Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ECHA_HUMAN

Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway (PubMed, PubMed, PubMed, PubMed). The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA (PubMed). Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids (PubMed). Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA described here carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities while the trifunctional enzyme subunit beta/HADHB bears the 3-ketoacyl-CoA thiolase activity (PubMed, PubMed, PubMed). Independently of the subunit beta, the trifunctional enzyme subunit alpha/HADHA also has a monolysocardiolipin acyltransferase activity (PubMed). It acylates monolysocardiolipin into cardiolipin, a major mitochondrial membrane phospholipid which plays a key role in apoptosis and supports mitochondrial respiratory chain complexes in the generation of ATP (PubMed). Allows the acylation of monolysocardiolipin with different acyl-CoA substrates including oleoyl-CoA for which it displays the highest activity (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in ECHA_HUMAN
GO:0017076 purine nucleotide binding 33.7748 4 yes
GO:0032555 purine ribonucleotide binding 33.7748 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 31.7881 4 no
GO:0030554 adenyl nucleotide binding 25.1656 5 yes
GO:0032559 adenyl ribonucleotide binding 25.1656 5 yes
GO:0005524 ATP binding 23.1788 5 no
GO:0046872 metal ion binding 23.1788 4 no
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 5.2980 4 yes
GO:0003988 acetyl-CoA C-acyltransferase activity 3.3113 6 yes
GO:0016408 C-acyltransferase activity 3.3113 5 yes
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3.3113 4 yes
GO:0016836 hydro-lyase activity 3.3113 4 yes
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity 2.6490 5 yes
GO:0003985 acetyl-CoA C-acetyltransferase activity 2.6490 7 yes
GO:0004300 enoyl-CoA hydratase activity 2.6490 5 yes
GO:0016407 acetyltransferase activity 2.6490 5 yes
GO:0016453 C-acetyltransferase activity 2.6490 6 yes
GO:0051287 NAD binding 2.6490 4 yes
GO:0000062 fatty-acyl-CoA binding 1.3245 4 yes
GO:0016508 long-chain-enoyl-CoA hydratase activity 1.3245 5 yes
GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity 1.3245 6 yes
GO:0070403 NAD+ binding 1.3245 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ECHA_HUMAN
GO:0048522 positive regulation of cellular process 45.6954 4 no
GO:0060255 regulation of macromolecule metabolic process 41.7219 4 no
GO:0080090 regulation of primary metabolic process 41.7219 4 no
GO:0031323 regulation of cellular metabolic process 40.3974 4 no
GO:0051171 regulation of nitrogen compound metabolic process 40.3974 4 no
GO:0048523 negative regulation of cellular process 39.7351 4 no
GO:0051128 regulation of cellular component organization 37.7483 4 no
GO:0006996 organelle organization 37.0861 4 no
GO:0009893 positive regulation of metabolic process 35.7616 4 no
GO:0010646 regulation of cell communication 34.4371 4 no
GO:0022607 cellular component assembly 32.4503 4 no
GO:0009966 regulation of signal transduction 31.7881 4 no
GO:0051246 regulation of protein metabolic process 31.7881 5 no
GO:0010604 positive regulation of macromolecule metabolic process 30.4636 5 no
GO:0010468 regulation of gene expression 29.8013 5 no
GO:0031325 positive regulation of cellular metabolic process 29.8013 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 29.1391 5 no
GO:0010941 regulation of cell death 27.1523 4 no
GO:0008104 protein localization 24.5033 4 no
GO:0019220 regulation of phosphate metabolic process 24.5033 6 no
GO:0051174 regulation of phosphorus metabolic process 24.5033 5 no
GO:0042981 regulation of apoptotic process 23.8411 6 no
GO:0043067 regulation of programmed cell death 23.8411 5 no
GO:0043412 macromolecule modification 23.1788 4 no
GO:0009892 negative regulation of metabolic process 23.1788 4 no
GO:1902531 regulation of intracellular signal transduction 23.1788 5 no
GO:0006796 phosphate-containing compound metabolic process 23.1788 4 yes
GO:0009889 regulation of biosynthetic process 22.5166 4 no
GO:0031326 regulation of cellular biosynthetic process 22.5166 5 no
GO:0036211 protein modification process 22.5166 4 no
GO:0051049 regulation of transport 22.5166 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 21.8543 5 no
GO:0031399 regulation of protein modification process 21.8543 6 no
GO:0043085 positive regulation of catalytic activity 21.8543 4 no
GO:0010556 regulation of macromolecule biosynthetic process 21.1921 5 no
GO:0044087 regulation of cellular component biogenesis 21.1921 4 no
GO:0010605 negative regulation of macromolecule metabolic process 21.1921 5 no
GO:0042325 regulation of phosphorylation 21.1921 7 no
GO:0048584 positive regulation of response to stimulus 21.1921 4 no
GO:0051247 positive regulation of protein metabolic process 20.5298 6 no
GO:0010243 response to organonitrogen compound 16.5563 4 yes
GO:0019752 carboxylic acid metabolic process 15.8940 5 yes
GO:0043436 oxoacid metabolic process 15.8940 4 yes
GO:0032787 monocarboxylic acid metabolic process 11.9205 6 yes
GO:0016054 organic acid catabolic process 9.9338 4 yes
GO:0046395 carboxylic acid catabolic process 9.9338 5 yes
GO:0016042 lipid catabolic process 8.6093 4 yes
GO:1901652 response to peptide 7.9470 4 yes
GO:0006631 fatty acid metabolic process 7.9470 4 yes
GO:0030258 lipid modification 7.9470 4 yes
GO:0072329 monocarboxylic acid catabolic process 7.2848 6 yes
GO:0006635 fatty acid beta-oxidation 7.2848 6 yes
GO:0009062 fatty acid catabolic process 7.2848 5 yes
GO:0019395 fatty acid oxidation 7.2848 5 yes
GO:0034440 lipid oxidation 7.2848 5 yes
GO:0044242 cellular lipid catabolic process 7.2848 4 yes
GO:0043434 response to peptide hormone 5.2980 4 yes
GO:0046486 glycerolipid metabolic process 3.3113 4 yes
GO:0032868 response to insulin 3.3113 5 yes
GO:0006644 phospholipid metabolic process 1.9868 4 yes
GO:0006650 glycerophospholipid metabolic process 1.9868 5 yes
GO:0032048 cardiolipin metabolic process 1.3245 7 yes
GO:0035965 cardiolipin acyl-chain remodeling 1.3245 8 yes
GO:0046471 phosphatidylglycerol metabolic process 1.3245 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in ECHA_HUMAN
DOID:1289 neurodegenerative disease 1.9868 4 no
DOID:3146 lipid metabolism disorder 1.9868 3 no
DOID:331 central nervous system disease 1.9868 3 no
DOID:700 mitochondrial metabolism disease 1.9868 3 no
DOID:10595 Charcot-Marie-Tooth disease 1.9868 6 no
DOID:440 neuromuscular disease 1.9868 5 no
DOID:574 peripheral nervous system disease 1.9868 3 no
DOID:870 neuropathy 1.9868 4 no
DOID:0050539 Charcot-Marie-Tooth disease type 2 1.3245 7 no
DOID:0060286 combined oxidative phosphorylation deficiency 1.3245 4 no
DOID:0050686 organ system cancer 1.3245 3 no
DOID:10283 prostate cancer 1.3245 6 no
DOID:193 reproductive organ cancer 1.3245 4 no
DOID:3856 male reproductive organ cancer 1.3245 5 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ECHA_HUMAN [view entry] [view interactions] Low throughput yes yes
ECHB_HUMAN [view entry] [view interactions] Low throughput yes yes
CFDP1_HUMAN [view interactions] High throughput no yes
COX6C_HUMAN [view entry] [view interactions] High throughput yes yes
TIFAB_HUMAN [view interactions] High throughput no no
CX7A2_HUMAN [view interactions] High throughput no no
AKIP_HUMAN [view interactions] High throughput no yes
COX7C_HUMAN [view interactions] High throughput no yes
BET1_HUMAN [view interactions] High throughput no no
COX8A_HUMAN [view interactions] High throughput no yes
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
CY1_HUMAN [view entry] [view interactions] High throughput yes yes
COX14_HUMAN [view interactions] High throughput no yes
FRIH_HUMAN [view entry] [view interactions] High throughput yes yes
COX41_HUMAN [view entry] [view interactions] High throughput yes yes
GNA11_HUMAN [view entry] [view interactions] High throughput yes yes
H31_HUMAN [view interactions] High throughput no yes
GNAO_HUMAN [view entry] [view interactions] High throughput yes yes
MGST3_HUMAN [view entry] [view interactions] High throughput yes yes
AP1S2_HUMAN [view interactions] High throughput no no
PDK1_HUMAN [view interactions] High throughput no yes
ASPH_HUMAN [view interactions] High throughput no yes
RS6_HUMAN [view entry] [view interactions] High throughput yes yes
RCAF1_HUMAN [view interactions] High throughput no yes
TOM20_HUMAN [view entry] [view interactions] High throughput yes yes
CLPP_HUMAN [view interactions] High throughput no yes
TOM22_HUMAN [view interactions] High throughput no yes
COA3_HUMAN [view interactions] High throughput no yes
MET_HUMAN [view interactions] High throughput no yes
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
FHI2B_HUMAN [view interactions] High throughput no yes
CPT1A_HUMAN [view entry] [view interactions] High throughput yes yes
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
CP51A_HUMAN [view interactions] High throughput no no
PSMD4_HUMAN [view interactions] High throughput no yes
EMC2_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
HMGC2_HUMAN [view interactions] High throughput no no
HDAC5_HUMAN [view interactions] High throughput no yes
MIC60_HUMAN [view entry] [view interactions] High throughput yes yes
LEO1_HUMAN [view interactions] High throughput no yes
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
RTF1_HUMAN [view interactions] High throughput no yes
NDUA9_HUMAN [view entry] [view interactions] High throughput yes yes
SIR7_HUMAN [view interactions] High throughput no yes
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
P5F1B_HUMAN [view interactions] High throughput no no
NIPS1_HUMAN [view entry] [view interactions] High throughput yes yes
PO5F1_HUMAN [view interactions] High throughput no yes
PRDX4_HUMAN [view interactions] High throughput no yes
CDK2_HUMAN [view interactions] High throughput no yes
TFAM_HUMAN [view entry] [view interactions] High throughput yes yes
CAH9_HUMAN [view interactions] High throughput no no
TOM5_HUMAN [view interactions] High throughput no yes
PAN2_HUMAN [view interactions] High throughput no no
ZN782_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
ENPL_HUMAN [view entry] [view interactions] High throughput yes yes
WWOX_HUMAN [view interactions] High throughput no yes
HSP74_HUMAN [view entry] [view interactions] High throughput yes yes
ZBTB1_HUMAN [view interactions] High throughput no no
COX2_HUMAN [view entry] [view interactions] High throughput yes yes
GRSF1_HUMAN [view interactions] High throughput no yes
ML12A_HUMAN [view interactions] High throughput no no
EMD_HUMAN [view interactions] High throughput no yes
NDUS1_HUMAN [view entry] [view interactions] High throughput yes no
TBG1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUS2_HUMAN [view entry] [view interactions] High throughput yes yes
STB5L_HUMAN [view interactions] High throughput no no
NDUS3_HUMAN [view entry] [view interactions] High throughput yes yes
CUL7_HUMAN [view interactions] High throughput no yes
NDUS5_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
NDUS7_HUMAN [view entry] [view interactions] High throughput yes no
EED_HUMAN [view interactions] High throughput no yes
NDUS8_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
PCCB_HUMAN [view interactions] High throughput no yes
SKI_HUMAN [view interactions] High throughput no yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
FBXW7_HUMAN [view interactions] High throughput no yes
ODPB_HUMAN [view entry] [view interactions] High throughput yes yes
MKRN1_HUMAN [view interactions] High throughput no no
PRDX3_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
QCR1_HUMAN [view entry] [view interactions] High throughput yes yes
MDM2_HUMAN [view interactions] High throughput no yes
QCR8_HUMAN [view interactions] High throughput no yes
NFAC2_HUMAN [view interactions] High throughput no yes
ORN_HUMAN [view interactions] High throughput no no
CDC73_HUMAN [view interactions] High throughput no yes
THIM_HUMAN [view interactions] High throughput no yes
RAD18_HUMAN [view interactions] High throughput no yes
DECR_HUMAN [view entry] [view interactions] High throughput yes yes
ZN746_HUMAN [view interactions] High throughput no no
ETFB_HUMAN [view entry] [view interactions] High throughput yes yes
PTN2_HUMAN [view interactions] High throughput no yes
ACADL_HUMAN [view interactions] High throughput no no
PTPRD_HUMAN [view entry] [view interactions] High throughput yes no
ACADM_HUMAN [view interactions] High throughput no yes
CD44_HUMAN [view interactions] High throughput no yes
ACADS_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
ACADV_HUMAN [view interactions] High throughput no yes
TES_HUMAN [view interactions] High throughput no yes
CPT2_HUMAN [view entry] [view interactions] High throughput yes yes
TEDC2_HUMAN [view interactions] High throughput no no
ECH1_HUMAN [view interactions] High throughput no yes
TRIP4_HUMAN [view interactions] High throughput no yes
ECI1_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
HSDL2_HUMAN [view entry] [view interactions] High throughput yes yes
LAP2A_HUMAN [view interactions] High throughput no yes
SUCB2_HUMAN [view interactions] High throughput no no
TPTE_HUMAN [view interactions] High throughput no no
ALKB3_HUMAN [view interactions] High throughput no yes
PRP8_HUMAN [view interactions] High throughput no yes
ACD11_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
ROCK1_HUMAN [view entry] [view interactions] High throughput yes yes
AAR2_HUMAN [view interactions] High throughput no no
S10AB_HUMAN [view interactions] High throughput no no
PIHD1_HUMAN [view interactions] High throughput no yes
LTMD1_HUMAN [view interactions] High throughput no no
AKTIP_HUMAN [view interactions] High throughput no yes
TAOK3_HUMAN [view interactions] High throughput no yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
TRI14_HUMAN [view interactions] High throughput no yes
REL_HUMAN [view interactions] High throughput no yes
MRM1_HUMAN [view interactions] High throughput no no
TNIP2_HUMAN [view interactions] High throughput no yes
DPPA3_HUMAN [view interactions] High throughput no no
CETN3_HUMAN [view interactions] High throughput no yes
ACAD9_HUMAN [view interactions] High throughput no yes
UB2R1_HUMAN [view interactions] High throughput no yes
AUHM_HUMAN [view entry] [view interactions] High throughput yes yes
FGF11_HUMAN [view interactions] High throughput no no
MTRFR_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
C1QBP_HUMAN [view entry] [view interactions] High throughput yes yes
MEPCE_HUMAN [view interactions] High throughput no yes
GAL3A_HUMAN [view interactions] High throughput no yes
LARP7_HUMAN [view interactions] High throughput no yes
GAL3B_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
MRES1_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
MCUR1_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
CC90B_HUMAN [view interactions] High throughput no yes
TISD_HUMAN [view interactions] High throughput no no
CISY_HUMAN [view entry] [view interactions] High throughput yes yes
WDR76_HUMAN [view interactions] High throughput no no
EFGM_HUMAN [view interactions] High throughput no yes
H4_HUMAN [view interactions] High throughput no yes
HINT2_HUMAN [view interactions] High throughput no yes
GRWD1_HUMAN [view interactions] High throughput no no
MCUB_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
MDHM_HUMAN [view entry] [view interactions] High throughput yes yes
RC3H1_HUMAN [view interactions] High throughput no yes
MET15_HUMAN [view interactions] High throughput no no
ZBT7A_HUMAN [view interactions] High throughput no yes
MET17_HUMAN [view interactions] High throughput no yes
ACTC_HUMAN [view interactions] High throughput no no
RM11_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
RT12_HUMAN [view interactions] High throughput no yes
CCND1_HUMAN [view interactions] High throughput no yes
RT26_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
RRFM_HUMAN [view interactions] High throughput no yes
HDAC2_HUMAN [view interactions] High throughput no yes
MTEF3_HUMAN [view interactions] High throughput no no
ATX1_HUMAN [view interactions] High throughput no yes
MTG2_HUMAN [view interactions] High throughput no yes
VRK1_HUMAN [view interactions] High throughput no yes
IF2M_HUMAN [view interactions] High throughput no yes
S15A3_HUMAN [view interactions] High throughput no yes
IF3M_HUMAN [view interactions] High throughput no yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
RF1M_HUMAN [view interactions] High throughput no yes
TIP_HUMAN [view entry] [view interactions] High throughput yes yes
RF1ML_HUMAN [view interactions] High throughput no yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
MPPA_HUMAN [view interactions] High throughput no yes
MRP6_HUMAN [view interactions] High throughput no no
MPPB_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
RMND1_HUMAN [view interactions] High throughput no yes
LMBRL_HUMAN [view interactions] High throughput no no
S2551_HUMAN [view interactions] High throughput no no
WWP2_HUMAN [view interactions] High throughput no no
SSBP_HUMAN [view entry] [view interactions] High throughput yes yes
P53_HUMAN [view interactions] High throughput no no
FAKD4_HUMAN [view interactions] High throughput no yes
BRD7_HUMAN [view interactions] High throughput no yes
TRUB2_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
EFTS_HUMAN [view interactions] High throughput no no
CUL9_HUMAN [view interactions] High throughput no no
EFTU_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
VWA8_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
EXD2_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
HSC20_HUMAN [view interactions] High throughput no yes
TFCP2_HUMAN [view interactions] High throughput no no
SYAM_HUMAN [view interactions] High throughput no yes
NGB_HUMAN [view interactions] High throughput no yes
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
TRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
TBB5_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
TOLIP_HUMAN [view entry] [view interactions] High throughput yes yes
ECT2_HUMAN [view interactions] High throughput no no
OPTN_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
PER2_HUMAN [view interactions] High throughput no yes
KI20A_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
NUPR1_HUMAN [view interactions] High throughput no no
HG2A_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
NR4A1_HUMAN [view interactions] High throughput no yes
FNDC5_HUMAN [view interactions] High throughput no no
ABCF2_HUMAN [view interactions] High throughput no yes
RBM39_HUMAN [view interactions] High throughput no yes
ATX2L_HUMAN [view interactions] High throughput no no
F16P1_HUMAN [view interactions] High throughput no no
GLUT4_HUMAN [view interactions] High throughput no no
DJC11_HUMAN [view entry] [view interactions] High throughput yes no
UBP49_HUMAN [view interactions] High throughput no yes
DJC15_HUMAN [view interactions] High throughput no no
MLP3A_HUMAN [view entry] [view interactions] High throughput yes yes
TIM14_HUMAN [view entry] [view interactions] High throughput yes yes
GBRAP_HUMAN [view interactions] High throughput no no
DNJC1_HUMAN [view interactions] High throughput no yes
MLP3B_HUMAN [view interactions] High throughput no yes
DJC25_HUMAN [view interactions] High throughput no yes
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
RIN3_HUMAN [view interactions] High throughput no yes
GBRL1_HUMAN [view interactions] High throughput no yes
DDX58_HUMAN [view interactions] High throughput no yes
SQSTM_HUMAN [view interactions] High throughput no yes
PD1L1_HUMAN [view interactions] High throughput no no
NIPS2_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
DDA1_HUMAN [view interactions] High throughput no yes
FZR1_HUMAN [view interactions] High throughput no no
ATGA1_HUMAN [view interactions] High throughput no yes
IL7RA_HUMAN [view interactions] High throughput no no
ICT1_HUMAN [view interactions] High throughput no yes
SAAL1_HUMAN [view interactions] High throughput no yes
FTM_HUMAN [view interactions] High throughput no yes
TGBR3_HUMAN [view interactions] High throughput no yes
IQCB1_HUMAN [view interactions] High throughput no no
DHRS2_HUMAN [view interactions] High throughput no no
ATF2_HUMAN [view interactions] High throughput no yes
NID2_HUMAN [view interactions] High throughput no yes
PP6R1_HUMAN [view interactions] High throughput no no
OSBL8_HUMAN [view interactions] High throughput no yes
NUMB_HUMAN [view entry] [view interactions] High throughput yes yes
LAMA4_HUMAN [view interactions] High throughput no no
RIPK4_HUMAN [view interactions] High throughput no no
GPC4_HUMAN [view entry] [view interactions] High throughput yes yes
PR15A_HUMAN [view interactions] High throughput no yes
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
SIR4_HUMAN [view interactions] High throughput no yes
GPC3_HUMAN [view interactions] High throughput no no
CBX1_HUMAN [view interactions] High throughput no yes
GSLG1_HUMAN [view entry] [view interactions] High throughput yes yes
KCTD5_HUMAN [view interactions] High throughput no no
CXCR4_HUMAN [view interactions] High throughput no no
SRP72_HUMAN [view interactions] High throughput no yes
SDC3_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
CCD50_HUMAN [view interactions] High throughput no yes
NAF1_HUMAN [view interactions] High throughput no yes
CSKP_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
GPC6_HUMAN [view entry] [view interactions] High throughput yes yes
KSR1_HUMAN [view interactions] High throughput no yes
HEAT3_HUMAN [view interactions] High throughput no yes
SDC2_HUMAN [view interactions] High throughput no yes
TEFF1_HUMAN [view interactions] High throughput no no
CADH8_HUMAN [view interactions] High throughput no no
YBEY_HUMAN [view interactions] High throughput no yes
CADH5_HUMAN [view interactions] High throughput no yes
GPC2_HUMAN [view interactions] High throughput no no
RELL2_HUMAN [view interactions] High throughput no no
AGRIN_HUMAN [view entry] [view interactions] High throughput yes yes
VANG1_HUMAN [view interactions] High throughput no no
COQ9_HUMAN [view interactions] High throughput no yes
FARP1_HUMAN [view entry] [view interactions] High throughput yes no
NDUA4_HUMAN [view entry] [view interactions] High throughput yes yes
TTC19_HUMAN [view interactions] High throughput no yes
PRD16_HUMAN [view interactions] High throughput no no
SDC4_HUMAN [view interactions] High throughput no yes
MECOM_HUMAN [view interactions] High throughput no yes
SDC1_HUMAN [view interactions] High throughput no no
PDPK1_HUMAN [view entry] [view interactions] High throughput yes yes
CQ080_HUMAN [view interactions] High throughput no yes
KPCZ_HUMAN [view entry] [view interactions] High throughput yes yes
GPC1_HUMAN [view entry] [view interactions] High throughput yes no
SRC_HUMAN [view entry] [view interactions] High throughput yes no
IPO9_HUMAN [view interactions] High throughput no no
MSPD2_HUMAN [view interactions] High throughput no yes
B3GT6_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
LEG1_HUMAN [view interactions] High throughput no yes
NCBP3_HUMAN [view interactions] High throughput no yes
SPRTN_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
BTF3_HUMAN [view interactions] High throughput no yes
CNR2_HUMAN [view interactions] High throughput no yes
THB_HUMAN [view interactions] High throughput no no
ZBT18_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
MOT11_HUMAN [view interactions] High throughput no no
EP300_HUMAN [view interactions] High throughput no yes
SRF_HUMAN [view interactions] High throughput no yes
FGD5_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
TMPS2_HUMAN [view interactions] High throughput no no
VCAM1_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
CATL1_HUMAN [view interactions] High throughput no yes
PARK7_HUMAN [view entry] [view interactions] High throughput yes yes
FURIN_HUMAN [view interactions] High throughput no yes
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
IFM1_HUMAN [view interactions] High throughput no no
MYO7B_HUMAN [view interactions] High throughput no no
DPP4_HUMAN [view interactions] High throughput no no
KIF1C_HUMAN [view interactions] High throughput no yes
IFM3_HUMAN [view interactions] High throughput no yes
ATP5H_HUMAN [view interactions] High throughput no yes
TM11B_HUMAN [view interactions] High throughput no no
SIR5_HUMAN [view interactions] High throughput no yes
CLC4D_HUMAN [view interactions] High throughput no no
DNAI7_HUMAN [view interactions] High throughput no no
ACE2_HUMAN [view interactions] High throughput no no
QRIC1_HUMAN [view interactions] High throughput no yes
CLC4E_HUMAN [view interactions] High throughput no no
ENTD1_HUMAN [view interactions] High throughput no no
ZN363_HUMAN [view interactions] High throughput no yes
TNS2_HUMAN [view interactions] High throughput no no
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
DDX3X_HUMAN [view entry] [view interactions] High throughput yes yes
BTK_HUMAN [view interactions] High throughput no no
CLU_HUMAN [view interactions] High throughput no yes
E2F3_HUMAN [view interactions] High throughput no no
BAG1_HUMAN [view interactions] High throughput no yes
MEX3C_HUMAN [view interactions] High throughput no yes
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
PPM1G_HUMAN [view interactions] High throughput no no
BAP1_HUMAN [view interactions] High throughput no yes
DTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
DDB1_HUMAN [view interactions] High throughput no yes
TBA1A_HUMAN [view entry] [view interactions] High throughput yes yes
SRP09_HUMAN [view interactions] High throughput no no
TGON2_HUMAN [view interactions] High throughput no yes
PIN1_HUMAN [view entry] [view interactions] High throughput yes yes
MED4_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
MED23_HUMAN [view interactions] High throughput no no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
NOD2_HUMAN [view interactions] High throughput no yes
STT3B_HUMAN [view interactions] High throughput no yes
P2RY6_HUMAN [view interactions] High throughput no no
PLOD3_HUMAN [view interactions] High throughput no yes
TRI63_HUMAN [view interactions] High throughput no no
MOES_HUMAN [view entry] [view interactions] High throughput yes no
M3K13_HUMAN [view interactions] High throughput no yes
ETFA_HUMAN [view interactions] High throughput no yes
CSK22_HUMAN [view entry] [view interactions] High throughput yes no
ZFR_HUMAN [view interactions] High throughput no yes
UFO_HUMAN [view interactions] High throughput no no
TBB4B_HUMAN [view interactions] High throughput no yes
KSYK_HUMAN [view interactions] High throughput no no
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
LIMK1_HUMAN [view interactions] High throughput no yes
ATLA3_HUMAN [view interactions] High throughput no no
LIMK2_HUMAN [view interactions] High throughput no yes
AT1B1_HUMAN [view entry] [view interactions] High throughput yes no
KC1G2_HUMAN [view interactions] High throughput no yes
HYEP_HUMAN [view interactions] High throughput no no
CDK13_HUMAN [view interactions] High throughput no no
RM40_HUMAN [view interactions] High throughput no yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
NDUB8_HUMAN [view entry] [view interactions] High throughput yes yes
ST32C_HUMAN [view entry] [view interactions] High throughput yes yes
TOM40_HUMAN [view interactions] High throughput no yes
MINK1_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
CAMKV_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
BRSK1_HUMAN [view entry] [view interactions] High throughput yes no
AASS_HUMAN [view interactions] High throughput no yes
TBCK_HUMAN [view interactions] High throughput no yes
NB5R3_HUMAN [view interactions] High throughput no yes
HASP_HUMAN [view interactions] High throughput no yes
SND1_HUMAN [view entry] [view interactions] High throughput yes yes
KPSH2_HUMAN [view interactions] High throughput no no
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
PMYT1_HUMAN [view interactions] High throughput no no
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
TAOK2_HUMAN [view entry] [view interactions] High throughput yes yes
SCPDL_HUMAN [view entry] [view interactions] High throughput yes yes
RPKL1_HUMAN [view interactions] High throughput no yes
NB5R1_HUMAN [view entry] [view interactions] High throughput yes yes
MAST1_HUMAN [view interactions] High throughput no yes
ADAS_HUMAN [view interactions] High throughput no yes
SG196_HUMAN [view interactions] High throughput no yes
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
SOX15_HUMAN [view interactions] High throughput no no
MCAT_HUMAN [view interactions] High throughput no yes
SOX2_HUMAN [view interactions] High throughput no yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
DDR2_HUMAN [view interactions] High throughput no no
ATPA_HUMAN [view interactions] High throughput no yes
EPHA4_HUMAN [view entry] [view interactions] High throughput yes yes
MGST1_HUMAN [view interactions] High throughput no no
EPHA5_HUMAN [view interactions] High throughput no no
QCR2_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA7_HUMAN [view entry] [view interactions] High throughput yes no
ICAM1_HUMAN [view interactions] High throughput no no
EPHB2_HUMAN [view entry] [view interactions] High throughput yes yes
ODO1_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR1_HUMAN [view interactions] High throughput no yes
GBG5_HUMAN [view interactions] High throughput no no
FGFR2_HUMAN [view interactions] High throughput no yes
SFXN1_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR3_HUMAN [view interactions] High throughput no yes
ATPB_HUMAN [view interactions] High throughput no yes
FGFR4_HUMAN [view interactions] High throughput no no
APOE_HUMAN [view entry] [view interactions] High throughput yes yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
OCAD2_HUMAN [view interactions] High throughput no yes
KPCE_HUMAN [view entry] [view interactions] High throughput yes yes
ATP5L_HUMAN [view interactions] High throughput no yes
EPB41_HUMAN [view entry] [view interactions] High throughput yes no
ATPG_HUMAN [view interactions] High throughput no yes
AAKB1_HUMAN [view interactions] High throughput no yes
P4HA1_HUMAN [view interactions] High throughput no yes
BCAR3_HUMAN [view interactions] High throughput no yes
VDAC2_HUMAN [view entry] [view interactions] High throughput yes yes
TRAF6_HUMAN [view interactions] High throughput no yes
VDAC3_HUMAN [view entry] [view interactions] High throughput yes yes
HLAB_HUMAN [view interactions] High throughput no yes
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
IKKE_HUMAN [view interactions] High throughput no yes
NDUA3_HUMAN [view interactions] High throughput no yes
MK03_HUMAN [view entry] [view interactions] High throughput yes yes
LPPRC_HUMAN [view entry] [view interactions] High throughput yes yes
YBOX1_HUMAN [view interactions] High throughput no yes
COX7R_HUMAN [view entry] [view interactions] High throughput yes no
JUN_HUMAN [view interactions] High throughput no yes
ACOT9_HUMAN [view interactions] High throughput no yes
PKHA7_HUMAN [view interactions] High throughput no yes
LETM1_HUMAN [view entry] [view interactions] High throughput yes yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
STML2_HUMAN [view entry] [view interactions] High throughput yes yes
LITD1_HUMAN [view interactions] High throughput no no
AT5F1_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
BMI1_HUMAN [view interactions] High throughput no yes
NDUA8_HUMAN [view entry] [view interactions] High throughput yes yes
ACPM_HUMAN [view interactions] High throughput no yes
PREB_HUMAN [view interactions] High throughput no yes
M3K1_HUMAN [view interactions] High throughput no yes
RAB5B_HUMAN [view entry] [view interactions] High throughput yes yes
NFKB2_HUMAN [view interactions] High throughput no yes
MPCP_HUMAN [view entry] [view interactions] High throughput yes no
RIPK3_HUMAN [view interactions] High throughput no no
ATPO_HUMAN [view interactions] High throughput no yes
TNR1A_HUMAN [view interactions] High throughput no yes
PHB2_HUMAN [view entry] [view interactions] High throughput yes yes
EDC4_HUMAN [view interactions] High throughput no yes
ATPMK_HUMAN [view interactions] High throughput no no
SPART_HUMAN [view interactions] High throughput no yes
PGES2_HUMAN [view interactions] High throughput no yes
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
AN34C_HUMAN [view interactions] High throughput no no
ESR2_HUMAN [view interactions] High throughput no no
ODBA_HUMAN [view interactions] High throughput no yes
FAKD3_HUMAN [view interactions] High throughput no yes
CALR_HUMAN [view interactions] High throughput no yes
ATD3B_HUMAN [view interactions] High throughput no yes
CO6A1_HUMAN [view interactions] High throughput no no
ATD3A_HUMAN [view entry] [view interactions] High throughput yes yes
COX5A_HUMAN [view entry] [view interactions] High throughput yes yes
THIK_HUMAN [view entry] [view interactions] Computational yes yes
MECR_HUMAN [view entry] [view interactions] Computational yes yes
ACDSB_HUMAN [view interactions] Computational no yes
ACOX3_HUMAN [view interactions] Computational no yes
THIL_HUMAN [view entry] [view interactions] Computational yes yes
HIBCH_HUMAN [view entry] [view interactions] Computational yes yes
ACAD8_HUMAN [view interactions] Computational no yes
ECHP_HUMAN [view interactions] Computational no no
GCDH_HUMAN [view interactions] Computational no yes
GNAQ_HUMAN [view entry] [view interactions] Computational yes yes
MCCA_HUMAN [view entry] [view interactions] Computational yes yes
MCCB_HUMAN [view entry] [view interactions] Computational yes yes
THIC_HUMAN [view interactions] Computational no yes
ACOX1_HUMAN [view interactions] Computational no yes
ECHM_HUMAN [view interactions] Computational no yes