Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

C1QA_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in C1QA_HUMAN
GO:0043169 cation binding 47.3684 4 no
GO:0046872 metal ion binding 47.3684 5 no
GO:0000166 nucleotide binding 21.0526 4 no
GO:0017076 purine nucleotide binding 21.0526 5 no
GO:0032555 purine ribonucleotide binding 21.0526 4 no
GO:0035639 purine ribonucleoside triphosphate binding 21.0526 4 no
GO:0043168 anion binding 21.0526 4 no
GO:0019900 kinase binding 21.0526 4 no
GO:0019901 protein kinase binding 21.0526 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in C1QA_HUMAN
GO:0048522 positive regulation of cellular process 57.8947 4 no
GO:0051128 regulation of cellular component organization 47.3684 4 no
GO:0048584 positive regulation of response to stimulus 47.3684 4 yes
GO:0060255 regulation of macromolecule metabolic process 42.1053 4 no
GO:0048523 negative regulation of cellular process 42.1053 4 no
GO:0010646 regulation of cell communication 36.8421 4 no
GO:0031323 regulation of cellular metabolic process 36.8421 4 no
GO:0080090 regulation of primary metabolic process 36.8421 4 no
GO:0051049 regulation of transport 36.8421 4 no
GO:0002684 positive regulation of immune system process 36.8421 4 yes
GO:0050776 regulation of immune response 36.8421 4 yes
GO:0006996 organelle organization 36.8421 4 no
GO:0009966 regulation of signal transduction 36.8421 4 no
GO:0031326 regulation of cellular biosynthetic process 31.5789 5 no
GO:0051246 regulation of protein metabolic process 31.5789 5 no
GO:0009892 negative regulation of metabolic process 31.5789 4 no
GO:0010605 negative regulation of macromolecule metabolic process 31.5789 5 no
GO:0022607 cellular component assembly 31.5789 4 no
GO:0030334 regulation of cell migration 31.5789 5 no
GO:0051130 positive regulation of cellular component organization 31.5789 5 no
GO:0051240 positive regulation of multicellular organismal process 31.5789 4 no
GO:2000026 regulation of multicellular organismal development 31.5789 4 no
GO:2000145 regulation of cell motility 31.5789 4 no
GO:0050778 positive regulation of immune response 31.5789 5 yes
GO:0009889 regulation of biosynthetic process 31.5789 4 no
GO:0010468 regulation of gene expression 31.5789 6 no
GO:0010556 regulation of macromolecule biosynthetic process 31.5789 5 no
GO:0010647 positive regulation of cell communication 26.3158 5 no
GO:0023056 positive regulation of signaling 26.3158 4 no
GO:0036211 protein modification process 26.3158 4 no
GO:0043412 macromolecule modification 26.3158 4 no
GO:0008104 protein localization 26.3158 4 no
GO:0009893 positive regulation of metabolic process 26.3158 4 no
GO:0051094 positive regulation of developmental process 26.3158 4 no
GO:0060341 regulation of cellular localization 26.3158 4 no
GO:0071310 cellular response to organic substance 26.3158 4 no
GO:1902531 regulation of intracellular signal transduction 26.3158 5 no
GO:0034330 cell junction organization 26.3158 4 yes
GO:0050808 synapse organization 26.3158 5 yes
GO:0030030 cell projection organization 26.3158 4 no
GO:0009894 regulation of catabolic process 26.3158 4 no
GO:0009967 positive regulation of signal transduction 26.3158 5 no
GO:0042981 regulation of apoptotic process 21.0526 5 no
GO:0043067 regulation of programmed cell death 21.0526 4 no
GO:0007167 enzyme-linked receptor protein signaling pathway 21.0526 4 no
GO:0009890 negative regulation of biosynthetic process 21.0526 5 no
GO:0009896 positive regulation of catabolic process 21.0526 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 21.0526 6 no
GO:0010604 positive regulation of macromolecule metabolic process 21.0526 5 no
GO:0010632 regulation of epithelial cell migration 21.0526 4 no
GO:0010634 positive regulation of epithelial cell migration 21.0526 5 no
GO:0022603 regulation of anatomical structure morphogenesis 21.0526 4 no
GO:0022604 regulation of cell morphogenesis 21.0526 5 no
GO:0030155 regulation of cell adhesion 21.0526 4 no
GO:0030335 positive regulation of cell migration 21.0526 6 no
GO:0031324 negative regulation of cellular metabolic process 21.0526 5 no
GO:0031327 negative regulation of cellular biosynthetic process 21.0526 6 no
GO:0032101 regulation of response to external stimulus 21.0526 4 no
GO:0032880 regulation of protein localization 21.0526 5 no
GO:0033043 regulation of organelle organization 21.0526 5 no
GO:0040017 positive regulation of locomotion 21.0526 4 no
GO:0044087 regulation of cellular component biogenesis 21.0526 4 no
GO:0045595 regulation of cell differentiation 21.0526 4 no
GO:0050807 regulation of synapse organization 21.0526 5 no
GO:0051050 positive regulation of transport 21.0526 4 no
GO:0051247 positive regulation of protein metabolic process 21.0526 6 no
GO:0051960 regulation of nervous system development 21.0526 5 no
GO:0060284 regulation of cell development 21.0526 5 no
GO:0060627 regulation of vesicle-mediated transport 21.0526 4 no
GO:0080134 regulation of response to stress 21.0526 4 no
GO:0141124 intracellular signaling cassette 21.0526 4 no
GO:1901701 cellular response to oxygen-containing compound 21.0526 4 no
GO:2000147 positive regulation of cell motility 21.0526 5 no
GO:0022411 cellular component disassembly 21.0526 4 yes
GO:0007411 axon guidance 21.0526 8 no
GO:0031175 neuron projection development 21.0526 6 no
GO:0097485 neuron projection guidance 21.0526 7 no
GO:0120036 plasma membrane bounded cell projection organization 21.0526 5 no
GO:0006796 phosphate-containing compound metabolic process 21.0526 4 no
GO:0010038 response to metal ion 21.0526 4 no
GO:0006958 complement activation, classical pathway 15.7895 4 yes
GO:0098883 synapse pruning 15.7895 6 yes
GO:0140546 defense response to symbiont 15.7895 4 yes
GO:0150146 cell junction disassembly 15.7895 5 yes
GO:0042116 macrophage activation 10.5263 4 yes
GO:0048143 astrocyte activation 10.5263 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
C1QB_HUMAN [view entry] [view interactions] Low throughput yes no
C1QC_HUMAN [view entry] [view interactions] Low throughput yes yes
LRP1_HUMAN [view entry] [view interactions] Low throughput yes yes
CD33_HUMAN [view interactions] Low throughput no no
BMP1_HUMAN [view interactions] Low throughput no yes
C1S_HUMAN [view interactions] Low throughput no no
C1R_HUMAN [view interactions] Low throughput no no
CRP_HUMAN [view interactions] Low throughput no no
PGS2_HUMAN [view interactions] Low throughput no no
FINC_HUMAN [view interactions] Low throughput no yes
HIPK3_HUMAN [view interactions] High throughput no yes
SGTA_HUMAN [view interactions] High throughput no yes
BAG6_HUMAN [view entry] [view interactions] High throughput yes yes
UBQL1_HUMAN [view interactions] High throughput no yes
UBQL2_HUMAN [view interactions] High throughput no yes
S2547_HUMAN [view interactions] High throughput no no
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
HSPB2_HUMAN [view interactions] High throughput no yes
HMGB1_HUMAN [view interactions] High throughput no yes
FZD8_HUMAN [view interactions] High throughput no yes
FZD1_HUMAN [view interactions] High throughput no yes
FZD4_HUMAN [view interactions] High throughput no yes
FZD7_HUMAN [view interactions] High throughput no yes
FZD2_HUMAN [view interactions] High throughput no no
KPCE_HUMAN [view entry] [view interactions] High throughput yes yes
APOA1_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
PIAS2_HUMAN [view interactions] High throughput no yes
GNA1_HUMAN [view interactions] High throughput no no
SGTB_HUMAN [view interactions] High throughput no yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
NLGN3_HUMAN [view entry] [view interactions] High throughput yes yes
UBP40_HUMAN [view interactions] High throughput no yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
FACD2_HUMAN [view interactions] High throughput no no
TBA4A_HUMAN [view entry] [view interactions] High throughput yes yes
MANBA_HUMAN [view interactions] High throughput no yes
NPTX1_HUMAN [view entry] [view interactions] High throughput yes yes
RN5A_HUMAN [view interactions] High throughput no yes
PLOD2_HUMAN [view interactions] High throughput no yes
CNTP3_HUMAN [view interactions] High throughput no yes
INSR_HUMAN [view interactions] High throughput no yes
ITAV_HUMAN [view interactions] High throughput no yes
MRC2_HUMAN [view interactions] High throughput no yes
T132A_HUMAN [view interactions] High throughput no yes
ACOX3_HUMAN [view interactions] High throughput no yes
PISD_HUMAN [view interactions] High throughput no yes
TBB8_HUMAN [view interactions] High throughput no no
PLXA2_HUMAN [view entry] [view interactions] High throughput yes yes
P3H3_HUMAN [view interactions] High throughput no yes
TBB3_HUMAN [view entry] [view interactions] High throughput yes yes
WNT5A_HUMAN [view entry] [view interactions] High throughput yes no
PGLT1_HUMAN [view interactions] High throughput no no
MP2K6_HUMAN [view interactions] High throughput no yes
NRP2_HUMAN [view entry] [view interactions] High throughput yes yes
SUSD1_HUMAN [view interactions] High throughput no no
FUT11_HUMAN [view interactions] High throughput no yes
NELFA_HUMAN [view interactions] High throughput no yes
SE1L1_HUMAN [view interactions] High throughput no yes
ITA7_HUMAN [view interactions] High throughput no yes
ITA4_HUMAN [view interactions] High throughput no no
UBP30_HUMAN [view interactions] High throughput no yes
DD19B_HUMAN [view interactions] High throughput no yes
LYOX_HUMAN [view interactions] High throughput no no
PLOD3_HUMAN [view interactions] High throughput no yes
ENPP1_HUMAN [view interactions] High throughput no yes
TECT2_HUMAN [view interactions] High throughput no yes
EST3_HUMAN [view interactions] High throughput no yes
CTU2_HUMAN [view interactions] High throughput no yes
GT252_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
SYT17_HUMAN [view entry] [view interactions] High throughput yes no