NLGN3_HUMAN
Evidence for PS localization
Functions
Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 451 | Arg | Cys | Aspergersyndrome,X-linked,1(ASPGX1) | - |
| 451 | Arg | Cys | Autism,X-linked1(AUTSX1) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in NLGN3_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 29.7297 | 4 | no |
| GO:0019901 | protein kinase binding | 24.3243 | 5 | no |
| GO:0046872 | metal ion binding | 24.3243 | 4 | no |
| GO:0042043 | neurexin family protein binding | 16.2162 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NLGN3_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 59.4595 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 59.4595 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 51.3514 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 45.9459 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 43.2432 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 43.2432 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 43.2432 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 40.5405 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 37.8378 | 6 | yes |
| GO:0010647 | positive regulation of cell communication | 37.8378 | 5 | yes |
| GO:0016192 | vesicle-mediated transport | 37.8378 | 4 | yes |
| GO:0022607 | cellular component assembly | 37.8378 | 4 | yes |
| GO:0023056 | positive regulation of signaling | 37.8378 | 4 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 37.8378 | 5 | yes |
| GO:0008104 | protein localization | 37.8378 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 35.1351 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 35.1351 | 4 | yes |
| GO:0051049 | regulation of transport | 35.1351 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 35.1351 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.1351 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 35.1351 | 4 | no |
| GO:0034330 | cell junction organization | 32.4324 | 4 | yes |
| GO:0050808 | synapse organization | 32.4324 | 5 | yes |
| GO:0050890 | cognition | 32.4324 | 4 | yes |
| GO:0007612 | learning | 29.7297 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 29.7297 | 4 | yes |
| GO:0061024 | membrane organization | 29.7297 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 29.7297 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 29.7297 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 29.7297 | 5 | no |
| GO:0031644 | regulation of nervous system process | 27.0270 | 5 | yes |
| GO:0043269 | regulation of ion transport | 27.0270 | 5 | yes |
| GO:0044057 | regulation of system process | 27.0270 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 27.0270 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 27.0270 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.0270 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 27.0270 | 5 | no |
| GO:0071702 | organic substance transport | 24.3243 | 4 | no |
| GO:0071705 | nitrogen compound transport | 24.3243 | 4 | no |
| GO:0007158 | neuron cell-cell adhesion | 24.3243 | 4 | yes |
| GO:0034762 | regulation of transmembrane transport | 24.3243 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 24.3243 | 4 | yes |
| GO:0071709 | membrane assembly | 24.3243 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 24.3243 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 24.3243 | 6 | no |
| GO:0043113 | receptor clustering | 24.3243 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 24.3243 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.3243 | 6 | no |
| GO:0072657 | protein localization to membrane | 24.3243 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 24.3243 | 5 | no |
| GO:0023057 | negative regulation of signaling | 24.3243 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.6216 | 5 | no |
| GO:0001941 | postsynaptic membrane organization | 21.6216 | 5 | yes |
| GO:0007416 | synapse assembly | 21.6216 | 6 | yes |
| GO:0034329 | cell junction assembly | 21.6216 | 5 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 21.6216 | 5 | yes |
| GO:0050807 | regulation of synapse organization | 21.6216 | 5 | yes |
| GO:0051050 | positive regulation of transport | 21.6216 | 4 | yes |
| GO:0051960 | regulation of nervous system development | 21.6216 | 5 | yes |
| GO:0097104 | postsynaptic membrane assembly | 21.6216 | 6 | yes |
| GO:0098815 | modulation of excitatory postsynaptic potential | 21.6216 | 4 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 21.6216 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 21.6216 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 21.6216 | 7 | no |
| GO:0043085 | positive regulation of catalytic activity | 21.6216 | 4 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 21.6216 | 7 | no |
| GO:0033043 | regulation of organelle organization | 21.6216 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 21.6216 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 21.6216 | 5 | no |
| GO:0006897 | endocytosis | 18.9189 | 5 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 18.9189 | 4 | yes |
| GO:0032412 | regulation of ion transmembrane transporter activity | 18.9189 | 5 | yes |
| GO:0044089 | positive regulation of cellular component biogenesis | 18.9189 | 5 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 18.9189 | 5 | yes |
| GO:0051962 | positive regulation of nervous system development | 18.9189 | 5 | yes |
| GO:0051966 | regulation of synaptic transmission, glutamatergic | 18.9189 | 6 | yes |
| GO:0097090 | presynaptic membrane organization | 18.9189 | 5 | yes |
| GO:0097105 | presynaptic membrane assembly | 18.9189 | 6 | yes |
| GO:0099601 | regulation of neurotransmitter receptor activity | 18.9189 | 4 | yes |
| GO:1904062 | regulation of cation transmembrane transport | 18.9189 | 6 | yes |
| GO:2000463 | positive regulation of excitatory postsynaptic potential | 18.9189 | 5 | yes |
| GO:0048488 | synaptic vesicle endocytosis | 16.2162 | 5 | yes |
| GO:0051963 | regulation of synapse assembly | 16.2162 | 6 | yes |
| GO:0051965 | positive regulation of synapse assembly | 16.2162 | 6 | yes |
| GO:0099003 | vesicle-mediated transport in synapse | 16.2162 | 5 | yes |
| GO:0099054 | presynapse assembly | 16.2162 | 5 | yes |
| GO:0099172 | presynapse organization | 16.2162 | 4 | yes |
| GO:0140238 | presynaptic endocytosis | 16.2162 | 4 | yes |
| GO:1901888 | regulation of cell junction assembly | 16.2162 | 5 | yes |
| GO:1901890 | positive regulation of cell junction assembly | 16.2162 | 6 | yes |
| GO:2001257 | regulation of cation channel activity | 16.2162 | 6 | yes |
| GO:0043270 | positive regulation of ion transport | 13.5135 | 5 | yes |
| GO:0051968 | positive regulation of synaptic transmission, glutamatergic | 13.5135 | 6 | yes |
| GO:2000311 | regulation of AMPA receptor activity | 13.5135 | 5 | yes |
| GO:0002087 | regulation of respiratory gaseous exchange by nervous system process | 10.8108 | 4 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 10.8108 | 5 | yes |
| GO:0043576 | regulation of respiratory gaseous exchange | 10.8108 | 4 | yes |
| GO:0044065 | regulation of respiratory system process | 10.8108 | 5 | yes |
| GO:0060078 | regulation of postsynaptic membrane potential | 10.8108 | 4 | yes |
| GO:0006898 | receptor-mediated endocytosis | 8.1081 | 6 | yes |
| GO:0034767 | positive regulation of ion transmembrane transport | 8.1081 | 6 | yes |
| GO:1904064 | positive regulation of cation transmembrane transport | 8.1081 | 7 | yes |
| GO:1990138 | neuron projection extension | 8.1081 | 4 | yes |
| GO:0032411 | positive regulation of transporter activity | 5.4054 | 4 | yes |
| GO:0032414 | positive regulation of ion transmembrane transporter activity | 5.4054 | 5 | yes |
| GO:0048675 | axon extension | 5.4054 | 5 | yes |
| GO:0060024 | rhythmic synaptic transmission | 5.4054 | 6 | yes |
| GO:0060080 | inhibitory postsynaptic potential | 5.4054 | 5 | yes |
| GO:2000273 | positive regulation of signaling receptor activity | 5.4054 | 4 | yes |
| GO:2000969 | positive regulation of AMPA receptor activity | 5.4054 | 5 | yes |
| GO:2001259 | positive regulation of cation channel activity | 5.4054 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ACOT2_HUMAN | [view interactions] | Low throughput | no | yes |
| NADC_HUMAN | [view interactions] | Low throughput | no | yes |
| IPRI_HUMAN | [view interactions] | Low throughput | no | no |
| TPRA1_HUMAN | [view interactions] | Low throughput | no | yes |
| PTPRD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NRX1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| RPGF4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NLGN3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| APBA1_HUMAN | [view interactions] | Low throughput | no | no |
| APBA2_HUMAN | [view interactions] | Low throughput | no | yes |
| COX2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FLNA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CP11A_HUMAN | [view interactions] | Low throughput | no | no |
| FKB1A_HUMAN | [view interactions] | High throughput | no | yes |
| PLCB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAP_HUMAN | [view interactions] | High throughput | no | yes |
| NFAC4_HUMAN | [view interactions] | High throughput | no | yes |
| CA122_HUMAN | [view interactions] | High throughput | no | no |
| KGUA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSRD_HUMAN | [view interactions] | High throughput | no | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPB1_HUMAN | [view interactions] | High throughput | no | no |
| ATF4_HUMAN | [view interactions] | High throughput | no | no |
| CATD_HUMAN | [view interactions] | High throughput | no | yes |
| LEG1_HUMAN | [view interactions] | High throughput | no | yes |
| NRDC_HUMAN | [view interactions] | High throughput | no | no |
| PSG4_HUMAN | [view interactions] | High throughput | no | no |
| PSG5_HUMAN | [view interactions] | High throughput | no | no |
| PSG11_HUMAN | [view interactions] | High throughput | no | no |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OAZ1_HUMAN | [view interactions] | High throughput | no | yes |
| FANCG_HUMAN | [view interactions] | High throughput | no | yes |
| GDF15_HUMAN | [view interactions] | High throughput | no | no |
| SYQ_HUMAN | [view interactions] | High throughput | no | yes |
| EFS_HUMAN | [view interactions] | High throughput | no | no |
| SPAG5_HUMAN | [view interactions] | High throughput | no | yes |
| TXNIP_HUMAN | [view interactions] | High throughput | no | no |
| FBLN1_HUMAN | [view interactions] | High throughput | no | yes |
| MA2C1_HUMAN | [view interactions] | High throughput | no | no |
| TNNT3_HUMAN | [view interactions] | High throughput | no | no |
| PSG1_HUMAN | [view interactions] | High throughput | no | no |
| FHOD1_HUMAN | [view interactions] | High throughput | no | no |
| TRI33_HUMAN | [view interactions] | High throughput | no | yes |
| C1QA_HUMAN | [view interactions] | High throughput | no | no |
| MAP1S_HUMAN | [view interactions] | High throughput | no | no |
| PSG3_HUMAN | [view interactions] | High throughput | no | no |
| CCAR2_HUMAN | [view interactions] | High throughput | no | yes |
| DPEP2_HUMAN | [view interactions] | High throughput | no | no |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HID1_HUMAN | [view interactions] | High throughput | no | yes |
| MIEN1_HUMAN | [view interactions] | High throughput | no | no |
| EBPL_HUMAN | [view interactions] | High throughput | no | no |
| PLB1_HUMAN | [view interactions] | High throughput | no | no |
| SPIT1_HUMAN | [view interactions] | High throughput | no | yes |
| IPKB_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| NLGNX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NLGNY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NLGN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NLGN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NLRX1_HUMAN | [view interactions] | High throughput | no | yes |
| TCAF2_HUMAN | [view interactions] | High throughput | no | no |
| UTP15_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| PK3CB_HUMAN | [view interactions] | High throughput | no | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM39A_HUMAN | [view interactions] | High throughput | no | yes |
| P55G_HUMAN | [view interactions] | High throughput | no | yes |
| P85A_HUMAN | [view interactions] | High throughput | no | yes |
| T131L_HUMAN | [view interactions] | High throughput | no | yes |
| TYK2_HUMAN | [view interactions] | High throughput | no | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| ACK1_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XPR1_HUMAN | [view interactions] | High throughput | no | yes |
| ACES_HUMAN | [view interactions] | High throughput | no | no |
| TGFR1_HUMAN | [view interactions] | High throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYFP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| APCL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AKT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLE5_HUMAN | [view interactions] | High throughput | no | no |
| COBL_HUMAN | [view interactions] | High throughput | no | yes |
| TDRD7_HUMAN | [view interactions] | High throughput | no | yes |
| RFOX2_HUMAN | [view interactions] | High throughput | no | yes |
| PICK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZEP1_HUMAN | [view interactions] | High throughput | no | yes |
| FBLN3_HUMAN | [view interactions] | High throughput | no | no |
| DLG3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| CGB7_HUMAN | [view interactions] | High throughput | no | no |
| CGB3_HUMAN | [view interactions] | High throughput | no | no |
| GRM1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GRM5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| DLGP2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SNTG2_HUMAN | [view interactions] | Computational | no | no |
| SHAN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NRX2A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NRX3A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SHAN1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |