Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

WDR91_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport (PubMed). It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (PubMed). May play a role in meiosis . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in WDR91_HUMAN
GO:0017076 purine nucleotide binding 35.2941 4 no
GO:0032555 purine ribonucleotide binding 35.2941 4 no
GO:0035639 purine ribonucleoside triphosphate binding 29.4118 4 no
GO:0019900 kinase binding 23.5294 4 no
GO:0016462 pyrophosphatase activity 23.5294 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 23.5294 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 23.5294 6 no
GO:0031267 small GTPase binding 23.5294 5 no
GO:0051020 GTPase binding 23.5294 4 no
GO:0031625 ubiquitin protein ligase binding 23.5294 5 no
GO:0044389 ubiquitin-like protein ligase binding 23.5294 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in WDR91_HUMAN
GO:0031323 regulation of cellular metabolic process 82.3529 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 82.3529 4 yes
GO:0060255 regulation of macromolecule metabolic process 82.3529 4 yes
GO:0080090 regulation of primary metabolic process 82.3529 4 yes
GO:0048522 positive regulation of cellular process 76.4706 4 no
GO:0009893 positive regulation of metabolic process 70.5882 4 no
GO:0051128 regulation of cellular component organization 70.5882 4 no
GO:0051246 regulation of protein metabolic process 64.7059 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 64.7059 5 no
GO:0048523 negative regulation of cellular process 64.7059 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 64.7059 5 no
GO:0022607 cellular component assembly 58.8235 4 no
GO:0016192 vesicle-mediated transport 52.9412 4 yes
GO:0031325 positive regulation of cellular metabolic process 52.9412 5 no
GO:0010646 regulation of cell communication 52.9412 4 no
GO:0008104 protein localization 52.9412 4 no
GO:0009894 regulation of catabolic process 47.0588 4 yes
GO:0019220 regulation of phosphate metabolic process 47.0588 6 yes
GO:0042325 regulation of phosphorylation 47.0588 7 yes
GO:0051174 regulation of phosphorus metabolic process 47.0588 5 yes
GO:0051338 regulation of transferase activity 47.0588 4 yes
GO:0051247 positive regulation of protein metabolic process 47.0588 6 no
GO:0006996 organelle organization 47.0588 4 no
GO:0009966 regulation of signal transduction 47.0588 4 no
GO:0051049 regulation of transport 47.0588 4 no
GO:0051130 positive regulation of cellular component organization 47.0588 5 no
GO:0043549 regulation of kinase activity 41.1765 5 yes
GO:0009889 regulation of biosynthetic process 41.1765 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 41.1765 5 no
GO:0031326 regulation of cellular biosynthetic process 41.1765 5 no
GO:1902531 regulation of intracellular signal transduction 41.1765 5 no
GO:0030030 cell projection organization 41.1765 4 no
GO:0042127 regulation of cell population proliferation 41.1765 4 no
GO:0009892 negative regulation of metabolic process 35.2941 4 no
GO:0031324 negative regulation of cellular metabolic process 35.2941 5 no
GO:0031329 regulation of cellular catabolic process 35.2941 5 no
GO:0071310 cellular response to organic substance 35.2941 4 no
GO:0010941 regulation of cell death 35.2941 4 no
GO:0031399 regulation of protein modification process 35.2941 6 no
GO:0033043 regulation of organelle organization 35.2941 5 no
GO:0042981 regulation of apoptotic process 35.2941 6 no
GO:0043067 regulation of programmed cell death 35.2941 5 no
GO:0044087 regulation of cellular component biogenesis 35.2941 4 no
GO:0048584 positive regulation of response to stimulus 35.2941 4 no
GO:0051050 positive regulation of transport 35.2941 4 no
GO:0006886 intracellular protein transport 35.2941 4 no
GO:0015031 protein transport 35.2941 4 no
GO:0071702 organic substance transport 35.2941 4 no
GO:0071705 nitrogen compound transport 35.2941 4 no
GO:0072657 protein localization to membrane 35.2941 4 no
GO:0120036 plasma membrane bounded cell projection organization 35.2941 5 no
GO:0010562 positive regulation of phosphorus metabolic process 35.2941 6 no
GO:0042327 positive regulation of phosphorylation 35.2941 8 no
GO:0043085 positive regulation of catalytic activity 35.2941 4 no
GO:0045937 positive regulation of phosphate metabolic process 35.2941 7 no
GO:0051347 positive regulation of transferase activity 35.2941 5 no
GO:0042176 regulation of protein catabolic process 29.4118 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 29.4118 5 no
GO:0010605 negative regulation of macromolecule metabolic process 29.4118 5 no
GO:0043412 macromolecule modification 29.4118 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 29.4118 5 no
GO:0001932 regulation of protein phosphorylation 29.4118 7 no
GO:0009967 positive regulation of signal transduction 29.4118 5 no
GO:0009968 negative regulation of signal transduction 29.4118 5 no
GO:0010638 positive regulation of organelle organization 29.4118 6 no
GO:0010647 positive regulation of cell communication 29.4118 5 no
GO:0010648 negative regulation of cell communication 29.4118 5 no
GO:0023056 positive regulation of signaling 29.4118 4 no
GO:0023057 negative regulation of signaling 29.4118 4 no
GO:0031344 regulation of cell projection organization 29.4118 5 no
GO:0048585 negative regulation of response to stimulus 29.4118 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 29.4118 6 no
GO:0010243 response to organonitrogen compound 29.4118 4 no
GO:0032880 regulation of protein localization 29.4118 5 no
GO:0060341 regulation of cellular localization 29.4118 4 no
GO:0060627 regulation of vesicle-mediated transport 29.4118 4 no
GO:0061024 membrane organization 29.4118 4 no
GO:0070201 regulation of establishment of protein localization 29.4118 6 no
GO:0031401 positive regulation of protein modification process 29.4118 7 no
GO:0033674 positive regulation of kinase activity 29.4118 6 no
GO:0051726 regulation of cell cycle 29.4118 4 no
GO:0051129 negative regulation of cellular component organization 29.4118 5 no
GO:0009890 negative regulation of biosynthetic process 23.5294 5 no
GO:0010468 regulation of gene expression 23.5294 5 no
GO:0031327 negative regulation of cellular biosynthetic process 23.5294 6 no
GO:0051248 negative regulation of protein metabolic process 23.5294 6 no
GO:0051252 regulation of RNA metabolic process 23.5294 5 no
GO:0007010 cytoskeleton organization 23.5294 5 no
GO:0010942 positive regulation of cell death 23.5294 5 no
GO:0031346 positive regulation of cell projection organization 23.5294 6 no
GO:0043065 positive regulation of apoptotic process 23.5294 7 no
GO:0043066 negative regulation of apoptotic process 23.5294 7 no
GO:0043068 positive regulation of programmed cell death 23.5294 6 no
GO:0043069 negative regulation of programmed cell death 23.5294 6 no
GO:0044089 positive regulation of cellular component biogenesis 23.5294 5 no
GO:0045859 regulation of protein kinase activity 23.5294 6 no
GO:0048193 Golgi vesicle transport 23.5294 5 no
GO:0060548 negative regulation of cell death 23.5294 5 no
GO:0016050 vesicle organization 23.5294 5 no
GO:0030031 cell projection assembly 23.5294 5 no
GO:0033365 protein localization to organelle 23.5294 5 no
GO:0051223 regulation of protein transport 23.5294 5 no
GO:0061025 membrane fusion 23.5294 5 no
GO:0071417 cellular response to organonitrogen compound 23.5294 4 no
GO:0090150 establishment of protein localization to membrane 23.5294 4 no
GO:0120031 plasma membrane bounded cell projection assembly 23.5294 6 no
GO:1901699 cellular response to nitrogen compound 23.5294 4 no
GO:1901701 cellular response to oxygen-containing compound 23.5294 4 no
GO:0001934 positive regulation of protein phosphorylation 23.5294 8 no
GO:0030162 regulation of proteolysis 23.5294 6 no
GO:0036211 protein modification process 23.5294 4 no
GO:0080134 regulation of response to stress 23.5294 4 no
GO:0080135 regulation of cellular response to stress 23.5294 4 no
GO:0010564 regulation of cell cycle process 23.5294 5 no
GO:0043933 protein-containing complex organization 23.5294 4 no
GO:0065003 protein-containing complex assembly 23.5294 5 no
GO:0008284 positive regulation of cell population proliferation 23.5294 5 no
GO:0043408 regulation of MAPK cascade 23.5294 6 no
GO:0043410 positive regulation of MAPK cascade 23.5294 7 no
GO:0051094 positive regulation of developmental process 23.5294 4 no
GO:1902533 positive regulation of intracellular signal transduction 23.5294 6 no
GO:0016482 cytosolic transport 17.6471 4 yes
GO:0043550 regulation of lipid kinase activity 11.7647 6 yes
GO:0043551 regulation of phosphatidylinositol 3-kinase activity 11.7647 7 yes
GO:0045022 early endosome to late endosome transport 11.7647 5 yes
GO:0098927 vesicle-mediated transport between endosomal compartments 11.7647 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
WDR81_HUMAN [view interactions] Low throughput no no
BECN1_HUMAN [view interactions] Low throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
RAB8A_HUMAN [view entry] [view interactions] High throughput yes no
LRRK2_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
BMX_HUMAN [view interactions] High throughput no no
CSF1R_HUMAN [view interactions] High throughput no yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
TIE1_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
HUWE1_HUMAN [view interactions] High throughput no yes
ARI2_HUMAN [view interactions] High throughput no no
SDCB1_HUMAN [view entry] [view interactions] High throughput yes yes
STX8_HUMAN [view interactions] High throughput no yes
NUDC_HUMAN [view interactions] High throughput no yes
WWOX_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
DLG3_HUMAN [view entry] [view interactions] High throughput yes yes
RPGF2_HUMAN [view entry] [view interactions] High throughput yes no
HNRPQ_HUMAN [view entry] [view interactions] High throughput yes yes
BAG6_HUMAN [view entry] [view interactions] High throughput yes yes
UBR5_HUMAN [view interactions] High throughput no no
BRWD3_HUMAN [view interactions] High throughput no yes
WFDC2_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
P53_HUMAN [view interactions] High throughput no no
DNAL4_HUMAN [view interactions] High throughput no yes
TCPB_HUMAN [view entry] [view interactions] High throughput yes yes
SNAA_HUMAN [view entry] [view interactions] High throughput yes yes
DDB1_HUMAN [view interactions] High throughput no yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
YTDC1_HUMAN [view interactions] High throughput no yes
ANFY1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB9A_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes