C1QC_HUMAN
Evidence for PS localization
Functions
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 34 | Gly | Arg | C1qdeficiency3(C1QD3) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in C1QC_HUMAN |
|---|---|---|---|---|
| GO:0015267 | channel activity | 36.3636 | 4 | no |
| GO:0043169 | cation binding | 27.2727 | 4 | no |
| GO:0046872 | metal ion binding | 27.2727 | 5 | no |
| GO:0043168 | anion binding | 27.2727 | 4 | no |
| GO:0005216 | monoatomic ion channel activity | 27.2727 | 4 | no |
| GO:0005261 | monoatomic cation channel activity | 27.2727 | 5 | no |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 27.2727 | 4 | no |
| GO:0022836 | gated channel activity | 27.2727 | 5 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 27.2727 | 4 | no |
| GO:0046873 | metal ion transmembrane transporter activity | 27.2727 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in C1QC_HUMAN |
|---|---|---|---|---|
| GO:0048584 | positive regulation of response to stimulus | 54.5455 | 4 | yes |
| GO:0022411 | cellular component disassembly | 45.4545 | 4 | yes |
| GO:0034330 | cell junction organization | 45.4545 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 45.4545 | 4 | yes |
| GO:0002684 | positive regulation of immune system process | 36.3636 | 4 | yes |
| GO:0006958 | complement activation, classical pathway | 36.3636 | 4 | yes |
| GO:0050776 | regulation of immune response | 36.3636 | 4 | yes |
| GO:0050778 | positive regulation of immune response | 36.3636 | 5 | yes |
| GO:0050808 | synapse organization | 36.3636 | 5 | yes |
| GO:0098883 | synapse pruning | 36.3636 | 6 | yes |
| GO:0140546 | defense response to symbiont | 36.3636 | 4 | yes |
| GO:0150146 | cell junction disassembly | 36.3636 | 5 | yes |
| GO:0010646 | regulation of cell communication | 36.3636 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 36.3636 | 4 | no |
| GO:0008104 | protein localization | 36.3636 | 4 | no |
| GO:0071310 | cellular response to organic substance | 36.3636 | 4 | no |
| GO:0006811 | monoatomic ion transport | 36.3636 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 27.2727 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 27.2727 | 4 | yes |
| GO:2000026 | regulation of multicellular organismal development | 27.2727 | 4 | yes |
| GO:0002009 | morphogenesis of an epithelium | 27.2727 | 4 | no |
| GO:0009966 | regulation of signal transduction | 27.2727 | 4 | no |
| GO:0043933 | protein-containing complex organization | 27.2727 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 27.2727 | 4 | no |
| GO:0001508 | action potential | 27.2727 | 4 | no |
| GO:0006812 | monoatomic cation transport | 27.2727 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 27.2727 | 4 | no |
| GO:0022607 | cellular component assembly | 27.2727 | 4 | no |
| GO:0030001 | metal ion transport | 27.2727 | 6 | no |
| GO:0071417 | cellular response to organonitrogen compound | 27.2727 | 4 | no |
| GO:0098655 | monoatomic cation transmembrane transport | 27.2727 | 4 | no |
| GO:0098662 | inorganic cation transmembrane transport | 27.2727 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 27.2727 | 4 | no |
| GO:0002683 | negative regulation of immune system process | 18.1818 | 4 | yes |
| GO:0002761 | regulation of myeloid leukocyte differentiation | 18.1818 | 6 | yes |
| GO:0002762 | negative regulation of myeloid leukocyte differentiation | 18.1818 | 7 | yes |
| GO:0010721 | negative regulation of cell development | 18.1818 | 6 | yes |
| GO:0030852 | regulation of granulocyte differentiation | 18.1818 | 7 | yes |
| GO:0030853 | negative regulation of granulocyte differentiation | 18.1818 | 8 | yes |
| GO:0045596 | negative regulation of cell differentiation | 18.1818 | 5 | yes |
| GO:0045637 | regulation of myeloid cell differentiation | 18.1818 | 5 | yes |
| GO:0045638 | negative regulation of myeloid cell differentiation | 18.1818 | 6 | yes |
| GO:0045649 | regulation of macrophage differentiation | 18.1818 | 7 | yes |
| GO:0045650 | negative regulation of macrophage differentiation | 18.1818 | 8 | yes |
| GO:0051093 | negative regulation of developmental process | 18.1818 | 4 | yes |
| GO:0060284 | regulation of cell development | 18.1818 | 5 | yes |
| GO:1902105 | regulation of leukocyte differentiation | 18.1818 | 5 | yes |
| GO:1902106 | negative regulation of leukocyte differentiation | 18.1818 | 6 | yes |
| GO:1903706 | regulation of hemopoiesis | 18.1818 | 4 | yes |
| GO:1903707 | negative regulation of hemopoiesis | 18.1818 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| C1QA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CD33_HUMAN | [view interactions] | Low throughput | no | no |
| C1QC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| C1QB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AP2A_HUMAN | [view interactions] | High throughput | no | no |
| APOA1_HUMAN | [view interactions] | High throughput | no | no |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RYR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| F13B_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN534_HUMAN | [view interactions] | High throughput | no | no |
| PTPS_HUMAN | [view interactions] | High throughput | no | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDP1_HUMAN | [view interactions] | High throughput | no | yes |
| DDI2_HUMAN | [view interactions] | High throughput | no | no |
| CO6A1_HUMAN | [view interactions] | High throughput | no | no |
| UBP30_HUMAN | [view interactions] | High throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CO5A1_HUMAN | [view interactions] | High throughput | no | no |
| CO4A2_HUMAN | [view interactions] | High throughput | no | no |
| CO2A1_HUMAN | [view interactions] | High throughput | no | no |
| CCNB1_HUMAN | [view interactions] | High throughput | no | no |
| BANP_HUMAN | [view interactions] | High throughput | no | yes |
| COIA1_HUMAN | [view interactions] | High throughput | no | no |
| C1QRF_HUMAN | [view interactions] | High throughput | no | no |
| HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
| COEA1_HUMAN | [view interactions] | High throughput | no | no |
| CO6A2_HUMAN | [view interactions] | High throughput | no | no |
| SERPH_HUMAN | [view interactions] | High throughput | no | no |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
| PLCA_HUMAN | [view interactions] | High throughput | no | yes |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI33_HUMAN | [view interactions] | High throughput | no | yes |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| GDIR2_HUMAN | [view interactions] | High throughput | no | no |
| TENS3_HUMAN | [view interactions] | High throughput | no | no |
| PROP_HUMAN | [view interactions] | High throughput | no | no |
| LGMN_HUMAN | [view interactions] | High throughput | no | yes |
| K1C16_HUMAN | [view interactions] | High throughput | no | no |
| UAP1L_HUMAN | [view interactions] | High throughput | no | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |