C1QC_HUMAN

G2C

SynGO

SynaptomeDB

C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. [View more on UniProt]

Transmembrane

Phase separation

ELM

Phosphorylation

PFAM

Coiled coil

Anchor

Disordered

Interacting regions

Sequence

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To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

C1QC_HUMAN

C1QA_HUMAN

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C1QC_HUMAN

C1QB_HUMAN

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C1QC_HUMAN has binary interactions with 10 proteins

Download full PS network for entry.

Interacting regions

Canonical [C1QC_HUMAN]

Isoform [A0A8Q3WKR2] alignment

Isoform [A0A8Q3WKR2] sequence

Isoform [A0A8Q3WKR6] alignment

Isoform [A0A8Q3WKR6] sequence

Isoform [A0A8Q3SIZ0] alignment

Isoform [A0A8Q3SIZ0] sequence

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Position	Amino acid	Mutation	Disease	Overlap with binding region
34	Gly	Arg	C1qdeficiency3(C1QD3)	-

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

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Search:

Term	Name	%	Distance from the top of the tree	Annotated in C1QC_HUMAN
GO:0015267	channel activity	36.3636	4	no
GO:0043169	cation binding	27.2727	4	no
GO:0046872	metal ion binding	27.2727	5	no
GO:0043168	anion binding	27.2727	4	no
GO:0005216	monoatomic ion channel activity	27.2727	4	no
GO:0005261	monoatomic cation channel activity	27.2727	5	no
GO:0008324	monoatomic cation transmembrane transporter activity	27.2727	4	no
GO:0022836	gated channel activity	27.2727	5	no
GO:0022890	inorganic cation transmembrane transporter activity	27.2727	4	no
GO:0046873	metal ion transmembrane transporter activity	27.2727	5	no

Showing 1 to 10 of 10 entries

Biological process

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Search:

Term	Name	%	Distance from top the of the tree	Annotated in C1QC_HUMAN
GO:0048584	positive regulation of response to stimulus	54.5455	4	yes
GO:0022411	cellular component disassembly	45.4545	4	yes
GO:0034330	cell junction organization	45.4545	4	yes
GO:0048523	negative regulation of cellular process	45.4545	4	yes
GO:0002684	positive regulation of immune system process	36.3636	4	yes
GO:0006958	complement activation, classical pathway	36.3636	4	yes
GO:0050776	regulation of immune response	36.3636	4	yes
GO:0050778	positive regulation of immune response	36.3636	5	yes
GO:0050808	synapse organization	36.3636	5	yes
GO:0098883	synapse pruning	36.3636	6	yes
GO:0140546	defense response to symbiont	36.3636	4	yes
GO:0150146	cell junction disassembly	36.3636	5	yes
GO:0010646	regulation of cell communication	36.3636	4	no
GO:0048522	positive regulation of cellular process	36.3636	4	no
GO:0008104	protein localization	36.3636	4	no
GO:0071310	cellular response to organic substance	36.3636	4	no
GO:0006811	monoatomic ion transport	36.3636	4	no
GO:0045595	regulation of cell differentiation	27.2727	4	yes
GO:0051241	negative regulation of multicellular organismal process	27.2727	4	yes
GO:2000026	regulation of multicellular organismal development	27.2727	4	yes
GO:0002009	morphogenesis of an epithelium	27.2727	4	no
GO:0009966	regulation of signal transduction	27.2727	4	no
GO:0043933	protein-containing complex organization	27.2727	4	no
GO:0060255	regulation of macromolecule metabolic process	27.2727	4	no
GO:0001508	action potential	27.2727	4	no

Showing 1 to 25 of 50 entries

Disease

No data found.

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Search:

Uniprot ID	Details	Highest evidence	Localizing into PSD	HPA (protein expression in neurons)
ANS1B_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
AP2A_HUMAN	[view interactions]	High throughput	no	no
APOA1_HUMAN	[view interactions]	High throughput	no	no
BANP_HUMAN	[view interactions]	High throughput	no	yes
BIP_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
C1QA_HUMAN	[view entry] [view interactions]	Low throughput	yes	no
C1QB_HUMAN	[view entry] [view interactions]	Low throughput	yes	no
C1QC_HUMAN	[view entry] [view interactions]	Low throughput	yes	yes
C1QRF_HUMAN	[view interactions]	High throughput	no	no
CCNB1_HUMAN	[view interactions]	High throughput	no	no
CCR1_HUMAN	[view interactions]	High throughput	no	no
CD33_HUMAN	[view interactions]	Low throughput	no	no
CO2A1_HUMAN	[view interactions]	High throughput	no	no
CO4A2_HUMAN	[view interactions]	High throughput	no	no
CO5A1_HUMAN	[view interactions]	High throughput	no	no
CO6A1_HUMAN	[view interactions]	High throughput	no	no
CO6A2_HUMAN	[view interactions]	High throughput	no	no
COEA1_HUMAN	[view interactions]	High throughput	no	no
COIA1_HUMAN	[view interactions]	High throughput	no	no
CXA1_HUMAN	[view entry] [view interactions]	High throughput	yes	yes
DDI2_HUMAN	[view interactions]	High throughput	no	no
F13B_HUMAN	[view interactions]	High throughput	no	no
FACD2_HUMAN	[view interactions]	High throughput	no	no
FINC_HUMAN	[view interactions]	High throughput	no	yes
GDIR2_HUMAN	[view interactions]	High throughput	no	no

Showing 1 to 25 of 50 entries

C1QC_HUMAN

Evidence for PS localization

Functions

Protein features

Binary interactions with known binding regions

Network

Isoforms

Disease-causing germline mutations

Linear motifs

Fingerprint

Molecular function

Biological process

Disease

All partners