Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CSN3_HUMAN

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. [View more on UniProt]

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in CSN3_HUMAN
GO:0017076 purine nucleotide binding 28.0000 4 no
GO:0032555 purine ribonucleotide binding 28.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 28.0000 4 no
GO:0046872 metal ion binding 22.0000 4 no
GO:0005524 ATP binding 22.0000 5 no
GO:0030554 adenyl nucleotide binding 22.0000 5 no
GO:0032559 adenyl ribonucleotide binding 22.0000 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in CSN3_HUMAN
GO:0048522 positive regulation of cellular process 58.0000 4 no
GO:0009966 regulation of signal transduction 54.0000 4 yes
GO:0010646 regulation of cell communication 54.0000 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 52.0000 4 no
GO:0060255 regulation of macromolecule metabolic process 52.0000 4 no
GO:0080090 regulation of primary metabolic process 52.0000 4 no
GO:0031323 regulation of cellular metabolic process 50.0000 4 no
GO:0048523 negative regulation of cellular process 50.0000 4 no
GO:0006996 organelle organization 44.0000 4 no
GO:0009893 positive regulation of metabolic process 44.0000 4 no
GO:0051246 regulation of protein metabolic process 44.0000 5 no
GO:0051128 regulation of cellular component organization 42.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 40.0000 5 no
GO:0022607 cellular component assembly 38.0000 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 38.0000 5 no
GO:1902531 regulation of intracellular signal transduction 36.0000 5 yes
GO:0036211 protein modification process 34.0000 4 yes
GO:0043412 macromolecule modification 34.0000 4 yes
GO:0031325 positive regulation of cellular metabolic process 34.0000 5 no
GO:0031399 regulation of protein modification process 34.0000 6 no
GO:0010941 regulation of cell death 34.0000 4 no
GO:0042981 regulation of apoptotic process 34.0000 6 no
GO:0043067 regulation of programmed cell death 34.0000 5 no
GO:0048585 negative regulation of response to stimulus 34.0000 4 no
GO:0010648 negative regulation of cell communication 34.0000 5 no
GO:0023057 negative regulation of signaling 34.0000 4 no
GO:0048584 positive regulation of response to stimulus 32.0000 4 no
GO:0051247 positive regulation of protein metabolic process 32.0000 6 no
GO:0009889 regulation of biosynthetic process 32.0000 4 no
GO:0009968 negative regulation of signal transduction 32.0000 5 no
GO:0010468 regulation of gene expression 32.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 32.0000 5 no
GO:0010556 regulation of macromolecule biosynthetic process 30.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.0000 5 no
GO:0006508 proteolysis 28.0000 4 yes
GO:0009057 macromolecule catabolic process 28.0000 4 yes
GO:0010647 positive regulation of cell communication 28.0000 5 no
GO:0019220 regulation of phosphate metabolic process 28.0000 6 no
GO:0023056 positive regulation of signaling 28.0000 4 no
GO:0051174 regulation of phosphorus metabolic process 28.0000 5 no
GO:0007010 cytoskeleton organization 28.0000 5 no
GO:0009967 positive regulation of signal transduction 26.0000 5 no
GO:0042325 regulation of phosphorylation 26.0000 7 no
GO:0060548 negative regulation of cell death 26.0000 5 no
GO:0009894 regulation of catabolic process 26.0000 4 no
GO:0019941 modification-dependent protein catabolic process 24.0000 6 yes
GO:0043632 modification-dependent macromolecule catabolic process 24.0000 5 yes
GO:0044265 cellular macromolecule catabolic process 24.0000 4 yes
GO:0051603 proteolysis involved in protein catabolic process 24.0000 5 yes
GO:0070647 protein modification by small protein conjugation or removal 24.0000 5 yes
GO:0043933 protein-containing complex organization 24.0000 4 no
GO:0001932 regulation of protein phosphorylation 24.0000 7 no
GO:0031401 positive regulation of protein modification process 24.0000 7 no
GO:0016192 vesicle-mediated transport 24.0000 4 no
GO:0009892 negative regulation of metabolic process 24.0000 4 no
GO:0043066 negative regulation of apoptotic process 24.0000 7 no
GO:0043069 negative regulation of programmed cell death 24.0000 6 no
GO:0008104 protein localization 24.0000 4 no
GO:0006511 ubiquitin-dependent protein catabolic process 22.0000 7 yes
GO:0080134 regulation of response to stress 22.0000 4 yes
GO:0042127 regulation of cell population proliferation 22.0000 4 no
GO:0051130 positive regulation of cellular component organization 22.0000 5 no
GO:0006355 regulation of DNA-templated transcription 22.0000 6 no
GO:0009891 positive regulation of biosynthetic process 22.0000 5 no
GO:0010605 negative regulation of macromolecule metabolic process 22.0000 5 no
GO:0031324 negative regulation of cellular metabolic process 22.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 22.0000 6 no
GO:0051172 negative regulation of nitrogen compound metabolic process 22.0000 5 no
GO:0051252 regulation of RNA metabolic process 22.0000 5 no
GO:1903506 regulation of nucleic acid-templated transcription 22.0000 7 no
GO:2001141 regulation of RNA biosynthetic process 22.0000 6 no
GO:0030030 cell projection organization 22.0000 4 no
GO:0044087 regulation of cellular component biogenesis 22.0000 4 no
GO:0033043 regulation of organelle organization 22.0000 5 no
GO:0080135 regulation of cellular response to stress 14.0000 4 yes
GO:0001701 in utero embryonic development 8.0000 6 yes
GO:0009416 response to light stimulus 8.0000 4 yes
GO:0009792 embryo development ending in birth or egg hatching 8.0000 4 yes
GO:0043009 chordate embryonic development 8.0000 5 yes
GO:0070646 protein modification by small protein removal 8.0000 5 yes
GO:1901796 regulation of signal transduction by p53 class mediator 6.0000 6 yes
GO:2001020 regulation of response to DNA damage stimulus 6.0000 5 yes
GO:0000338 protein deneddylation 4.0000 6 yes
GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator 4.0000 6 yes
GO:1902162 regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 4.0000 7 yes

Disease

Term Name % Distance from top the of the tree Annotated in CSN3_HUMAN
DOID:440 neuromuscular disease 6.0000 5 no
DOID:574 peripheral nervous system disease 6.0000 3 no
DOID:870 neuropathy 6.0000 4 no
DOID:3490 Noonan syndrome 4.0000 3 no
DOID:0050539 Charcot-Marie-Tooth disease type 2 4.0000 7 no
DOID:10595 Charcot-Marie-Tooth disease 4.0000 6 no
DOID:331 central nervous system disease 4.0000 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
IRF5_HUMAN [view interactions] Low throughput no no
BECN1_HUMAN [view interactions] Low throughput no yes
MLP3A_HUMAN [view entry] [view interactions] Low throughput yes yes
CSK21_HUMAN [view entry] [view interactions] Low throughput yes yes
CSK2B_HUMAN [view entry] [view interactions] Low throughput yes yes
IL1RA_HUMAN [view interactions] Low throughput no no
DDIT3_HUMAN [view interactions] Low throughput no yes
VHL_HUMAN [view entry] [view interactions] Low throughput yes yes
ITB2_HUMAN [view interactions] Low throughput no no
DDB1_HUMAN [view interactions] Low throughput no yes
NEMO_HUMAN [view interactions] Low throughput no yes
RAF1_HUMAN [view entry] [view interactions] Low throughput yes no
SOS1_HUMAN [view entry] [view interactions] Low throughput yes yes
CSN5_HUMAN [view interactions] Low throughput no yes
CSN6_HUMAN [view interactions] Low throughput no yes
CUL4B_HUMAN [view interactions] Low throughput no yes
CSN1_HUMAN [view interactions] Low throughput no no
CSN2_HUMAN [view interactions] Low throughput no yes
CSN7A_HUMAN [view interactions] Low throughput no yes
CSN7B_HUMAN [view interactions] Low throughput no yes
DET1_HUMAN [view interactions] Low throughput no no
CSN8_HUMAN [view interactions] Low throughput no yes
CSN4_HUMAN [view interactions] Low throughput no yes
CSN9_HUMAN [view interactions] Low throughput no yes
CUL2_HUMAN [view interactions] Low throughput no yes
NEDD8_HUMAN [view interactions] Low throughput no yes
IKKB_HUMAN [view interactions] Low throughput no yes
CEBPE_HUMAN [view interactions] Low throughput no no
PGH2_HUMAN [view interactions] Low throughput no no
MLF1_HUMAN [view entry] [view interactions] Low throughput yes yes
RBX1_HUMAN [view entry] [view interactions] Low throughput yes no
ELOB_HUMAN [view interactions] Low throughput no no
ELOC_HUMAN [view interactions] Low throughput no no
IKKA_HUMAN [view interactions] Low throughput no yes
IKBA_HUMAN [view interactions] Low throughput no yes
PHIP_HUMAN [view interactions] High throughput no yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
SOCS2_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
REQU_HUMAN [view interactions] High throughput no yes
RECQ4_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
AMRA1_HUMAN [view interactions] High throughput no yes
TCTP_HUMAN [view entry] [view interactions] High throughput yes yes
APEX1_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
MAFB_HUMAN [view interactions] High throughput no yes
CIC_HUMAN [view interactions] High throughput no yes
M3K7_HUMAN [view interactions] High throughput no yes
INSI1_HUMAN [view interactions] High throughput no no
INSI2_HUMAN [view interactions] High throughput no yes
TULP3_HUMAN [view interactions] High throughput no yes
UFL1_HUMAN [view interactions] High throughput no yes
ANR39_HUMAN [view interactions] High throughput no no
DENR_HUMAN [view interactions] High throughput no yes
SYT2_HUMAN [view entry] [view interactions] High throughput yes no
NHRF2_HUMAN [view entry] [view interactions] High throughput yes no
HS12A_HUMAN [view entry] [view interactions] High throughput yes yes
POTEF_HUMAN [view interactions] High throughput no no
BICD2_HUMAN [view interactions] High throughput no yes
ASB6_HUMAN [view interactions] High throughput no yes
DCAF6_HUMAN [view interactions] High throughput no no
KLDC3_HUMAN [view interactions] High throughput no yes
KLHL8_HUMAN [view interactions] High throughput no no
CYTSA_HUMAN [view interactions] High throughput no yes
AP5S1_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
PRAME_HUMAN [view interactions] High throughput no no
FBX32_HUMAN [view interactions] High throughput no no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
FBXW7_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
E41L1_HUMAN [view entry] [view interactions] High throughput yes yes
NC2B_HUMAN [view interactions] High throughput no yes
PB1_HUMAN [view interactions] High throughput no yes
PSD11_HUMAN [view entry] [view interactions] High throughput yes yes
SF3A3_HUMAN [view interactions] High throughput no yes
SMCA5_HUMAN [view interactions] High throughput no yes
ATPA_HUMAN [view interactions] High throughput no yes
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
BABA1_HUMAN [view interactions] High throughput no yes
DC1I2_HUMAN [view entry] [view interactions] High throughput yes yes
E41L2_HUMAN [view entry] [view interactions] High throughput yes yes
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
MYH9_HUMAN [view entry] [view interactions] High throughput yes no
PLCG1_HUMAN [view entry] [view interactions] High throughput yes yes
PSMD7_HUMAN [view interactions] High throughput no yes
TMOD1_HUMAN [view entry] [view interactions] High throughput yes yes
EWS_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
ARAF_HUMAN [view interactions] High throughput no yes
STK11_HUMAN [view interactions] High throughput no yes
CUL1_HUMAN [view interactions] High throughput no yes
DTL_HUMAN [view interactions] High throughput no no
LLR1_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
DDB2_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
LCA5_HUMAN [view interactions] High throughput no no
APBB3_HUMAN [view interactions] High throughput no no
KLH10_HUMAN [view interactions] High throughput no no
FBXL5_HUMAN [view interactions] High throughput no yes
FXL14_HUMAN [view interactions] High throughput no yes
FBX7_HUMAN [view interactions] High throughput no yes
FEM1B_HUMAN [view interactions] High throughput no yes
BTBD1_HUMAN [view interactions] High throughput no yes
BTBD2_HUMAN [view interactions] High throughput no no
APBP2_HUMAN [view interactions] High throughput no yes
DCAF4_HUMAN [view interactions] High throughput no yes
DCA11_HUMAN [view interactions] High throughput no yes
HBB_HUMAN [view interactions] High throughput no no
LRRK2_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
SOX2_HUMAN [view interactions] High throughput no yes
SPN90_HUMAN [view entry] [view interactions] High throughput yes no
FBX6_HUMAN [view interactions] High throughput no yes
IRF2_HUMAN [view interactions] High throughput no yes
TN13B_HUMAN [view interactions] High throughput no no
WRP73_HUMAN [view interactions] High throughput no no
HLAB_HUMAN [view interactions] High throughput no yes
PAHX_HUMAN [view interactions] High throughput no yes
SNW1_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
CSN3_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA7_HUMAN [view interactions] High throughput no yes
ARF4_HUMAN [view entry] [view interactions] High throughput yes no
PXL2B_HUMAN [view interactions] High throughput no yes
NJMU_HUMAN [view interactions] High throughput no yes
SOSB2_HUMAN [view interactions] High throughput no no
FRS3_HUMAN [view interactions] High throughput no no
A2MG_HUMAN [view interactions] High throughput no yes
ACY2_HUMAN [view interactions] High throughput no no
DOPO_HUMAN [view interactions] High throughput no no
TOR1A_HUMAN [view interactions] High throughput no yes
GARS_HUMAN [view interactions] High throughput no yes
GLE1_HUMAN [view interactions] High throughput no yes
GRN_HUMAN [view interactions] High throughput no no
HEXB_HUMAN [view interactions] High throughput no no
HXD10_HUMAN [view interactions] High throughput no no
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
MECP2_HUMAN [view interactions] High throughput no yes
NDUV2_HUMAN [view entry] [view interactions] High throughput yes yes
MERL_HUMAN [view interactions] High throughput no yes
NOS3_HUMAN [view interactions] High throughput no no
PEX1_HUMAN [view interactions] High throughput no no
PERI_HUMAN [view entry] [view interactions] High throughput yes no
SYUB_HUMAN [view interactions] High throughput no yes
TTHY_HUMAN [view interactions] High throughput no no
UCHL1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
SYYC_HUMAN [view interactions] High throughput no yes
TCPE_HUMAN [view entry] [view interactions] High throughput yes yes
ATX10_HUMAN [view entry] [view interactions] High throughput yes yes
RNF11_HUMAN [view interactions] High throughput no yes
PEX26_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
ABRX2_HUMAN [view interactions] High throughput no yes
DCNL1_HUMAN [view interactions] High throughput no yes
CUL5_HUMAN [view entry] [view interactions] High throughput yes yes
KLH13_HUMAN [view interactions] High throughput no no
TIFAB_HUMAN [view interactions] High throughput no no
CRBN_HUMAN [view interactions] High throughput no yes
CENPJ_HUMAN [view interactions] High throughput no no
RON_HUMAN [view interactions] High throughput no yes
MCPH1_HUMAN [view interactions] High throughput no yes
FAD1_HUMAN [view interactions] High throughput no yes
K2C80_HUMAN [view interactions] High throughput no no
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
DDA1_HUMAN [view interactions] High throughput no yes
ERCC8_HUMAN [view interactions] High throughput no no
DCAF1_HUMAN [view interactions] High throughput no yes
LRC14_HUMAN [view interactions] High throughput no no
COP1_HUMAN [view interactions] High throughput no no
SKP1_HUMAN [view interactions] High throughput no yes
FBX17_HUMAN [view interactions] High throughput no no
KLH42_HUMAN [view interactions] High throughput no yes
KLH18_HUMAN [view interactions] High throughput no yes
TOIP2_HUMAN [view interactions] High throughput no no
DCAF8_HUMAN [view interactions] High throughput no yes
ERCC6_HUMAN [view interactions] High throughput no no
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
FBXW4_HUMAN [view interactions] High throughput no no
EED_HUMAN [view interactions] High throughput no yes
KLH15_HUMAN [view interactions] High throughput no yes
SRP14_HUMAN [view interactions] High throughput no no
UNK_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
IBTK_HUMAN [view interactions] High throughput no yes
CAF1A_HUMAN [view interactions] High throughput no yes
WDTC1_HUMAN [view interactions] High throughput no yes
DC4L2_HUMAN [view interactions] High throughput no no
RBBP5_HUMAN [view interactions] Computational no yes
COMD3_HUMAN [view interactions] Computational no yes
TYY1_HUMAN [view interactions] Computational no yes
MCRS1_HUMAN [view interactions] Computational no yes
ACL6A_HUMAN [view interactions] Computational no yes
COMDA_HUMAN [view interactions] Computational no yes
COMD7_HUMAN [view interactions] Computational no no
DCNL4_HUMAN [view interactions] Computational no yes
IN80E_HUMAN [view interactions] Computational no yes
RBBP7_HUMAN [view interactions] Computational no yes
IN80D_HUMAN [view interactions] Computational no yes
PSMD6_HUMAN [view interactions] Computational no yes
DCAF5_HUMAN [view interactions] Computational no yes
DCNL2_HUMAN [view interactions] Computational no yes
DCA17_HUMAN [view interactions] Computational no no
COMD4_HUMAN [view interactions] Computational no no
NT5M_HUMAN [view interactions] Computational no yes
TFPT_HUMAN [view interactions] Computational no yes
COMD6_HUMAN [view interactions] Computational no no
CCD22_HUMAN [view entry] [view interactions] Computational yes no
COMD9_HUMAN [view interactions] Computational no yes
DCNL5_HUMAN [view interactions] Computational no yes
DCA16_HUMAN [view interactions] Computational no no
PRS7_HUMAN [view interactions] Computational no yes
TESP1_HUMAN [view interactions] Computational no yes
COMD8_HUMAN [view interactions] Computational no yes
ARP8_HUMAN [view interactions] Computational no no
RUVB1_HUMAN [view interactions] Computational no yes
NFRKB_HUMAN [view interactions] Computational no yes
DCAF7_HUMAN [view interactions] Computational no yes
COMD1_HUMAN [view interactions] Computational no yes
ARP5_HUMAN [view interactions] Computational no yes
COMD2_HUMAN [view interactions] Computational no yes
IN80B_HUMAN [view interactions] Computational no no
WDR5_HUMAN [view interactions] Computational no no
DCA10_HUMAN [view interactions] Computational no no
COMD5_HUMAN [view interactions] Computational no no