C1QC_HUMAN
Evidence for PS localization
Functions
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 34 | Gly | Arg | ComplementcomponentC1qdeficiency(C1QD) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in C1QC_HUMAN |
|---|---|---|---|---|
| GO:0015267 | channel activity | 37.5000 | 4 | no |
| GO:0046872 | metal ion binding | 37.5000 | 4 | no |
| GO:0005216 | ion channel activity | 25.0000 | 4 | no |
| GO:0005261 | cation channel activity | 25.0000 | 5 | no |
| GO:0008324 | cation transmembrane transporter activity | 25.0000 | 4 | no |
| GO:0022836 | gated channel activity | 25.0000 | 5 | no |
| GO:0022890 | inorganic cation transmembrane transporter activity | 25.0000 | 4 | no |
| GO:0046873 | metal ion transmembrane transporter activity | 25.0000 | 5 | no |
| GO:0005509 | calcium ion binding | 25.0000 | 5 | no |
| GO:0019900 | kinase binding | 25.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 25.0000 | 5 | no |
| GO:0045296 | cadherin binding | 25.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in C1QC_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 62.5000 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 50.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
| GO:0022411 | cellular component disassembly | 37.5000 | 4 | yes |
| GO:0034330 | cell junction organization | 37.5000 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 37.5000 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 37.5000 | 4 | yes |
| GO:2000026 | regulation of multicellular organismal development | 37.5000 | 4 | yes |
| GO:0006811 | ion transport | 37.5000 | 4 | no |
| GO:0051049 | regulation of transport | 37.5000 | 4 | no |
| GO:0002009 | morphogenesis of an epithelium | 37.5000 | 4 | no |
| GO:0008104 | protein localization | 37.5000 | 4 | no |
| GO:0010038 | response to metal ion | 37.5000 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 37.5000 | 4 | no |
| GO:0071310 | cellular response to organic substance | 37.5000 | 4 | no |
| GO:0071417 | cellular response to organonitrogen compound | 37.5000 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 37.5000 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 37.5000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 37.5000 | 4 | no |
| GO:0010468 | regulation of gene expression | 37.5000 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 37.5000 | 4 | no |
| GO:0002683 | negative regulation of immune system process | 25.0000 | 4 | yes |
| GO:0002684 | positive regulation of immune system process | 25.0000 | 4 | yes |
| GO:0002761 | regulation of myeloid leukocyte differentiation | 25.0000 | 6 | yes |
| GO:0002762 | negative regulation of myeloid leukocyte differentiation | 25.0000 | 7 | yes |
| GO:0006958 | complement activation, classical pathway | 25.0000 | 4 | yes |
| GO:0030852 | regulation of granulocyte differentiation | 25.0000 | 7 | yes |
| GO:0030853 | negative regulation of granulocyte differentiation | 25.0000 | 8 | yes |
| GO:0045596 | negative regulation of cell differentiation | 25.0000 | 5 | yes |
| GO:0045637 | regulation of myeloid cell differentiation | 25.0000 | 5 | yes |
| GO:0045638 | negative regulation of myeloid cell differentiation | 25.0000 | 6 | yes |
| GO:0045649 | regulation of macrophage differentiation | 25.0000 | 7 | yes |
| GO:0045650 | negative regulation of macrophage differentiation | 25.0000 | 8 | yes |
| GO:0050776 | regulation of immune response | 25.0000 | 4 | yes |
| GO:0050778 | positive regulation of immune response | 25.0000 | 5 | yes |
| GO:0050808 | synapse organization | 25.0000 | 5 | yes |
| GO:0051093 | negative regulation of developmental process | 25.0000 | 4 | yes |
| GO:0098883 | synapse pruning | 25.0000 | 6 | yes |
| GO:0150146 | cell junction disassembly | 25.0000 | 5 | yes |
| GO:1902105 | regulation of leukocyte differentiation | 25.0000 | 5 | yes |
| GO:1902106 | negative regulation of leukocyte differentiation | 25.0000 | 6 | yes |
| GO:1903706 | regulation of hemopoiesis | 25.0000 | 4 | yes |
| GO:1903707 | negative regulation of hemopoiesis | 25.0000 | 5 | yes |
| GO:0006812 | cation transport | 25.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
| GO:0030001 | metal ion transport | 25.0000 | 6 | no |
| GO:0034762 | regulation of transmembrane transport | 25.0000 | 4 | no |
| GO:0034765 | regulation of ion transmembrane transport | 25.0000 | 5 | no |
| GO:0043269 | regulation of ion transport | 25.0000 | 5 | no |
| GO:0043933 | protein-containing complex organization | 25.0000 | 4 | no |
| GO:0098655 | cation transmembrane transport | 25.0000 | 4 | no |
| GO:0098660 | inorganic ion transmembrane transport | 25.0000 | 4 | no |
| GO:0098662 | inorganic cation transmembrane transport | 25.0000 | 5 | no |
| GO:0001508 | action potential | 25.0000 | 4 | no |
| GO:0003143 | embryonic heart tube morphogenesis | 25.0000 | 4 | no |
| GO:0006915 | apoptotic process | 25.0000 | 4 | no |
| GO:0014070 | response to organic cyclic compound | 25.0000 | 4 | no |
| GO:0014074 | response to purine-containing compound | 25.0000 | 5 | no |
| GO:0043279 | response to alkaloid | 25.0000 | 5 | no |
| GO:0044057 | regulation of system process | 25.0000 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.0000 | 4 | no |
| GO:0051592 | response to calcium ion | 25.0000 | 5 | no |
| GO:0060562 | epithelial tube morphogenesis | 25.0000 | 4 | no |
| GO:0071407 | cellular response to organic cyclic compound | 25.0000 | 5 | no |
| GO:0086001 | cardiac muscle cell action potential | 25.0000 | 5 | no |
| GO:0086002 | cardiac muscle cell action potential involved in contraction | 25.0000 | 6 | no |
| GO:0086064 | cell communication by electrical coupling involved in cardiac conduction | 25.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 25.0000 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 25.0000 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.0000 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0010941 | regulation of cell death | 25.0000 | 4 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 25.0000 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.0000 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 25.0000 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 25.0000 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 25.0000 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 25.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 25.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 25.0000 | 4 | no |
| GO:0030334 | regulation of cell migration | 25.0000 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 25.0000 | 4 | no |
| GO:0071702 | organic substance transport | 25.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
| GO:2000145 | regulation of cell motility | 25.0000 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| C1QA_HUMAN | [view interactions] | Low throughput | no | no |
| C1QB_HUMAN | [view interactions] | Low throughput | no | no |
| CD33_HUMAN | [view interactions] | Low throughput | no | no |
| C1QC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
| COEA1_HUMAN | [view interactions] | High throughput | no | no |
| CO6A2_HUMAN | [view interactions] | High throughput | no | no |
| SERPH_HUMAN | [view interactions] | High throughput | no | no |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
| PLCA_HUMAN | [view interactions] | High throughput | no | yes |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| KCNA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GDIR2_HUMAN | [view interactions] | High throughput | no | no |
| TENS3_HUMAN | [view interactions] | High throughput | no | no |
| PROP_HUMAN | [view interactions] | High throughput | no | no |
| LGMN_HUMAN | [view interactions] | High throughput | no | yes |
| K1C16_HUMAN | [view interactions] | High throughput | no | no |
| UAP1L_HUMAN | [view interactions] | High throughput | no | yes |
| AP2A_HUMAN | [view interactions] | High throughput | no | no |
| APOA1_HUMAN | [view interactions] | High throughput | no | no |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RYR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| F13B_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN534_HUMAN | [view interactions] | High throughput | no | no |
| PTPS_HUMAN | [view interactions] | High throughput | no | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDP1_HUMAN | [view interactions] | High throughput | no | yes |
| DDI2_HUMAN | [view interactions] | High throughput | no | no |
| CO6A1_HUMAN | [view interactions] | High throughput | no | no |
| UBP30_HUMAN | [view interactions] | High throughput | no | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CO5A1_HUMAN | [view interactions] | High throughput | no | no |
| CO4A2_HUMAN | [view interactions] | High throughput | no | no |
| CO2A1_HUMAN | [view interactions] | High throughput | no | no |
| CCNB1_HUMAN | [view interactions] | High throughput | no | no |
| BANP_HUMAN | [view interactions] | High throughput | no | yes |
| COIA1_HUMAN | [view interactions] | High throughput | no | no |
| C1QRF_HUMAN | [view interactions] | High throughput | no | no |
| VSIG4_HUMAN | [view interactions] | Computational | no | no |
| CATS_HUMAN | [view interactions] | Computational | no | no |
| CO2_HUMAN | [view interactions] | Computational | no | no |
| CSF1R_HUMAN | [view interactions] | Computational | no | yes |
| RAB28_HUMAN | [view interactions] | Computational | no | yes |
| CALR_HUMAN | [view interactions] | Computational | no | yes |
| C1S_HUMAN | [view interactions] | Computational | no | no |
| TYOBP_HUMAN | [view interactions] | Computational | no | no |
| CO4B_HUMAN | [view interactions] | Computational | no | no |
| IC1_HUMAN | [view interactions] | Computational | no | no |
| CO4A_HUMAN | [view interactions] | Computational | no | no |