RIN1_HUMAN
Evidence for PS localization
Functions
Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RIN1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 32.3529 | 4 | no |
| GO:0000166 | nucleotide binding | 29.4118 | 4 | no |
| GO:0017076 | purine nucleotide binding | 29.4118 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 29.4118 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.4118 | 4 | no |
| GO:0019900 | kinase binding | 26.4706 | 4 | no |
| GO:0019901 | protein kinase binding | 23.5294 | 5 | no |
| GO:0051020 | GTPase binding | 14.7059 | 4 | yes |
| GO:0031267 | small GTPase binding | 11.7647 | 5 | yes |
| GO:0005085 | guanyl-nucleotide exchange factor activity | 8.8235 | 5 | yes |
| GO:0030695 | GTPase regulator activity | 8.8235 | 4 | yes |
| GO:0005096 | GTPase activator activity | 5.8824 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RIN1_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 55.8824 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 55.8824 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 52.9412 | 4 | no |
| GO:0010646 | regulation of cell communication | 52.9412 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 44.1176 | 4 | no |
| GO:0009966 | regulation of signal transduction | 44.1176 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 44.1176 | 4 | no |
| GO:0008104 | protein localization | 38.2353 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 38.2353 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 38.2353 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 38.2353 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 38.2353 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 35.2941 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 35.2941 | 5 | no |
| GO:0031399 | regulation of protein modification process | 35.2941 | 6 | no |
| GO:0051246 | regulation of protein metabolic process | 35.2941 | 5 | no |
| GO:0010468 | regulation of gene expression | 35.2941 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 32.3529 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 32.3529 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 32.3529 | 6 | no |
| GO:0051049 | regulation of transport | 32.3529 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 32.3529 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.4118 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.4118 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 26.4706 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 26.4706 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 26.4706 | 4 | no |
| GO:0022607 | cellular component assembly | 23.5294 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 23.5294 | 7 | no |
| GO:0036211 | protein modification process | 23.5294 | 4 | no |
| GO:0043412 | macromolecule modification | 23.5294 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.5294 | 6 | no |
| GO:0071702 | organic substance transport | 23.5294 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.5294 | 7 | no |
| GO:0010648 | negative regulation of cell communication | 23.5294 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.5294 | 4 | no |
| GO:0023057 | negative regulation of signaling | 23.5294 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 23.5294 | 5 | no |
| GO:0033043 | regulation of organelle organization | 23.5294 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 23.5294 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 23.5294 | 7 | no |
| GO:0042981 | regulation of apoptotic process | 23.5294 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 23.5294 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.5294 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.5294 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 20.5882 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.5882 | 6 | no |
| GO:0006996 | organelle organization | 20.5882 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 20.5882 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.5882 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.5882 | 6 | no |
| GO:0043933 | protein-containing complex organization | 20.5882 | 4 | no |
| GO:0071705 | nitrogen compound transport | 20.5882 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 20.5882 | 8 | no |
| GO:0006355 | regulation of DNA-templated transcription | 20.5882 | 7 | no |
| GO:0006468 | protein phosphorylation | 20.5882 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 20.5882 | 4 | no |
| GO:0008284 | positive regulation of cell population proliferation | 20.5882 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 20.5882 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 20.5882 | 5 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 20.5882 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 20.5882 | 5 | no |
| GO:0016310 | phosphorylation | 20.5882 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.5882 | 5 | no |
| GO:0023056 | positive regulation of signaling | 20.5882 | 4 | no |
| GO:0030030 | cell projection organization | 20.5882 | 4 | no |
| GO:0042327 | positive regulation of phosphorylation | 20.5882 | 8 | no |
| GO:0043549 | regulation of kinase activity | 20.5882 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 20.5882 | 4 | no |
| GO:0045859 | regulation of protein kinase activity | 20.5882 | 6 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 20.5882 | 7 | no |
| GO:0048585 | negative regulation of response to stimulus | 20.5882 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.5882 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.5882 | 5 | no |
| GO:0051338 | regulation of transferase activity | 20.5882 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.5882 | 6 | no |
| GO:0141124 | intracellular signaling cassette | 20.5882 | 4 | no |
| GO:0098657 | import into cell | 17.6471 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ABL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RASH_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| 1433E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| STAM2_HUMAN | [view interactions] | Low throughput | no | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| RAB5A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RRAS2_HUMAN | [view interactions] | Low throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPHA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SV2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNDS_HUMAN | [view interactions] | Low throughput | no | yes |
| AFAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB5B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| 1433B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| INSR_HUMAN | [view interactions] | Low throughput | no | yes |
| PGFRB_HUMAN | [view interactions] | Low throughput | no | yes |
| FGFR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FLCN_HUMAN | [view interactions] | High throughput | no | yes |
| RIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFXK_HUMAN | [view interactions] | High throughput | no | yes |
| YPEL3_HUMAN | [view interactions] | High throughput | no | yes |
| PKHG7_HUMAN | [view interactions] | High throughput | no | no |
| CRBB3_HUMAN | [view interactions] | High throughput | no | no |
| AMZ1_HUMAN | [view interactions] | High throughput | no | no |
| NT5C_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSG11_HUMAN | [view interactions] | High throughput | no | no |
| DCTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAK2_HUMAN | [view interactions] | High throughput | no | yes |
| PPARD_HUMAN | [view interactions] | High throughput | no | yes |
| UBP32_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLH34_HUMAN | [view interactions] | High throughput | no | no |
| GSTM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
| INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPRL2_HUMAN | [view interactions] | High throughput | no | yes |
| DNAI2_HUMAN | [view interactions] | High throughput | no | no |
| SOLH1_HUMAN | [view interactions] | High throughput | no | no |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| KLH29_HUMAN | [view interactions] | High throughput | no | yes |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| B4GT2_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| GRB7_HUMAN | [view interactions] | High throughput | no | no |
| RB_HUMAN | [view interactions] | High throughput | no | yes |
| LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NID2_HUMAN | [view interactions] | High throughput | no | yes |
| MYPT2_HUMAN | [view interactions] | High throughput | no | no |
| DCA12_HUMAN | [view interactions] | High throughput | no | yes |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLE2_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CACO2_HUMAN | [view interactions] | High throughput | no | yes |
| ZWINT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COMT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RRAS_HUMAN | [view interactions] | High throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANS1A_HUMAN | [view interactions] | High throughput | no | yes |
| ISCA1_HUMAN | [view interactions] | High throughput | no | yes |
| SH2D3_HUMAN | [view interactions] | High throughput | no | no |
| NS1BP_HUMAN | [view interactions] | High throughput | no | yes |
| SPIN1_HUMAN | [view interactions] | High throughput | no | no |
| SPNDC_HUMAN | [view interactions] | High throughput | no | yes |
| MYCBP_HUMAN | [view interactions] | High throughput | no | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| RBM10_HUMAN | [view interactions] | High throughput | no | yes |
| H14_HUMAN | [view interactions] | High throughput | no | yes |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| VINEX_HUMAN | [view interactions] | High throughput | no | no |
| KLH12_HUMAN | [view interactions] | High throughput | no | no |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI23_HUMAN | [view interactions] | High throughput | no | yes |
| SC23B_HUMAN | [view interactions] | High throughput | no | yes |
| TRI27_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM7_HUMAN | [view interactions] | High throughput | no | yes |
| HSF2B_HUMAN | [view interactions] | High throughput | no | yes |
| TFP11_HUMAN | [view interactions] | High throughput | no | no |
| CCM2_HUMAN | [view interactions] | High throughput | no | yes |
| KRT34_HUMAN | [view interactions] | High throughput | no | no |
| PKHG4_HUMAN | [view interactions] | High throughput | no | no |
| PICK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAR10_HUMAN | [view interactions] | High throughput | no | yes |
| ZBED1_HUMAN | [view interactions] | High throughput | no | yes |
| MDFI_HUMAN | [view interactions] | High throughput | no | no |
| TBCD1_HUMAN | [view interactions] | High throughput | no | no |
| GG6L9_HUMAN | [view interactions] | High throughput | no | no |
| KR151_HUMAN | [view interactions] | High throughput | no | no |
| SPRE1_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3F_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HM20A_HUMAN | [view interactions] | High throughput | no | yes |
| SNX17_HUMAN | [view interactions] | High throughput | no | yes |
| CPNS2_HUMAN | [view interactions] | High throughput | no | no |
| ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD2_HUMAN | [view interactions] | High throughput | no | yes |
| DPP8_HUMAN | [view interactions] | High throughput | no | yes |
| RAP2B_HUMAN | [view interactions] | High throughput | no | no |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KR131_HUMAN | [view interactions] | High throughput | no | no |
| CIP4_HUMAN | [view interactions] | High throughput | no | no |
| SH3R1_HUMAN | [view interactions] | High throughput | no | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFC4A_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |