AMPD2_HUMAN
Evidence for PS localization
Functions
AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 620 | Arg | His | Pontocerebellarhypoplasia9(PCH9) | - |
| 739 | Asp | Tyr | Pontocerebellarhypoplasia9(PCH9) | - |
| 724 | Glu | Asp | Pontocerebellarhypoplasia9(PCH9) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AMPD2_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 25.8065 | 4 | yes |
| GO:0046872 | metal ion binding | 25.8065 | 5 | yes |
| GO:0003723 | RNA binding | 25.8065 | 4 | no |
| GO:0000166 | nucleotide binding | 22.5806 | 4 | no |
| GO:0017076 | purine nucleotide binding | 22.5806 | 5 | no |
| GO:0043168 | anion binding | 22.5806 | 4 | no |
| GO:0003876 | AMP deaminase activity | 6.4516 | 6 | yes |
| GO:0016814 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines | 6.4516 | 4 | yes |
| GO:0019239 | deaminase activity | 6.4516 | 4 | yes |
| GO:0047623 | adenosine-phosphate deaminase activity | 6.4516 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AMPD2_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 67.7419 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 61.2903 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 61.2903 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 61.2903 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 48.3871 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 48.3871 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 48.3871 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 45.1613 | 4 | no |
| GO:0008104 | protein localization | 45.1613 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 45.1613 | 5 | no |
| GO:0010646 | regulation of cell communication | 41.9355 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 41.9355 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 41.9355 | 5 | no |
| GO:0009966 | regulation of signal transduction | 38.7097 | 4 | no |
| GO:0010468 | regulation of gene expression | 38.7097 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 38.7097 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 38.7097 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 38.7097 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 35.4839 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 32.2581 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 32.2581 | 7 | no |
| GO:0009890 | negative regulation of biosynthetic process | 32.2581 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 32.2581 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 32.2581 | 6 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 32.2581 | 6 | no |
| GO:0031399 | regulation of protein modification process | 32.2581 | 6 | no |
| GO:0051049 | regulation of transport | 29.0323 | 4 | no |
| GO:0006996 | organelle organization | 29.0323 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 29.0323 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 29.0323 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 29.0323 | 6 | no |
| GO:0023057 | negative regulation of signaling | 29.0323 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 29.0323 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 29.0323 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 29.0323 | 6 | no |
| GO:0071702 | organic substance transport | 29.0323 | 4 | no |
| GO:0060341 | regulation of cellular localization | 29.0323 | 4 | no |
| GO:0022607 | cellular component assembly | 25.8065 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.8065 | 4 | no |
| GO:0045892 | negative regulation of DNA-templated transcription | 25.8065 | 8 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 25.8065 | 5 | no |
| GO:0051253 | negative regulation of RNA metabolic process | 25.8065 | 6 | no |
| GO:1902679 | negative regulation of RNA biosynthetic process | 25.8065 | 7 | no |
| GO:0042981 | regulation of apoptotic process | 25.8065 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 25.8065 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.8065 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 25.8065 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 22.5806 | 5 | no |
| GO:0006605 | protein targeting | 22.5806 | 4 | no |
| GO:0036211 | protein modification process | 22.5806 | 4 | no |
| GO:0043412 | macromolecule modification | 22.5806 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 22.5806 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 22.5806 | 5 | no |
| GO:0006886 | intracellular protein transport | 22.5806 | 4 | no |
| GO:0015031 | protein transport | 22.5806 | 4 | no |
| GO:0032880 | regulation of protein localization | 22.5806 | 5 | no |
| GO:0009057 | macromolecule catabolic process | 22.5806 | 4 | no |
| GO:0033365 | protein localization to organelle | 22.5806 | 5 | no |
| GO:0009259 | ribonucleotide metabolic process | 16.1290 | 5 | yes |
| GO:0019693 | ribose phosphate metabolic process | 16.1290 | 4 | yes |
| GO:0072521 | purine-containing compound metabolic process | 16.1290 | 4 | yes |
| GO:0006163 | purine nucleotide metabolic process | 16.1290 | 5 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 16.1290 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 16.1290 | 5 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 16.1290 | 6 | yes |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 12.9032 | 4 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 12.9032 | 4 | yes |
| GO:0009165 | nucleotide biosynthetic process | 9.6774 | 6 | yes |
| GO:0009260 | ribonucleotide biosynthetic process | 9.6774 | 6 | yes |
| GO:0046390 | ribose phosphate biosynthetic process | 9.6774 | 5 | yes |
| GO:0072522 | purine-containing compound biosynthetic process | 9.6774 | 5 | yes |
| GO:0090407 | organophosphate biosynthetic process | 9.6774 | 4 | yes |
| GO:1901137 | carbohydrate derivative biosynthetic process | 9.6774 | 4 | yes |
| GO:1901293 | nucleoside phosphate biosynthetic process | 9.6774 | 5 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 9.6774 | 4 | yes |
| GO:0006164 | purine nucleotide biosynthetic process | 9.6774 | 6 | yes |
| GO:0009152 | purine ribonucleotide biosynthetic process | 9.6774 | 7 | yes |
| GO:0009156 | ribonucleoside monophosphate biosynthetic process | 6.4516 | 7 | yes |
| GO:0009161 | ribonucleoside monophosphate metabolic process | 6.4516 | 6 | yes |
| GO:0009167 | purine ribonucleoside monophosphate metabolic process | 6.4516 | 7 | yes |
| GO:0009168 | purine ribonucleoside monophosphate biosynthetic process | 6.4516 | 8 | yes |
| GO:0009187 | cyclic nucleotide metabolic process | 6.4516 | 6 | yes |
| GO:0032261 | purine nucleotide salvage | 6.4516 | 5 | yes |
| GO:0032264 | IMP salvage | 6.4516 | 7 | yes |
| GO:0043101 | purine-containing compound salvage | 6.4516 | 4 | yes |
| GO:0043173 | nucleotide salvage | 6.4516 | 4 | yes |
| GO:0046033 | AMP metabolic process | 6.4516 | 7 | yes |
| GO:0046040 | IMP metabolic process | 6.4516 | 7 | yes |
| GO:0052652 | cyclic purine nucleotide metabolic process | 6.4516 | 6 | yes |
| GO:0106380 | purine ribonucleotide salvage | 6.4516 | 6 | yes |
| GO:0006188 | IMP biosynthetic process | 6.4516 | 8 | yes |
| GO:0009123 | nucleoside monophosphate metabolic process | 6.4516 | 5 | yes |
| GO:0009124 | nucleoside monophosphate biosynthetic process | 6.4516 | 6 | yes |
| GO:0009126 | purine nucleoside monophosphate metabolic process | 6.4516 | 6 | yes |
| GO:0009127 | purine nucleoside monophosphate biosynthetic process | 6.4516 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| HLAA_HUMAN | [view interactions] | Low throughput | no | no |
| B2MG_HUMAN | [view interactions] | Low throughput | no | yes |
| AMPD2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| PSMG2_HUMAN | [view interactions] | High throughput | no | yes |
| ARL6_HUMAN | [view interactions] | High throughput | no | yes |
| PHF8_HUMAN | [view interactions] | High throughput | no | yes |
| RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
| HIRP3_HUMAN | [view interactions] | High throughput | no | no |
| IDE_HUMAN | [view interactions] | High throughput | no | yes |
| ANGE2_HUMAN | [view interactions] | High throughput | no | yes |
| IL7RA_HUMAN | [view interactions] | High throughput | no | no |
| CRYAB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AMPD3_HUMAN | [view interactions] | High throughput | no | no |
| PREP_HUMAN | [view interactions] | High throughput | no | yes |
| KRA61_HUMAN | [view interactions] | High throughput | no | no |
| EIF1A_HUMAN | [view interactions] | High throughput | no | no |
| FACE1_HUMAN | [view interactions] | High throughput | no | yes |
| XIAP_HUMAN | [view interactions] | High throughput | no | yes |
| F136A_HUMAN | [view interactions] | High throughput | no | yes |
| HDGR2_HUMAN | [view interactions] | High throughput | no | yes |
| KR196_HUMAN | [view interactions] | High throughput | no | no |
| CD6_HUMAN | [view interactions] | High throughput | no | no |
| PAGE1_HUMAN | [view interactions] | High throughput | no | no |
| KR197_HUMAN | [view interactions] | High throughput | no | no |
| SDC4_HUMAN | [view interactions] | High throughput | no | yes |
| R3GEF_HUMAN | [view interactions] | High throughput | no | yes |
| GLYC_HUMAN | [view interactions] | High throughput | no | no |
| PRPS2_HUMAN | [view interactions] | High throughput | no | no |
| BRD2_HUMAN | [view interactions] | High throughput | no | yes |
| PSA5_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| P4R3A_HUMAN | [view interactions] | High throughput | no | yes |
| PP4R2_HUMAN | [view interactions] | High throughput | no | yes |
| TBC9B_HUMAN | [view interactions] | High throughput | no | yes |
| ACLY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNPO2_HUMAN | [view interactions] | High throughput | no | yes |
| SF3B1_HUMAN | [view interactions] | High throughput | no | yes |
| RO60_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DEK_HUMAN | [view interactions] | High throughput | no | yes |
| COPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLII_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SF3B2_HUMAN | [view interactions] | High throughput | no | yes |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF7_HUMAN | [view interactions] | High throughput | no | yes |
| P66A_HUMAN | [view interactions] | High throughput | no | yes |
| SMRC1_HUMAN | [view interactions] | High throughput | no | yes |
| TNPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARI3A_HUMAN | [view interactions] | High throughput | no | yes |
| CND3_HUMAN | [view interactions] | High throughput | no | yes |
| EMAL4_HUMAN | [view interactions] | High throughput | no | yes |
| RCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| CSN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL26L_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYOME_HUMAN | [view interactions] | High throughput | no | no |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCDB1_HUMAN | [view interactions] | High throughput | no | yes |
| NDK7_HUMAN | [view interactions] | High throughput | no | yes |
| POTE1_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| TBG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCHP_HUMAN | [view interactions] | High throughput | no | yes |
| GCP4_HUMAN | [view interactions] | High throughput | no | yes |
| AMPD1_HUMAN | [view interactions] | High throughput | no | yes |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| FAME_HUMAN | [view interactions] | High throughput | no | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| EPS8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD44_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPBL1_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF8_HUMAN | [view interactions] | High throughput | no | yes |
| SDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| GP156_HUMAN | [view interactions] | High throughput | no | no |
| SDC1_HUMAN | [view interactions] | High throughput | no | no |
| MLX_HUMAN | [view interactions] | High throughput | no | yes |
| DDX17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |