Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PTPRF_HUMAN

The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in PTPRF_HUMAN
GO:0017076 purine nucleotide binding 41.3333 4 no
GO:0032555 purine ribonucleotide binding 41.3333 4 no
GO:0035639 purine ribonucleoside triphosphate binding 40.0000 4 no
GO:0016462 pyrophosphatase activity 29.3333 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 29.3333 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 29.3333 6 no
GO:0019900 kinase binding 26.6667 4 no
GO:0019901 protein kinase binding 25.3333 5 no
GO:0030554 adenyl nucleotide binding 21.3333 5 no
GO:0032559 adenyl ribonucleotide binding 21.3333 5 no
GO:0016791 phosphatase activity 12.0000 5 yes
GO:0042578 phosphoric ester hydrolase activity 12.0000 4 yes
GO:0004725 protein tyrosine phosphatase activity 9.3333 4 yes
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 6.6667 5 yes
GO:0019198 transmembrane receptor protein phosphatase activity 6.6667 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PTPRF_HUMAN
GO:0048522 positive regulation of cellular process 62.6667 4 no
GO:0051128 regulation of cellular component organization 56.0000 4 yes
GO:0048523 negative regulation of cellular process 52.0000 4 no
GO:0010646 regulation of cell communication 50.6667 4 no
GO:0060255 regulation of macromolecule metabolic process 46.6667 4 no
GO:0009966 regulation of signal transduction 46.6667 4 no
GO:0031323 regulation of cellular metabolic process 44.0000 4 no
GO:0080090 regulation of primary metabolic process 42.6667 4 no
GO:0051171 regulation of nitrogen compound metabolic process 40.0000 4 no
GO:0009893 positive regulation of metabolic process 40.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 38.6667 5 no
GO:0051049 regulation of transport 36.0000 4 no
GO:0010468 regulation of gene expression 36.0000 5 no
GO:0031325 positive regulation of cellular metabolic process 36.0000 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 34.6667 5 no
GO:0048584 positive regulation of response to stimulus 34.6667 4 no
GO:0060341 regulation of cellular localization 34.6667 4 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0071310 cellular response to organic substance 32.0000 4 no
GO:0010647 positive regulation of cell communication 32.0000 5 no
GO:0023056 positive regulation of signaling 32.0000 4 no
GO:0033043 regulation of organelle organization 32.0000 5 no
GO:0051246 regulation of protein metabolic process 30.6667 5 no
GO:0006996 organelle organization 30.6667 4 no
GO:0006796 phosphate-containing compound metabolic process 30.6667 4 yes
GO:0044087 regulation of cellular component biogenesis 30.6667 4 no
GO:1902531 regulation of intracellular signal transduction 29.3333 5 no
GO:0009967 positive regulation of signal transduction 29.3333 5 no
GO:0051130 positive regulation of cellular component organization 28.0000 5 no
GO:0080134 regulation of response to stress 28.0000 4 yes
GO:0009889 regulation of biosynthetic process 28.0000 4 no
GO:0031326 regulation of cellular biosynthetic process 28.0000 5 no
GO:0051247 positive regulation of protein metabolic process 26.6667 6 no
GO:0030030 cell projection organization 26.6667 4 yes
GO:0008104 protein localization 26.6667 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.6667 5 no
GO:0048585 negative regulation of response to stimulus 25.3333 4 no
GO:0051174 regulation of phosphorus metabolic process 25.3333 5 no
GO:0016192 vesicle-mediated transport 25.3333 4 no
GO:0036211 protein modification process 25.3333 4 yes
GO:0043412 macromolecule modification 25.3333 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 25.3333 5 no
GO:0019220 regulation of phosphate metabolic process 25.3333 6 no
GO:0031399 regulation of protein modification process 25.3333 6 no
GO:0045595 regulation of cell differentiation 25.3333 4 no
GO:0051094 positive regulation of developmental process 24.0000 4 no
GO:0051129 negative regulation of cellular component organization 24.0000 5 no
GO:0051240 positive regulation of multicellular organismal process 24.0000 4 no
GO:1902533 positive regulation of intracellular signal transduction 24.0000 6 no
GO:0031344 regulation of cell projection organization 24.0000 5 yes
GO:0042127 regulation of cell population proliferation 24.0000 4 no
GO:0042325 regulation of phosphorylation 24.0000 7 no
GO:0051493 regulation of cytoskeleton organization 22.6667 6 no
GO:0022603 regulation of anatomical structure morphogenesis 22.6667 4 no
GO:0043085 positive regulation of catalytic activity 22.6667 4 no
GO:0010941 regulation of cell death 22.6667 4 no
GO:0045937 positive regulation of phosphate metabolic process 21.3333 7 no
GO:0009892 negative regulation of metabolic process 21.3333 4 no
GO:0032101 regulation of response to external stimulus 21.3333 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 21.3333 6 yes
GO:0010562 positive regulation of phosphorus metabolic process 21.3333 6 no
GO:0010628 positive regulation of gene expression 21.3333 6 no
GO:0010648 negative regulation of cell communication 21.3333 5 no
GO:0023057 negative regulation of signaling 21.3333 4 no
GO:0031401 positive regulation of protein modification process 21.3333 7 no
GO:0120036 plasma membrane bounded cell projection organization 20.0000 5 yes
GO:0080135 regulation of cellular response to stress 18.6667 4 yes
GO:0031175 neuron projection development 17.3333 6 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 14.6667 4 yes
GO:0010975 regulation of neuron projection development 14.6667 7 yes
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 12.0000 4 yes
GO:0006470 protein dephosphorylation 10.6667 5 yes
GO:0016311 dephosphorylation 10.6667 5 yes
GO:0099560 synaptic membrane adhesion 10.6667 5 yes
GO:0035335 peptidyl-tyrosine dephosphorylation 8.0000 6 yes
GO:1903034 regulation of response to wounding 8.0000 5 yes
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway 5.3333 5 yes
GO:0043393 regulation of protein binding 5.3333 4 yes
GO:0032091 negative regulation of protein binding 4.0000 5 yes
GO:0048679 regulation of axon regeneration 4.0000 5 yes
GO:0051100 negative regulation of binding 4.0000 4 yes
GO:0070570 regulation of neuron projection regeneration 4.0000 4 yes
GO:0031102 neuron projection regeneration 2.6667 4 yes
GO:1900120 regulation of receptor binding 2.6667 5 yes
GO:1900121 negative regulation of receptor binding 2.6667 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in PTPRF_HUMAN
DOID:0111962 combined immunodeficiency 2.6667 4 no
DOID:612 primary immunodeficiency disease 2.6667 3 no
DOID:0060038 specific developmental disorder 2.6667 3 no
DOID:0060307 autosomal dominant intellectual developmental disorder 2.6667 5 no
DOID:1059 intellectual disability 2.6667 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRIA2_HUMAN [view entry] [view interactions] Low throughput yes yes
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
LIPA2_HUMAN [view entry] [view interactions] Low throughput yes no
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
IRS1_HUMAN [view entry] [view interactions] Low throughput yes yes
LIPA1_HUMAN [view entry] [view interactions] Low throughput yes yes
LIPA3_HUMAN [view entry] [view interactions] Low throughput yes yes
PTPRA_HUMAN [view interactions] Low throughput no yes
DEP1B_HUMAN [view interactions] Low throughput no yes
ACTB_HUMAN [view entry] [view interactions] Low throughput yes no
GDS1_HUMAN [view entry] [view interactions] Low throughput yes yes
SEPT9_HUMAN [view interactions] Low throughput no no
RHOA_HUMAN [view entry] [view interactions] Low throughput yes yes
ARHG2_HUMAN [view entry] [view interactions] Low throughput yes yes
ROCK2_HUMAN [view entry] [view interactions] Low throughput yes yes
DIAP1_HUMAN [view interactions] Low throughput no yes
ARHGB_HUMAN [view interactions] Low throughput no yes
ARHGC_HUMAN [view interactions] Low throughput no yes
CTNB1_HUMAN [view entry] [view interactions] Low throughput yes yes
GIT1_HUMAN [view entry] [view interactions] Low throughput yes yes
TRIO_HUMAN [view entry] [view interactions] Low throughput yes yes
LCK_HUMAN [view entry] [view interactions] Low throughput yes no
PTPRD_HUMAN [view entry] [view interactions] Low throughput yes no
CADH2_HUMAN [view entry] [view interactions] Low throughput yes no
RET_HUMAN [view interactions] Low throughput no yes
NID1_HUMAN [view interactions] Low throughput no no
PLAK_HUMAN [view entry] [view interactions] Low throughput yes yes
GPC4_HUMAN [view entry] [view interactions] Low throughput yes yes
NCAN_HUMAN [view entry] [view interactions] Low throughput yes no
CSPG2_HUMAN [view entry] [view interactions] Low throughput yes no
PTPRZ_HUMAN [view entry] [view interactions] Low throughput yes yes
IL1AP_HUMAN [view entry] [view interactions] Low throughput yes yes
LRC4B_HUMAN [view entry] [view interactions] Low throughput yes no
CAV1_HUMAN [view interactions] Low throughput no no
APBB1_HUMAN [view interactions] High throughput no yes
CARL2_HUMAN [view interactions] High throughput no yes
PHAG1_HUMAN [view interactions] High throughput no yes
GRIP1_HUMAN [view entry] [view interactions] High throughput yes yes
CD9_HUMAN [view entry] [view interactions] High throughput yes no
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
MET_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
NFKB1_HUMAN [view interactions] High throughput no yes
PTPRF_HUMAN [view entry] [view interactions] High throughput yes yes
THIL_HUMAN [view entry] [view interactions] High throughput yes yes
ATPA_HUMAN [view interactions] High throughput no yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
EF1A1_HUMAN [view entry] [view interactions] High throughput yes yes
EF1G_HUMAN [view entry] [view interactions] High throughput yes yes
CBR1_HUMAN [view entry] [view interactions] High throughput yes yes
G3P_HUMAN [view entry] [view interactions] High throughput yes yes
LDHB_HUMAN [view entry] [view interactions] High throughput yes yes
SEMG1_HUMAN [view interactions] High throughput no no
SEMG2_HUMAN [view interactions] High throughput no no
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
HS71L_HUMAN [view entry] [view interactions] High throughput yes no
LDHA_HUMAN [view entry] [view interactions] High throughput yes yes
TBA1B_HUMAN [view entry] [view interactions] High throughput yes yes
TBB4B_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
SWAHC_HUMAN [view interactions] High throughput no no
LACTB_HUMAN [view interactions] High throughput no yes
CBP_HUMAN [view interactions] High throughput no yes
RYK_HUMAN [view interactions] High throughput no no
CUL7_HUMAN [view interactions] High throughput no yes
ABCE1_HUMAN [view interactions] High throughput no yes
CEA21_HUMAN [view interactions] High throughput no yes
TGFR2_HUMAN [view interactions] High throughput no no
SCN2B_HUMAN [view interactions] High throughput no no
HECA2_HUMAN [view interactions] High throughput no no
UNK_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
CARF_HUMAN [view interactions] High throughput no yes
PODO_HUMAN [view interactions] High throughput no no
NUDC3_HUMAN [view interactions] High throughput no yes
WFDC2_HUMAN [view interactions] High throughput no yes
I13R2_HUMAN [view interactions] High throughput no no
CLUS_HUMAN [view entry] [view interactions] High throughput yes yes
LRIQ1_HUMAN [view interactions] High throughput no no
CC50B_HUMAN [view interactions] High throughput no yes
PCDGD_HUMAN [view interactions] High throughput no no
VA0E1_HUMAN [view interactions] High throughput no no
MANS1_HUMAN [view interactions] High throughput no yes
PCDBG_HUMAN [view interactions] High throughput no no
MRAP2_HUMAN [view interactions] High throughput no no
PIANP_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
TPTE_HUMAN [view interactions] High throughput no no
RNF4_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
GPC1_HUMAN [view entry] [view interactions] High throughput yes no
VIR_HUMAN [view interactions] High throughput no yes
PTPRE_HUMAN [view interactions] High throughput no no
PTPRS_HUMAN [view entry] [view interactions] High throughput yes no
DNJC5_HUMAN [view interactions] High throughput no yes
PTPRO_HUMAN [view entry] [view interactions] High throughput yes no
LMBRL_HUMAN [view interactions] High throughput no no
MARH2_HUMAN [view interactions] High throughput no yes
MARH3_HUMAN [view interactions] High throughput no no
MARH8_HUMAN [view interactions] High throughput no no
RN128_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
NGAL_HUMAN [view interactions] High throughput no no
OPT_HUMAN [view interactions] High throughput no no
CAD16_HUMAN [view interactions] High throughput no no
KCNE3_HUMAN [view interactions] High throughput no yes
FCGRN_HUMAN [view interactions] High throughput no yes
MARH1_HUMAN [view interactions] High throughput no yes
EDAR_HUMAN [view interactions] High throughput no yes
RN149_HUMAN [view interactions] High throughput no no
PCD12_HUMAN [view interactions] High throughput no no
TR19L_HUMAN [view interactions] High throughput no no
NPDC1_HUMAN [view interactions] High throughput no yes
KCNE4_HUMAN [view interactions] High throughput no no
CYYR1_HUMAN [view interactions] High throughput no yes
LRTM1_HUMAN [view interactions] High throughput no no
GPC5B_HUMAN [view entry] [view interactions] High throughput yes no
KCNC3_HUMAN [view entry] [view interactions] High throughput yes yes
TNR3_HUMAN [view interactions] High throughput no yes
SYT11_HUMAN [view entry] [view interactions] High throughput yes yes
BT2A1_HUMAN [view interactions] High throughput no yes
OPALI_HUMAN [view interactions] High throughput no yes
IZUM1_HUMAN [view interactions] High throughput no no
SGCA_HUMAN [view interactions] High throughput no yes
CD83_HUMAN [view interactions] High throughput no yes
TM231_HUMAN [view interactions] High throughput no yes
RNF11_HUMAN [view interactions] High throughput no yes
SHSL1_HUMAN [view interactions] High throughput no yes
CLC4A_HUMAN [view interactions] High throughput no no
I20RB_HUMAN [view interactions] High throughput no no
CLDN1_HUMAN [view interactions] High throughput no yes
AVR2B_HUMAN [view interactions] High throughput no no
BSND_HUMAN [view interactions] High throughput no no
I22R2_HUMAN [view interactions] High throughput no no
EFNB1_HUMAN [view interactions] High throughput no yes
KC1G2_HUMAN [view interactions] High throughput no yes
T150A_HUMAN [view interactions] High throughput no yes
RN133_HUMAN [view interactions] High throughput no no
DLK1_HUMAN [view interactions] High throughput no no
TM171_HUMAN [view interactions] High throughput no yes
DLL1_HUMAN [view interactions] High throughput no no
PTPR2_HUMAN [view interactions] High throughput no yes
PE2R3_HUMAN [view interactions] High throughput no no
FFAR1_HUMAN [view interactions] High throughput no no
TIGIT_HUMAN [view interactions] High throughput no no
PKR1_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
TSN17_HUMAN [view interactions] High throughput no yes
PCDC1_HUMAN [view interactions] High throughput no no
IFM1_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND1_HUMAN [view interactions] High throughput no no
RND2_HUMAN [view interactions] High throughput no no
RND3_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
ETAA1_HUMAN [view interactions] High throughput no no
ARBK1_HUMAN [view entry] [view interactions] High throughput yes yes
DAAF5_HUMAN [view interactions] High throughput no no
NAA50_HUMAN [view interactions] High throughput no yes
NPL4_HUMAN [view interactions] High throughput no yes
PFKAM_HUMAN [view entry] [view interactions] High throughput yes yes
PICAL_HUMAN [view entry] [view interactions] High throughput yes yes
PPWD1_HUMAN [view interactions] High throughput no yes
ARPC3_HUMAN [view entry] [view interactions] High throughput yes yes
HACL1_HUMAN [view interactions] High throughput no no
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
2A5D_HUMAN [view entry] [view interactions] High throughput yes yes
SPS1_HUMAN [view interactions] High throughput no yes
FCL_HUMAN [view interactions] High throughput no yes
UFD1_HUMAN [view interactions] High throughput no no
APOB_HUMAN [view interactions] High throughput no no
ARMC8_HUMAN [view interactions] High throughput no yes
DBR1_HUMAN [view interactions] High throughput no no
NELL1_HUMAN [view interactions] High throughput no yes
PTN13_HUMAN [view interactions] High throughput no yes
PTN6_HUMAN [view interactions] High throughput no no
PTPRK_HUMAN [view interactions] High throughput no no
PTPRM_HUMAN [view interactions] High throughput no yes
PTPRQ_HUMAN [view interactions] High throughput no no
PTPRU_HUMAN [view interactions] High throughput no yes
SRP54_HUMAN [view interactions] High throughput no yes
VP13A_HUMAN [view interactions] High throughput no yes
TTI1_HUMAN [view interactions] High throughput no yes
F1712_HUMAN [view interactions] High throughput no no
SGT1_HUMAN [view interactions] High throughput no no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
SC61B_HUMAN [view interactions] High throughput no yes
DPP4_HUMAN [view interactions] High throughput no no
TM11B_HUMAN [view interactions] High throughput no no
Z512B_HUMAN [view interactions] High throughput no yes
SKIL_HUMAN [view interactions] High throughput no yes
PR40A_HUMAN [view interactions] High throughput no yes
SH2D3_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
CNR2_HUMAN [view interactions] High throughput no yes
H4_HUMAN [view interactions] High throughput no yes
IRS2_HUMAN [view interactions] Computational no yes
PTN11_HUMAN [view entry] [view interactions] Computational yes yes
PTN1_HUMAN [view interactions] Computational no yes
LRFN5_HUMAN [view entry] [view interactions] Computational yes no
INSR_HUMAN [view interactions] Computational no yes
LIPA4_HUMAN [view entry] [view interactions] Computational yes yes
LIPB2_HUMAN [view interactions] Computational no yes
LIPB1_HUMAN [view interactions] Computational no yes