Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AMPD2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
674 Arg His Pontocerebellarhypoplasia9(PCH9) -
793 Asp Tyr Pontocerebellarhypoplasia9(PCH9) -
778 Glu Asp Pontocerebellarhypoplasia9(PCH9) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AMPD2_HUMAN
GO:0046872 metal ion binding 35.2941 4 yes
GO:0003876 AMP deaminase activity 11.7647 5 yes
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 11.7647 4 yes
GO:0047623 adenosine-phosphate deaminase activity 11.7647 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AMPD2_HUMAN
GO:0031323 regulation of cellular metabolic process 64.7059 4 no
GO:0048523 negative regulation of cellular process 64.7059 4 no
GO:0051171 regulation of nitrogen compound metabolic process 58.8235 4 no
GO:0060255 regulation of macromolecule metabolic process 58.8235 4 no
GO:0080090 regulation of primary metabolic process 58.8235 4 no
GO:0048522 positive regulation of cellular process 47.0588 4 no
GO:0009892 negative regulation of metabolic process 47.0588 4 no
GO:0051246 regulation of protein metabolic process 47.0588 5 no
GO:0031326 regulation of cellular biosynthetic process 41.1765 5 no
GO:0051128 regulation of cellular component organization 41.1765 4 no
GO:0010605 negative regulation of macromolecule metabolic process 41.1765 5 no
GO:0031324 negative regulation of cellular metabolic process 41.1765 5 no
GO:0009889 regulation of biosynthetic process 41.1765 4 no
GO:0009893 positive regulation of metabolic process 41.1765 4 no
GO:0010468 regulation of gene expression 41.1765 5 no
GO:0010556 regulation of macromolecule biosynthetic process 41.1765 5 no
GO:0010646 regulation of cell communication 41.1765 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 35.2941 5 no
GO:0051129 negative regulation of cellular component organization 35.2941 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 35.2941 5 no
GO:0051252 regulation of RNA metabolic process 35.2941 5 no
GO:0071702 organic substance transport 35.2941 4 no
GO:0071705 nitrogen compound transport 35.2941 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 35.2941 5 no
GO:0009966 regulation of signal transduction 35.2941 4 no
GO:0010604 positive regulation of macromolecule metabolic process 35.2941 5 no
GO:0015031 protein transport 29.4118 4 no
GO:0031325 positive regulation of cellular metabolic process 29.4118 5 no
GO:0031344 regulation of cell projection organization 29.4118 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 29.4118 6 no
GO:1903506 regulation of nucleic acid-templated transcription 29.4118 7 no
GO:2001141 regulation of RNA biosynthetic process 29.4118 6 no
GO:0031399 regulation of protein modification process 29.4118 6 no
GO:0051248 negative regulation of protein metabolic process 29.4118 6 no
GO:0006996 organelle organization 29.4118 4 no
GO:0006796 phosphate-containing compound metabolic process 29.4118 4 yes
GO:0006355 regulation of DNA-templated transcription 29.4118 6 no
GO:0006886 intracellular protein transport 29.4118 4 no
GO:0008104 protein localization 29.4118 4 no
GO:0010975 regulation of neuron projection development 23.5294 7 no
GO:0051049 regulation of transport 23.5294 4 no
GO:0009890 negative regulation of biosynthetic process 23.5294 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 23.5294 6 no
GO:0010629 negative regulation of gene expression 23.5294 6 no
GO:0031327 negative regulation of cellular biosynthetic process 23.5294 6 no
GO:0051247 positive regulation of protein metabolic process 23.5294 6 no
GO:0019220 regulation of phosphate metabolic process 23.5294 6 no
GO:0022607 cellular component assembly 23.5294 4 no
GO:0051174 regulation of phosphorus metabolic process 23.5294 5 no
GO:0007010 cytoskeleton organization 23.5294 5 no
GO:0009894 regulation of catabolic process 23.5294 4 no
GO:0031329 regulation of cellular catabolic process 23.5294 5 no
GO:0044087 regulation of cellular component biogenesis 23.5294 4 no
GO:0006605 protein targeting 23.5294 5 no
GO:0010941 regulation of cell death 23.5294 4 no
GO:0006163 purine nucleotide metabolic process 17.6471 5 yes
GO:0006164 purine nucleotide biosynthetic process 17.6471 6 yes
GO:0006753 nucleoside phosphate metabolic process 17.6471 4 yes
GO:0009117 nucleotide metabolic process 17.6471 5 yes
GO:0009150 purine ribonucleotide metabolic process 17.6471 6 yes
GO:0009152 purine ribonucleotide biosynthetic process 17.6471 7 yes
GO:0009165 nucleotide biosynthetic process 17.6471 6 yes
GO:0009259 ribonucleotide metabolic process 17.6471 5 yes
GO:0009260 ribonucleotide biosynthetic process 17.6471 6 yes
GO:0018130 heterocycle biosynthetic process 17.6471 4 yes
GO:0019438 aromatic compound biosynthetic process 17.6471 4 yes
GO:0019693 ribose phosphate metabolic process 17.6471 4 yes
GO:0034654 nucleobase-containing compound biosynthetic process 17.6471 4 yes
GO:0044271 cellular nitrogen compound biosynthetic process 17.6471 4 yes
GO:0046390 ribose phosphate biosynthetic process 17.6471 5 yes
GO:0072521 purine-containing compound metabolic process 17.6471 4 yes
GO:0072522 purine-containing compound biosynthetic process 17.6471 5 yes
GO:0090407 organophosphate biosynthetic process 17.6471 4 yes
GO:1901137 carbohydrate derivative biosynthetic process 17.6471 4 yes
GO:1901293 nucleoside phosphate biosynthetic process 17.6471 5 yes
GO:1901362 organic cyclic compound biosynthetic process 17.6471 4 yes
GO:1901566 organonitrogen compound biosynthetic process 17.6471 4 yes
GO:0006188 IMP biosynthetic process 11.7647 8 yes
GO:0009123 nucleoside monophosphate metabolic process 11.7647 5 yes
GO:0009124 nucleoside monophosphate biosynthetic process 11.7647 6 yes
GO:0009126 purine nucleoside monophosphate metabolic process 11.7647 6 yes
GO:0009127 purine nucleoside monophosphate biosynthetic process 11.7647 7 yes
GO:0009156 ribonucleoside monophosphate biosynthetic process 11.7647 7 yes
GO:0009161 ribonucleoside monophosphate metabolic process 11.7647 6 yes
GO:0009167 purine ribonucleoside monophosphate metabolic process 11.7647 7 yes
GO:0009168 purine ribonucleoside monophosphate biosynthetic process 11.7647 8 yes
GO:0009187 cyclic nucleotide metabolic process 11.7647 6 yes
GO:0009190 cyclic nucleotide biosynthetic process 11.7647 7 yes
GO:0032261 purine nucleotide salvage 11.7647 5 yes
GO:0032264 IMP salvage 11.7647 7 yes
GO:0043101 purine-containing compound salvage 11.7647 4 yes
GO:0043173 nucleotide salvage 11.7647 4 yes
GO:0046033 AMP metabolic process 11.7647 7 yes
GO:0046040 IMP metabolic process 11.7647 7 yes
GO:0052652 cyclic purine nucleotide metabolic process 11.7647 7 yes
GO:0106380 purine ribonucleotide salvage 11.7647 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in AMPD2_HUMAN
DOID:0060264 pontocerebellar hypoplasia 11.7647 5 yes
DOID:0060278 pontocerebellar hypoplasia type 9 11.7647 6 yes
DOID:1289 neurodegenerative disease 11.7647 4 yes
DOID:331 central nervous system disease 11.7647 3 yes

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
HLAA_HUMAN [view interactions] Low throughput no no
B2MG_HUMAN [view interactions] Low throughput no yes
MLX_HUMAN [view interactions] High throughput no yes
DDX17_HUMAN [view entry] [view interactions] High throughput yes yes
PIHD1_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
LMBRL_HUMAN [view interactions] High throughput no no
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
PRC1_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
DDX58_HUMAN [view interactions] High throughput no yes
TULP3_HUMAN [view interactions] High throughput no yes
PSMG2_HUMAN [view interactions] High throughput no yes
ARL6_HUMAN [view interactions] High throughput no yes
PHF8_HUMAN [view interactions] High throughput no yes
RNPS1_HUMAN [view interactions] High throughput no yes
HIRP3_HUMAN [view interactions] High throughput no no
IDE_HUMAN [view interactions] High throughput no yes
ANGE2_HUMAN [view interactions] High throughput no yes
IL7RA_HUMAN [view interactions] High throughput no no
CRYAB_HUMAN [view entry] [view interactions] High throughput yes no
AMPD3_HUMAN [view interactions] High throughput no no
PREP_HUMAN [view interactions] High throughput no yes
KRA61_HUMAN [view interactions] High throughput no no
EIF1A_HUMAN [view interactions] High throughput no no
FACE1_HUMAN [view interactions] High throughput no yes
XIAP_HUMAN [view interactions] High throughput no yes
F136A_HUMAN [view interactions] High throughput no yes
HDGR2_HUMAN [view interactions] High throughput no yes
KR196_HUMAN [view interactions] High throughput no no
CD6_HUMAN [view interactions] High throughput no no
PAGE1_HUMAN [view interactions] High throughput no no
KR197_HUMAN [view interactions] High throughput no no
SDC4_HUMAN [view interactions] High throughput no yes
R3GEF_HUMAN [view interactions] High throughput no yes
GLYC_HUMAN [view interactions] High throughput no no
PRPS2_HUMAN [view interactions] High throughput no no
BRD2_HUMAN [view interactions] High throughput no yes
PSA5_HUMAN [view interactions] High throughput no yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
CSK2B_HUMAN [view entry] [view interactions] High throughput yes yes
SHIP2_HUMAN [view interactions] High throughput no yes
P4R3A_HUMAN [view interactions] High throughput no yes
PP4R2_HUMAN [view interactions] High throughput no yes
TBC9B_HUMAN [view interactions] High throughput no yes
ACLY_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
TERF1_HUMAN [view interactions] High throughput no no
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
MYOME_HUMAN [view interactions] High throughput no no
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
CCDB1_HUMAN [view interactions] High throughput no yes
AMPD2_HUMAN [view entry] [view interactions] High throughput yes yes
NDK7_HUMAN [view interactions] High throughput no yes
POTE1_HUMAN [view interactions] High throughput no no
TBG1_HUMAN [view entry] [view interactions] High throughput yes yes
TCHP_HUMAN [view interactions] High throughput no yes
GCP4_HUMAN [view interactions] High throughput no yes
AMPD1_HUMAN [view interactions] High throughput no yes
NTAQ1_HUMAN [view interactions] High throughput no yes
CC198_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
EPS8_HUMAN [view entry] [view interactions] High throughput yes yes
CD44_HUMAN [view interactions] High throughput no yes
GPBL1_HUMAN [view interactions] High throughput no yes
DCAF8_HUMAN [view interactions] High throughput no yes
SDC2_HUMAN [view interactions] High throughput no yes
LZTS2_HUMAN [view interactions] High throughput no no
GP156_HUMAN [view interactions] High throughput no no
SDC1_HUMAN [view interactions] High throughput no no