Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

HECW1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in HECW1_HUMAN
GO:0043169 cation binding 36.3636 4 no
GO:0046872 metal ion binding 36.3636 5 no
GO:0004842 ubiquitin-protein transferase activity 27.2727 4 yes
GO:0016755 aminoacyltransferase activity 27.2727 4 yes
GO:0061630 ubiquitin protein ligase activity 27.2727 5 yes
GO:0061659 ubiquitin-like protein ligase activity 27.2727 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in HECW1_HUMAN
GO:0051128 regulation of cellular component organization 81.8182 4 yes
GO:0010646 regulation of cell communication 63.6364 4 yes
GO:0048523 negative regulation of cellular process 63.6364 4 yes
GO:0009966 regulation of signal transduction 54.5455 4 yes
GO:0010975 regulation of neuron projection development 54.5455 7 yes
GO:0022603 regulation of anatomical structure morphogenesis 54.5455 4 yes
GO:0031344 regulation of cell projection organization 54.5455 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 54.5455 6 yes
GO:0048522 positive regulation of cellular process 54.5455 4 no
GO:0036211 protein modification process 45.4545 4 yes
GO:0043412 macromolecule modification 45.4545 4 yes
GO:0019220 regulation of phosphate metabolic process 45.4545 6 no
GO:0031323 regulation of cellular metabolic process 45.4545 4 no
GO:0031399 regulation of protein modification process 45.4545 6 no
GO:0051174 regulation of phosphorus metabolic process 45.4545 5 no
GO:0051246 regulation of protein metabolic process 45.4545 5 no
GO:0060255 regulation of macromolecule metabolic process 45.4545 4 no
GO:0080090 regulation of primary metabolic process 45.4545 4 no
GO:0016567 protein ubiquitination 36.3636 8 yes
GO:0032446 protein modification by small protein conjugation 36.3636 7 yes
GO:0043687 post-translational protein modification 36.3636 5 yes
GO:0048585 negative regulation of response to stimulus 36.3636 4 yes
GO:0070647 protein modification by small protein conjugation or removal 36.3636 6 yes
GO:0050804 modulation of chemical synaptic transmission 36.3636 5 no
GO:0099177 regulation of trans-synaptic signaling 36.3636 4 no
GO:0001932 regulation of protein phosphorylation 36.3636 7 no
GO:0001934 positive regulation of protein phosphorylation 36.3636 8 no
GO:0009893 positive regulation of metabolic process 36.3636 4 no
GO:0010562 positive regulation of phosphorus metabolic process 36.3636 6 no
GO:0010604 positive regulation of macromolecule metabolic process 36.3636 5 no
GO:0031325 positive regulation of cellular metabolic process 36.3636 5 no
GO:0031401 positive regulation of protein modification process 36.3636 7 no
GO:0042325 regulation of phosphorylation 36.3636 7 no
GO:0042327 positive regulation of phosphorylation 36.3636 8 no
GO:0045937 positive regulation of phosphate metabolic process 36.3636 7 no
GO:0051049 regulation of transport 36.3636 4 no
GO:0051247 positive regulation of protein metabolic process 36.3636 6 no
GO:0030030 cell projection organization 36.3636 4 no
GO:0034330 cell junction organization 36.3636 4 no
GO:0050807 regulation of synapse organization 36.3636 5 no
GO:0050808 synapse organization 36.3636 5 no
GO:0051130 positive regulation of cellular component organization 36.3636 5 no
GO:0009892 negative regulation of metabolic process 36.3636 4 no
GO:0010605 negative regulation of macromolecule metabolic process 36.3636 5 no
GO:0031324 negative regulation of cellular metabolic process 36.3636 5 no
GO:0009968 negative regulation of signal transduction 27.2727 5 yes
GO:0010648 negative regulation of cell communication 27.2727 5 yes
GO:0023057 negative regulation of signaling 27.2727 4 yes
GO:0030111 regulation of Wnt signaling pathway 27.2727 5 yes
GO:0048814 regulation of dendrite morphogenesis 27.2727 5 yes
GO:0050773 regulation of dendrite development 27.2727 4 yes
GO:0010243 response to organonitrogen compound 27.2727 4 no
GO:0098657 import into cell 27.2727 4 no
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 27.2727 8 no
GO:0006996 organelle organization 27.2727 4 no
GO:0007612 learning 27.2727 4 no
GO:0009967 positive regulation of signal transduction 27.2727 5 no
GO:0010647 positive regulation of cell communication 27.2727 5 no
GO:0022607 cellular component assembly 27.2727 4 no
GO:0023056 positive regulation of signaling 27.2727 4 no
GO:0031175 neuron projection development 27.2727 6 no
GO:0031644 regulation of nervous system process 27.2727 5 no
GO:0033043 regulation of organelle organization 27.2727 5 no
GO:0044057 regulation of system process 27.2727 4 no
GO:0044087 regulation of cellular component biogenesis 27.2727 4 no
GO:0048584 positive regulation of response to stimulus 27.2727 4 no
GO:0048812 neuron projection morphogenesis 27.2727 5 no
GO:0050890 cognition 27.2727 4 no
GO:0098815 modulation of excitatory postsynaptic potential 27.2727 4 no
GO:0099175 regulation of postsynapse organization 27.2727 6 no
GO:0106027 neuron projection organization 27.2727 6 no
GO:0120036 plasma membrane bounded cell projection organization 27.2727 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 27.2727 4 no
GO:1902903 regulation of supramolecular fiber organization 27.2727 5 no
GO:0009889 regulation of biosynthetic process 27.2727 4 no
GO:0009894 regulation of catabolic process 27.2727 4 no
GO:0010468 regulation of gene expression 27.2727 6 no
GO:0010556 regulation of macromolecule biosynthetic process 27.2727 5 no
GO:0031326 regulation of cellular biosynthetic process 27.2727 5 no
GO:0051248 negative regulation of protein metabolic process 27.2727 6 no
GO:0051726 regulation of cell cycle 27.2727 4 no
GO:0030178 negative regulation of Wnt signaling pathway 18.1818 6 yes
GO:0060828 regulation of canonical Wnt signaling pathway 18.1818 6 yes
GO:0090090 negative regulation of canonical Wnt signaling pathway 18.1818 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DVL1_HUMAN [view entry] [view interactions] Low throughput yes yes
RNF43_HUMAN [view interactions] Low throughput no yes
SSRD_HUMAN [view interactions] Low throughput no yes
SODC_HUMAN [view interactions] Low throughput no yes
P53_HUMAN [view interactions] Low throughput no no
TMG4_HUMAN [view interactions] High throughput no yes
GFI1B_HUMAN [view interactions] High throughput no no
UBP7_HUMAN [view interactions] High throughput no yes
CAC1A_HUMAN [view entry] [view interactions] High throughput yes no
FXL15_HUMAN [view interactions] High throughput no no
MPP8_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
VAX1_HUMAN [view interactions] High throughput no no
HECW2_HUMAN [view entry] [view interactions] High throughput yes no
LRAD4_HUMAN [view interactions] High throughput no yes
EREP3_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
TM171_HUMAN [view interactions] High throughput no yes
ILDR1_HUMAN [view interactions] High throughput no no
ZN707_HUMAN [view interactions] High throughput no yes
TMG1_HUMAN [view interactions] High throughput no no
SLN11_HUMAN [view interactions] High throughput no yes
HERC5_HUMAN [view interactions] High throughput no yes
SMUF1_HUMAN [view interactions] High throughput no yes
ACK1_HUMAN [view entry] [view interactions] High throughput yes yes
UB2D1_HUMAN [view interactions] High throughput no yes
UB2D2_HUMAN [view interactions] High throughput no yes
UB2D3_HUMAN [view interactions] High throughput no yes
UB2L3_HUMAN [view interactions] High throughput no yes
UB2J2_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
HECW1_HUMAN [view entry] [view interactions] High throughput yes yes
SCNNA_HUMAN [view interactions] High throughput no yes
SCNNB_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
PTK7_HUMAN [view interactions] High throughput no yes