GPC4_HUMAN
Evidence for PS localization
Functions
Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GPC4_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 26.4706 | 4 | no |
| GO:0017076 | purine nucleotide binding | 23.5294 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 23.5294 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 20.5882 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 20.5882 | 5 | no |
| GO:0071936 | coreceptor activity involved in Wnt signaling pathway | 5.8824 | 4 | yes |
| GO:1904929 | coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway | 5.8824 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GPC4_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 55.8824 | 4 | no |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 41.1765 | 4 | yes |
| GO:0036211 | protein modification process | 41.1765 | 4 | no |
| GO:0043412 | macromolecule modification | 41.1765 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 41.1765 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 38.2353 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 38.2353 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 38.2353 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 38.2353 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 35.2941 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 35.2941 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 32.3529 | 5 | no |
| GO:0051049 | regulation of transport | 32.3529 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 32.3529 | 5 | no |
| GO:0032880 | regulation of protein localization | 29.4118 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 29.4118 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.4118 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 29.4118 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 29.4118 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 29.4118 | 5 | no |
| GO:0010941 | regulation of cell death | 29.4118 | 4 | no |
| GO:0023057 | negative regulation of signaling | 29.4118 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 29.4118 | 4 | no |
| GO:0050807 | regulation of synapse organization | 26.4706 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 26.4706 | 6 | no |
| GO:0009968 | negative regulation of signal transduction | 26.4706 | 5 | no |
| GO:0010468 | regulation of gene expression | 26.4706 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 26.4706 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 26.4706 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.4706 | 5 | no |
| GO:0071310 | cellular response to organic substance | 23.5294 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.5294 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 23.5294 | 7 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.5294 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.5294 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 23.5294 | 7 | no |
| GO:0031344 | regulation of cell projection organization | 23.5294 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 23.5294 | 6 | no |
| GO:0080134 | regulation of response to stress | 23.5294 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.5294 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.5294 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 20.5882 | 4 | yes |
| GO:0010243 | response to organonitrogen compound | 20.5882 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 20.5882 | 7 | no |
| GO:0031401 | positive regulation of protein modification process | 20.5882 | 7 | no |
| GO:0051050 | positive regulation of transport | 20.5882 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 20.5882 | 6 | no |
| GO:0008104 | protein localization | 20.5882 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 20.5882 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 20.5882 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.5882 | 5 | no |
| GO:0030334 | regulation of cell migration | 20.5882 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 20.5882 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.5882 | 5 | no |
| GO:0060548 | negative regulation of cell death | 20.5882 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 20.5882 | 7 | no |
| GO:2000145 | regulation of cell motility | 20.5882 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.5882 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.5882 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 20.5882 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 20.5882 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.5882 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 20.5882 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.5882 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 20.5882 | 5 | no |
| GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 14.7059 | 4 | yes |
| GO:0099560 | synaptic membrane adhesion | 14.7059 | 5 | yes |
| GO:1901888 | regulation of cell junction assembly | 14.7059 | 5 | yes |
| GO:0051963 | regulation of synapse assembly | 11.7647 | 6 | yes |
| GO:1904375 | regulation of protein localization to cell periphery | 11.7647 | 6 | yes |
| GO:1905475 | regulation of protein localization to membrane | 11.7647 | 6 | yes |
| GO:0016055 | Wnt signaling pathway | 8.8235 | 5 | yes |
| GO:0099174 | regulation of presynapse organization | 8.8235 | 6 | yes |
| GO:1905114 | cell surface receptor signaling pathway involved in cell-cell signaling | 8.8235 | 4 | yes |
| GO:1905606 | regulation of presynapse assembly | 8.8235 | 7 | yes |
| GO:1902473 | regulation of protein localization to synapse | 5.8824 | 6 | yes |
| GO:1902683 | regulation of receptor localization to synapse | 5.8824 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in GPC4_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 5.8824 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 5.8824 | 5 | no |
| DOID:114 | heart disease | 5.8824 | 3 | no |
| DOID:1697 | ichthyosis | 5.8824 | 4 | no |
| DOID:37 | skin disease | 5.8824 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PTPRS_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CD36_HUMAN | [view interactions] | Low throughput | no | no |
| FGF2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PTPRD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PTPRF_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CCNC_HUMAN | [view interactions] | High throughput | no | yes |
| AB17A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRAP_HUMAN | [view interactions] | High throughput | no | no |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| IFIX_HUMAN | [view interactions] | High throughput | no | no |
| KSR1_HUMAN | [view interactions] | High throughput | no | yes |
| GP183_HUMAN | [view interactions] | High throughput | no | yes |
| ADA21_HUMAN | [view interactions] | High throughput | no | no |
| GPC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPCS2_HUMAN | [view interactions] | High throughput | no | yes |
| PDPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| SRF_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GP158_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MINK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAMKV_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LITD1_HUMAN | [view interactions] | High throughput | no | no |
| PICK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMAD6_HUMAN | [view interactions] | High throughput | no | no |
| SPICE_HUMAN | [view interactions] | High throughput | no | yes |
| AKAP9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SG2A2_HUMAN | [view interactions] | High throughput | no | no |
| MPPE1_HUMAN | [view interactions] | High throughput | no | no |
| REL_HUMAN | [view interactions] | High throughput | no | yes |
| TF65_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| CEAM8_HUMAN | [view interactions] | High throughput | no | no |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCN6_HUMAN | [view interactions] | High throughput | no | no |
| SRP14_HUMAN | [view interactions] | High throughput | no | no |
| TMPSD_HUMAN | [view interactions] | High throughput | no | no |
| FGF4_HUMAN | [view interactions] | High throughput | no | no |
| LRRT4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ST14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CL12B_HUMAN | [view interactions] | High throughput | no | no |
| LRRT3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HEPS_HUMAN | [view interactions] | High throughput | no | yes |
| SG2A1_HUMAN | [view interactions] | High throughput | no | no |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MA1A1_HUMAN | [view interactions] | High throughput | no | yes |
| CA054_HUMAN | [view interactions] | High throughput | no | yes |
| SPCS1_HUMAN | [view interactions] | High throughput | no | yes |
| BRID5_HUMAN | [view interactions] | High throughput | no | no |
| HBEGF_HUMAN | [view interactions] | High throughput | no | no |
| FGF1_HUMAN | [view interactions] | High throughput | no | no |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P55G_HUMAN | [view interactions] | High throughput | no | yes |
| SRP09_HUMAN | [view interactions] | High throughput | no | no |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASCC2_HUMAN | [view interactions] | High throughput | no | yes |
| COIA1_HUMAN | [view interactions] | High throughput | no | no |
| NDST3_HUMAN | [view interactions] | Computational | no | yes |
| B3GA1_HUMAN | [view interactions] | Computational | no | yes |
| HS3S1_HUMAN | [view interactions] | Computational | no | yes |
| HS3SA_HUMAN | [view interactions] | Computational | no | yes |
| H6ST1_HUMAN | [view interactions] | Computational | no | no |
| NCAN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| HPSE_HUMAN | [view interactions] | Computational | no | no |
| FZD2_HUMAN | [view interactions] | Computational | no | no |
| PGS2_HUMAN | [view interactions] | Computational | no | no |
| B4GT7_HUMAN | [view interactions] | Computational | no | yes |
| HS3S2_HUMAN | [view interactions] | Computational | no | yes |
| EXT1_HUMAN | [view interactions] | Computational | no | yes |
| PGBM_HUMAN | [view interactions] | Computational | no | no |
| EXT2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| FZD7_HUMAN | [view interactions] | Computational | no | yes |
| NDST4_HUMAN | [view interactions] | Computational | no | no |
| B3GA2_HUMAN | [view interactions] | Computational | no | no |
| CSPG5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CSPG2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| XYLT1_HUMAN | [view interactions] | Computational | no | yes |
| XYLT2_HUMAN | [view interactions] | Computational | no | no |
| HS3S6_HUMAN | [view interactions] | Computational | no | no |
| HS3S5_HUMAN | [view interactions] | Computational | no | yes |
| LRP12_HUMAN | [view interactions] | Computational | no | yes |
| NDST2_HUMAN | [view interactions] | Computational | no | no |
| GLCE_HUMAN | [view interactions] | Computational | no | yes |
| LRP8_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| H6ST2_HUMAN | [view interactions] | Computational | no | no |
| HS2ST_HUMAN | [view interactions] | Computational | no | yes |
| H6ST3_HUMAN | [view interactions] | Computational | no | no |
| HS3SB_HUMAN | [view interactions] | Computational | no | no |
| B3GT6_HUMAN | [view interactions] | Computational | no | no |
| NDST1_HUMAN | [view interactions] | Computational | no | yes |
| SDC2_HUMAN | [view interactions] | Computational | no | yes |
| LRP10_HUMAN | [view interactions] | Computational | no | no |
| LRP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PGCB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HS3S4_HUMAN | [view interactions] | Computational | no | no |
| PGS1_HUMAN | [view interactions] | Computational | no | no |
| CSPG4_HUMAN | [view interactions] | Computational | no | yes |
| B3GA3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| HPSE2_HUMAN | [view interactions] | Computational | no | yes |