO:0006915 apoptotic process 26.3158 4 no
GO:0031347 regulation of defense response 26.3158 5 no
GO:0051252 regulation of RNA metabolic process 26.3158 5 no
GO:2001141 regulation of RNA biosynthetic process 26.3158 6 no
GO:0009890 negative regulation of biosynthetic process 26.3158 5 no
GO:0009892 negative regulation of metabolic process 26.3158 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 26.3158 6 no
GO:0010605 negative regulation of macromolecule metabolic process 26.3158 5 no
GO:0016310 phosphorylation 26.3158 5 no
GO:0019220 regulation of phosphate metabolic process 26.3158 6 no
GO:0031324 negative regulation of cellular metabolic process 26.3158 5 no
GO:0031327 negative regulation of cellular biosynthetic process 26.3158 6 no
GO:0051174 regulation of phosphorus metabolic process 26.3158 5 no
GO:0051247 positive regulation of protein metabolic process 26.3158 6 no
GO:0006996 organelle organization 26.3158 4 no
GO:0031399 regulation of protein modification process 26.3158 6 no
GO:1902533 positive regulation of intracellular signal transduction 26.3158 6 no
GO:0001819 positive regulation of cytokine production 21.0526 5 yes
GO:0006954 inflammatory response 21.0526 4 yes
GO:0043933 protein-containing complex organization 21.0526 4 yes
GO:0044089 positive regulation of cellular component biogenesis 21.0526 5 yes
GO:0050807 regulation of synapse organization 21.0526 5 yes
GO:0051962 positive regulation of nervous system development 21.0526 5 yes
GO:0070498 interleukin-1-mediated signaling pathway 21.0526 5 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 21.0526 4 yes
GO:0099560 synaptic membrane adhesion 21.0526 5 yes
GO:0140546 defense response to symbiont 21.0526 4 yes
GO:1901888 regulation of cell junction assembly 21.0526 5 yes
GO:0043085 positive regulation of catalytic activity 21.0526 4 no
GO:0051049 regulation of transport 21.0526 4 no
GO:0010720 positive regulation of cell development 21.0526 6 no
GO:0010975 regulation of neuron projection development 21.0526 7 no
GO:0031346 positive regulation of cell projection organization 21.0526 6 no
GO:0048585 negative regulation of response to stimulus 21.0526 4 no
GO:0050767 regulation of neurogenesis 21.0526 6 no
GO:0050804 modulation of chemical synaptic transmission 21.0526 5 no
GO:0099177 regulation of trans-synaptic signaling 21.0526 4 no
GO:0002831 regulation of response to biotic stimulus 21.0526 4 no
GO:0032103 positive regulation of response to external stimulus 21.0526 5 no
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 21.0526 5 no
GO:0010243 response to organonitrogen compound 21.0526 4 no
GO:0010629 negative regulation of gene expression 21.0526 7 no
GO:0014070 response to organic cyclic compound 21.0526 4 no
GO:0030334 regulation of cell migration 21.0526 5 no
GO:0030335 positive regulation of cell migration 21.0526 6 no
GO:0034097 response to cytokine 21.0526 4 no
GO:0040017 positive regulation of locomotion 21.0526 4 no
GO:2000145 regulation of cell motility 21.0526 4 no
GO:2000147 positive regulation of cell motility 21.0526 5 no
GO:0007010 cytoskeleton organization 21.0526 5 no
GO:0001932 regulation of protein phosphorylation 21.0526 7 no
GO:0031401 positive regulation of protein modification process 21.0526 7 no
GO:0042325 regulation of phosphorylation 21.0526 7 no
GO:0032675 regulation of interleukin-6 production 15.7895 5 yes
GO:0032755 positive regulation of interleukin-6 production 15.7895 6 yes
GO:0051963 regulation of synapse assembly 15.7895 6 yes
GO:0065003 protein-containing complex assembly 15.7895 5 yes
GO:0099150 regulation of postsynaptic specialization assembly 15.7895 6 yes
GO:0099151 regulation of postsynaptic density assembly 15.7895 7 yes
GO:0099175 regulation of postsynapse organization 15.7895 6 yes
GO:0099536 synaptic signaling 15.7895 4 yes
GO:0099537 trans-synaptic signaling 15.7895 5 yes
GO:1901890 positive regulation of cell junction assembly 15.7895 6 yes
GO:1902115 regulation of organelle assembly 15.7895 5 yes
GO:1904889 regulation of excitatory synapse assembly 15.7895 7 yes
GO:1905874 regulation of postsynaptic density organization 15.7895 6 yes
GO:0038172 interleukin-33-mediated signaling pathway 10.5263 5 yes
GO:0051965 positive regulation of synapse assembly 10.5263 6 yes
GO:0099545 trans-synaptic signaling by trans-synaptic complex 10.5263 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TOLIP_HUMAN [view entry] [view interactions] Low throughput yes yes
ILRL1_HUMAN [view interactions] Low throughput no no
TCAM2_HUMAN [view interactions] Low throughput no no
IL1R1_HUMAN [view interactions] Low throughput no no
IL1R2_HUMAN [view interactions] Low throughput no no
IL1B_HUMAN [view interactions] Low throughput no no
TRAF6_HUMAN [view entry] [view interactions] Low throughput yes yes
TRAF3_HUMAN [view entry] [view interactions] Low throughput yes yes
IRAK1_HUMAN [view interactions] Low throughput no yes
STAT3_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
MYD88_HUMAN [view interactions] Low throughput no yes
MARH8_HUMAN [view interactions] Low throughput no no
ILRL2_HUMAN [view interactions] Low throughput no no
IL18R_HUMAN [view interactions] Low throughput no yes
PTPRD_HUMAN [view entry] [view interactions] Low throughput yes no
PTPRF_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRS_HUMAN [view entry] [view interactions] Low throughput yes no
IL33_HUMAN [view interactions] Low throughput no yes
PR40A_HUMAN [view interactions] High throughput no no
PK3CA_HUMAN [view entry] [view interactions] High throughput yes yes
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
CD81_HUMAN [view interactions] High throughput no no
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
IMA5_HUMAN [view entry] [view interactions] High throughput yes yes
MC4R_HUMAN [view interactions] High throughput no yes
KPCI_HUMAN [view entry] [view interactions] High throughput yes yes
CCNI_HUMAN [view interactions] High throughput no yes
SMAD2_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
HAVR2_HUMAN [view interactions] High throughput no no
PCDAC_HUMAN [view interactions] High throughput no yes
PCDGG_HUMAN [view interactions] High throughput no no
SIDT2_HUMAN [view interactions] High throughput no yes
NRSN1_HUMAN [view interactions] High throughput no yes
GLT10_HUMAN [view interactions] High throughput no no
COPT1_HUMAN [view interactions] High throughput no no
TMM74_HUMAN [view interactions] High throughput no no
TTMP_HUMAN [view interactions] High throughput no no
RAMP3_HUMAN [view interactions] High throughput no no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
UBE2H_HUMAN [view interactions] High throughput no yes
TIRAP_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
H2B2F_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
MUC18_HUMAN [view interactions] High throughput no yes