ECHA_HUMAN
Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway (PubMed, PubMed, PubMed, PubMed). The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA (PubMed). Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids (PubMed). Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA described here carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities while the trifunctional enzyme subunit beta/HADHB bears the 3-ketoacyl-CoA thiolase activity (PubMed, PubMed, PubMed). Independently of the subunit beta, the trifunctional enzyme subunit alpha/HADHA also has a monolysocardiolipin acyltransferase activity (PubMed). It acylates monolysocardiolipin into cardiolipin, a major mitochondrial membrane phospholipid which plays a key role in apoptosis and supports mitochondrial respiratory chain complexes in the generation of ATP (PubMed). Allows the acylation of monolysocardiolipin with different acyl-CoA substrates including oleoyl-CoA for which it displays the highest activity (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ECHA_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 33.7748 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 33.7748 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 31.7881 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 25.1656 | 5 | yes |
GO:0032559 | adenyl ribonucleotide binding | 25.1656 | 5 | yes |
GO:0005524 | ATP binding | 23.1788 | 5 | no |
GO:0046872 | metal ion binding | 23.1788 | 4 | no |
GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 5.2980 | 4 | yes |
GO:0003988 | acetyl-CoA C-acyltransferase activity | 3.3113 | 6 | yes |
GO:0016408 | C-acyltransferase activity | 3.3113 | 5 | yes |
GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | 3.3113 | 4 | yes |
GO:0016836 | hydro-lyase activity | 3.3113 | 4 | yes |
GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity | 2.6490 | 5 | yes |
GO:0003985 | acetyl-CoA C-acetyltransferase activity | 2.6490 | 7 | yes |
GO:0004300 | enoyl-CoA hydratase activity | 2.6490 | 5 | yes |
GO:0016407 | acetyltransferase activity | 2.6490 | 5 | yes |
GO:0016453 | C-acetyltransferase activity | 2.6490 | 6 | yes |
GO:0051287 | NAD binding | 2.6490 | 4 | yes |
GO:0000062 | fatty-acyl-CoA binding | 1.3245 | 4 | yes |
GO:0016508 | long-chain-enoyl-CoA hydratase activity | 1.3245 | 5 | yes |
GO:0016509 | long-chain-3-hydroxyacyl-CoA dehydrogenase activity | 1.3245 | 6 | yes |
GO:0070403 | NAD+ binding | 1.3245 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ECHA_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 45.6954 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 41.7219 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 41.7219 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 40.3974 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 40.3974 | 4 | no |
GO:0048523 | negative regulation of cellular process | 39.7351 | 4 | no |
GO:0051128 | regulation of cellular component organization | 37.7483 | 4 | no |
GO:0006996 | organelle organization | 37.0861 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 35.7616 | 4 | no |
GO:0010646 | regulation of cell communication | 34.4371 | 4 | no |
GO:0022607 | cellular component assembly | 32.4503 | 4 | no |
GO:0009966 | regulation of signal transduction | 31.7881 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 31.7881 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 30.4636 | 5 | no |
GO:0010468 | regulation of gene expression | 29.8013 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 29.8013 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 29.1391 | 5 | no |
GO:0010941 | regulation of cell death | 27.1523 | 4 | no |
GO:0008104 | protein localization | 24.5033 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 24.5033 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 24.5033 | 5 | no |
GO:0042981 | regulation of apoptotic process | 23.8411 | 6 | no |
GO:0043067 | regulation of programmed cell death | 23.8411 | 5 | no |
GO:0043412 | macromolecule modification | 23.1788 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 23.1788 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 23.1788 | 5 | no |
GO:0006796 | phosphate-containing compound metabolic process | 23.1788 | 4 | yes |
GO:0009889 | regulation of biosynthetic process | 22.5166 | 4 | no |
GO:0031326 | regulation of cellular biosynthetic process | 22.5166 | 5 | no |
GO:0036211 | protein modification process | 22.5166 | 4 | no |
GO:0051049 | regulation of transport | 22.5166 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 21.8543 | 5 | no |
GO:0031399 | regulation of protein modification process | 21.8543 | 6 | no |
GO:0043085 | positive regulation of catalytic activity | 21.8543 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 21.1921 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 21.1921 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 21.1921 | 5 | no |
GO:0042325 | regulation of phosphorylation | 21.1921 | 7 | no |
GO:0048584 | positive regulation of response to stimulus | 21.1921 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 20.5298 | 6 | no |
GO:0010243 | response to organonitrogen compound | 16.5563 | 4 | yes |
GO:0019752 | carboxylic acid metabolic process | 15.8940 | 5 | yes |
GO:0043436 | oxoacid metabolic process | 15.8940 | 4 | yes |
GO:0032787 | monocarboxylic acid metabolic process | 11.9205 | 6 | yes |
GO:0016054 | organic acid catabolic process | 9.9338 | 4 | yes |
GO:0046395 | carboxylic acid catabolic process | 9.9338 | 5 | yes |
GO:0016042 | lipid catabolic process | 8.6093 | 4 | yes |
GO:1901652 | response to peptide | 7.9470 | 4 | yes |
GO:0006631 | fatty acid metabolic process | 7.9470 | 4 | yes |
GO:0030258 | lipid modification | 7.9470 | 4 | yes |
GO:0072329 | monocarboxylic acid catabolic process | 7.2848 | 6 | yes |
GO:0006635 | fatty acid beta-oxidation | 7.2848 | 6 | yes |
GO:0009062 | fatty acid catabolic process | 7.2848 | 5 | yes |
GO:0019395 | fatty acid oxidation | 7.2848 | 5 | yes |
GO:0034440 | lipid oxidation | 7.2848 | 5 | yes |
GO:0044242 | cellular lipid catabolic process | 7.2848 | 4 | yes |
GO:0043434 | response to peptide hormone | 5.2980 | 4 | yes |
GO:0046486 | glycerolipid metabolic process | 3.3113 | 4 | yes |
GO:0032868 | response to insulin | 3.3113 | 5 | yes |
GO:0006644 | phospholipid metabolic process | 1.9868 | 4 | yes |
GO:0006650 | glycerophospholipid metabolic process | 1.9868 | 5 | yes |
GO:0032048 | cardiolipin metabolic process | 1.3245 | 7 | yes |
GO:0035965 | cardiolipin acyl-chain remodeling | 1.3245 | 8 | yes |
GO:0046471 | phosphatidylglycerol metabolic process | 1.3245 | 6 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in ECHA_HUMAN |
---|---|---|---|---|
DOID:1289 | neurodegenerative disease | 1.9868 | 4 | no |
DOID:3146 | lipid metabolism disorder | 1.9868 | 3 | no |
DOID:331 | central nervous system disease | 1.9868 | 3 | no |
DOID:700 | mitochondrial metabolism disease | 1.9868 | 3 | no |
DOID:10595 | Charcot-Marie-Tooth disease | 1.9868 | 6 | no |
DOID:440 | neuromuscular disease | 1.9868 | 5 | no |
DOID:574 | peripheral nervous system disease | 1.9868 | 3 | no |
DOID:870 | neuropathy | 1.9868 | 4 | no |
DOID:0050539 | Charcot-Marie-Tooth disease type 2 | 1.3245 | 7 | no |
DOID:0060286 | combined oxidative phosphorylation deficiency | 1.3245 | 4 | no |
DOID:0050686 | organ system cancer | 1.3245 | 3 | no |
DOID:10283 | prostate cancer | 1.3245 | 6 | no |
DOID:193 | reproductive organ cancer | 1.3245 | 4 | no |
DOID:3856 | male reproductive organ cancer | 1.3245 | 5 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
ECHA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ECHB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CFDP1_HUMAN | [view interactions] | High throughput | no | yes |
COX6C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIFAB_HUMAN | [view interactions] | High throughput | no | no |
CX7A2_HUMAN | [view interactions] | High throughput | no | no |
AKIP_HUMAN | [view interactions] | High throughput | no | yes |
COX7C_HUMAN | [view interactions] | High throughput | no | yes |
BET1_HUMAN | [view interactions] | High throughput | no | no |
COX8A_HUMAN | [view interactions] | High throughput | no | yes |
CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COX14_HUMAN | [view interactions] | High throughput | no | yes |
FRIH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GNA11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
H31_HUMAN | [view interactions] | High throughput | no | yes |
GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP1S2_HUMAN | [view interactions] | High throughput | no | no |
PDK1_HUMAN | [view interactions] | High throughput | no | yes |
ASPH_HUMAN | [view interactions] | High throughput | no | yes |
RS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RCAF1_HUMAN | [view interactions] | High throughput | no | yes |
TOM20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CLPP_HUMAN | [view interactions] | High throughput | no | yes |
TOM22_HUMAN | [view interactions] | High throughput | no | yes |
COA3_HUMAN | [view interactions] | High throughput | no | yes |
MET_HUMAN | [view interactions] | High throughput | no | yes |
COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
CPT1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CP51A_HUMAN | [view interactions] | High throughput | no | no |
PSMD4_HUMAN | [view interactions] | High throughput | no | yes |
EMC2_HUMAN | [view interactions] | High throughput | no | yes |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HMGC2_HUMAN | [view interactions] | High throughput | no | no |
HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
MIC60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LEO1_HUMAN | [view interactions] | High throughput | no | yes |
MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RTF1_HUMAN | [view interactions] | High throughput | no | yes |
NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SIR7_HUMAN | [view interactions] | High throughput | no | yes |
NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
P5F1B_HUMAN | [view interactions] | High throughput | no | no |
NIPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PO5F1_HUMAN | [view interactions] | High throughput | no | yes |
PRDX4_HUMAN | [view interactions] | High throughput | no | yes |
CDK2_HUMAN | [view interactions] | High throughput | no | yes |
TFAM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAH9_HUMAN | [view interactions] | High throughput | no | no |
TOM5_HUMAN | [view interactions] | High throughput | no | yes |
PAN2_HUMAN | [view interactions] | High throughput | no | no |
ZN782_HUMAN | [view interactions] | High throughput | no | yes |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ENPL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WWOX_HUMAN | [view interactions] | High throughput | no | yes |
HSP74_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZBTB1_HUMAN | [view interactions] | High throughput | no | no |
COX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRSF1_HUMAN | [view interactions] | High throughput | no | yes |
ML12A_HUMAN | [view interactions] | High throughput | no | no |
EMD_HUMAN | [view interactions] | High throughput | no | yes |
NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STB5L_HUMAN | [view interactions] | High throughput | no | no |
NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CUL7_HUMAN | [view interactions] | High throughput | no | yes |
NDUS5_HUMAN | [view interactions] | High throughput | no | yes |
CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EED_HUMAN | [view interactions] | High throughput | no | yes |
NDUS8_HUMAN | [view interactions] | High throughput | no | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
PCCB_HUMAN | [view interactions] | High throughput | no | yes |
SKI_HUMAN | [view interactions] | High throughput | no | yes |
ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
ODPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MKRN1_HUMAN | [view interactions] | High throughput | no | no |
PRDX3_HUMAN | [view interactions] | High throughput | no | yes |
MCM2_HUMAN | [view interactions] | High throughput | no | no |
QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MDM2_HUMAN | [view interactions] | High throughput | no | yes |
QCR8_HUMAN | [view interactions] | High throughput | no | yes |
NFAC2_HUMAN | [view interactions] | High throughput | no | yes |
ORN_HUMAN | [view interactions] | High throughput | no | no |
CDC73_HUMAN | [view interactions] | High throughput | no | yes |
THIM_HUMAN | [view interactions] | High throughput | no | yes |
RAD18_HUMAN | [view interactions] | High throughput | no | yes |
DECR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZN746_HUMAN | [view interactions] | High throughput | no | no |
ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTN2_HUMAN | [view interactions] | High throughput | no | yes |
ACADL_HUMAN | [view interactions] | High throughput | no | no |
PTPRD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACADM_HUMAN | [view interactions] | High throughput | no | yes |
CD44_HUMAN | [view interactions] | High throughput | no | yes |
ACADS_HUMAN | [view interactions] | High throughput | no | yes |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
ACADV_HUMAN | [view interactions] | High throughput | no | yes |
TES_HUMAN | [view interactions] | High throughput | no | yes |
CPT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TEDC2_HUMAN | [view interactions] | High throughput | no | no |
ECH1_HUMAN | [view interactions] | High throughput | no | yes |
TRIP4_HUMAN | [view interactions] | High throughput | no | yes |
ECI1_HUMAN | [view interactions] | High throughput | no | yes |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
HSDL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
SUCB2_HUMAN | [view interactions] | High throughput | no | no |
TPTE_HUMAN | [view interactions] | High throughput | no | no |
ALKB3_HUMAN | [view interactions] | High throughput | no | yes |
PRP8_HUMAN | [view interactions] | High throughput | no | yes |
ACD11_HUMAN | [view interactions] | High throughput | no | yes |
U5S1_HUMAN | [view interactions] | High throughput | no | yes |
ROCK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AAR2_HUMAN | [view interactions] | High throughput | no | no |
S10AB_HUMAN | [view interactions] | High throughput | no | no |
PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
LTMD1_HUMAN | [view interactions] | High throughput | no | no |
AKTIP_HUMAN | [view interactions] | High throughput | no | yes |
TAOK3_HUMAN | [view interactions] | High throughput | no | yes |
UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI14_HUMAN | [view interactions] | High throughput | no | yes |
REL_HUMAN | [view interactions] | High throughput | no | yes |
MRM1_HUMAN | [view interactions] | High throughput | no | no |
TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
DPPA3_HUMAN | [view interactions] | High throughput | no | no |
CETN3_HUMAN | [view interactions] | High throughput | no | yes |
ACAD9_HUMAN | [view interactions] | High throughput | no | yes |
UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
AUHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FGF11_HUMAN | [view interactions] | High throughput | no | no |
MTRFR_HUMAN | [view interactions] | High throughput | no | yes |
HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
C1QBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
LARP7_HUMAN | [view interactions] | High throughput | no | yes |
GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
RN123_HUMAN | [view interactions] | High throughput | no | yes |
MRES1_HUMAN | [view interactions] | High throughput | no | yes |
AGR2_HUMAN | [view interactions] | High throughput | no | no |
MCUR1_HUMAN | [view interactions] | High throughput | no | no |
RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
CC90B_HUMAN | [view interactions] | High throughput | no | yes |
TISD_HUMAN | [view interactions] | High throughput | no | no |
CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
WDR76_HUMAN | [view interactions] | High throughput | no | no |
EFGM_HUMAN | [view interactions] | High throughput | no | yes |
H4_HUMAN | [view interactions] | High throughput | no | yes |
HINT2_HUMAN | [view interactions] | High throughput | no | yes |
GRWD1_HUMAN | [view interactions] | High throughput | no | no |
MCUB_HUMAN | [view interactions] | High throughput | no | no |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
MET15_HUMAN | [view interactions] | High throughput | no | no |
ZBT7A_HUMAN | [view interactions] | High throughput | no | yes |
MET17_HUMAN | [view interactions] | High throughput | no | yes |
ACTC_HUMAN | [view interactions] | High throughput | no | no |
RM11_HUMAN | [view interactions] | High throughput | no | yes |
PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RT12_HUMAN | [view interactions] | High throughput | no | yes |
CCND1_HUMAN | [view interactions] | High throughput | no | yes |
RT26_HUMAN | [view interactions] | High throughput | no | yes |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
RRFM_HUMAN | [view interactions] | High throughput | no | yes |
HDAC2_HUMAN | [view interactions] | High throughput | no | yes |
MTEF3_HUMAN | [view interactions] | High throughput | no | no |
ATX1_HUMAN | [view interactions] | High throughput | no | yes |
MTG2_HUMAN | [view interactions] | High throughput | no | yes |
VRK1_HUMAN | [view interactions] | High throughput | no | yes |
IF2M_HUMAN | [view interactions] | High throughput | no | yes |
S15A3_HUMAN | [view interactions] | High throughput | no | yes |
IF3M_HUMAN | [view interactions] | High throughput | no | yes |
HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RF1M_HUMAN | [view interactions] | High throughput | no | yes |
TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RF1ML_HUMAN | [view interactions] | High throughput | no | yes |
GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MPPA_HUMAN | [view interactions] | High throughput | no | yes |
MRP6_HUMAN | [view interactions] | High throughput | no | no |
MPPB_HUMAN | [view interactions] | High throughput | no | yes |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
RMND1_HUMAN | [view interactions] | High throughput | no | yes |
LMBRL_HUMAN | [view interactions] | High throughput | no | no |
S2551_HUMAN | [view interactions] | High throughput | no | no |
WWP2_HUMAN | [view interactions] | High throughput | no | no |
SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
P53_HUMAN | [view interactions] | High throughput | no | no |
FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
BRD7_HUMAN | [view interactions] | High throughput | no | yes |
TRUB2_HUMAN | [view interactions] | High throughput | no | yes |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
EFTS_HUMAN | [view interactions] | High throughput | no | no |
CUL9_HUMAN | [view interactions] | High throughput | no | no |
EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
VWA8_HUMAN | [view interactions] | High throughput | no | yes |
PINK1_HUMAN | [view interactions] | High throughput | no | yes |
EXD2_HUMAN | [view interactions] | High throughput | no | yes |
YAP1_HUMAN | [view interactions] | High throughput | no | yes |
HSC20_HUMAN | [view interactions] | High throughput | no | yes |
TFCP2_HUMAN | [view interactions] | High throughput | no | no |
SYAM_HUMAN | [view interactions] | High throughput | no | yes |
NGB_HUMAN | [view interactions] | High throughput | no | yes |
AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
TBB5_HUMAN | [view interactions] | High throughput | no | yes |
CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECT2_HUMAN | [view interactions] | High throughput | no | no |
OPTN_HUMAN | [view interactions] | High throughput | no | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
PER2_HUMAN | [view interactions] | High throughput | no | yes |
KI20A_HUMAN | [view interactions] | High throughput | no | yes |
KIF23_HUMAN | [view interactions] | High throughput | no | yes |
PRC1_HUMAN | [view interactions] | High throughput | no | yes |
BRD4_HUMAN | [view interactions] | High throughput | no | yes |
MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NUPR1_HUMAN | [view interactions] | High throughput | no | no |
HG2A_HUMAN | [view interactions] | High throughput | no | yes |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
NR4A1_HUMAN | [view interactions] | High throughput | no | yes |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
ABCF2_HUMAN | [view interactions] | High throughput | no | yes |
RBM39_HUMAN | [view interactions] | High throughput | no | yes |
ATX2L_HUMAN | [view interactions] | High throughput | no | no |
F16P1_HUMAN | [view interactions] | High throughput | no | no |
GLUT4_HUMAN | [view interactions] | High throughput | no | no |
DJC11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UBP49_HUMAN | [view interactions] | High throughput | no | yes |
DJC15_HUMAN | [view interactions] | High throughput | no | no |
MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIM14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GBRAP_HUMAN | [view interactions] | High throughput | no | no |
DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
DJC25_HUMAN | [view interactions] | High throughput | no | yes |
GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RIN3_HUMAN | [view interactions] | High throughput | no | yes |
GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
DDX58_HUMAN | [view interactions] | High throughput | no | yes |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
PD1L1_HUMAN | [view interactions] | High throughput | no | no |
NIPS2_HUMAN | [view interactions] | High throughput | no | yes |
DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DDA1_HUMAN | [view interactions] | High throughput | no | yes |
FZR1_HUMAN | [view interactions] | High throughput | no | no |
ATGA1_HUMAN | [view interactions] | High throughput | no | yes |
IL7RA_HUMAN | [view interactions] | High throughput | no | no |
ICT1_HUMAN | [view interactions] | High throughput | no | yes |
SAAL1_HUMAN | [view interactions] | High throughput | no | yes |
FTM_HUMAN | [view interactions] | High throughput | no | yes |
TGBR3_HUMAN | [view interactions] | High throughput | no | yes |
IQCB1_HUMAN | [view interactions] | High throughput | no | no |
DHRS2_HUMAN | [view interactions] | High throughput | no | no |
ATF2_HUMAN | [view interactions] | High throughput | no | yes |
NID2_HUMAN | [view interactions] | High throughput | no | yes |
PP6R1_HUMAN | [view interactions] | High throughput | no | no |
OSBL8_HUMAN | [view interactions] | High throughput | no | yes |
NUMB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LAMA4_HUMAN | [view interactions] | High throughput | no | no |
RIPK4_HUMAN | [view interactions] | High throughput | no | no |
GPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PR15A_HUMAN | [view interactions] | High throughput | no | yes |
NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SIR4_HUMAN | [view interactions] | High throughput | no | yes |
GPC3_HUMAN | [view interactions] | High throughput | no | no |
CBX1_HUMAN | [view interactions] | High throughput | no | yes |
GSLG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCTD5_HUMAN | [view interactions] | High throughput | no | no |
CXCR4_HUMAN | [view interactions] | High throughput | no | no |
SRP72_HUMAN | [view interactions] | High throughput | no | yes |
SDC3_HUMAN | [view interactions] | High throughput | no | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
CCD50_HUMAN | [view interactions] | High throughput | no | yes |
NAF1_HUMAN | [view interactions] | High throughput | no | yes |
CSKP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GPC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KSR1_HUMAN | [view interactions] | High throughput | no | yes |
HEAT3_HUMAN | [view interactions] | High throughput | no | yes |
SDC2_HUMAN | [view interactions] | High throughput | no | yes |
TEFF1_HUMAN | [view interactions] | High throughput | no | no |
CADH8_HUMAN | [view interactions] | High throughput | no | no |
YBEY_HUMAN | [view interactions] | High throughput | no | yes |
CADH5_HUMAN | [view interactions] | High throughput | no | yes |
GPC2_HUMAN | [view interactions] | High throughput | no | no |
RELL2_HUMAN | [view interactions] | High throughput | no | no |
AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VANG1_HUMAN | [view interactions] | High throughput | no | no |
COQ9_HUMAN | [view interactions] | High throughput | no | yes |
FARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NDUA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TTC19_HUMAN | [view interactions] | High throughput | no | yes |
PRD16_HUMAN | [view interactions] | High throughput | no | no |
SDC4_HUMAN | [view interactions] | High throughput | no | yes |
MECOM_HUMAN | [view interactions] | High throughput | no | yes |
SDC1_HUMAN | [view interactions] | High throughput | no | no |
PDPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CQ080_HUMAN | [view interactions] | High throughput | no | yes |
KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GPC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SRC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
IPO9_HUMAN | [view interactions] | High throughput | no | no |
MSPD2_HUMAN | [view interactions] | High throughput | no | yes |
B3GT6_HUMAN | [view interactions] | High throughput | no | no |
ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LEG1_HUMAN | [view interactions] | High throughput | no | yes |
NCBP3_HUMAN | [view interactions] | High throughput | no | yes |
SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BTF3_HUMAN | [view interactions] | High throughput | no | yes |
CNR2_HUMAN | [view interactions] | High throughput | no | yes |
THB_HUMAN | [view interactions] | High throughput | no | no |
ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
MOT11_HUMAN | [view interactions] | High throughput | no | no |
EP300_HUMAN | [view interactions] | High throughput | no | yes |
SRF_HUMAN | [view interactions] | High throughput | no | yes |
FGD5_HUMAN | [view interactions] | High throughput | no | yes |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TMPS2_HUMAN | [view interactions] | High throughput | no | no |
VCAM1_HUMAN | [view interactions] | High throughput | no | no |
TOP3B_HUMAN | [view interactions] | High throughput | no | no |
FINC_HUMAN | [view interactions] | High throughput | no | yes |
CATL1_HUMAN | [view interactions] | High throughput | no | yes |
PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FURIN_HUMAN | [view interactions] | High throughput | no | yes |
VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IFM1_HUMAN | [view interactions] | High throughput | no | no |
MYO7B_HUMAN | [view interactions] | High throughput | no | no |
DPP4_HUMAN | [view interactions] | High throughput | no | no |
KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
IFM3_HUMAN | [view interactions] | High throughput | no | yes |
ATP5H_HUMAN | [view interactions] | High throughput | no | yes |
TM11B_HUMAN | [view interactions] | High throughput | no | no |
SIR5_HUMAN | [view interactions] | High throughput | no | yes |
CLC4D_HUMAN | [view interactions] | High throughput | no | no |
DNAI7_HUMAN | [view interactions] | High throughput | no | no |
ACE2_HUMAN | [view interactions] | High throughput | no | no |
QRIC1_HUMAN | [view interactions] | High throughput | no | yes |
CLC4E_HUMAN | [view interactions] | High throughput | no | no |
ENTD1_HUMAN | [view interactions] | High throughput | no | no |
ZN363_HUMAN | [view interactions] | High throughput | no | yes |
TNS2_HUMAN | [view interactions] | High throughput | no | no |
GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BTK_HUMAN | [view interactions] | High throughput | no | no |
CLU_HUMAN | [view interactions] | High throughput | no | yes |
E2F3_HUMAN | [view interactions] | High throughput | no | no |
BAG1_HUMAN | [view interactions] | High throughput | no | yes |
MEX3C_HUMAN | [view interactions] | High throughput | no | yes |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PPM1G_HUMAN | [view interactions] | High throughput | no | no |
BAP1_HUMAN | [view interactions] | High throughput | no | yes |
DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DDB1_HUMAN | [view interactions] | High throughput | no | yes |
TBA1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRP09_HUMAN | [view interactions] | High throughput | no | no |
TGON2_HUMAN | [view interactions] | High throughput | no | yes |
PIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MED4_HUMAN | [view interactions] | High throughput | no | yes |
1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MED23_HUMAN | [view interactions] | High throughput | no | no |
PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NOD2_HUMAN | [view interactions] | High throughput | no | yes |
STT3B_HUMAN | [view interactions] | High throughput | no | yes |
P2RY6_HUMAN | [view interactions] | High throughput | no | no |
PLOD3_HUMAN | [view interactions] | High throughput | no | yes |
TRI63_HUMAN | [view interactions] | High throughput | no | no |
MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
M3K13_HUMAN | [view interactions] | High throughput | no | yes |
ETFA_HUMAN | [view interactions] | High throughput | no | yes |
CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ZFR_HUMAN | [view interactions] | High throughput | no | yes |
UFO_HUMAN | [view interactions] | High throughput | no | no |
TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
KSYK_HUMAN | [view interactions] | High throughput | no | no |
HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LIMK1_HUMAN | [view interactions] | High throughput | no | yes |
ATLA3_HUMAN | [view interactions] | High throughput | no | no |
LIMK2_HUMAN | [view interactions] | High throughput | no | yes |
AT1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KC1G2_HUMAN | [view interactions] | High throughput | no | yes |
HYEP_HUMAN | [view interactions] | High throughput | no | no |
CDK13_HUMAN | [view interactions] | High throughput | no | no |
RM40_HUMAN | [view interactions] | High throughput | no | yes |
NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NDUB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ST32C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOM40_HUMAN | [view interactions] | High throughput | no | yes |
MINK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAMKV_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BRSK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AASS_HUMAN | [view interactions] | High throughput | no | yes |
TBCK_HUMAN | [view interactions] | High throughput | no | yes |
NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
HASP_HUMAN | [view interactions] | High throughput | no | yes |
SND1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KPSH2_HUMAN | [view interactions] | High throughput | no | no |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PMYT1_HUMAN | [view interactions] | High throughput | no | no |
GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TAOK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCPDL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RPKL1_HUMAN | [view interactions] | High throughput | no | yes |
NB5R1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MAST1_HUMAN | [view interactions] | High throughput | no | yes |
ADAS_HUMAN | [view interactions] | High throughput | no | yes |
SG196_HUMAN | [view interactions] | High throughput | no | yes |
RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SOX15_HUMAN | [view interactions] | High throughput | no | no |
MCAT_HUMAN | [view interactions] | High throughput | no | yes |
SOX2_HUMAN | [view interactions] | High throughput | no | yes |
RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
DDR2_HUMAN | [view interactions] | High throughput | no | no |
ATPA_HUMAN | [view interactions] | High throughput | no | yes |
EPHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MGST1_HUMAN | [view interactions] | High throughput | no | no |
EPHA5_HUMAN | [view interactions] | High throughput | no | no |
QCR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ICAM1_HUMAN | [view interactions] | High throughput | no | no |
EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ODO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
GBG5_HUMAN | [view interactions] | High throughput | no | no |
FGFR2_HUMAN | [view interactions] | High throughput | no | yes |
SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
ATPB_HUMAN | [view interactions] | High throughput | no | yes |
FGFR4_HUMAN | [view interactions] | High throughput | no | no |
APOE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OCAD2_HUMAN | [view interactions] | High throughput | no | yes |
KPCE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATP5L_HUMAN | [view interactions] | High throughput | no | yes |
EPB41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ATPG_HUMAN | [view interactions] | High throughput | no | yes |
AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
P4HA1_HUMAN | [view interactions] | High throughput | no | yes |
BCAR3_HUMAN | [view interactions] | High throughput | no | yes |
VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HLAB_HUMAN | [view interactions] | High throughput | no | yes |
GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IKKE_HUMAN | [view interactions] | High throughput | no | yes |
NDUA3_HUMAN | [view interactions] | High throughput | no | yes |
MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
COX7R_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
JUN_HUMAN | [view interactions] | High throughput | no | yes |
ACOT9_HUMAN | [view interactions] | High throughput | no | yes |
PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
LETM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STML2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LITD1_HUMAN | [view interactions] | High throughput | no | no |
AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
NDUA8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACPM_HUMAN | [view interactions] | High throughput | no | yes |
PREB_HUMAN | [view interactions] | High throughput | no | yes |
M3K1_HUMAN | [view interactions] | High throughput | no | yes |
RAB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NFKB2_HUMAN | [view interactions] | High throughput | no | yes |
MPCP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RIPK3_HUMAN | [view interactions] | High throughput | no | no |
ATPO_HUMAN | [view interactions] | High throughput | no | yes |
TNR1A_HUMAN | [view interactions] | High throughput | no | yes |
PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EDC4_HUMAN | [view interactions] | High throughput | no | yes |
ATPMK_HUMAN | [view interactions] | High throughput | no | no |
SPART_HUMAN | [view interactions] | High throughput | no | yes |
PGES2_HUMAN | [view interactions] | High throughput | no | yes |
CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AN34C_HUMAN | [view interactions] | High throughput | no | no |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
ODBA_HUMAN | [view interactions] | High throughput | no | yes |
FAKD3_HUMAN | [view interactions] | High throughput | no | yes |
CALR_HUMAN | [view interactions] | High throughput | no | yes |
ATD3B_HUMAN | [view interactions] | High throughput | no | yes |
CO6A1_HUMAN | [view interactions] | High throughput | no | no |
ATD3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COX5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
THIK_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MECR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ACDSB_HUMAN | [view interactions] | Computational | no | yes |
ACOX3_HUMAN | [view interactions] | Computational | no | yes |
THIL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
HIBCH_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ACAD8_HUMAN | [view interactions] | Computational | no | yes |
ECHP_HUMAN | [view interactions] | Computational | no | no |
GCDH_HUMAN | [view interactions] | Computational | no | yes |
GNAQ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MCCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MCCB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
THIC_HUMAN | [view interactions] | Computational | no | yes |
ACOX1_HUMAN | [view interactions] | Computational | no | yes |
ECHM_HUMAN | [view interactions] | Computational | no | yes |