Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

DLG3_HUMAN

Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. [View more on UniProt]

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in DLG3_HUMAN
GO:0019900 kinase binding 22.4299 4 yes
GO:0017076 purine nucleotide binding 22.4299 4 no
GO:0032555 purine ribonucleotide binding 21.4953 4 no
GO:0035639 purine ribonucleoside triphosphate binding 21.4953 4 no
GO:0046872 metal ion binding 21.4953 4 no
GO:0008324 cation transmembrane transporter activity 20.5607 4 no
GO:0022890 inorganic cation transmembrane transporter activity 20.5607 4 no
GO:0019902 phosphatase binding 9.3458 4 yes
GO:0031625 ubiquitin protein ligase binding 5.6075 5 yes
GO:0044389 ubiquitin-like protein ligase binding 5.6075 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DLG3_HUMAN
GO:0048522 positive regulation of cellular process 63.5514 4 yes
GO:0010646 regulation of cell communication 61.6822 4 no
GO:0009966 regulation of signal transduction 52.3364 4 no
GO:0050804 modulation of chemical synaptic transmission 42.9907 5 no
GO:0099177 regulation of trans-synaptic signaling 42.9907 4 no
GO:0048523 negative regulation of cellular process 41.1215 4 yes
GO:0008104 protein localization 39.2523 4 yes
GO:0060255 regulation of macromolecule metabolic process 39.2523 4 yes
GO:0051049 regulation of transport 39.2523 4 no
GO:0031323 regulation of cellular metabolic process 38.3178 4 yes
GO:0080090 regulation of primary metabolic process 37.3832 4 yes
GO:0051128 regulation of cellular component organization 36.4486 4 no
GO:0051171 regulation of nitrogen compound metabolic process 35.5140 4 yes
GO:0023056 positive regulation of signaling 34.5794 4 no
GO:0022607 cellular component assembly 34.5794 4 no
GO:0010647 positive regulation of cell communication 33.6449 5 no
GO:0009893 positive regulation of metabolic process 31.7757 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 29.9065 5 yes
GO:0043269 regulation of ion transport 29.9065 5 no
GO:0044057 regulation of system process 28.9720 4 no
GO:0051246 regulation of protein metabolic process 28.0374 5 yes
GO:0031325 positive regulation of cellular metabolic process 27.1028 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 26.1682 5 yes
GO:0034762 regulation of transmembrane transport 26.1682 4 no
GO:0034765 regulation of ion transmembrane transport 26.1682 5 no
GO:0010468 regulation of gene expression 26.1682 5 no
GO:1902531 regulation of intracellular signal transduction 25.2336 5 no
GO:0006996 organelle organization 25.2336 4 no
GO:1904062 regulation of cation transmembrane transport 25.2336 6 no
GO:0048584 positive regulation of response to stimulus 24.2991 4 no
GO:0016192 vesicle-mediated transport 24.2991 4 no
GO:0019220 regulation of phosphate metabolic process 23.3645 6 yes
GO:0042325 regulation of phosphorylation 23.3645 7 yes
GO:0051174 regulation of phosphorus metabolic process 23.3645 5 yes
GO:0051247 positive regulation of protein metabolic process 23.3645 6 yes
GO:0072657 protein localization to membrane 23.3645 4 yes
GO:0099537 trans-synaptic signaling 23.3645 4 no
GO:0010941 regulation of cell death 23.3645 4 no
GO:0060341 regulation of cellular localization 23.3645 4 no
GO:0043085 positive regulation of catalytic activity 22.4299 4 yes
GO:0009967 positive regulation of signal transduction 22.4299 5 no
GO:0007268 chemical synaptic transmission 22.4299 6 no
GO:0030030 cell projection organization 22.4299 4 no
GO:0098916 anterograde trans-synaptic signaling 22.4299 5 no
GO:0051050 positive regulation of transport 22.4299 4 no
GO:0043067 regulation of programmed cell death 22.4299 5 no
GO:0009892 negative regulation of metabolic process 21.4953 4 no
GO:0022898 regulation of transmembrane transporter activity 21.4953 4 no
GO:0032412 regulation of ion transmembrane transporter activity 21.4953 5 no
GO:0042981 regulation of apoptotic process 21.4953 6 no
GO:0031399 regulation of protein modification process 20.5607 6 yes
GO:0042127 regulation of cell population proliferation 20.5607 4 yes
GO:0034330 cell junction organization 20.5607 4 no
GO:0009889 regulation of biosynthetic process 20.5607 4 no
GO:0031326 regulation of cellular biosynthetic process 20.5607 5 no
GO:0001932 regulation of protein phosphorylation 19.6262 7 yes
GO:0010562 positive regulation of phosphorus metabolic process 18.6916 6 yes
GO:0042327 positive regulation of phosphorylation 18.6916 8 yes
GO:0045937 positive regulation of phosphate metabolic process 18.6916 7 yes
GO:0051338 regulation of transferase activity 18.6916 4 yes
GO:0031401 positive regulation of protein modification process 17.7570 7 yes
GO:0043549 regulation of kinase activity 17.7570 5 yes
GO:0001934 positive regulation of protein phosphorylation 16.8224 8 yes
GO:0051347 positive regulation of transferase activity 16.8224 5 yes
GO:0033674 positive regulation of kinase activity 15.8879 6 yes
GO:0045859 regulation of protein kinase activity 14.9533 6 yes
GO:0043113 receptor clustering 13.0841 5 yes
GO:0045860 positive regulation of protein kinase activity 13.0841 7 yes
GO:0008285 negative regulation of cell population proliferation 10.2804 5 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 6.5421 8 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 6.5421 9 yes
GO:0035088 establishment or maintenance of apical/basal cell polarity 5.6075 4 yes
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 5.6075 5 yes
GO:0061097 regulation of protein tyrosine kinase activity 4.6729 7 yes
GO:0061098 positive regulation of protein tyrosine kinase activity 4.6729 8 yes
GO:0001736 establishment of planar polarity 1.8692 4 yes

Disease

Term Name % Distance from top the of the tree Annotated in DLG3_HUMAN
DOID:0050700 cardiomyopathy 3.7383 4 no
DOID:0060036 intrinsic cardiomyopathy 3.7383 5 no
DOID:114 heart disease 3.7383 3 no
DOID:2843 long QT syndrome 2.8037 6 no
DOID:10273 heart conduction disease 1.8692 4 no
DOID:0050686 organ system cancer 1.8692 3 no
DOID:1289 neurodegenerative disease 1.8692 4 no
DOID:331 central nervous system disease 1.8692 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
ABCA1_HUMAN [view interactions] Low throughput no yes
ERBB4_HUMAN [view entry] [view interactions] Low throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] Low throughput yes no
BAIP2_HUMAN [view entry] [view interactions] Low throughput yes yes
DGKZ_HUMAN [view entry] [view interactions] Low throughput yes yes
NETO1_HUMAN [view entry] [view interactions] Low throughput yes no
GUAD_HUMAN [view interactions] Low throughput no yes
CRFR1_HUMAN [view interactions] Low throughput no yes
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
GCYA2_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
DGKI_HUMAN [view entry] [view interactions] Low throughput yes no
PTHD1_HUMAN [view interactions] Low throughput no no
NMDE1_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE3_HUMAN [view entry] [view interactions] Low throughput yes no
CRIPT_HUMAN [view entry] [view interactions] Low throughput yes no
KCNA4_HUMAN [view entry] [view interactions] Low throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
SSR2_HUMAN [view interactions] Low throughput no yes
ARHG8_HUMAN [view interactions] Low throughput no yes
LRP2_HUMAN [view interactions] Low throughput no no
APC_HUMAN [view entry] [view interactions] Low throughput yes no
EXOC4_HUMAN [view entry] [view interactions] Low throughput yes yes
SEM4C_HUMAN [view entry] [view interactions] Low throughput yes no
FAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIK2_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIK5_HUMAN [view entry] [view interactions] Low throughput yes no
AT2B2_HUMAN [view entry] [view interactions] Low throughput yes yes
AT2B4_HUMAN [view entry] [view interactions] Low throughput yes yes
NBEA_HUMAN [view entry] [view interactions] Low throughput yes yes
EXOC7_HUMAN [view entry] [view interactions] Low throughput yes yes
SHSA9_HUMAN [view entry] [view interactions] Low throughput yes no
MK10_HUMAN [view entry] [view interactions] Low throughput yes yes
CCG2_HUMAN [view entry] [view interactions] Low throughput yes no
CCG3_HUMAN [view entry] [view interactions] Low throughput yes no
CCG4_HUMAN [view entry] [view interactions] Low throughput yes no
CCG8_HUMAN [view entry] [view interactions] Low throughput yes no
SLIK2_HUMAN [view entry] [view interactions] Low throughput yes no
TANC1_HUMAN [view entry] [view interactions] Low throughput yes yes
TANC2_HUMAN [view entry] [view interactions] Low throughput yes yes
IQEC2_HUMAN [view entry] [view interactions] Low throughput yes no
EPHB2_HUMAN [view entry] [view interactions] Low throughput yes yes
DLGP2_HUMAN [view entry] [view interactions] High throughput yes no
DLGP3_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP4_HUMAN [view entry] [view interactions] High throughput yes yes
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
RM18_HUMAN [view interactions] High throughput no yes
KCTD2_HUMAN [view interactions] High throughput no no
RT26_HUMAN [view interactions] High throughput no yes
AP3B1_HUMAN [view entry] [view interactions] High throughput yes yes
S18L2_HUMAN [view interactions] High throughput no no
ACAD8_HUMAN [view interactions] High throughput no yes
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
KCJ12_HUMAN [view interactions] High throughput no no
MEMO1_HUMAN [view interactions] High throughput no yes
NHRF2_HUMAN [view entry] [view interactions] High throughput yes no
CSKP_HUMAN [view entry] [view interactions] High throughput yes yes
NMDE4_HUMAN [view entry] [view interactions] High throughput yes yes
KCNA1_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
LRFN2_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
KRT35_HUMAN [view interactions] High throughput no no
ANXA1_HUMAN [view entry] [view interactions] High throughput yes no
KRT34_HUMAN [view interactions] High throughput no no
KLDC3_HUMAN [view interactions] High throughput no yes
S10A3_HUMAN [view interactions] High throughput no no
CUL2_HUMAN [view interactions] High throughput no yes
H2B1C_HUMAN [view interactions] High throughput no yes
K1H1_HUMAN [view interactions] High throughput no no
KRT82_HUMAN [view interactions] High throughput no no
KRT85_HUMAN [view interactions] High throughput no no
HSC20_HUMAN [view interactions] High throughput no yes
CNKR2_HUMAN [view entry] [view interactions] High throughput yes no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
RS8_HUMAN [view entry] [view interactions] High throughput yes no
PKHA2_HUMAN [view interactions] High throughput no no
VTNC_HUMAN [view interactions] High throughput no no
ERD21_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
NLGN1_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
FRPD4_HUMAN [view entry] [view interactions] High throughput yes no
F163B_HUMAN [view interactions] High throughput no yes
CLTR2_HUMAN [view interactions] High throughput no no
NLGN2_HUMAN [view entry] [view interactions] High throughput yes yes
NLGN3_HUMAN [view entry] [view interactions] High throughput yes yes
IF4H_HUMAN [view interactions] High throughput no yes
OSBP2_HUMAN [view interactions] High throughput no no
DHR11_HUMAN [view interactions] High throughput no no
EXOC3_HUMAN [view entry] [view interactions] High throughput yes no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
TJAP1_HUMAN [view entry] [view interactions] High throughput yes yes
DC1I1_HUMAN [view entry] [view interactions] High throughput yes yes
DLG2_HUMAN [view entry] [view interactions] High throughput yes yes
N4BP3_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
TEAD4_HUMAN [view interactions] High throughput no no
RHBL1_HUMAN [view interactions] High throughput no no
DLG1_HUMAN [view entry] [view interactions] High throughput yes yes
RGAP1_HUMAN [view interactions] High throughput no no
RBCC1_HUMAN [view interactions] High throughput no no
COBL1_HUMAN [view interactions] High throughput no yes
WDR91_HUMAN [view entry] [view interactions] High throughput yes no
RM22_HUMAN [view interactions] High throughput no yes
ZFP91_HUMAN [view interactions] High throughput no yes
CNPY2_HUMAN [view interactions] High throughput no yes
ZN232_HUMAN [view interactions] High throughput no no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
RHG17_HUMAN [view interactions] High throughput no no
ARHGQ_HUMAN [view interactions] High throughput no yes
TARB1_HUMAN [view interactions] High throughput no no
RLGPB_HUMAN [view interactions] High throughput no yes
NED4L_HUMAN [view interactions] High throughput no yes
EIF1A_HUMAN [view interactions] High throughput no no
RGPA2_HUMAN [view interactions] High throughput no yes
RGPA1_HUMAN [view entry] [view interactions] High throughput yes yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
KHDR1_HUMAN [view interactions] High throughput no yes
ARFG1_HUMAN [view interactions] High throughput no no
KS6A4_HUMAN [view interactions] High throughput no yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
CK052_HUMAN [view interactions] High throughput no no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
SHSA6_HUMAN [view entry] [view interactions] High throughput yes no
SHSA7_HUMAN [view entry] [view interactions] High throughput yes no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
NRX1A_HUMAN [view entry] [view interactions] Computational yes no
NCALD_HUMAN [view entry] [view interactions] Computational yes yes
RASN_HUMAN [view entry] [view interactions] Computational yes no
APBA1_HUMAN [view interactions] Computational no no
SCRIB_HUMAN [view entry] [view interactions] Computational yes no
SRC_HUMAN [view entry] [view interactions] Computational yes no
GRIA1_HUMAN [view entry] [view interactions] Computational yes yes
LIN7A_HUMAN [view entry] [view interactions] Computational yes yes
GRIA3_HUMAN [view entry] [view interactions] Computational yes yes
SHAN2_HUMAN [view entry] [view interactions] Computational yes yes
NRX2A_HUMAN [view entry] [view interactions] Computational yes no
KIF17_HUMAN [view interactions] Computational no no
NRCAM_HUMAN [view entry] [view interactions] Computational yes no
L2GL1_HUMAN [view entry] [view interactions] Computational yes yes
L2GL2_HUMAN [view interactions] Computational no yes
GRIA4_HUMAN [view entry] [view interactions] Computational yes no
GRIA2_HUMAN [view entry] [view interactions] Computational yes yes
SHAN1_HUMAN [view entry] [view interactions] Computational yes yes