TSC1_HUMAN
Evidence for PS localization
Functions
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed, PubMed). Seems not to be required for TSC2 GAP activity towards RHEB (PubMed). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling . Acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1 (PubMed). Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity (PubMed). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed). Recruits TSC2 to HSP90AA1 and stabilizes TSC2 by preventing the interaction between TSC2 and ubiquitin ligase HERC1 (PubMed, PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 191 | Leu | His | Tuberoussclerosis1(TSC1) | - |
| 224 | Met | Arg | Tuberoussclerosis1(TSC1) | - |
| 654 | Gln | Glu | Tuberoussclerosis1(TSC1) | - |
| 726 | Ala | Glu | Tuberoussclerosis1(TSC1) | - |
| 899 | Thr | Ser | Tuberoussclerosis1(TSC1) | - |
| 72 | Leu | Pro | Tuberoussclerosis1(TSC1) | - |
| 500 | Arg | Gln | Tuberoussclerosis1(TSC1) | - |
| 117 | Leu | Pro | Tuberoussclerosis1(TSC1) | - |
| 180 | Leu | Pro | Tuberoussclerosis1(TSC1) | - |
| 22 | Arg | Trp | Focalcorticaldysplasia2(FCORD2) | - |
| 204 | Arg | Cys | Focalcorticaldysplasia2(FCORD2) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TSC1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 35.2941 | 4 | no |
| GO:0000166 | nucleotide binding | 32.6797 | 4 | no |
| GO:0017076 | purine nucleotide binding | 32.6797 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 32.6797 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 32.6797 | 4 | no |
| GO:0043169 | cation binding | 22.2222 | 4 | no |
| GO:0046872 | metal ion binding | 22.2222 | 5 | no |
| GO:0005524 | ATP binding | 20.9150 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 20.9150 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 20.9150 | 5 | no |
| GO:0030544 | Hsp70 protein binding | 2.6144 | 4 | yes |
| GO:0051879 | Hsp90 protein binding | 2.6144 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TSC1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 68.6275 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 57.5163 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 56.8627 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 56.2092 | 4 | yes |
| GO:0010646 | regulation of cell communication | 52.9412 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 52.9412 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 52.2876 | 4 | yes |
| GO:0008104 | protein localization | 45.0980 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 43.1373 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 43.1373 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 42.4837 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 41.8301 | 4 | no |
| GO:0009966 | regulation of signal transduction | 41.8301 | 4 | yes |
| GO:0051049 | regulation of transport | 39.8693 | 4 | no |
| GO:0010468 | regulation of gene expression | 39.2157 | 6 | yes |
| GO:0051246 | regulation of protein metabolic process | 39.2157 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 38.5621 | 5 | no |
| GO:0006996 | organelle organization | 37.2549 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 35.2941 | 5 | no |
| GO:0071702 | organic substance transport | 33.9869 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 32.0261 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 32.0261 | 4 | yes |
| GO:0015031 | protein transport | 30.7190 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.4118 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 28.7582 | 4 | no |
| GO:0022607 | cellular component assembly | 28.1046 | 4 | no |
| GO:0023056 | positive regulation of signaling | 28.1046 | 4 | no |
| GO:0030030 | cell projection organization | 28.1046 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 27.4510 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.4510 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 26.7974 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.1438 | 5 | no |
| GO:0033043 | regulation of organelle organization | 26.1438 | 5 | yes |
| GO:0031344 | regulation of cell projection organization | 25.4902 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.4902 | 6 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.8366 | 6 | no |
| GO:0051094 | positive regulation of developmental process | 24.8366 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 24.1830 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 24.1830 | 4 | no |
| GO:0036211 | protein modification process | 24.1830 | 4 | no |
| GO:0043412 | macromolecule modification | 24.1830 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 24.1830 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 24.1830 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 24.1830 | 4 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.5294 | 6 | no |
| GO:0006886 | intracellular protein transport | 23.5294 | 4 | no |
| GO:0031399 | regulation of protein modification process | 23.5294 | 6 | yes |
| GO:0048585 | negative regulation of response to stimulus | 23.5294 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.8758 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 22.8758 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.8758 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 22.8758 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 22.8758 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 22.8758 | 4 | no |
| GO:0060341 | regulation of cellular localization | 22.8758 | 4 | no |
| GO:0009894 | regulation of catabolic process | 22.8758 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 22.8758 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 22.8758 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 22.8758 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 22.2222 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 21.5686 | 4 | no |
| GO:0032880 | regulation of protein localization | 21.5686 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.5686 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 20.9150 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 20.9150 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 20.9150 | 6 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 20.9150 | 6 | yes |
| GO:0009968 | negative regulation of signal transduction | 19.6078 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 19.6078 | 6 | yes |
| GO:0042127 | regulation of cell population proliferation | 19.6078 | 4 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 19.6078 | 5 | yes |
| GO:0051726 | regulation of cell cycle | 16.9935 | 4 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 16.3399 | 6 | yes |
| GO:0010243 | response to organonitrogen compound | 15.6863 | 4 | yes |
| GO:0010629 | negative regulation of gene expression | 14.3791 | 7 | yes |
| GO:0043085 | positive regulation of catalytic activity | 14.3791 | 4 | yes |
| GO:0051336 | regulation of hydrolase activity | 14.3791 | 4 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 14.3791 | 6 | yes |
| GO:1902532 | negative regulation of intracellular signal transduction | 12.4183 | 6 | yes |
| GO:0032535 | regulation of cellular component size | 12.4183 | 4 | yes |
| GO:0034330 | cell junction organization | 12.4183 | 4 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 11.7647 | 5 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 11.7647 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 11.7647 | 4 | yes |
| GO:0010506 | regulation of autophagy | 11.1111 | 6 | yes |
| GO:0031329 | regulation of cellular catabolic process | 11.1111 | 5 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 11.1111 | 5 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 11.1111 | 5 | yes |
| GO:0006417 | regulation of translation | 10.4575 | 6 | yes |
| GO:0010608 | post-transcriptional regulation of gene expression | 10.4575 | 7 | yes |
| GO:0030155 | regulation of cell adhesion | 10.4575 | 4 | yes |
| GO:0050808 | synapse organization | 10.4575 | 5 | yes |
| GO:0110053 | regulation of actin filament organization | 10.4575 | 6 | yes |
| GO:0032006 | regulation of TOR signaling | 8.4967 | 6 | yes |
| GO:0050890 | cognition | 8.4967 | 4 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 7.8431 | 5 | yes |
| GO:1903432 | regulation of TORC1 signaling | 7.1895 | 7 | yes |
| GO:0050821 | protein stabilization | 7.1895 | 4 | yes |
| GO:0009895 | negative regulation of catabolic process | 6.5359 | 5 | yes |
| GO:0016241 | regulation of macroautophagy | 6.5359 | 7 | yes |
| GO:0043087 | regulation of GTPase activity | 6.5359 | 5 | yes |
| GO:0006811 | monoatomic ion transport | 5.8824 | 4 | yes |
| GO:0006812 | monoatomic cation transport | 5.8824 | 5 | yes |
| GO:0007612 | learning | 5.8824 | 4 | yes |
| GO:0009267 | cellular response to starvation | 5.8824 | 4 | yes |
| GO:0030001 | metal ion transport | 5.8824 | 6 | yes |
| GO:0035303 | regulation of dephosphorylation | 5.8824 | 7 | yes |
| GO:0035304 | regulation of protein dephosphorylation | 5.8824 | 7 | yes |
| GO:0043434 | response to peptide hormone | 5.8824 | 4 | yes |
| GO:0045785 | positive regulation of cell adhesion | 5.8824 | 5 | yes |
| GO:0001952 | regulation of cell-matrix adhesion | 5.2288 | 6 | yes |
| GO:0008361 | regulation of cell size | 5.2288 | 5 | yes |
| GO:0010810 | regulation of cell-substrate adhesion | 5.2288 | 5 | yes |
| GO:0017148 | negative regulation of translation | 5.2288 | 7 | yes |
| GO:0032231 | regulation of actin filament bundle assembly | 5.2288 | 5 | yes |
| GO:1901888 | regulation of cell junction assembly | 4.5752 | 5 | yes |
| GO:0008306 | associative learning | 4.5752 | 5 | yes |
| GO:0010921 | regulation of phosphatase activity | 4.5752 | 5 | yes |
| GO:0032007 | negative regulation of TOR signaling | 4.5752 | 7 | yes |
| GO:0032868 | response to insulin | 4.5752 | 5 | yes |
| GO:0043547 | positive regulation of GTPase activity | 4.5752 | 6 | yes |
| GO:0043666 | regulation of phosphoprotein phosphatase activity | 4.5752 | 6 | yes |
| GO:1904262 | negative regulation of TORC1 signaling | 3.9216 | 8 | yes |
| GO:0007160 | cell-matrix adhesion | 3.9216 | 4 | yes |
| GO:0010507 | negative regulation of autophagy | 3.9216 | 7 | yes |
| GO:0031330 | negative regulation of cellular catabolic process | 3.9216 | 6 | yes |
| GO:0036293 | response to decreased oxygen levels | 3.9216 | 4 | yes |
| GO:0036294 | cellular response to decreased oxygen levels | 3.9216 | 5 | yes |
| GO:0071453 | cellular response to oxygen levels | 3.9216 | 4 | yes |
| GO:0001843 | neural tube closure | 3.2680 | 5 | yes |
| GO:0001954 | positive regulation of cell-matrix adhesion | 3.2680 | 7 | yes |
| GO:0010811 | positive regulation of cell-substrate adhesion | 3.2680 | 6 | yes |
| GO:0042110 | T cell activation | 3.2680 | 4 | yes |
| GO:0042692 | muscle cell differentiation | 3.2680 | 4 | yes |
| GO:0051492 | regulation of stress fiber assembly | 3.2680 | 6 | yes |
| GO:0051893 | regulation of focal adhesion assembly | 3.2680 | 7 | yes |
| GO:0060606 | tube closure | 3.2680 | 4 | yes |
| GO:0090109 | regulation of cell-substrate junction assembly | 3.2680 | 6 | yes |
| GO:0090630 | activation of GTPase activity | 3.2680 | 7 | yes |
| GO:0110020 | regulation of actomyosin structure organization | 3.2680 | 6 | yes |
| GO:0150116 | regulation of cell-substrate junction organization | 3.2680 | 5 | yes |
| GO:1903131 | mononuclear cell differentiation | 2.6144 | 5 | yes |
| GO:0002521 | leukocyte differentiation | 2.6144 | 4 | yes |
| GO:0008344 | adult locomotory behavior | 2.6144 | 4 | yes |
| GO:0008643 | carbohydrate transport | 2.6144 | 5 | yes |
| GO:0016242 | negative regulation of macroautophagy | 2.6144 | 8 | yes |
| GO:0042552 | myelination | 2.6144 | 4 | yes |
| GO:0051146 | striated muscle cell differentiation | 2.6144 | 5 | yes |
| GO:0150117 | positive regulation of cell-substrate junction organization | 1.9608 | 6 | yes |
| GO:1901890 | positive regulation of cell junction assembly | 1.9608 | 6 | yes |
| GO:0006813 | potassium ion transport | 1.9608 | 7 | yes |
| GO:0030098 | lymphocyte differentiation | 1.9608 | 4 | yes |
| GO:0030217 | T cell differentiation | 1.9608 | 5 | yes |
| GO:0045792 | negative regulation of cell size | 1.9608 | 6 | yes |
| GO:0051894 | positive regulation of focal adhesion assembly | 1.9608 | 7 | yes |
| GO:1904659 | glucose transmembrane transport | 1.3072 | 6 | yes |
| GO:0001822 | kidney development | 1.3072 | 4 | yes |
| GO:0002285 | lymphocyte activation involved in immune response | 1.3072 | 4 | yes |
| GO:0002286 | T cell activation involved in immune response | 1.3072 | 5 | yes |
| GO:0002292 | T cell differentiation involved in immune response | 1.3072 | 6 | yes |
| GO:0008645 | hexose transmembrane transport | 1.3072 | 5 | yes |
| GO:0015749 | monosaccharide transmembrane transport | 1.3072 | 4 | yes |
| GO:0032780 | negative regulation of ATP-dependent activity | 1.3072 | 4 | yes |
| GO:0035051 | cardiocyte differentiation | 1.3072 | 4 | yes |
| GO:0043379 | memory T cell differentiation | 1.3072 | 4 | yes |
| GO:0046323 | glucose import | 1.3072 | 7 | yes |
| GO:0055007 | cardiac muscle cell differentiation | 1.3072 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| KS6B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RHEB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MOES_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NFL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RADI_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EZRI_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BEX3_HUMAN | [view interactions] | Low throughput | no | yes |
| TSC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TSC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AKT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KS6A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FBXW5_HUMAN | [view interactions] | Low throughput | no | no |
| CDN1B_HUMAN | [view interactions] | Low throughput | no | yes |
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TBCD7_HUMAN | [view interactions] | Low throughput | no | no |
| 1433B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK14_HUMAN | [view interactions] | Low throughput | no | yes |
| TNR16_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| IKKB_HUMAN | [view interactions] | Low throughput | no | yes |
| DAPK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLK1_HUMAN | [view interactions] | Low throughput | no | yes |
| CDK1_HUMAN | [view interactions] | Low throughput | no | no |
| CCNB1_HUMAN | [view interactions] | Low throughput | no | no |
| PK3C3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DOCK7_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACTS_HUMAN | [view interactions] | Low throughput | no | no |
| AMD_HUMAN | [view interactions] | Low throughput | no | yes |
| RENI_HUMAN | [view interactions] | Low throughput | no | no |
| SHAN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AXIN1_HUMAN | [view interactions] | Low throughput | no | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZN423_HUMAN | [view interactions] | High throughput | no | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLH20_HUMAN | [view interactions] | High throughput | no | yes |
| ETS1_HUMAN | [view interactions] | High throughput | no | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1H_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| DOK5_HUMAN | [view interactions] | High throughput | no | no |
| MYLIP_HUMAN | [view interactions] | High throughput | no | no |
| AP2D_HUMAN | [view interactions] | High throughput | no | no |
| HXC8_HUMAN | [view interactions] | High throughput | no | no |
| DMRT3_HUMAN | [view interactions] | High throughput | no | no |
| PITX1_HUMAN | [view interactions] | High throughput | no | yes |
| YPEL3_HUMAN | [view interactions] | High throughput | no | yes |
| PATZ1_HUMAN | [view interactions] | High throughput | no | yes |
| CSTF2_HUMAN | [view interactions] | High throughput | no | yes |
| TLE5_HUMAN | [view interactions] | High throughput | no | no |
| LENG1_HUMAN | [view interactions] | High throughput | no | no |
| SMG9_HUMAN | [view interactions] | High throughput | no | yes |
| CHCH2_HUMAN | [view interactions] | High throughput | no | yes |
| PO6F2_HUMAN | [view interactions] | High throughput | no | no |
| TSH3_HUMAN | [view interactions] | High throughput | no | yes |
| ENKD1_HUMAN | [view interactions] | High throughput | no | yes |
| F110A_HUMAN | [view interactions] | High throughput | no | yes |
| GLIS2_HUMAN | [view interactions] | High throughput | no | no |
| RBTN2_HUMAN | [view interactions] | High throughput | no | yes |
| VEZF1_HUMAN | [view interactions] | High throughput | no | yes |
| SPAG8_HUMAN | [view interactions] | High throughput | no | no |
| FRS3_HUMAN | [view interactions] | High throughput | no | no |
| SUOX_HUMAN | [view interactions] | High throughput | no | no |
| CA094_HUMAN | [view interactions] | High throughput | no | no |
| POGZ_HUMAN | [view interactions] | High throughput | no | yes |
| PPR18_HUMAN | [view interactions] | High throughput | no | no |
| CC120_HUMAN | [view interactions] | High throughput | no | no |
| SHC3_HUMAN | [view interactions] | High throughput | no | yes |
| TF7L2_HUMAN | [view interactions] | High throughput | no | yes |
| TBX6_HUMAN | [view interactions] | High throughput | no | no |
| VENTX_HUMAN | [view interactions] | High throughput | no | no |
| CCL28_HUMAN | [view interactions] | High throughput | no | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZIC1_HUMAN | [view interactions] | High throughput | no | yes |
| RBPMS_HUMAN | [view interactions] | High throughput | no | no |
| FOXH1_HUMAN | [view interactions] | High throughput | no | no |
| FRIH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAXO4_HUMAN | [view interactions] | High throughput | no | no |
| MAT1_HUMAN | [view interactions] | High throughput | no | yes |
| IGFN1_HUMAN | [view interactions] | High throughput | no | no |
| SDCG8_HUMAN | [view interactions] | High throughput | no | yes |
| MYOZ3_HUMAN | [view interactions] | High throughput | no | no |
| PATL1_HUMAN | [view interactions] | High throughput | no | yes |
| HBA_HUMAN | [view interactions] | High throughput | no | no |
| VP37C_HUMAN | [view interactions] | High throughput | no | yes |
| RFIP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAIR_HUMAN | [view interactions] | High throughput | no | no |
| CD63_HUMAN | [view interactions] | High throughput | no | no |
| F222B_HUMAN | [view interactions] | High throughput | no | yes |
| NDUBA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN417_HUMAN | [view interactions] | High throughput | no | yes |
| ID3_HUMAN | [view interactions] | High throughput | no | yes |
| RIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASA1_HUMAN | [view interactions] | High throughput | no | yes |
| T10IP_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SAMD7_HUMAN | [view interactions] | High throughput | no | no |
| ACTA_HUMAN | [view interactions] | High throughput | no | no |
| SAM11_HUMAN | [view interactions] | High throughput | no | no |
| SFPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZN765_HUMAN | [view interactions] | High throughput | no | no |
| EIF3F_HUMAN | [view interactions] | High throughput | no | yes |
| ARI5A_HUMAN | [view interactions] | High throughput | no | yes |
| RASF7_HUMAN | [view interactions] | High throughput | no | no |
| ZN587_HUMAN | [view interactions] | High throughput | no | yes |
| GPAN1_HUMAN | [view interactions] | High throughput | no | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| VGLL3_HUMAN | [view interactions] | High throughput | no | no |
| ANM6_HUMAN | [view interactions] | High throughput | no | yes |
| AQP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BECN1_HUMAN | [view interactions] | High throughput | no | yes |
| VINEX_HUMAN | [view interactions] | High throughput | no | no |
| ANO3_HUMAN | [view interactions] | High throughput | no | yes |
| JAK1_HUMAN | [view interactions] | High throughput | no | yes |
| SLU7_HUMAN | [view interactions] | High throughput | no | yes |
| LTMD1_HUMAN | [view interactions] | High throughput | no | no |
| ZBED6_HUMAN | [view interactions] | High throughput | no | no |
| 4ET_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZNF3_HUMAN | [view interactions] | High throughput | no | yes |
| PYGB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DEFM_HUMAN | [view interactions] | High throughput | no | yes |
| SGF29_HUMAN | [view interactions] | High throughput | no | yes |
| RT09_HUMAN | [view interactions] | High throughput | no | yes |
| CIAO1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RRAGA_HUMAN | [view interactions] | High throughput | no | yes |
| TANK_HUMAN | [view interactions] | High throughput | no | yes |
| RRAGC_HUMAN | [view interactions] | High throughput | no | yes |
| PICK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKTIP_HUMAN | [view interactions] | High throughput | no | yes |
| KAZRN_HUMAN | [view interactions] | High throughput | no | yes |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOGA4_HUMAN | [view interactions] | High throughput | no | yes |
| RT29_HUMAN | [view interactions] | High throughput | no | yes |
| CCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| TEX14_HUMAN | [view interactions] | High throughput | no | no |
| CPVL_HUMAN | [view interactions] | High throughput | no | no |
| PCM1_HUMAN | [view interactions] | High throughput | no | yes |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| RPAP3_HUMAN | [view interactions] | High throughput | no | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUVB1_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
| CDK5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RMP_HUMAN | [view interactions] | High throughput | no | yes |
| CNRP1_HUMAN | [view interactions] | High throughput | no | no |
| DAA10_HUMAN | [view interactions] | High throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP1_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA4_HUMAN | [view interactions] | High throughput | no | yes |
| WDR48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYRIB_HUMAN | [view interactions] | High throughput | no | yes |
| PHLP1_HUMAN | [view interactions] | High throughput | no | yes |
| FBX41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FOXO3_HUMAN | [view interactions] | High throughput | no | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| DAB2_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EDEM1_HUMAN | [view interactions] | High throughput | no | yes |
| LGI1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LURA1_HUMAN | [view interactions] | High throughput | no | yes |
| KPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K1C27_HUMAN | [view interactions] | High throughput | no | no |
| KPCG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PURA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KRT38_HUMAN | [view interactions] | High throughput | no | no |
| RAB14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMED5_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAP2B_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RASL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC23A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GATA4_HUMAN | [view interactions] | High throughput | no | no |
| TENR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TRIM3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WASF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| KDM5C_HUMAN | [view interactions] | High throughput | no | no |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOP1_HUMAN | [view interactions] | High throughput | no | yes |
| DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B4GT1_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAZP1_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B4GT3_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARFG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC8_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPC13_HUMAN | [view interactions] | High throughput | no | yes |
| MINK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP2BA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPC2L_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VPS53_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC24B_HUMAN | [view interactions] | High throughput | no | yes |
| AMPD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPC2A_HUMAN | [view interactions] | High throughput | no | yes |
| PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC24A_HUMAN | [view interactions] | High throughput | no | no |
| TCPG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNT2A_HUMAN | [view interactions] | High throughput | no | yes |
| TCPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S23IP_HUMAN | [view interactions] | High throughput | no | yes |
| CELR2_HUMAN | [view interactions] | High throughput | no | no |
| S39A3_HUMAN | [view interactions] | High throughput | no | yes |
| CLAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF2B1_HUMAN | [view interactions] | High throughput | no | no |
| DCX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC23B_HUMAN | [view interactions] | High throughput | no | yes |
| SC24C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| TPC12_HUMAN | [view interactions] | High throughput | no | yes |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S39A7_HUMAN | [view interactions] | High throughput | no | yes |
| IF4A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCAF1_HUMAN | [view interactions] | High throughput | no | no |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P63_HUMAN | [view interactions] | High throughput | no | no |
| FOXG1_HUMAN | [view interactions] | High throughput | no | no |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRBP1_HUMAN | [view interactions] | High throughput | no | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MERL_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNE1_HUMAN | [view interactions] | High throughput | no | no |
| MPRI_HUMAN | [view interactions] | High throughput | no | yes |
| ARAF_HUMAN | [view interactions] | High throughput | no | yes |
| KIF5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCND2_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK4_HUMAN | [view interactions] | High throughput | no | no |
| MAGD1_HUMAN | [view interactions] | High throughput | no | no |
| CDK6_HUMAN | [view interactions] | High throughput | no | yes |
| MAGD2_HUMAN | [view interactions] | High throughput | no | yes |
| KAT2A_HUMAN | [view interactions] | High throughput | no | no |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| MP2K5_HUMAN | [view interactions] | High throughput | no | yes |
| NCAN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASF1_HUMAN | [view interactions] | High throughput | no | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX4_HUMAN | [view interactions] | High throughput | no | yes |
| NISCH_HUMAN | [view interactions] | High throughput | no | yes |
| CDN2B_HUMAN | [view interactions] | High throughput | no | no |
| PAK5_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| PP2AB_HUMAN | [view interactions] | High throughput | no | yes |
| LATS2_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| QSER1_HUMAN | [view interactions] | High throughput | no | no |
| RPTOR_HUMAN | [view interactions] | High throughput | no | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SESD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| SMC2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| MTCL3_HUMAN | [view interactions] | High throughput | no | no |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| TDRD3_HUMAN | [view interactions] | High throughput | no | yes |
| NU155_HUMAN | [view interactions] | High throughput | no | yes |
| TEN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMED9_HUMAN | [view interactions] | High throughput | no | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNKS1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TP53B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TTC3_HUMAN | [view interactions] | High throughput | no | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| USP9X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| WNK2_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WNK3_HUMAN | [view interactions] | High throughput | no | no |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| SH22A_HUMAN | [view interactions] | High throughput | no | no |
| RAB25_HUMAN | [view interactions] | High throughput | no | no |
| HSH2D_HUMAN | [view interactions] | High throughput | no | no |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TENS2_HUMAN | [view interactions] | High throughput | no | no |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DP13B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| AKIB1_HUMAN | [view interactions] | High throughput | no | yes |
| ACTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANR24_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANR35_HUMAN | [view interactions] | High throughput | no | no |
| ATN1_HUMAN | [view interactions] | High throughput | no | yes |
| CNTRB_HUMAN | [view interactions] | High throughput | no | yes |
| COG6_HUMAN | [view interactions] | High throughput | no | yes |
| DACH2_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBF1_HUMAN | [view interactions] | High throughput | no | no |
| GCC1_HUMAN | [view interactions] | High throughput | no | yes |
| GEMI8_HUMAN | [view interactions] | High throughput | no | yes |
| GFAP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPTC1_HUMAN | [view interactions] | High throughput | no | yes |
| HECW1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOME3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| ICA69_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
| KIF5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KLC4_HUMAN | [view interactions] | High throughput | no | yes |
| CC160_HUMAN | [view interactions] | High throughput | no | no |
| LRSM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LUC7L_HUMAN | [view interactions] | High throughput | no | yes |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| MBIP1_HUMAN | [view interactions] | High throughput | no | yes |
| MBP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NU1M_HUMAN | [view interactions] | High throughput | no | yes |
| NECA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| NKD2_HUMAN | [view interactions] | High throughput | no | no |
| NRBF2_HUMAN | [view interactions] | High throughput | no | yes |
| PHLB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BC11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BEND5_HUMAN | [view interactions] | High throughput | no | no |
| KANL2_HUMAN | [view interactions] | High throughput | no | yes |
| MSD3_HUMAN | [view interactions] | High throughput | no | no |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| CASC3_HUMAN | [view interactions] | High throughput | no | yes |
| CC88B_HUMAN | [view interactions] | High throughput | no | no |
| CDR2_HUMAN | [view interactions] | High throughput | no | yes |
| CNTRL_HUMAN | [view interactions] | High throughput | no | yes |
| CNIH1_HUMAN | [view interactions] | High throughput | no | yes |
| LIPA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RALYL_HUMAN | [view interactions] | High throughput | no | yes |
| RUN3A_HUMAN | [view interactions] | High throughput | no | yes |
| SCMH1_HUMAN | [view interactions] | High throughput | no | no |
| SC31A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SELW_HUMAN | [view interactions] | High throughput | no | no |
| SRTD1_HUMAN | [view interactions] | High throughput | no | no |
| SPAG5_HUMAN | [view interactions] | High throughput | no | yes |
| TFP11_HUMAN | [view interactions] | High throughput | no | no |
| TARA_HUMAN | [view interactions] | High throughput | no | yes |