Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

HECW1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in HECW1_HUMAN
GO:0031625 ubiquitin protein ligase binding 33.3333 5 no
GO:0044389 ubiquitin-like protein ligase binding 33.3333 4 no
GO:0004842 ubiquitin-protein transferase activity 25.0000 4 yes
GO:0061630 ubiquitin protein ligase activity 25.0000 5 yes
GO:0061659 ubiquitin-like protein ligase activity 25.0000 4 yes
GO:0046872 metal ion binding 25.0000 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in HECW1_HUMAN
GO:0009893 positive regulation of metabolic process 66.6667 4 yes
GO:0031344 regulation of cell projection organization 66.6667 5 yes
GO:0036211 protein modification process 66.6667 4 yes
GO:0043412 macromolecule modification 66.6667 4 yes
GO:0048523 negative regulation of cellular process 66.6667 4 yes
GO:0051128 regulation of cellular component organization 66.6667 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 66.6667 4 yes
GO:0051246 regulation of protein metabolic process 66.6667 5 yes
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 yes
GO:0080090 regulation of primary metabolic process 66.6667 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 66.6667 6 yes
GO:0006508 proteolysis 58.3333 4 yes
GO:0009057 macromolecule catabolic process 58.3333 4 yes
GO:0009894 regulation of catabolic process 58.3333 4 yes
GO:0009966 regulation of signal transduction 58.3333 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 58.3333 5 yes
GO:0010646 regulation of cell communication 58.3333 4 yes
GO:0010975 regulation of neuron projection development 58.3333 7 yes
GO:0016567 protein ubiquitination 58.3333 7 yes
GO:0019941 modification-dependent protein catabolic process 58.3333 6 yes
GO:0032446 protein modification by small protein conjugation 58.3333 6 yes
GO:0043632 modification-dependent macromolecule catabolic process 58.3333 5 yes
GO:0044265 cellular macromolecule catabolic process 58.3333 4 yes
GO:0051049 regulation of transport 58.3333 4 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 58.3333 5 yes
GO:0051247 positive regulation of protein metabolic process 58.3333 6 yes
GO:0051603 proteolysis involved in protein catabolic process 58.3333 5 yes
GO:0070647 protein modification by small protein conjugation or removal 58.3333 5 yes
GO:0009896 positive regulation of catabolic process 50.0000 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 50.0000 4 yes
GO:0042176 regulation of protein catabolic process 50.0000 5 yes
GO:0048522 positive regulation of cellular process 50.0000 4 no
GO:0022898 regulation of transmembrane transporter activity 41.6667 4 yes
GO:0032412 regulation of ion transmembrane transporter activity 41.6667 5 yes
GO:0034762 regulation of transmembrane transport 41.6667 4 yes
GO:0034765 regulation of ion transmembrane transport 41.6667 5 yes
GO:0043269 regulation of ion transport 41.6667 5 yes
GO:0045732 positive regulation of protein catabolic process 41.6667 6 yes
GO:0048585 negative regulation of response to stimulus 41.6667 4 yes
GO:1904062 regulation of cation transmembrane transport 41.6667 6 yes
GO:0031399 regulation of protein modification process 41.6667 6 no
GO:0030030 cell projection organization 41.6667 4 no
GO:0009968 negative regulation of signal transduction 33.3333 5 yes
GO:0010648 negative regulation of cell communication 33.3333 5 yes
GO:0023057 negative regulation of signaling 33.3333 4 yes
GO:0051051 negative regulation of transport 33.3333 4 yes
GO:0001932 regulation of protein phosphorylation 33.3333 7 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0019220 regulation of phosphate metabolic process 33.3333 6 no
GO:0031323 regulation of cellular metabolic process 33.3333 4 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0031401 positive regulation of protein modification process 33.3333 7 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0043549 regulation of kinase activity 33.3333 5 no
GO:0045859 regulation of protein kinase activity 33.3333 6 no
GO:0051172 negative regulation of nitrogen compound metabolic process 33.3333 5 no
GO:0051174 regulation of phosphorus metabolic process 33.3333 5 no
GO:0051338 regulation of transferase activity 33.3333 4 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0009967 positive regulation of signal transduction 33.3333 5 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:0023056 positive regulation of signaling 33.3333 4 no
GO:0032990 cell part morphogenesis 33.3333 4 no
GO:0034330 cell junction organization 33.3333 4 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0048812 neuron projection morphogenesis 33.3333 7 no
GO:0048858 cell projection morphogenesis 33.3333 5 no
GO:0050808 synapse organization 33.3333 5 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 33.3333 6 no
GO:0000209 protein polyubiquitination 25.0000 8 yes
GO:0002028 regulation of sodium ion transport 25.0000 7 yes
GO:0006511 ubiquitin-dependent protein catabolic process 25.0000 7 yes
GO:0010498 proteasomal protein catabolic process 25.0000 5 yes
GO:0010766 negative regulation of sodium ion transport 25.0000 6 yes
GO:0010959 regulation of metal ion transport 25.0000 6 yes
GO:0030111 regulation of Wnt signaling pathway 25.0000 5 yes
GO:0030163 protein catabolic process 25.0000 4 yes
GO:0030178 negative regulation of Wnt signaling pathway 25.0000 6 yes
GO:0032410 negative regulation of transporter activity 25.0000 4 yes
GO:0032413 negative regulation of ion transmembrane transporter activity 25.0000 5 yes
GO:0034763 negative regulation of transmembrane transport 25.0000 5 yes
GO:0034766 negative regulation of ion transmembrane transport 25.0000 6 yes
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 25.0000 6 yes
GO:0043271 negative regulation of ion transport 25.0000 5 yes
GO:0048814 regulation of dendrite morphogenesis 25.0000 5 yes
GO:0050773 regulation of dendrite development 25.0000 4 yes
GO:0060828 regulation of canonical Wnt signaling pathway 25.0000 6 yes
GO:0090090 negative regulation of canonical Wnt signaling pathway 25.0000 7 yes
GO:1901565 organonitrogen compound catabolic process 25.0000 4 yes
GO:1902305 regulation of sodium ion transmembrane transport 25.0000 7 yes
GO:1902306 negative regulation of sodium ion transmembrane transport 25.0000 7 yes
GO:1904063 negative regulation of cation transmembrane transport 25.0000 7 yes
GO:2000649 regulation of sodium ion transmembrane transporter activity 25.0000 6 yes
GO:2000650 negative regulation of sodium ion transmembrane transporter activity 25.0000 6 yes
GO:0001934 positive regulation of protein phosphorylation 25.0000 8 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0032880 regulation of protein localization 25.0000 5 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 no
GO:0043086 negative regulation of catalytic activity 25.0000 4 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0050807 regulation of synapse organization 25.0000 5 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0060341 regulation of cellular localization 25.0000 4 no
GO:0099175 regulation of postsynapse organization 25.0000 6 no
GO:0051726 regulation of cell cycle 25.0000 4 no
GO:0007612 learning 25.0000 4 no
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0010468 regulation of gene expression 25.0000 5 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0010941 regulation of cell death 25.0000 4 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0030162 regulation of proteolysis 25.0000 6 no
GO:0031175 neuron projection development 25.0000 6 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0031329 regulation of cellular catabolic process 25.0000 5 no
GO:0031331 positive regulation of cellular catabolic process 25.0000 6 no
GO:0031644 regulation of nervous system process 25.0000 5 no
GO:0044057 regulation of system process 25.0000 4 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0050890 cognition 25.0000 4 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0051129 negative regulation of cellular component organization 25.0000 5 no
GO:0098815 modulation of excitatory postsynaptic potential 25.0000 4 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:0106027 neuron projection organization 25.0000 6 no
GO:0120036 plasma membrane bounded cell projection organization 25.0000 5 no
GO:1901214 regulation of neuron death 25.0000 5 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:1902903 regulation of supramolecular fiber organization 25.0000 5 no
GO:2000463 positive regulation of excitatory postsynaptic potential 25.0000 5 no
GO:0006996 organelle organization 25.0000 4 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DVL1_HUMAN [view entry] [view interactions] Low throughput yes yes
RNF43_HUMAN [view interactions] Low throughput no yes
SSRD_HUMAN [view interactions] Low throughput no yes
SODC_HUMAN [view interactions] Low throughput no yes
P53_HUMAN [view interactions] Low throughput no no
TMG4_HUMAN [view interactions] High throughput no yes
GFI1B_HUMAN [view interactions] High throughput no no
UBP7_HUMAN [view interactions] High throughput no yes
CAC1A_HUMAN [view interactions] High throughput no no
FXL15_HUMAN [view interactions] High throughput no no
MPP8_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
VAX1_HUMAN [view interactions] High throughput no no
HECW2_HUMAN [view entry] [view interactions] High throughput yes no
LRAD4_HUMAN [view interactions] High throughput no yes
F189B_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
TM171_HUMAN [view interactions] High throughput no yes
ILDR1_HUMAN [view interactions] High throughput no no
ZN707_HUMAN [view interactions] High throughput no yes
TMG1_HUMAN [view interactions] High throughput no no
SLN11_HUMAN [view interactions] High throughput no yes
ACK1_HUMAN [view interactions] High throughput no yes
UB2D1_HUMAN [view interactions] High throughput no yes
UB2D2_HUMAN [view interactions] High throughput no yes
UB2D3_HUMAN [view interactions] High throughput no yes
UB2L3_HUMAN [view interactions] High throughput no yes
UB2J2_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
HECW1_HUMAN [view entry] [view interactions] High throughput yes yes
SCNNA_HUMAN [view interactions] High throughput no yes
SCNNB_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
RL40_HUMAN [view entry] [view interactions] Computational yes yes
UBB_HUMAN [view entry] [view interactions] Computational yes yes
RS27A_HUMAN [view entry] [view interactions] Computational yes yes