DLG3_HUMAN
Evidence for PS localization
Functions
Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DLG3_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 30.6122 | 4 | no |
| GO:0019900 | kinase binding | 23.4694 | 4 | yes |
| GO:0000166 | nucleotide binding | 23.4694 | 4 | no |
| GO:0017076 | purine nucleotide binding | 23.4694 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 23.4694 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.4694 | 4 | no |
| GO:0043169 | cation binding | 21.4286 | 4 | no |
| GO:0046872 | metal ion binding | 21.4286 | 5 | no |
| GO:0019902 | phosphatase binding | 9.1837 | 4 | yes |
| GO:0031625 | ubiquitin protein ligase binding | 6.1224 | 5 | yes |
| GO:0044389 | ubiquitin-like protein ligase binding | 6.1224 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DLG3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 65.3061 | 4 | yes |
| GO:0010646 | regulation of cell communication | 64.2857 | 4 | no |
| GO:0009966 | regulation of signal transduction | 51.0204 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 42.8571 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 41.8367 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 40.8163 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 39.7959 | 5 | no |
| GO:0023056 | positive regulation of signaling | 39.7959 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 39.7959 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 39.7959 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 39.7959 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 38.7755 | 4 | yes |
| GO:0051049 | regulation of transport | 36.7347 | 4 | no |
| GO:0008104 | protein localization | 36.7347 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 33.6735 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 32.6531 | 5 | yes |
| GO:0048584 | positive regulation of response to stimulus | 31.6327 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 29.5918 | 5 | yes |
| GO:0022607 | cellular component assembly | 29.5918 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 28.5714 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.5714 | 5 | yes |
| GO:0034762 | regulation of transmembrane transport | 27.5510 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.5306 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 26.5306 | 4 | no |
| GO:0006996 | organelle organization | 25.5102 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.5102 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 25.5102 | 5 | no |
| GO:0044057 | regulation of system process | 25.5102 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.4898 | 6 | yes |
| GO:0060341 | regulation of cellular localization | 24.4898 | 4 | no |
| GO:0010468 | regulation of gene expression | 24.4898 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.4694 | 4 | no |
| GO:0043269 | regulation of monoatomic ion transport | 23.4694 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.4490 | 5 | yes |
| GO:0099536 | synaptic signaling | 22.4490 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 22.4490 | 5 | yes |
| GO:0031344 | regulation of cell projection organization | 22.4490 | 5 | no |
| GO:0050807 | regulation of synapse organization | 22.4490 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.4490 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 21.4286 | 7 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 21.4286 | 6 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.4286 | 6 | no |
| GO:0050806 | positive regulation of synaptic transmission | 21.4286 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 21.4286 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 21.4286 | 7 | yes |
| GO:0031399 | regulation of protein modification process | 21.4286 | 6 | yes |
| GO:0043085 | positive regulation of catalytic activity | 20.4082 | 4 | yes |
| GO:0072657 | protein localization to membrane | 20.4082 | 4 | yes |
| GO:0036211 | protein modification process | 20.4082 | 4 | no |
| GO:0043412 | macromolecule modification | 20.4082 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 20.4082 | 4 | no |
| GO:0032880 | regulation of protein localization | 20.4082 | 5 | no |
| GO:0034765 | regulation of monoatomic ion transmembrane transport | 20.4082 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 20.4082 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.4082 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 20.4082 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 20.4082 | 7 | yes |
| GO:0042127 | regulation of cell population proliferation | 19.3878 | 4 | yes |
| GO:0042327 | positive regulation of phosphorylation | 17.3469 | 8 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 17.3469 | 7 | yes |
| GO:0001934 | positive regulation of protein phosphorylation | 17.3469 | 8 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 17.3469 | 6 | yes |
| GO:0031401 | positive regulation of protein modification process | 17.3469 | 7 | yes |
| GO:0051338 | regulation of transferase activity | 16.3265 | 4 | yes |
| GO:0043549 | regulation of kinase activity | 15.3061 | 5 | yes |
| GO:0045859 | regulation of protein kinase activity | 15.3061 | 6 | yes |
| GO:0051347 | positive regulation of transferase activity | 14.2857 | 5 | yes |
| GO:0045860 | positive regulation of protein kinase activity | 13.2653 | 7 | yes |
| GO:0033674 | positive regulation of kinase activity | 13.2653 | 6 | yes |
| GO:0043113 | receptor clustering | 10.2041 | 5 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 9.1837 | 5 | yes |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 6.1224 | 8 | yes |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 6.1224 | 9 | yes |
| GO:0035088 | establishment or maintenance of apical/basal cell polarity | 5.1020 | 4 | yes |
| GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity | 5.1020 | 5 | yes |
| GO:0061097 | regulation of protein tyrosine kinase activity | 4.0816 | 7 | yes |
| GO:0061098 | positive regulation of protein tyrosine kinase activity | 4.0816 | 8 | yes |
| GO:0001736 | establishment of planar polarity | 2.0408 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NBEA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EXOC7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHSA9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MK10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CCG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CCG3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CCG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CCG8_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SLIK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TANC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TANC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IQEC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EPHB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ABCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| ERBB4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| BAIP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DGKZ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NETO1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GUAD_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CRFR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GCYA2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DGKI_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| PTHD1_HUMAN | [view interactions] | Low throughput | no | no |
| NMDE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NMDE3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CRIPT_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KCNA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SSR2_HUMAN | [view interactions] | Low throughput | no | yes |
| ARHG8_HUMAN | [view interactions] | Low throughput | no | yes |
| LRP2_HUMAN | [view interactions] | Low throughput | no | no |
| APC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| EXOC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SEM4C_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| FAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIK5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AT2B2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AT2B4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG17_HUMAN | [view interactions] | High throughput | no | no |
| ARHGQ_HUMAN | [view interactions] | High throughput | no | yes |
| TARB1_HUMAN | [view interactions] | High throughput | no | no |
| RLGPB_HUMAN | [view interactions] | High throughput | no | yes |
| NED4L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF1A_HUMAN | [view interactions] | High throughput | no | no |
| RGPA2_HUMAN | [view interactions] | High throughput | no | yes |
| RGPA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DVL2_HUMAN | [view interactions] | High throughput | no | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
| ARFG1_HUMAN | [view interactions] | High throughput | no | no |
| KS6A4_HUMAN | [view interactions] | High throughput | no | yes |
| PHLA1_HUMAN | [view interactions] | High throughput | no | yes |
| PPCS_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARL14_HUMAN | [view interactions] | High throughput | no | no |
| CDKL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC4C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAOK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHSA6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHSA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLGP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACAD8_HUMAN | [view interactions] | High throughput | no | yes |
| S18L2_HUMAN | [view interactions] | High throughput | no | no |
| AP3B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT26_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD2_HUMAN | [view interactions] | High throughput | no | no |
| RM18_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCJ12_HUMAN | [view interactions] | High throughput | no | no |
| NHRF2_HUMAN | [view interactions] | High throughput | no | no |
| MEMO1_HUMAN | [view interactions] | High throughput | no | yes |
| CSKP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDE4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRFN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KRT35_HUMAN | [view interactions] | High throughput | no | no |
| ANXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KRT34_HUMAN | [view interactions] | High throughput | no | no |
| KLDC3_HUMAN | [view interactions] | High throughput | no | yes |
| S10A3_HUMAN | [view interactions] | High throughput | no | no |
| CUL2_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| K1H1_HUMAN | [view interactions] | High throughput | no | no |
| KRT82_HUMAN | [view interactions] | High throughput | no | no |
| KRT85_HUMAN | [view interactions] | High throughput | no | no |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| CNKR2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLK2_HUMAN | [view interactions] | High throughput | no | no |
| RS8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PKHA2_HUMAN | [view interactions] | High throughput | no | no |
| VTNC_HUMAN | [view interactions] | High throughput | no | no |
| ERD21_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| NLGN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F163B_HUMAN | [view interactions] | High throughput | no | yes |
| CLTR2_HUMAN | [view interactions] | High throughput | no | no |
| FRPD4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NLGN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NLGN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4H_HUMAN | [view interactions] | High throughput | no | yes |
| OSBP2_HUMAN | [view interactions] | High throughput | no | no |
| DHR11_HUMAN | [view interactions] | High throughput | no | no |
| EXOC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TJAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| N4BP3_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TEAD4_HUMAN | [view interactions] | High throughput | no | no |
| RHBL1_HUMAN | [view interactions] | High throughput | no | no |
| RGAP1_HUMAN | [view interactions] | High throughput | no | no |
| RBCC1_HUMAN | [view interactions] | High throughput | no | no |
| COBL1_HUMAN | [view interactions] | High throughput | no | yes |
| WDR91_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RM22_HUMAN | [view interactions] | High throughput | no | yes |
| ZFP91_HUMAN | [view interactions] | High throughput | no | yes |
| CNPY2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN232_HUMAN | [view interactions] | High throughput | no | no |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |