Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TSC1_HUMAN

In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed, PubMed). Seems not to be required for TSC2 GAP activity towards RHEB (PubMed). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling . Acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed, PubMed). [View more on UniProt]

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Position Amino acid Mutation Disease Overlap with binding region
191 Leu His Tuberoussclerosis1(TSC1) -
224 Met Arg Tuberoussclerosis1(TSC1) -
654 Gln Glu Tuberoussclerosis1(TSC1) -
726 Ala Glu Tuberoussclerosis1(TSC1) -
899 Thr Ser Tuberoussclerosis1(TSC1) -
72 Leu Pro Tuberoussclerosis1(TSC1) -
500 Arg Gln Tuberoussclerosis1(TSC1) -
117 Leu Pro Tuberoussclerosis1(TSC1) -
180 Leu Pro Tuberoussclerosis1(TSC1) -
22 Arg Trp Focalcorticaldysplasia2(FCORD2) -
204 Arg Cys Focalcorticaldysplasia2(FCORD2) -

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in TSC1_HUMAN
GO:0017076 purine nucleotide binding 37.0370 4 no
GO:0032555 purine ribonucleotide binding 35.8025 4 no
GO:0035639 purine ribonucleoside triphosphate binding 35.8025 4 no
GO:0030554 adenyl nucleotide binding 26.5432 5 no
GO:0005524 ATP binding 25.3086 5 no
GO:0032559 adenyl ribonucleotide binding 25.3086 5 no
GO:0019900 kinase binding 21.6049 4 no
GO:0046872 metal ion binding 20.9877 4 no
GO:0019901 protein kinase binding 20.9877 5 no
GO:0051879 Hsp90 protein binding 3.7037 4 yes
GO:0030544 Hsp70 protein binding 2.4691 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TSC1_HUMAN
GO:0048522 positive regulation of cellular process 68.5185 4 yes
GO:0060255 regulation of macromolecule metabolic process 59.8765 4 yes
GO:0080090 regulation of primary metabolic process 57.4074 4 yes
GO:0051128 regulation of cellular component organization 56.1728 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 56.1728 4 yes
GO:0031323 regulation of cellular metabolic process 55.5556 4 yes
GO:0048523 negative regulation of cellular process 54.9383 4 yes
GO:0010646 regulation of cell communication 48.7654 4 yes
GO:0009893 positive regulation of metabolic process 46.9136 4 yes
GO:0008104 protein localization 43.2099 4 no
GO:0010604 positive regulation of macromolecule metabolic process 43.2099 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 41.3580 5 no
GO:0051049 regulation of transport 40.7407 4 no
GO:0031325 positive regulation of cellular metabolic process 40.1235 5 yes
GO:0009966 regulation of signal transduction 39.5062 4 yes
GO:0010468 regulation of gene expression 38.8889 5 yes
GO:0051246 regulation of protein metabolic process 38.8889 5 yes
GO:0009889 regulation of biosynthetic process 37.6543 4 yes
GO:0031326 regulation of cellular biosynthetic process 37.6543 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 35.8025 5 yes
GO:0071702 organic substance transport 34.5679 4 yes
GO:0006996 organelle organization 34.5679 4 no
GO:0071705 nitrogen compound transport 33.3333 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 32.7160 5 no
GO:0009892 negative regulation of metabolic process 32.0988 4 yes
GO:0015031 protein transport 30.8642 4 no
GO:0033043 regulation of organelle organization 30.2469 5 yes
GO:0051130 positive regulation of cellular component organization 30.2469 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 29.6296 5 yes
GO:0036211 protein modification process 27.7778 4 no
GO:0043412 macromolecule modification 27.7778 4 no
GO:0051247 positive regulation of protein metabolic process 27.7778 6 no
GO:0022607 cellular component assembly 27.1605 4 no
GO:0030030 cell projection organization 27.1605 4 yes
GO:0031344 regulation of cell projection organization 27.1605 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 26.5432 6 yes
GO:1902531 regulation of intracellular signal transduction 26.5432 5 yes
GO:0060341 regulation of cellular localization 26.5432 4 no
GO:0048584 positive regulation of response to stimulus 25.9259 4 no
GO:0031399 regulation of protein modification process 25.9259 6 yes
GO:0051172 negative regulation of nitrogen compound metabolic process 25.3086 5 yes
GO:0045595 regulation of cell differentiation 24.6914 4 no
GO:0010941 regulation of cell death 24.6914 4 yes
GO:0031324 negative regulation of cellular metabolic process 24.6914 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 24.0741 4 no
GO:0032880 regulation of protein localization 24.0741 5 no
GO:0006886 intracellular protein transport 23.4568 4 no
GO:0051252 regulation of RNA metabolic process 23.4568 5 no
GO:0042981 regulation of apoptotic process 23.4568 6 no
GO:0043067 regulation of programmed cell death 23.4568 5 no
GO:0009891 positive regulation of biosynthetic process 22.8395 5 no
GO:0031328 positive regulation of cellular biosynthetic process 22.8395 6 no
GO:0023056 positive regulation of signaling 22.8395 4 no
GO:0051094 positive regulation of developmental process 22.8395 4 no
GO:0010648 negative regulation of cell communication 22.8395 5 yes
GO:0019220 regulation of phosphate metabolic process 22.8395 6 yes
GO:0023057 negative regulation of signaling 22.8395 4 yes
GO:0051174 regulation of phosphorus metabolic process 22.8395 5 yes
GO:0071310 cellular response to organic substance 22.2222 4 no
GO:0010647 positive regulation of cell communication 22.2222 5 no
GO:0080134 regulation of response to stress 21.6049 4 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 21.6049 6 no
GO:0120036 plasma membrane bounded cell projection organization 21.6049 5 no
GO:0009894 regulation of catabolic process 21.6049 4 yes
GO:0044087 regulation of cellular component biogenesis 21.6049 4 yes
GO:0006796 phosphate-containing compound metabolic process 20.9877 4 no
GO:0042325 regulation of phosphorylation 20.9877 7 yes
GO:0048585 negative regulation of response to stimulus 20.9877 4 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 20.3704 6 no
GO:0051050 positive regulation of transport 20.3704 4 no
GO:1903506 regulation of nucleic acid-templated transcription 20.3704 7 no
GO:2001141 regulation of RNA biosynthetic process 20.3704 6 no
GO:0016192 vesicle-mediated transport 20.3704 4 no
GO:0001932 regulation of protein phosphorylation 20.3704 7 yes
GO:0043085 positive regulation of catalytic activity 20.3704 4 yes
GO:0042127 regulation of cell population proliferation 19.7531 4 yes
GO:0010243 response to organonitrogen compound 19.1358 4 yes
GO:0051129 negative regulation of cellular component organization 19.1358 5 yes
GO:0009968 negative regulation of signal transduction 18.5185 5 yes
GO:0010638 positive regulation of organelle organization 18.5185 6 yes
GO:0051338 regulation of transferase activity 18.5185 4 yes
GO:0010975 regulation of neuron projection development 17.9012 7 yes
GO:0051336 regulation of hydrolase activity 17.9012 4 yes
GO:0051726 regulation of cell cycle 17.9012 4 yes
GO:0060548 negative regulation of cell death 16.6667 5 yes
GO:0080135 regulation of cellular response to stress 16.6667 4 yes
GO:0031329 regulation of cellular catabolic process 16.6667 5 yes
GO:0051493 regulation of cytoskeleton organization 16.0494 6 yes
GO:0051248 negative regulation of protein metabolic process 15.4321 6 yes
GO:0009890 negative regulation of biosynthetic process 14.1975 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 14.1975 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 14.1975 6 yes
GO:0009896 positive regulation of catabolic process 13.5802 5 yes
GO:0043549 regulation of kinase activity 13.5802 5 yes
GO:0032535 regulation of cellular component size 12.9630 4 yes
GO:0045859 regulation of protein kinase activity 12.9630 6 yes
GO:0010629 negative regulation of gene expression 12.3457 6 yes
GO:0032956 regulation of actin cytoskeleton organization 12.3457 5 yes
GO:0032970 regulation of actin filament-based process 12.3457 4 yes
GO:0034330 cell junction organization 12.3457 4 yes
GO:0051345 positive regulation of hydrolase activity 12.3457 5 yes
GO:1902903 regulation of supramolecular fiber organization 11.7284 5 yes
GO:2000112 regulation of cellular macromolecule biosynthetic process 11.7284 6 yes
GO:0044089 positive regulation of cellular component biogenesis 11.7284 5 yes
GO:0050821 protein stabilization 11.1111 4 yes
GO:0110053 regulation of actin filament organization 10.4938 6 yes
GO:1902532 negative regulation of intracellular signal transduction 10.4938 6 yes
GO:0010608 post-transcriptional regulation of gene expression 10.4938 6 yes
GO:0030155 regulation of cell adhesion 10.4938 4 yes
GO:0034248 regulation of cellular amide metabolic process 10.4938 5 yes
GO:0050808 synapse organization 10.4938 5 yes
GO:1901652 response to peptide 9.8765 4 yes
GO:0006417 regulation of translation 9.8765 6 yes
GO:0010506 regulation of autophagy 9.2593 6 yes
GO:0031345 negative regulation of cell projection organization 9.2593 6 yes
GO:0043086 negative regulation of catalytic activity 9.2593 4 yes
GO:0043087 regulation of GTPase activity 9.2593 5 yes
GO:0050890 cognition 9.2593 4 yes
GO:0008285 negative regulation of cell population proliferation 8.6420 5 yes
GO:0031331 positive regulation of cellular catabolic process 8.6420 6 yes
GO:1901214 regulation of neuron death 7.4074 5 yes
GO:1901215 negative regulation of neuron death 7.4074 6 yes
GO:0010977 negative regulation of neuron projection development 7.4074 7 yes
GO:0051495 positive regulation of cytoskeleton organization 7.4074 7 yes
GO:0006811 ion transport 6.7901 4 yes
GO:0016241 regulation of macroautophagy 6.7901 7 yes
GO:0031667 response to nutrient levels 6.7901 4 yes
GO:1902905 positive regulation of supramolecular fiber organization 6.1728 6 yes
GO:0006812 cation transport 6.1728 5 yes
GO:0007612 learning 6.1728 4 yes
GO:0008361 regulation of cell size 6.1728 5 yes
GO:0010810 regulation of cell-substrate adhesion 6.1728 5 yes
GO:0030001 metal ion transport 6.1728 6 yes
GO:0035303 regulation of dephosphorylation 6.1728 7 yes
GO:0035304 regulation of protein dephosphorylation 6.1728 7 yes
GO:0043434 response to peptide hormone 6.1728 4 yes
GO:0051346 negative regulation of hydrolase activity 6.1728 5 yes
GO:0001952 regulation of cell-matrix adhesion 5.5556 6 yes
GO:0006913 nucleocytoplasmic transport 5.5556 5 yes
GO:0009895 negative regulation of catabolic process 5.5556 5 yes
GO:0032231 regulation of actin filament bundle assembly 5.5556 5 yes
GO:0043547 positive regulation of GTPase activity 5.5556 6 yes
GO:0045785 positive regulation of cell adhesion 5.5556 5 yes
GO:0051169 nuclear transport 5.5556 4 yes
GO:0008306 associative learning 4.9383 5 yes
GO:0010508 positive regulation of autophagy 4.9383 7 yes
GO:0010921 regulation of phosphatase activity 4.9383 5 yes
GO:0031330 negative regulation of cellular catabolic process 4.9383 6 yes
GO:0031669 cellular response to nutrient levels 4.9383 4 yes
GO:0032868 response to insulin 4.9383 5 yes
GO:0043666 regulation of phosphoprotein phosphatase activity 4.9383 6 yes
GO:0071453 cellular response to oxygen levels 4.3210 4 yes
GO:2000113 negative regulation of cellular macromolecule biosynthetic process 4.3210 7 yes
GO:0036293 response to decreased oxygen levels 4.3210 4 yes
GO:0036294 cellular response to decreased oxygen levels 4.3210 5 yes
GO:0090109 regulation of cell-substrate junction assembly 3.7037 6 yes
GO:0090630 activation of GTPase activity 3.7037 7 yes
GO:0110020 regulation of actomyosin structure organization 3.7037 6 yes
GO:0150116 regulation of cell-substrate junction organization 3.7037 5 yes
GO:1901888 regulation of cell junction assembly 3.7037 5 yes
GO:0007160 cell-matrix adhesion 3.7037 4 yes
GO:0008643 carbohydrate transport 3.7037 5 yes
GO:0010507 negative regulation of autophagy 3.7037 7 yes
GO:0010811 positive regulation of cell-substrate adhesion 3.7037 6 yes
GO:0016239 positive regulation of macroautophagy 3.7037 8 yes
GO:0017148 negative regulation of translation 3.7037 7 yes
GO:0034249 negative regulation of cellular amide metabolic process 3.7037 6 yes
GO:0051492 regulation of stress fiber assembly 3.7037 6 yes
GO:0051893 regulation of focal adhesion assembly 3.7037 7 yes
GO:0060606 tube closure 3.0864 4 yes
GO:1900407 regulation of cellular response to oxidative stress 3.0864 5 yes
GO:1902882 regulation of response to oxidative stress 3.0864 5 yes
GO:1903201 regulation of oxidative stress-induced cell death 3.0864 5 yes
GO:0001843 neural tube closure 3.0864 5 yes
GO:0001954 positive regulation of cell-matrix adhesion 3.0864 7 yes
GO:0015931 nucleobase-containing compound transport 3.0864 5 yes
GO:0016242 negative regulation of macroautophagy 3.0864 8 yes
GO:0032006 regulation of TOR signaling 3.0864 6 yes
GO:0032233 positive regulation of actin filament bundle assembly 3.0864 6 yes
GO:0042110 T cell activation 3.0864 4 yes
GO:0042692 muscle cell differentiation 3.0864 4 yes
GO:0045792 negative regulation of cell size 3.0864 6 yes
GO:0050657 nucleic acid transport 3.0864 6 yes
GO:0050658 RNA transport 3.0864 4 yes
GO:1903131 mononuclear cell differentiation 2.4691 5 yes
GO:1903202 negative regulation of oxidative stress-induced cell death 2.4691 6 yes
GO:0002521 leukocyte differentiation 2.4691 4 yes
GO:0006813 potassium ion transport 2.4691 7 yes
GO:0008344 adult locomotory behavior 2.4691 4 yes
GO:0034260 negative regulation of GTPase activity 2.4691 4 yes
GO:0051146 striated muscle cell differentiation 2.4691 5 yes
GO:0051496 positive regulation of stress fiber assembly 2.4691 7 yes
GO:0051894 positive regulation of focal adhesion assembly 1.8519 7 yes
GO:0150117 positive regulation of cell-substrate junction organization 1.8519 6 yes
GO:1901890 positive regulation of cell junction assembly 1.8519 6 yes
GO:1903203 regulation of oxidative stress-induced neuron death 1.8519 6 yes
GO:1903204 negative regulation of oxidative stress-induced neuron death 1.8519 7 yes
GO:0006405 RNA export from nucleus 1.8519 5 yes
GO:0030098 lymphocyte differentiation 1.8519 4 yes
GO:0030217 T cell differentiation 1.8519 5 yes
GO:0032007 negative regulation of TOR signaling 1.8519 7 yes
GO:0042552 myelination 1.8519 4 yes
GO:0051168 nuclear export 1.8519 6 yes
GO:0055007 cardiac muscle cell differentiation 1.2346 5 yes
GO:0090649 response to oxygen-glucose deprivation 1.2346 5 yes
GO:0090650 cellular response to oxygen-glucose deprivation 1.2346 5 yes
GO:0097064 ncRNA export from nucleus 1.2346 6 yes
GO:1904659 glucose transmembrane transport 1.2346 6 yes
GO:0001822 kidney development 1.2346 4 yes
GO:0002285 lymphocyte activation involved in immune response 1.2346 4 yes
GO:0002286 T cell activation involved in immune response 1.2346 5 yes
GO:0002292 T cell differentiation involved in immune response 1.2346 6 yes
GO:0006407 rRNA export from nucleus 1.2346 6 yes
GO:0008645 hexose transmembrane transport 1.2346 5 yes
GO:0015749 monosaccharide transmembrane transport 1.2346 4 yes
GO:0032780 negative regulation of ATP-dependent activity 1.2346 4 yes
GO:0035051 cardiocyte differentiation 1.2346 4 yes
GO:0043379 memory T cell differentiation 1.2346 4 yes
GO:0046323 glucose import 1.2346 7 yes
GO:0051029 rRNA transport 1.2346 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in TSC1_HUMAN
DOID:331 central nervous system disease 3.7037 3 no
DOID:0050700 cardiomyopathy 2.4691 4 no
DOID:0060036 intrinsic cardiomyopathy 2.4691 5 no
DOID:114 heart disease 2.4691 3 no
DOID:0050686 organ system cancer 1.8519 3 no
DOID:0060038 specific developmental disorder 1.8519 3 no
DOID:1059 intellectual disability 1.8519 4 no
DOID:936 brain disease 1.8519 4 no
DOID:0080324 tuberous sclerosis 1 1.2346 3 yes
DOID:2843 long QT syndrome 1.2346 6 no
DOID:0060307 autosomal dominant intellectual developmental disorder 1.2346 5 no
DOID:12930 dilated cardiomyopathy 1.2346 6 no
DOID:0060264 pontocerebellar hypoplasia 1.2346 5 no
DOID:1289 neurodegenerative disease 1.2346 4 no
DOID:6457 Cowden syndrome 1.2346 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SHAN1_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
AXIN1_HUMAN [view interactions] Low throughput no yes
KS6B1_HUMAN [view entry] [view interactions] Low throughput yes yes
RHEB_HUMAN [view entry] [view interactions] Low throughput yes yes
MOES_HUMAN [view entry] [view interactions] Low throughput yes no
NFL_HUMAN [view entry] [view interactions] Low throughput yes yes
RADI_HUMAN [view entry] [view interactions] Low throughput yes yes
EZRI_HUMAN [view entry] [view interactions] Low throughput yes no
BEX3_HUMAN [view interactions] Low throughput no yes
TSC1_HUMAN [view entry] [view interactions] Low throughput yes yes
TSC2_HUMAN [view entry] [view interactions] Low throughput yes yes
AKT1_HUMAN [view entry] [view interactions] Low throughput yes yes
KS6A1_HUMAN [view interactions] Low throughput no yes
GSK3B_HUMAN [view entry] [view interactions] Low throughput yes yes
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
FBXW5_HUMAN [view interactions] Low throughput no no
CDN1B_HUMAN [view interactions] Low throughput no yes
ESR1_HUMAN [view interactions] Low throughput no no
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
TBCD7_HUMAN [view interactions] Low throughput no no
1433B_HUMAN [view entry] [view interactions] Low throughput yes yes
MK14_HUMAN [view interactions] Low throughput no yes
TNR16_HUMAN [view entry] [view interactions] Low throughput yes no
IKKB_HUMAN [view interactions] Low throughput no yes
DAPK1_HUMAN [view entry] [view interactions] Low throughput yes yes
PLK2_HUMAN [view interactions] Low throughput no yes
PLK1_HUMAN [view interactions] Low throughput no yes
DOCK7_HUMAN [view entry] [view interactions] Low throughput yes no
CDK1_HUMAN [view interactions] Low throughput no no
1433Z_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTS_HUMAN [view interactions] Low throughput no no
AMD_HUMAN [view interactions] Low throughput no yes
RENI_HUMAN [view interactions] Low throughput no no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RACK1_HUMAN [view interactions] High throughput no yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
FBX41_HUMAN [view entry] [view interactions] High throughput yes no
RAB9A_HUMAN [view interactions] High throughput no yes
DNJA2_HUMAN [view entry] [view interactions] High throughput yes yes
STX6_HUMAN [view interactions] High throughput no yes
DNJA1_HUMAN [view entry] [view interactions] High throughput yes yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP2_HUMAN [view entry] [view interactions] High throughput yes yes
SYNE3_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
TMOD1_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
NAA40_HUMAN [view interactions] High throughput no no
CNRP1_HUMAN [view interactions] High throughput no no
CDK5_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
SH22A_HUMAN [view interactions] High throughput no no
HSH2D_HUMAN [view interactions] High throughput no no
TNS2_HUMAN [view interactions] High throughput no no
DP13B_HUMAN [view entry] [view interactions] High throughput yes yes
RIN3_HUMAN [view interactions] High throughput no yes
AKIB1_HUMAN [view interactions] High throughput no yes
ACTN2_HUMAN [view entry] [view interactions] High throughput yes yes
ATN1_HUMAN [view interactions] High throughput no yes
ANR24_HUMAN [view entry] [view interactions] High throughput yes no
ANR35_HUMAN [view interactions] High throughput no no
GEMI8_HUMAN [view interactions] High throughput no yes
GFAP_HUMAN [view entry] [view interactions] High throughput yes no
FBF1_HUMAN [view interactions] High throughput no no
EIF3A_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN2_HUMAN [view entry] [view interactions] High throughput yes yes
DACH2_HUMAN [view interactions] High throughput no yes
COG6_HUMAN [view interactions] High throughput no yes
CNTRB_HUMAN [view interactions] High throughput no yes
CNIH1_HUMAN [view interactions] High throughput no yes
CNTRL_HUMAN [view interactions] High throughput no yes
CDR2_HUMAN [view interactions] High throughput no yes
CC88B_HUMAN [view interactions] High throughput no no
CASC3_HUMAN [view interactions] High throughput no yes
CACO2_HUMAN [view interactions] High throughput no yes
MSD3_HUMAN [view interactions] High throughput no no
KANL2_HUMAN [view interactions] High throughput no yes
BEND5_HUMAN [view interactions] High throughput no no
BC11A_HUMAN [view entry] [view interactions] High throughput yes yes
PHLB1_HUMAN [view entry] [view interactions] High throughput yes yes
NRBF2_HUMAN [view interactions] High throughput no yes
NKD2_HUMAN [view interactions] High throughput no no
NINL_HUMAN [view interactions] High throughput no yes
NECA2_HUMAN [view interactions] High throughput no yes
NU1M_HUMAN [view interactions] High throughput no yes
MBP_HUMAN [view entry] [view interactions] High throughput yes no
MBIP1_HUMAN [view interactions] High throughput no yes
LZTS2_HUMAN [view interactions] High throughput no no
LUC7L_HUMAN [view interactions] High throughput no yes
LRSM1_HUMAN [view entry] [view interactions] High throughput yes yes
CC160_HUMAN [view interactions] High throughput no no
KLC4_HUMAN [view interactions] High throughput no yes
KLC1_HUMAN [view entry] [view interactions] High throughput yes no
KIF5A_HUMAN [view entry] [view interactions] High throughput yes yes
KIF1C_HUMAN [view interactions] High throughput no yes
ICA69_HUMAN [view entry] [view interactions] High throughput yes no
HOOK2_HUMAN [view interactions] High throughput no yes
HOME3_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPM_HUMAN [view entry] [view interactions] High throughput yes yes
HGS_HUMAN [view entry] [view interactions] High throughput yes yes
HECW1_HUMAN [view entry] [view interactions] High throughput yes yes
GPTC1_HUMAN [view interactions] High throughput no yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
GCC1_HUMAN [view interactions] High throughput no yes
ZN423_HUMAN [view interactions] High throughput no no
VIME_HUMAN [view entry] [view interactions] High throughput yes no
TARA_HUMAN [view interactions] High throughput no yes
TFP11_HUMAN [view interactions] High throughput no no
SPAG5_HUMAN [view interactions] High throughput no yes
SRTD1_HUMAN [view interactions] High throughput no no
SELW_HUMAN [view interactions] High throughput no no
SC31A_HUMAN [view entry] [view interactions] High throughput yes yes
SCMH1_HUMAN [view interactions] High throughput no no
RUN3A_HUMAN [view interactions] High throughput no yes
RALYL_HUMAN [view interactions] High throughput no yes
LIPA2_HUMAN [view entry] [view interactions] High throughput yes no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
PCNA_HUMAN [view interactions] High throughput no no
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
KLH20_HUMAN [view interactions] High throughput no yes
ETS1_HUMAN [view interactions] High throughput no no
ATX1_HUMAN [view interactions] High throughput no yes
PPM1H_HUMAN [view interactions] High throughput no yes
DOK5_HUMAN [view interactions] High throughput no no
MYLIP_HUMAN [view interactions] High throughput no no
AP2D_HUMAN [view interactions] High throughput no no
HXC8_HUMAN [view interactions] High throughput no no
DMRT3_HUMAN [view interactions] High throughput no no
PITX1_HUMAN [view interactions] High throughput no yes
YPEL3_HUMAN [view interactions] High throughput no yes
PATZ1_HUMAN [view interactions] High throughput no yes
CSTF2_HUMAN [view interactions] High throughput no yes
TLE5_HUMAN [view interactions] High throughput no no
LENG1_HUMAN [view interactions] High throughput no no
SMG9_HUMAN [view interactions] High throughput no yes
CHCH2_HUMAN [view interactions] High throughput no yes
PO6F2_HUMAN [view interactions] High throughput no no
TSH3_HUMAN [view interactions] High throughput no yes
ENKD1_HUMAN [view interactions] High throughput no yes
F110A_HUMAN [view interactions] High throughput no yes
GLIS2_HUMAN [view interactions] High throughput no no
RBTN2_HUMAN [view interactions] High throughput no yes
VEZF1_HUMAN [view interactions] High throughput no yes
SPAG8_HUMAN [view interactions] High throughput no no
FRS3_HUMAN [view interactions] High throughput no no
SUOX_HUMAN [view interactions] High throughput no no
CA094_HUMAN [view interactions] High throughput no no
POGZ_HUMAN [view interactions] High throughput no yes
PPR18_HUMAN [view interactions] High throughput no no
CC120_HUMAN [view interactions] High throughput no no
SHC3_HUMAN [view interactions] High throughput no yes
TF7L2_HUMAN [view interactions] High throughput no yes
TBX6_HUMAN [view interactions] High throughput no no
VENTX_HUMAN [view interactions] High throughput no no
CCL28_HUMAN [view interactions] High throughput no yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
ZIC1_HUMAN [view interactions] High throughput no yes
RBPMS_HUMAN [view interactions] High throughput no no
MLP3A_HUMAN [view entry] [view interactions] High throughput yes yes
FOXH1_HUMAN [view interactions] High throughput no no
MLP3B_HUMAN [view interactions] High throughput no yes
PPR32_HUMAN [view interactions] High throughput no no
IGFN1_HUMAN [view interactions] High throughput no no
FRIH_HUMAN [view entry] [view interactions] High throughput yes yes
MYOZ3_HUMAN [view interactions] High throughput no no
MAT1_HUMAN [view interactions] High throughput no yes
PATL1_HUMAN [view interactions] High throughput no yes
SDCG8_HUMAN [view interactions] High throughput no yes
VP37C_HUMAN [view interactions] High throughput no yes
HAIR_HUMAN [view interactions] High throughput no no
HBA_HUMAN [view interactions] High throughput no no
F222B_HUMAN [view interactions] High throughput no yes
RFIP5_HUMAN [view entry] [view interactions] High throughput yes yes
ZN417_HUMAN [view interactions] High throughput no yes
CD63_HUMAN [view interactions] High throughput no no
RIN1_HUMAN [view entry] [view interactions] High throughput yes yes
NDUBA_HUMAN [view entry] [view interactions] High throughput yes yes
T10IP_HUMAN [view interactions] High throughput no no
ID3_HUMAN [view interactions] High throughput no yes
SAMD7_HUMAN [view interactions] High throughput no no
RASA1_HUMAN [view interactions] High throughput no yes
SAM11_HUMAN [view interactions] High throughput no no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
ZN765_HUMAN [view interactions] High throughput no no
ACTA_HUMAN [view interactions] High throughput no no
ARI5A_HUMAN [view interactions] High throughput no yes
SFPQ_HUMAN [view entry] [view interactions] High throughput yes yes
ZN587_HUMAN [view interactions] High throughput no yes
EIF3F_HUMAN [view interactions] High throughput no yes
GPAN1_HUMAN [view interactions] High throughput no yes
RASF7_HUMAN [view interactions] High throughput no no
VGLL3_HUMAN [view interactions] High throughput no no
AQP1_HUMAN [view entry] [view interactions] High throughput yes no
KDM1A_HUMAN [view interactions] High throughput no yes
VINEX_HUMAN [view interactions] High throughput no no
ANM6_HUMAN [view interactions] High throughput no yes
BECN1_HUMAN [view interactions] High throughput no yes
LTMD1_HUMAN [view interactions] High throughput no no
SLU7_HUMAN [view interactions] High throughput no yes
JAK1_HUMAN [view interactions] High throughput no yes
ANO3_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
RT09_HUMAN [view interactions] High throughput no yes
SGF29_HUMAN [view interactions] High throughput no yes
DEFM_HUMAN [view interactions] High throughput no yes
PYGB_HUMAN [view entry] [view interactions] High throughput yes no
ZNF3_HUMAN [view interactions] High throughput no yes
4ET_HUMAN [view interactions] High throughput no yes
CIAO1_HUMAN [view interactions] High throughput no yes
ZBED6_HUMAN [view interactions] High throughput no no
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
1433T_HUMAN [view entry] [view interactions] High throughput yes yes
RRAGA_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
RRAGC_HUMAN [view interactions] High throughput no yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
AKTIP_HUMAN [view interactions] High throughput no yes
TANK_HUMAN [view interactions] High throughput no yes
DC1I2_HUMAN [view entry] [view interactions] High throughput yes yes
PICK1_HUMAN [view entry] [view interactions] High throughput yes yes
DYN2_HUMAN [view entry] [view interactions] High throughput yes yes
KAZRN_HUMAN [view interactions] High throughput no yes
RT29_HUMAN [view interactions] High throughput no yes
CCAR1_HUMAN [view interactions] High throughput no yes
GOGA4_HUMAN [view interactions] High throughput no yes
CPVL_HUMAN [view interactions] High throughput no no
PCM1_HUMAN [view interactions] High throughput no yes
TEX14_HUMAN [view interactions] High throughput no no
PIHD1_HUMAN [view interactions] High throughput no yes
RPAP3_HUMAN [view interactions] High throughput no yes
RUVB1_HUMAN [view interactions] High throughput no yes
RUVB2_HUMAN [view interactions] High throughput no yes
NCKP1_HUMAN [view entry] [view interactions] High throughput yes yes
RMP_HUMAN [view interactions] High throughput no yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
DAA10_HUMAN [view interactions] High throughput no yes
TMEDA_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
TDRD3_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
PP2AB_HUMAN [view interactions] High throughput no yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
PRC1_HUMAN [view interactions] High throughput no yes
FXR2_HUMAN [view entry] [view interactions] High throughput yes yes
UBP1_HUMAN [view interactions] High throughput no yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
WDR48_HUMAN [view entry] [view interactions] High throughput yes yes
CELR2_HUMAN [view interactions] High throughput no no
PHLP1_HUMAN [view interactions] High throughput no yes
AMPD2_HUMAN [view entry] [view interactions] High throughput yes yes
FOXO3_HUMAN [view interactions] High throughput no yes
RHG32_HUMAN [view entry] [view interactions] High throughput yes yes
DAB2_HUMAN [view interactions] High throughput no yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
DDX58_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
EDEM1_HUMAN [view interactions] High throughput no yes
CYRIB_HUMAN [view interactions] High throughput no yes
LURA1_HUMAN [view interactions] High throughput no yes
DNJA4_HUMAN [view interactions] High throughput no yes
K1C27_HUMAN [view interactions] High throughput no no
WNK3_HUMAN [view interactions] High throughput no no
NPTN_HUMAN [view entry] [view interactions] High throughput yes yes
WNK2_HUMAN [view interactions] High throughput no yes
KRT38_HUMAN [view interactions] High throughput no no
USP9X_HUMAN [view entry] [view interactions] High throughput yes yes
TMED5_HUMAN [view interactions] High throughput no yes
TTC3_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
TP53B_HUMAN [view entry] [view interactions] High throughput yes yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
TNKS1_HUMAN [view interactions] High throughput no yes
RHOH_HUMAN [view interactions] High throughput no yes
TMED9_HUMAN [view interactions] High throughput no yes
KDM5C_HUMAN [view interactions] High throughput no no
TEN2_HUMAN [view entry] [view interactions] High throughput yes no
TOP1_HUMAN [view interactions] High throughput no yes
SOGA3_HUMAN [view interactions] High throughput no no
VHL_HUMAN [view entry] [view interactions] High throughput yes yes
SMC2_HUMAN [view interactions] High throughput no yes
ARF1_HUMAN [view entry] [view interactions] High throughput yes yes
SESD1_HUMAN [view entry] [view interactions] High throughput yes no
B4GT1_HUMAN [view interactions] High throughput no yes
SCRIB_HUMAN [view entry] [view interactions] High throughput yes no
EZH2_HUMAN [view interactions] High throughput no no
RPTOR_HUMAN [view interactions] High throughput no yes
DAZP1_HUMAN [view interactions] High throughput no yes
QSER1_HUMAN [view interactions] High throughput no yes
B4GT3_HUMAN [view interactions] High throughput no yes
PTPRS_HUMAN [view entry] [view interactions] High throughput yes no
ARFG2_HUMAN [view entry] [view interactions] High throughput yes yes
PAK5_HUMAN [view interactions] High throughput no yes
HDAC8_HUMAN [view interactions] High throughput no yes
NISCH_HUMAN [view interactions] High throughput no yes
TPC13_HUMAN [view interactions] High throughput no yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
CUL5_HUMAN [view entry] [view interactions] High throughput yes yes
NCAN_HUMAN [view entry] [view interactions] High throughput yes no
TPC2L_HUMAN [view interactions] High throughput no yes
MATR3_HUMAN [view interactions] High throughput no yes
VPS53_HUMAN [view entry] [view interactions] High throughput yes yes
MAGD2_HUMAN [view interactions] High throughput no yes
SC24B_HUMAN [view interactions] High throughput no yes
MAGD1_HUMAN [view interactions] High throughput no no
TPC2A_HUMAN [view interactions] High throughput no yes
KIF5C_HUMAN [view entry] [view interactions] High throughput yes yes
SC24A_HUMAN [view interactions] High throughput no no
MPRI_HUMAN [view interactions] High throughput no yes
GNT2A_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
S23IP_HUMAN [view interactions] High throughput no yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
S39A3_HUMAN [view interactions] High throughput no yes
FOXG1_HUMAN [view interactions] High throughput no no
IF2B1_HUMAN [view interactions] High throughput no no
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
SC23B_HUMAN [view interactions] High throughput no yes
TCAF1_HUMAN [view interactions] High throughput no no
SC24C_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA4_HUMAN [view entry] [view interactions] High throughput yes yes
TPC12_HUMAN [view interactions] High throughput no yes
IF4A2_HUMAN [view entry] [view interactions] High throughput yes yes
S39A7_HUMAN [view interactions] High throughput no yes
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
SAR1A_HUMAN [view entry] [view interactions] High throughput yes yes
RICTR_HUMAN [view interactions] High throughput no yes
DCX_HUMAN [view entry] [view interactions] High throughput yes yes
P63_HUMAN [view interactions] High throughput no no
CLAP1_HUMAN [view entry] [view interactions] High throughput yes yes
FAS_HUMAN [view entry] [view interactions] High throughput yes no
TCPQ_HUMAN [view entry] [view interactions] High throughput yes yes
SRBP1_HUMAN [view interactions] High throughput no yes
TCPG_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
PYR1_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
AURKA_HUMAN [view entry] [view interactions] High throughput yes no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
MERL_HUMAN [view interactions] High throughput no yes
PP2BA_HUMAN [view entry] [view interactions] High throughput yes yes
CCNE1_HUMAN [view interactions] High throughput no no
MINK1_HUMAN [view entry] [view interactions] High throughput yes yes
ARAF_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
CCND2_HUMAN [view interactions] High throughput no yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
CDK4_HUMAN [view interactions] High throughput no no
KCC2G_HUMAN [view entry] [view interactions] High throughput yes yes
CDK6_HUMAN [view interactions] High throughput no yes
KCC2D_HUMAN [view entry] [view interactions] High throughput yes yes
KAT2A_HUMAN [view interactions] High throughput no no
KCC2B_HUMAN [view entry] [view interactions] High throughput yes yes
MP2K5_HUMAN [view interactions] High throughput no yes
ARHG2_HUMAN [view entry] [view interactions] High throughput yes yes
RASF1_HUMAN [view interactions] High throughput no yes
DP13A_HUMAN [view entry] [view interactions] High throughput yes yes
SOX4_HUMAN [view interactions] High throughput no yes
ABI1_HUMAN [view entry] [view interactions] High throughput yes yes
CDN2B_HUMAN [view interactions] High throughput no no
FGFR4_HUMAN [view interactions] High throughput no no
WASF1_HUMAN [view entry] [view interactions] High throughput yes yes
LATS2_HUMAN [view interactions] High throughput no yes
TRIM3_HUMAN [view entry] [view interactions] High throughput yes no
TENR_HUMAN [view entry] [view interactions] High throughput yes no
SC23A_HUMAN [view entry] [view interactions] High throughput yes yes
RASL1_HUMAN [view entry] [view interactions] High throughput yes yes
CCNB1_HUMAN [view interactions] High throughput no no
RAP2B_HUMAN [view interactions] High throughput no no
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
RAN_HUMAN [view entry] [view interactions] High throughput yes no
DERL1_HUMAN [view interactions] High throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
LAMP2_HUMAN [view interactions] High throughput no yes
RAB14_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP3_HUMAN [view interactions] High throughput no no
PURA_HUMAN [view entry] [view interactions] High throughput yes no
NU155_HUMAN [view interactions] High throughput no yes
KPCG_HUMAN [view entry] [view interactions] High throughput yes yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
KPCB_HUMAN [view entry] [view interactions] High throughput yes yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
LGI1_HUMAN [view entry] [view interactions] High throughput yes no
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
AAKB1_HUMAN [view interactions] Computational no yes
KS6A3_HUMAN [view entry] [view interactions] Computational yes yes
AAKB2_HUMAN [view interactions] Computational no yes
CDC37_HUMAN [view interactions] Computational no yes
PSMG2_HUMAN [view interactions] Computational no yes
TCPD_HUMAN [view entry] [view interactions] Computational yes yes
KS6A6_HUMAN [view interactions] Computational no yes
MK03_HUMAN [view entry] [view interactions] Computational yes yes
S38A9_HUMAN [view interactions] Computational no yes
PRR5_HUMAN [view interactions] Computational no yes
TCPE_HUMAN [view entry] [view interactions] Computational yes yes
AAKG1_HUMAN [view interactions] Computational no no
SIN1_HUMAN [view interactions] Computational no yes
MTOR_HUMAN [view entry] [view interactions] Computational yes yes
LTOR4_HUMAN [view interactions] Computational no yes
PPP5_HUMAN [view entry] [view interactions] Computational yes yes
AKT2_HUMAN [view entry] [view interactions] Computational yes yes
AKT3_HUMAN [view interactions] Computational no yes
AAKG2_HUMAN [view interactions] Computational no yes
RRAGB_HUMAN [view interactions] Computational no yes
AAPK2_HUMAN [view interactions] Computational no yes
PTEN_HUMAN [view entry] [view interactions] Computational yes yes
AAKG3_HUMAN [view interactions] Computational no no
1433S_HUMAN [view entry] [view interactions] Computational yes yes
PSMG1_HUMAN [view interactions] Computational no yes
RRAGD_HUMAN [view interactions] Computational no yes
LST8_HUMAN [view interactions] Computational no yes
TCPH_HUMAN [view entry] [view interactions] Computational yes yes
DPTOR_HUMAN [view interactions] Computational no no
RAB28_HUMAN [view interactions] Computational no yes
AAPK1_HUMAN [view interactions] Computational no no
DDIT4_HUMAN [view interactions] Computational no yes
TCPZ_HUMAN [view entry] [view interactions] Computational yes yes
STIP1_HUMAN [view entry] [view interactions] Computational yes yes
LTOR2_HUMAN [view interactions] Computational no yes
LTOR3_HUMAN [view interactions] Computational no yes
TCPA_HUMAN [view entry] [view interactions] Computational yes yes
KS6A2_HUMAN [view interactions] Computational no yes
MK01_HUMAN [view entry] [view interactions] Computational yes yes
TCPB_HUMAN [view entry] [view interactions] Computational yes yes