ANS1B_HUMAN
Evidence for PS localization
Functions
Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ANS1B_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 29.8507 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 29.8507 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.1045 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 22.3881 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 22.3881 | 5 | no |
| GO:0005524 | ATP binding | 21.6418 | 5 | no |
| GO:0046875 | ephrin receptor binding | 2.2388 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ANS1B_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 43.2836 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 42.5373 | 4 | no |
| GO:0010646 | regulation of cell communication | 38.0597 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 34.3284 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 32.0896 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 29.8507 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 29.8507 | 4 | no |
| GO:0009966 | regulation of signal transduction | 29.1045 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 28.3582 | 4 | no |
| GO:0006996 | organelle organization | 26.8657 | 4 | no |
| GO:0008104 | protein localization | 26.1194 | 4 | no |
| GO:0030030 | cell projection organization | 24.6269 | 4 | no |
| GO:0022607 | cellular component assembly | 23.8806 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 23.8806 | 4 | no |
| GO:0051049 | regulation of transport | 23.8806 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 23.1343 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 22.3881 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 21.6418 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 21.6418 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.8955 | 5 | no |
| GO:0010468 | regulation of gene expression | 20.1493 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 20.1493 | 5 | no |
| GO:0023056 | positive regulation of signaling | 20.1493 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 20.1493 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 20.1493 | 4 | no |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 8.9552 | 4 | yes |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 8.2090 | 5 | yes |
| GO:0048013 | ephrin receptor signaling pathway | 2.9851 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ANS1B_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 3.7313 | 3 | no |
| DOID:2476 | hereditary spastic paraplegia | 1.4925 | 5 | no |
| DOID:607 | paraplegia | 1.4925 | 4 | no |
| DOID:0090131 | complex cortical dysplasia with other brain malformations | 1.4925 | 5 | no |
| DOID:936 | brain disease | 1.4925 | 4 | no |
| DOID:0050700 | cardiomyopathy | 1.4925 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 1.4925 | 5 | no |
| DOID:114 | heart disease | 1.4925 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| COIL_HUMAN | [view interactions] | Low throughput | no | yes |
| LRP2_HUMAN | [view interactions] | Low throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EPHA8_HUMAN | [view interactions] | Low throughput | no | no |
| 5HT2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITB7_HUMAN | [view interactions] | High throughput | no | no |
| ITB3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DIDO1_HUMAN | [view interactions] | High throughput | no | yes |
| BTBDH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AT2A3_HUMAN | [view interactions] | High throughput | no | yes |
| ATLA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XPP1_HUMAN | [view interactions] | High throughput | no | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMM11_HUMAN | [view interactions] | High throughput | no | no |
| STAM1_HUMAN | [view interactions] | High throughput | no | yes |
| SYSC_HUMAN | [view interactions] | High throughput | no | yes |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHEB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTGR2_HUMAN | [view interactions] | High throughput | no | yes |
| KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPM1F_HUMAN | [view interactions] | High throughput | no | yes |
| PITM1_HUMAN | [view interactions] | High throughput | no | yes |
| C1TC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYMC_HUMAN | [view interactions] | High throughput | no | yes |
| KHDR2_HUMAN | [view interactions] | High throughput | no | yes |
| IGSF8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HS74L_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GIT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF2B_HUMAN | [view interactions] | High throughput | no | yes |
| EFR3B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX3Y_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCLK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KC1A_HUMAN | [view interactions] | High throughput | no | yes |
| CNTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNRP1_HUMAN | [view interactions] | High throughput | no | no |
| KCY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCC1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCAR2_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C1QC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C1QB_HUMAN | [view interactions] | High throughput | no | no |
| C1QA_HUMAN | [view interactions] | High throughput | no | no |
| BSN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARG33_HUMAN | [view interactions] | High throughput | no | no |
| AP3M2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADPRH_HUMAN | [view interactions] | High throughput | no | yes |
| ARP3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WASF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VWA8_HUMAN | [view interactions] | High throughput | no | yes |
| CSPG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| QCR9_HUMAN | [view interactions] | High throughput | no | no |
| UCHL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| TBB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBAL3_HUMAN | [view interactions] | High throughput | no | no |
| TOLIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TENR_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| S27A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3G2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RYR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RTCB_HUMAN | [view interactions] | High throughput | no | yes |
| RS8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NCOA3_HUMAN | [view interactions] | High throughput | no | yes |
| RAB6B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFIP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTPRZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PMM1_HUMAN | [view interactions] | High throughput | no | yes |
| PLCL1_HUMAN | [view interactions] | High throughput | no | yes |
| PITM2_HUMAN | [view interactions] | High throughput | no | yes |
| PI4KA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PFKAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODPX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PACN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OMGP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
| NDUB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C1TM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PALS2_HUMAN | [view interactions] | High throughput | no | yes |
| MPC2_HUMAN | [view interactions] | High throughput | no | yes |
| MLC1_HUMAN | [view interactions] | High throughput | no | no |
| MCCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCAB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IP3KA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYIC_HUMAN | [view interactions] | High throughput | no | yes |
| DHB12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HPLN4_HUMAN | [view interactions] | High throughput | no | no |
| HPLN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HPLN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOPC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD2AP_HUMAN | [view interactions] | High throughput | no | no |
| RIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CASS4_HUMAN | [view interactions] | High throughput | no | yes |
| HSF2B_HUMAN | [view interactions] | High throughput | no | yes |
| CBP_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| NGAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIN2_HUMAN | [view interactions] | High throughput | no | yes |
| DAB2P_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHG26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NLGN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |