RIN1_HUMAN
Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in RIN1_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 32.3529 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 32.3529 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 32.3529 | 4 | no |
GO:0019900 | kinase binding | 23.5294 | 4 | no |
GO:0019901 | protein kinase binding | 23.5294 | 5 | no |
GO:0003924 | GTPase activity | 20.5882 | 7 | no |
GO:0005525 | GTP binding | 20.5882 | 5 | no |
GO:0016462 | pyrophosphatase activity | 20.5882 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 20.5882 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 20.5882 | 6 | no |
GO:0019001 | guanyl nucleotide binding | 20.5882 | 5 | no |
GO:0019003 | GDP binding | 20.5882 | 4 | no |
GO:0032561 | guanyl ribonucleotide binding | 20.5882 | 5 | no |
GO:0030695 | GTPase regulator activity | 11.7647 | 4 | yes |
GO:0005085 | guanyl-nucleotide exchange factor activity | 5.8824 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in RIN1_HUMAN |
---|---|---|---|---|
GO:0048523 | negative regulation of cellular process | 55.8824 | 4 | no |
GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 47.0588 | 4 | no |
GO:0010646 | regulation of cell communication | 44.1176 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 41.1765 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 41.1765 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 41.1765 | 4 | no |
GO:0008104 | protein localization | 41.1765 | 4 | no |
GO:0071702 | organic substance transport | 38.2353 | 4 | no |
GO:0071705 | nitrogen compound transport | 38.2353 | 4 | no |
GO:0051049 | regulation of transport | 38.2353 | 4 | no |
GO:0016192 | vesicle-mediated transport | 35.2941 | 4 | yes |
GO:0009966 | regulation of signal transduction | 35.2941 | 4 | no |
GO:0015031 | protein transport | 35.2941 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 32.3529 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 32.3529 | 5 | no |
GO:0031399 | regulation of protein modification process | 32.3529 | 6 | no |
GO:0051246 | regulation of protein metabolic process | 32.3529 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 29.4118 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 29.4118 | 6 | no |
GO:0031344 | regulation of cell projection organization | 29.4118 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 29.4118 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 26.4706 | 5 | no |
GO:0050804 | modulation of chemical synaptic transmission | 26.4706 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 26.4706 | 4 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 26.4706 | 6 | no |
GO:1902531 | regulation of intracellular signal transduction | 26.4706 | 5 | no |
GO:0006996 | organelle organization | 26.4706 | 4 | no |
GO:0033043 | regulation of organelle organization | 26.4706 | 5 | no |
GO:0006886 | intracellular protein transport | 26.4706 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 23.5294 | 7 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 23.5294 | 5 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 23.5294 | 4 | no |
GO:0042325 | regulation of phosphorylation | 23.5294 | 7 | no |
GO:0043085 | positive regulation of catalytic activity | 23.5294 | 4 | no |
GO:0051129 | negative regulation of cellular component organization | 23.5294 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 23.5294 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 23.5294 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 23.5294 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 23.5294 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 23.5294 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 23.5294 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 23.5294 | 5 | no |
GO:0010468 | regulation of gene expression | 23.5294 | 5 | no |
GO:0006897 | endocytosis | 20.5882 | 5 | yes |
GO:0009967 | positive regulation of signal transduction | 20.5882 | 5 | no |
GO:0010647 | positive regulation of cell communication | 20.5882 | 5 | no |
GO:0023056 | positive regulation of signaling | 20.5882 | 4 | no |
GO:0031401 | positive regulation of protein modification process | 20.5882 | 7 | no |
GO:0036211 | protein modification process | 20.5882 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 20.5882 | 4 | no |
GO:0043412 | macromolecule modification | 20.5882 | 4 | no |
GO:0043549 | regulation of kinase activity | 20.5882 | 5 | no |
GO:0045595 | regulation of cell differentiation | 20.5882 | 4 | no |
GO:0045859 | regulation of protein kinase activity | 20.5882 | 6 | no |
GO:0048584 | positive regulation of response to stimulus | 20.5882 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 20.5882 | 6 | no |
GO:0051338 | regulation of transferase activity | 20.5882 | 4 | no |
GO:0071310 | cellular response to organic substance | 20.5882 | 4 | no |
GO:0030100 | regulation of endocytosis | 20.5882 | 5 | no |
GO:0060627 | regulation of vesicle-mediated transport | 20.5882 | 4 | no |
GO:0032880 | regulation of protein localization | 20.5882 | 5 | no |
GO:0060341 | regulation of cellular localization | 20.5882 | 4 | no |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
RASH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
1433E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ABL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
STAM2_HUMAN | [view interactions] | Low throughput | no | yes |
EGFR_HUMAN | [view interactions] | Low throughput | no | no |
RAB5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RRAS2_HUMAN | [view interactions] | Low throughput | no | yes |
1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ABL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
EPHA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SV2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GNDS_HUMAN | [view interactions] | Low throughput | no | yes |
AFAD_HUMAN | [view interactions] | Low throughput | no | yes |
RAB5B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
1433B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
INSR_HUMAN | [view interactions] | Low throughput | no | yes |
PGFRB_HUMAN | [view interactions] | Low throughput | no | yes |
FGFR1_HUMAN | [view interactions] | Low throughput | no | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CACO2_HUMAN | [view interactions] | High throughput | no | yes |
ZWINT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
COMT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RRAS_HUMAN | [view interactions] | High throughput | no | yes |
ISCA1_HUMAN | [view interactions] | High throughput | no | yes |
ANS1A_HUMAN | [view interactions] | High throughput | no | yes |
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SH2D3_HUMAN | [view interactions] | High throughput | no | no |
NS1BP_HUMAN | [view interactions] | High throughput | no | yes |
H14_HUMAN | [view interactions] | High throughput | no | yes |
RBM10_HUMAN | [view interactions] | High throughput | no | yes |
OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
MYCBP_HUMAN | [view interactions] | High throughput | no | yes |
SPNDC_HUMAN | [view interactions] | High throughput | no | yes |
SPIN1_HUMAN | [view interactions] | High throughput | no | no |
LZTS2_HUMAN | [view interactions] | High throughput | no | no |
VINEX_HUMAN | [view interactions] | High throughput | no | no |
KLH12_HUMAN | [view interactions] | High throughput | no | no |
TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
TRI23_HUMAN | [view interactions] | High throughput | no | yes |
SC23B_HUMAN | [view interactions] | High throughput | no | yes |
TRI27_HUMAN | [view interactions] | High throughput | no | yes |
TRIM7_HUMAN | [view interactions] | High throughput | no | yes |
HSF2B_HUMAN | [view interactions] | High throughput | no | yes |
TFP11_HUMAN | [view interactions] | High throughput | no | no |
CCM2_HUMAN | [view interactions] | High throughput | no | yes |
KRT34_HUMAN | [view interactions] | High throughput | no | no |
PKHG4_HUMAN | [view interactions] | High throughput | no | no |
PICK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAR10_HUMAN | [view interactions] | High throughput | no | yes |
ZBED1_HUMAN | [view interactions] | High throughput | no | yes |
MDFI_HUMAN | [view interactions] | High throughput | no | no |
TBCD1_HUMAN | [view interactions] | High throughput | no | no |
GG6L9_HUMAN | [view interactions] | High throughput | no | no |
KR151_HUMAN | [view interactions] | High throughput | no | no |
SPRE1_HUMAN | [view interactions] | High throughput | no | yes |
EIF3F_HUMAN | [view interactions] | High throughput | no | yes |
GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HM20A_HUMAN | [view interactions] | High throughput | no | yes |
SNX17_HUMAN | [view interactions] | High throughput | no | yes |
CPNS2_HUMAN | [view interactions] | High throughput | no | no |
ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
DPP8_HUMAN | [view interactions] | High throughput | no | yes |
RAP2B_HUMAN | [view interactions] | High throughput | no | no |
ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KR131_HUMAN | [view interactions] | High throughput | no | no |
CIP4_HUMAN | [view interactions] | High throughput | no | no |
SH3R1_HUMAN | [view interactions] | High throughput | no | yes |
TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EFC4A_HUMAN | [view interactions] | High throughput | no | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TES_HUMAN | [view interactions] | High throughput | no | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
FLCN_HUMAN | [view interactions] | High throughput | no | yes |
RIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RFXK_HUMAN | [view interactions] | High throughput | no | yes |
YPEL3_HUMAN | [view interactions] | High throughput | no | yes |
PKHG7_HUMAN | [view interactions] | High throughput | no | no |
CRBB3_HUMAN | [view interactions] | High throughput | no | no |
AMZ1_HUMAN | [view interactions] | High throughput | no | no |
NT5C_HUMAN | [view interactions] | High throughput | no | yes |
HSPB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PSG11_HUMAN | [view interactions] | High throughput | no | no |
DCTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRAK2_HUMAN | [view interactions] | High throughput | no | yes |
PPARD_HUMAN | [view interactions] | High throughput | no | yes |
UBP32_HUMAN | [view interactions] | High throughput | no | yes |
UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KLH34_HUMAN | [view interactions] | High throughput | no | no |
GSTM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NPRL2_HUMAN | [view interactions] | High throughput | no | yes |
DNAI2_HUMAN | [view interactions] | High throughput | no | no |
SOLH1_HUMAN | [view interactions] | High throughput | no | no |
EFMT3_HUMAN | [view interactions] | High throughput | no | no |
KLH29_HUMAN | [view interactions] | High throughput | no | yes |
NPAS1_HUMAN | [view interactions] | High throughput | no | no |
B4GT2_HUMAN | [view interactions] | High throughput | no | no |
LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NID2_HUMAN | [view interactions] | High throughput | no | yes |
MYPT2_HUMAN | [view interactions] | High throughput | no | no |
GDIB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RAE2_HUMAN | [view interactions] | Computational | no | yes |
GDIA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RAB5C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RASM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RAE1_HUMAN | [view interactions] | Computational | no | yes |