C1QA_HUMAN
Evidence for PS localization
Functions
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. [View more on UniProt]
Protein features
Transmembrane
Phase separation
ELM
Phosphorylation
PFAM
Coiled coil
Anchor
Disordered
Interacting regions
Sequence
LOADING 46%
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
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C1QA_HUMAN has binary interactions with 18 proteins
Isoforms
Interacting regions
Canonical [C1QA_HUMAN]
Isoform [X6RLJ0] alignment
Isoform [A0A8Q3SI41] alignment
Isoform [A0A8Q3SI63] alignment
Isoform [A0A8Q3SI59] alignment
Isoform [A0A8Q3SI02] alignment
Isoform [A0A8Q3SI08] alignment
LOADING 34%
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
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Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in C1QA_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 47.3684 | 4 | no |
| GO:0046872 | metal ion binding | 47.3684 | 5 | no |
| GO:0000166 | nucleotide binding | 21.0526 | 4 | no |
| GO:0017076 | purine nucleotide binding | 21.0526 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 21.0526 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.0526 | 4 | no |
| GO:0043168 | anion binding | 21.0526 | 4 | no |
| GO:0019900 | kinase binding | 21.0526 | 4 | no |
| GO:0019901 | protein kinase binding | 21.0526 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in C1QA_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 57.8947 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 47.3684 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 47.3684 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 42.1053 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 42.1053 | 4 | no |
| GO:0010646 | regulation of cell communication | 36.8421 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 36.8421 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.8421 | 4 | no |
| GO:0051049 | regulation of transport | 36.8421 | 4 | no |
| GO:0002684 | positive regulation of immune system process | 36.8421 | 4 | yes |
| GO:0050776 | regulation of immune response | 36.8421 | 4 | yes |
| GO:0006996 | organelle organization | 36.8421 | 4 | no |
| GO:0009966 | regulation of signal transduction | 36.8421 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 31.5789 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 31.5789 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 31.5789 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.5789 | 5 | no |
| GO:0022607 | cellular component assembly | 31.5789 | 4 | no |
| GO:0030334 | regulation of cell migration | 31.5789 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 31.5789 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 31.5789 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 31.5789 | 4 | no |
| GO:2000145 | regulation of cell motility | 31.5789 | 4 | no |
| GO:0050778 | positive regulation of immune response | 31.5789 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 31.5789 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACOX3_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APOA1_HUMAN | [view interactions] | High throughput | no | no |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMP1_HUMAN | [view interactions] | Low throughput | no | yes |
| C1QB_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| C1QC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| C1R_HUMAN | [view interactions] | Low throughput | no | no |
| C1S_HUMAN | [view interactions] | Low throughput | no | no |
| CD33_HUMAN | [view interactions] | Low throughput | no | no |
| CNTP3_HUMAN | [view interactions] | High throughput | no | yes |
| CRP_HUMAN | [view interactions] | Low throughput | no | no |
| CTU2_HUMAN | [view interactions] | High throughput | no | yes |
| DD19B_HUMAN | [view interactions] | High throughput | no | yes |
| ENPP1_HUMAN | [view interactions] | High throughput | no | yes |
| EST3_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | Low throughput | no | yes |
| FUT11_HUMAN | [view interactions] | High throughput | no | yes |
| FZD1_HUMAN | [view interactions] | High throughput | no | yes |
| FZD2_HUMAN | [view interactions] | High throughput | no | no |
| FZD4_HUMAN | [view interactions] | High throughput | no | yes |
| FZD7_HUMAN | [view interactions] | High throughput | no | yes |
| FZD8_HUMAN | [view interactions] | High throughput | no | yes |