Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RAB8A_HUMAN

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed). Together with MYO5B and RAB11A participates in epithelial cell polarization (PubMed). May be involved in ciliogenesis (PubMed, PubMed). Together with MICALL2, may also regulate adherens junction assembly . May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis . Involved in autophagy (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in RAB8A_HUMAN
GO:0017076 purine nucleotide binding 40.5941 4 yes
GO:0032555 purine ribonucleotide binding 40.5941 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 40.5941 4 yes
GO:0005525 GTP binding 34.6535 5 yes
GO:0019001 guanyl nucleotide binding 34.6535 5 yes
GO:0032561 guanyl ribonucleotide binding 34.6535 5 yes
GO:0016462 pyrophosphatase activity 32.6733 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 32.6733 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 32.6733 6 yes
GO:0003924 GTPase activity 31.6832 7 yes
GO:0019900 kinase binding 17.8218 4 yes
GO:0051020 GTPase binding 17.8218 4 yes
GO:0019003 GDP binding 16.8317 4 yes
GO:0019901 protein kinase binding 16.8317 5 yes
GO:0031267 small GTPase binding 16.8317 5 yes
GO:0017022 myosin binding 8.9109 4 yes
GO:0031489 myosin V binding 6.9307 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RAB8A_HUMAN
GO:0008104 protein localization 62.3762 4 yes
GO:0071702 organic substance transport 57.4257 4 yes
GO:0071705 nitrogen compound transport 56.4356 4 yes
GO:0015031 protein transport 54.4554 4 yes
GO:0016192 vesicle-mediated transport 53.4653 4 yes
GO:0048522 positive regulation of cellular process 48.5149 4 no
GO:0006996 organelle organization 46.5347 4 yes
GO:0051049 regulation of transport 42.5743 4 yes
GO:0022607 cellular component assembly 39.6040 4 yes
GO:0051128 regulation of cellular component organization 35.6436 4 no
GO:0048523 negative regulation of cellular process 33.6634 4 no
GO:0031323 regulation of cellular metabolic process 32.6733 4 yes
GO:0006886 intracellular protein transport 31.6832 4 yes
GO:0010646 regulation of cell communication 30.6931 4 yes
GO:0030030 cell projection organization 27.7228 4 yes
GO:0060627 regulation of vesicle-mediated transport 27.7228 4 yes
GO:0060255 regulation of macromolecule metabolic process 27.7228 4 no
GO:0080090 regulation of primary metabolic process 26.7327 4 no
GO:0046903 secretion 26.7327 4 yes
GO:0071310 cellular response to organic substance 25.7426 4 yes
GO:0120036 plasma membrane bounded cell projection organization 25.7426 5 yes
GO:0061024 membrane organization 24.7525 4 yes
GO:0033043 regulation of organelle organization 24.7525 5 no
GO:0051171 regulation of nitrogen compound metabolic process 24.7525 4 no
GO:0051046 regulation of secretion 23.7624 5 yes
GO:0072657 protein localization to membrane 23.7624 4 yes
GO:1903530 regulation of secretion by cell 23.7624 4 yes
GO:0033365 protein localization to organelle 22.7723 5 yes
GO:0009893 positive regulation of metabolic process 22.7723 4 no
GO:0010604 positive regulation of macromolecule metabolic process 21.7822 5 no
GO:0060341 regulation of cellular localization 21.7822 4 yes
GO:0098876 vesicle-mediated transport to the plasma membrane 21.7822 4 yes
GO:0032880 regulation of protein localization 20.7921 5 yes
GO:0009966 regulation of signal transduction 20.7921 4 no
GO:0023056 positive regulation of signaling 20.7921 4 no
GO:0044087 regulation of cellular component biogenesis 20.7921 4 no
GO:0010243 response to organonitrogen compound 19.8020 4 yes
GO:1990778 protein localization to cell periphery 19.8020 5 yes
GO:0016197 endosomal transport 16.8317 4 yes
GO:0017157 regulation of exocytosis 16.8317 5 yes
GO:0030031 cell projection assembly 16.8317 5 yes
GO:1901701 cellular response to oxygen-containing compound 16.8317 4 yes
GO:0072659 protein localization to plasma membrane 15.8416 5 yes
GO:0050804 modulation of chemical synaptic transmission 14.8515 5 yes
GO:0099177 regulation of trans-synaptic signaling 14.8515 4 yes
GO:0016050 vesicle organization 13.8614 5 yes
GO:0051223 regulation of protein transport 13.8614 5 yes
GO:0070201 regulation of establishment of protein localization 13.8614 6 yes
GO:0070925 organelle assembly 13.8614 5 yes
GO:0071417 cellular response to organonitrogen compound 13.8614 4 yes
GO:0120031 plasma membrane bounded cell projection assembly 13.8614 6 yes
GO:1901699 cellular response to nitrogen compound 13.8614 4 yes
GO:0009894 regulation of catabolic process 12.8713 4 yes
GO:0090150 establishment of protein localization to membrane 12.8713 4 yes
GO:0061025 membrane fusion 11.8812 5 yes
GO:0031329 regulation of cellular catabolic process 10.8911 5 yes
GO:0032456 endocytic recycling 10.8911 5 yes
GO:0048278 vesicle docking 10.8911 4 yes
GO:0048284 organelle fusion 10.8911 5 yes
GO:0006906 vesicle fusion 9.9010 6 yes
GO:0090174 organelle membrane fusion 9.9010 6 yes
GO:1901652 response to peptide 9.9010 4 yes
GO:0009306 protein secretion 8.9109 4 yes
GO:0010506 regulation of autophagy 8.9109 6 yes
GO:0035592 establishment of protein localization to extracellular region 8.9109 4 yes
GO:0043434 response to peptide hormone 8.9109 4 yes
GO:0044782 cilium organization 8.9109 5 yes
GO:0060271 cilium assembly 8.9109 6 yes
GO:0071692 protein localization to extracellular region 8.9109 5 yes
GO:0032868 response to insulin 7.9208 5 yes
GO:0032870 cellular response to hormone stimulus 7.9208 4 yes
GO:0061512 protein localization to cilium 7.9208 6 yes
GO:1901653 cellular response to peptide 7.9208 5 yes
GO:0032869 cellular response to insulin stimulus 6.9307 6 yes
GO:0032990 cell part morphogenesis 6.9307 4 yes
GO:0048812 neuron projection morphogenesis 6.9307 7 yes
GO:0048858 cell projection morphogenesis 6.9307 5 yes
GO:0061951 establishment of protein localization to plasma membrane 6.9307 5 yes
GO:0071375 cellular response to peptide hormone stimulus 6.9307 5 yes
GO:0099003 vesicle-mediated transport in synapse 6.9307 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 6.9307 6 yes
GO:0007409 axonogenesis 4.9505 8 yes
GO:0048168 regulation of neuronal synaptic plasticity 4.9505 4 yes
GO:0035418 protein localization to synapse 3.9604 6 yes
GO:0048169 regulation of long-term neuronal synaptic plasticity 3.9604 5 yes
GO:0048210 Golgi vesicle fusion to target membrane 3.9604 7 yes
GO:0098877 neurotransmitter receptor transport to plasma membrane 3.9604 4 yes
GO:0099638 endosome to plasma membrane protein transport 3.9604 5 yes
GO:1902414 protein localization to cell junction 3.9604 5 yes
GO:0062237 protein localization to postsynapse 2.9703 7 yes
GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane 2.9703 5 yes
GO:0098969 neurotransmitter receptor transport to postsynaptic membrane 2.9703 4 yes
GO:0099639 neurotransmitter receptor transport, endosome to plasma membrane 2.9703 5 yes
GO:1903539 protein localization to postsynaptic membrane 2.9703 5 yes
GO:1903540 establishment of protein localization to postsynaptic membrane 2.9703 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MICA2_HUMAN [view interactions] Low throughput no yes
OCRL_HUMAN [view interactions] Low throughput no yes
RAB3I_HUMAN [view interactions] Low throughput no no
OPTN_HUMAN [view interactions] Low throughput no yes
TBC17_HUMAN [view entry] [view interactions] Low throughput yes yes
CE290_HUMAN [view interactions] Low throughput no no
LRRK2_HUMAN [view interactions] Low throughput no yes
MICA1_HUMAN [view interactions] Low throughput no yes
MSS4_HUMAN [view interactions] Low throughput no yes
MILK2_HUMAN [view interactions] Low throughput no no
MILK1_HUMAN [view interactions] Low throughput no yes
GDIB_HUMAN [view entry] [view interactions] Low throughput yes yes
SYTL4_HUMAN [view interactions] Low throughput no yes
R3GEF_HUMAN [view interactions] Low throughput no yes
EH1L1_HUMAN [view interactions] Low throughput no yes
EHBP1_HUMAN [view interactions] Low throughput no yes
JIP4_HUMAN [view interactions] Low throughput no yes
RIPL2_HUMAN [view interactions] Low throughput no yes
RIPL1_HUMAN [view interactions] Low throughput no yes
JIP3_HUMAN [view entry] [view interactions] Low throughput yes yes
SMCR8_HUMAN [view interactions] Low throughput no yes
TALD3_HUMAN [view interactions] Low throughput no yes
RP3A_HUMAN [view entry] [view interactions] Low throughput yes yes
TFR1_HUMAN [view interactions] Low throughput no yes
EHD1_HUMAN [view entry] [view interactions] Low throughput yes no
LAX1_HUMAN [view interactions] Low throughput no no
SYUA_HUMAN [view entry] [view interactions] Low throughput yes no
DZIP1_HUMAN [view interactions] Low throughput no yes
TRI25_HUMAN [view interactions] Low throughput no yes
CTLA4_HUMAN [view interactions] Low throughput no no
RAB8A_HUMAN [view entry] [view interactions] Low throughput yes no
CI072_HUMAN [view interactions] Low throughput no no
ARF6_HUMAN [view entry] [view interactions] Low throughput yes yes
RAB13_HUMAN [view entry] [view interactions] Low throughput yes yes
M4K2_HUMAN [view interactions] Low throughput no yes
MYO5B_HUMAN [view entry] [view interactions] Low throughput yes yes
MYO5C_HUMAN [view entry] [view interactions] Low throughput yes yes
ODFP2_HUMAN [view interactions] Low throughput no no
SYTL1_HUMAN [view interactions] Low throughput no yes
RB11A_HUMAN [view entry] [view interactions] Low throughput yes yes
NEMO_HUMAN [view interactions] Low throughput no yes
EHD3_HUMAN [view entry] [view interactions] Low throughput yes no
BIN1_HUMAN [view entry] [view interactions] Low throughput yes yes
TYRO_HUMAN [view interactions] Low throughput no no
GDIA_HUMAN [view entry] [view interactions] High throughput yes yes
GOT1B_HUMAN [view interactions] High throughput no yes
DVL2_HUMAN [view interactions] High throughput no yes
ERLN2_HUMAN [view entry] [view interactions] High throughput yes yes
GBF1_HUMAN [view interactions] High throughput no yes
RB39A_HUMAN [view interactions] High throughput no no
TBC15_HUMAN [view interactions] High throughput no yes
RAB6A_HUMAN [view entry] [view interactions] High throughput yes yes
I5P2_HUMAN [view interactions] High throughput no yes
WDR91_HUMAN [view entry] [view interactions] High throughput yes no
MICA3_HUMAN [view interactions] High throughput no yes
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
ARF5_HUMAN [view entry] [view interactions] High throughput yes no
RAB1A_HUMAN [view entry] [view interactions] High throughput yes yes
RAE1_HUMAN [view interactions] High throughput no yes
WDR81_HUMAN [view interactions] High throughput no no
PGTA_HUMAN [view interactions] High throughput no yes
ARL1_HUMAN [view interactions] High throughput no yes
RAB8B_HUMAN [view entry] [view interactions] High throughput yes no
TBC9B_HUMAN [view interactions] High throughput no yes
ARF1_HUMAN [view entry] [view interactions] High throughput yes yes
ERLN1_HUMAN [view entry] [view interactions] High throughput yes yes
PGTB2_HUMAN [view interactions] High throughput no yes
ESYT1_HUMAN [view entry] [view interactions] High throughput yes yes
ARF4_HUMAN [view entry] [view interactions] High throughput yes no
ARL8B_HUMAN [view interactions] High throughput no yes
TBC8B_HUMAN [view interactions] High throughput no yes
RAE2_HUMAN [view interactions] High throughput no yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
RAB6C_HUMAN [view interactions] High throughput no no
EAA3_HUMAN [view entry] [view interactions] High throughput yes yes
SRPRB_HUMAN [view entry] [view interactions] High throughput yes no
MECOM_HUMAN [view interactions] High throughput no yes
ACAP2_HUMAN [view interactions] High throughput no yes
M4K3_HUMAN [view interactions] High throughput no no
PPM1H_HUMAN [view interactions] High throughput no yes
SQSTM_HUMAN [view interactions] High throughput no yes
TAGL_HUMAN [view interactions] High throughput no no
MOT11_HUMAN [view interactions] High throughput no no
ENPL_HUMAN [view entry] [view interactions] High throughput yes yes
KLF16_HUMAN [view interactions] High throughput no yes
RAB10_HUMAN [view entry] [view interactions] High throughput yes yes
EPB41_HUMAN [view entry] [view interactions] High throughput yes no
CP110_HUMAN [view interactions] High throughput no yes
AAKB1_HUMAN [view interactions] High throughput no yes
INSR_HUMAN [view interactions] High throughput no yes
CD177_HUMAN [view interactions] High throughput no no
RYBP_HUMAN [view interactions] High throughput no no
BAG6_HUMAN [view entry] [view interactions] High throughput yes yes
PQBP1_HUMAN [view interactions] High throughput no yes
RAB3C_HUMAN [view entry] [view interactions] High throughput yes yes
RB39B_HUMAN [view interactions] High throughput no no
PTPA_HUMAN [view interactions] High throughput no yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
BBS1_HUMAN [view interactions] High throughput no no
EXOC6_HUMAN [view entry] [view interactions] High throughput yes yes
EXOC5_HUMAN [view entry] [view interactions] High throughput yes yes
NDUAA_HUMAN [view entry] [view interactions] High throughput yes yes
SAM50_HUMAN [view entry] [view interactions] High throughput yes yes
STOM_HUMAN [view entry] [view interactions] High throughput yes yes
MIC19_HUMAN [view entry] [view interactions] High throughput yes yes
NDUA5_HUMAN [view entry] [view interactions] High throughput yes yes
FXL19_HUMAN [view interactions] High throughput no no
RAB1B_HUMAN [view entry] [view interactions] High throughput yes yes
BBS2_HUMAN [view interactions] High throughput no no
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
ARL6_HUMAN [view interactions] High throughput no yes
STK4_HUMAN [view interactions] High throughput no yes
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
CNTRL_HUMAN [view interactions] High throughput no yes
CP135_HUMAN [view interactions] High throughput no no
CEP97_HUMAN [view interactions] High throughput no yes
POC5_HUMAN [view interactions] High throughput no yes
FOS_HUMAN [view interactions] High throughput no yes
DDR2_HUMAN [view interactions] High throughput no no
PTN11_HUMAN [view entry] [view interactions] High throughput yes yes
MKLN1_HUMAN [view interactions] High throughput no yes
GID8_HUMAN [view interactions] High throughput no yes
RMD5A_HUMAN [view interactions] High throughput no yes
RANB9_HUMAN [view entry] [view interactions] High throughput yes yes
RMD5B_HUMAN [view interactions] High throughput no yes
EXOC8_HUMAN [view entry] [view interactions] High throughput yes yes
MAEA_HUMAN [view interactions] High throughput no yes
YPEL5_HUMAN [view interactions] High throughput no yes
RBP10_HUMAN [view interactions] High throughput no no
ARMC8_HUMAN [view interactions] High throughput no yes
WDR26_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
UBL4A_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
RIMS2_HUMAN [view entry] [view interactions] High throughput yes no
RPH3L_HUMAN [view interactions] High throughput no no
RAB3B_HUMAN [view interactions] High throughput no no
STX3_HUMAN [view entry] [view interactions] High throughput yes no
VAMP3_HUMAN [view entry] [view interactions] High throughput yes no
CDC73_HUMAN [view interactions] High throughput no yes
MTMR4_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
UB2R1_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
FLCN_HUMAN [view interactions] High throughput no yes
TM41B_HUMAN [view interactions] High throughput no yes
NR2C2_HUMAN [view interactions] High throughput no yes
CYBP_HUMAN [view entry] [view interactions] High throughput yes yes
RNF41_HUMAN [view interactions] High throughput no yes
BIRC6_HUMAN [view entry] [view interactions] High throughput yes yes
MLP3B_HUMAN [view interactions] High throughput no yes
BCAR1_HUMAN [view interactions] High throughput no yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
MKRN2_HUMAN [view interactions] High throughput no yes
WDR5_HUMAN [view interactions] High throughput no no
2ABB_HUMAN [view interactions] High throughput no yes
CENPM_HUMAN [view interactions] High throughput no yes
SSMM1_HUMAN [view interactions] High throughput no no
WIF1_HUMAN [view entry] [view interactions] High throughput yes no
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
IFM1_HUMAN [view interactions] High throughput no no
BASI_HUMAN [view entry] [view interactions] High throughput yes no
CLC4D_HUMAN [view interactions] High throughput no no
CLC4E_HUMAN [view interactions] High throughput no no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND2_HUMAN [view interactions] High throughput no no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
MDM2_HUMAN [view interactions] High throughput no yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
RB11B_HUMAN [view entry] [view interactions] High throughput yes no
NDUA7_HUMAN [view entry] [view interactions] High throughput yes yes
SCP2_HUMAN [view interactions] High throughput no no
RAB31_HUMAN [view interactions] High throughput no yes
COX5A_HUMAN [view entry] [view interactions] High throughput yes yes
IDH3G_HUMAN [view entry] [view interactions] High throughput yes yes
RRBP1_HUMAN [view entry] [view interactions] High throughput yes yes
ANXA4_HUMAN [view interactions] High throughput no no
HCD2_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5B_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
RAP1A_HUMAN [view entry] [view interactions] High throughput yes no
RAP1B_HUMAN [view entry] [view interactions] High throughput yes no
SDHB_HUMAN [view interactions] High throughput no yes
RFFL_HUMAN [view interactions] High throughput no yes
MIRO2_HUMAN [view entry] [view interactions] High throughput yes yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
FURIN_HUMAN [view interactions] High throughput no yes
CACO2_HUMAN [view interactions] High throughput no yes
PLK1_HUMAN [view interactions] Computational no yes
MIPT3_HUMAN [view interactions] Computational no yes
OPSD_HUMAN [view interactions] Computational no no
ASAP1_HUMAN [view entry] [view interactions] Computational yes yes
MYO5A_HUMAN [view entry] [view interactions] Computational yes yes
SNP23_HUMAN [view entry] [view interactions] Computational yes no
HD_HUMAN [view entry] [view interactions] Computational yes yes
EXOC2_HUMAN [view entry] [view interactions] Computational yes no
DEN1C_HUMAN [view interactions] Computational no no
IFT20_HUMAN [view interactions] Computational no yes
LCAP_HUMAN [view interactions] Computational no yes
RFIP3_HUMAN [view entry] [view interactions] Computational yes no
RALA_HUMAN [view entry] [view interactions] Computational yes yes
PTHB1_HUMAN [view interactions] Computational no yes
EXOC4_HUMAN [view entry] [view interactions] Computational yes yes
WDR41_HUMAN [view interactions] Computational no yes
TBCD1_HUMAN [view interactions] Computational no no
PKD2_HUMAN [view interactions] Computational no yes
AHI1_HUMAN [view interactions] Computational no yes
STXB2_HUMAN [view interactions] Computational no no
GLUT4_HUMAN [view interactions] Computational no no
ADRB2_HUMAN [view entry] [view interactions] Computational yes no
STXB3_HUMAN [view entry] [view interactions] Computational yes yes
EXOC1_HUMAN [view entry] [view interactions] Computational yes yes
ADA2B_HUMAN [view interactions] Computational no no
VAMP2_HUMAN [view entry] [view interactions] Computational yes no
RABE1_HUMAN [view entry] [view interactions] Computational yes yes
STX4_HUMAN [view entry] [view interactions] Computational yes no
EXOC3_HUMAN [view entry] [view interactions] Computational yes no
PK3CG_HUMAN [view interactions] Computational no yes
TBCD4_HUMAN [view interactions] Computational no yes
EXOC7_HUMAN [view entry] [view interactions] Computational yes yes