Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

IL1AP_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Unable to mediate canonical IL-1 signaling (PubMed). Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in IL1AP_HUMAN
GO:0017076 purine nucleotide binding 35.2941 4 no
GO:0019900 kinase binding 35.2941 4 no
GO:0032555 purine ribonucleotide binding 35.2941 4 no
GO:0035639 purine ribonucleoside triphosphate binding 35.2941 4 no
GO:0019901 protein kinase binding 29.4118 5 no
GO:0005126 cytokine receptor binding 23.5294 4 yes
GO:0031625 ubiquitin protein ligase binding 23.5294 5 no
GO:0044389 ubiquitin-like protein ligase binding 23.5294 4 no
GO:0005149 interleukin-1 receptor binding 17.6471 5 yes
GO:0070851 growth factor receptor binding 17.6471 4 yes
GO:0003953 NAD+ nucleosidase activity 11.7647 5 yes
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds 11.7647 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in IL1AP_HUMAN
GO:0060255 regulation of macromolecule metabolic process 76.4706 4 yes
GO:0048522 positive regulation of cellular process 70.5882 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 70.5882 4 yes
GO:0080090 regulation of primary metabolic process 70.5882 4 yes
GO:0009966 regulation of signal transduction 70.5882 4 no
GO:0010646 regulation of cell communication 70.5882 4 no
GO:0010468 regulation of gene expression 64.7059 5 yes
GO:0031323 regulation of cellular metabolic process 64.7059 4 yes
GO:0051128 regulation of cellular component organization 58.8235 4 yes
GO:0048523 negative regulation of cellular process 58.8235 4 no
GO:0009893 positive regulation of metabolic process 52.9412 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 52.9412 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 52.9412 5 yes
GO:0009967 positive regulation of signal transduction 52.9412 5 no
GO:0010647 positive regulation of cell communication 52.9412 5 no
GO:0023056 positive regulation of signaling 52.9412 4 no
GO:0048584 positive regulation of response to stimulus 52.9412 4 no
GO:0009889 regulation of biosynthetic process 47.0588 4 yes
GO:0031326 regulation of cellular biosynthetic process 47.0588 5 yes
GO:0006796 phosphate-containing compound metabolic process 47.0588 4 no
GO:0051246 regulation of protein metabolic process 47.0588 5 no
GO:0001817 regulation of cytokine production 41.1765 4 yes
GO:0006355 regulation of DNA-templated transcription 41.1765 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 41.1765 5 yes
GO:0051130 positive regulation of cellular component organization 41.1765 5 yes
GO:0051240 positive regulation of multicellular organismal process 41.1765 4 yes
GO:0051252 regulation of RNA metabolic process 41.1765 5 yes
GO:1903506 regulation of nucleic acid-templated transcription 41.1765 7 yes
GO:2001141 regulation of RNA biosynthetic process 41.1765 6 yes
GO:0010941 regulation of cell death 41.1765 4 no
GO:0042981 regulation of apoptotic process 41.1765 6 no
GO:0043067 regulation of programmed cell death 41.1765 5 no
GO:0008284 positive regulation of cell population proliferation 41.1765 5 no
GO:0036211 protein modification process 41.1765 4 no
GO:0042127 regulation of cell population proliferation 41.1765 4 no
GO:0043412 macromolecule modification 41.1765 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 41.1765 5 no
GO:0051247 positive regulation of protein metabolic process 41.1765 6 no
GO:1902531 regulation of intracellular signal transduction 41.1765 5 no
GO:1902533 positive regulation of intracellular signal transduction 41.1765 6 no
GO:0032101 regulation of response to external stimulus 41.1765 4 no
GO:0010628 positive regulation of gene expression 35.2941 6 yes
GO:0033043 regulation of organelle organization 35.2941 5 yes
GO:0051094 positive regulation of developmental process 35.2941 4 yes
GO:2000026 regulation of multicellular organismal development 35.2941 4 yes
GO:1901701 cellular response to oxygen-containing compound 35.2941 4 no
GO:0010243 response to organonitrogen compound 35.2941 4 no
GO:0031344 regulation of cell projection organization 35.2941 5 no
GO:0045595 regulation of cell differentiation 35.2941 4 no
GO:0071310 cellular response to organic substance 35.2941 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 35.2941 6 no
GO:0007167 enzyme-linked receptor protein signaling pathway 35.2941 4 no
GO:0009892 negative regulation of metabolic process 35.2941 4 no
GO:0010605 negative regulation of macromolecule metabolic process 35.2941 5 no
GO:0031325 positive regulation of cellular metabolic process 35.2941 5 no
GO:0031399 regulation of protein modification process 35.2941 6 no
GO:0050776 regulation of immune response 35.2941 4 no
GO:0019221 cytokine-mediated signaling pathway 35.2941 4 no
GO:0080134 regulation of response to stress 35.2941 4 no
GO:0006954 inflammatory response 29.4118 4 yes
GO:0044087 regulation of cellular component biogenesis 29.4118 4 yes
GO:0044089 positive regulation of cellular component biogenesis 29.4118 5 yes
GO:0051091 positive regulation of DNA-binding transcription factor activity 29.4118 4 yes
GO:0051092 positive regulation of NF-kappaB transcription factor activity 29.4118 5 yes
GO:0008104 protein localization 29.4118 4 no
GO:0006915 apoptotic process 29.4118 4 no
GO:0006996 organelle organization 29.4118 4 no
GO:0007010 cytoskeleton organization 29.4118 5 no
GO:0016192 vesicle-mediated transport 29.4118 4 no
GO:0022603 regulation of anatomical structure morphogenesis 29.4118 4 no
GO:0030334 regulation of cell migration 29.4118 5 no
GO:2000145 regulation of cell motility 29.4118 4 no
GO:0016310 phosphorylation 29.4118 5 no
GO:0002684 positive regulation of immune system process 29.4118 4 no
GO:0009894 regulation of catabolic process 29.4118 4 no
GO:0019220 regulation of phosphate metabolic process 29.4118 6 no
GO:0031401 positive regulation of protein modification process 29.4118 7 no
GO:0042325 regulation of phosphorylation 29.4118 7 no
GO:0051174 regulation of phosphorus metabolic process 29.4118 5 no
GO:0080135 regulation of cellular response to stress 29.4118 4 no
GO:0001819 positive regulation of cytokine production 23.5294 5 yes
GO:0051960 regulation of nervous system development 23.5294 5 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 23.5294 4 yes
GO:0099560 synaptic membrane adhesion 23.5294 5 yes
GO:0006886 intracellular protein transport 23.5294 4 no
GO:0015031 protein transport 23.5294 4 no
GO:0071702 organic substance transport 23.5294 4 no
GO:0071705 nitrogen compound transport 23.5294 4 no
GO:0030335 positive regulation of cell migration 23.5294 6 no
GO:0040017 positive regulation of locomotion 23.5294 4 no
GO:0051493 regulation of cytoskeleton organization 23.5294 6 no
GO:0062197 cellular response to chemical stress 23.5294 4 no
GO:2000147 positive regulation of cell motility 23.5294 5 no
GO:0010975 regulation of neuron projection development 23.5294 7 no
GO:0031346 positive regulation of cell projection organization 23.5294 6 no
GO:0034097 response to cytokine 23.5294 4 no
GO:0043066 negative regulation of apoptotic process 23.5294 7 no
GO:0043069 negative regulation of programmed cell death 23.5294 6 no
GO:0045597 positive regulation of cell differentiation 23.5294 5 no
GO:0060284 regulation of cell development 23.5294 5 no
GO:0060548 negative regulation of cell death 23.5294 5 no
GO:0001932 regulation of protein phosphorylation 23.5294 7 no
GO:0001934 positive regulation of protein phosphorylation 23.5294 8 no
GO:0009895 negative regulation of catabolic process 23.5294 5 no
GO:0010562 positive regulation of phosphorus metabolic process 23.5294 6 no
GO:0010629 negative regulation of gene expression 23.5294 6 no
GO:0031324 negative regulation of cellular metabolic process 23.5294 5 no
GO:0031329 regulation of cellular catabolic process 23.5294 5 no
GO:0033993 response to lipid 23.5294 4 no
GO:0042327 positive regulation of phosphorylation 23.5294 8 no
GO:0045937 positive regulation of phosphate metabolic process 23.5294 7 no
GO:0031347 regulation of defense response 23.5294 5 no
GO:0070498 interleukin-1-mediated signaling pathway 23.5294 5 no
GO:0022607 cellular component assembly 17.6471 4 yes
GO:0032675 regulation of interleukin-6 production 17.6471 5 yes
GO:0032755 positive regulation of interleukin-6 production 17.6471 6 yes
GO:0051962 positive regulation of nervous system development 17.6471 5 yes
GO:1901888 regulation of cell junction assembly 17.6471 5 yes
GO:1901890 positive regulation of cell junction assembly 17.6471 6 yes
GO:0043933 protein-containing complex organization 11.7647 4 yes
GO:0050807 regulation of synapse organization 11.7647 5 yes
GO:0051963 regulation of synapse assembly 11.7647 6 yes
GO:0051965 positive regulation of synapse assembly 11.7647 6 yes
GO:0065003 protein-containing complex assembly 11.7647 5 yes
GO:0099150 regulation of postsynaptic specialization assembly 11.7647 6 yes
GO:0099151 regulation of postsynaptic density assembly 11.7647 7 yes
GO:0099174 regulation of presynapse organization 11.7647 6 yes
GO:0099175 regulation of postsynapse organization 11.7647 6 yes
GO:0099537 trans-synaptic signaling 11.7647 4 yes
GO:0099545 trans-synaptic signaling by trans-synaptic complex 11.7647 5 yes
GO:1902115 regulation of organelle assembly 11.7647 5 yes
GO:1904889 regulation of excitatory synapse assembly 11.7647 7 yes
GO:1905606 regulation of presynapse assembly 11.7647 7 yes
GO:1905874 regulation of postsynaptic density organization 11.7647 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TOLIP_HUMAN [view entry] [view interactions] Low throughput yes yes
ILRL1_HUMAN [view interactions] Low throughput no no
TCAM2_HUMAN [view interactions] Low throughput no no
IL1R1_HUMAN [view interactions] Low throughput no no
IL1B_HUMAN [view interactions] Low throughput no no
IL1R2_HUMAN [view interactions] Low throughput no no
TRAF6_HUMAN [view interactions] Low throughput no yes
TRAF3_HUMAN [view entry] [view interactions] Low throughput yes yes
IRAK1_HUMAN [view interactions] Low throughput no yes
STAT3_HUMAN [view entry] [view interactions] Low throughput yes yes
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
MYD88_HUMAN [view entry] [view interactions] Low throughput yes yes
MARH8_HUMAN [view interactions] Low throughput no no
ILRL2_HUMAN [view interactions] Low throughput no no
IL18R_HUMAN [view interactions] Low throughput no yes
PTPRD_HUMAN [view entry] [view interactions] Low throughput yes no
PTPRF_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRS_HUMAN [view entry] [view interactions] Low throughput yes no
IL33_HUMAN [view interactions] Low throughput no yes
PR40A_HUMAN [view interactions] High throughput no yes
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
CD81_HUMAN [view interactions] High throughput no no
IMA5_HUMAN [view entry] [view interactions] High throughput yes yes
MC4R_HUMAN [view interactions] High throughput no yes
KPCI_HUMAN [view entry] [view interactions] High throughput yes yes
CCNI_HUMAN [view interactions] High throughput no yes
SMAD2_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
HAVR2_HUMAN [view interactions] High throughput no no
PCDAC_HUMAN [view interactions] High throughput no yes
PCDGG_HUMAN [view interactions] High throughput no no
SIDT2_HUMAN [view interactions] High throughput no yes
NRSN1_HUMAN [view interactions] High throughput no yes
GLT10_HUMAN [view interactions] High throughput no no
COPT1_HUMAN [view interactions] High throughput no no
TMM74_HUMAN [view interactions] High throughput no no
TTMP_HUMAN [view interactions] High throughput no no
RAMP3_HUMAN [view interactions] High throughput no no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
TIRAP_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
H2B2F_HUMAN [view interactions] High throughput no yes
IRAK2_HUMAN [view interactions] Computational no yes
PK3CA_HUMAN [view entry] [view interactions] Computational yes yes
IL1RA_HUMAN [view interactions] Computational no no
TF65_HUMAN [view entry] [view interactions] Computational yes yes
NFKB1_HUMAN [view interactions] Computational no yes
IL36B_HUMAN [view interactions] Computational no no
IL36A_HUMAN [view interactions] Computational no no
IRAK3_HUMAN [view interactions] Computational no yes
I36RA_HUMAN [view interactions] Computational no no
IL1FA_HUMAN [view interactions] Computational no no
P85A_HUMAN [view interactions] Computational no yes
KIT_HUMAN [view interactions] Computational no no
IL1A_HUMAN [view interactions] Computational no no