TBC17_HUMAN
Evidence for PS localization
Functions
Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TBC17_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 27.5862 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 27.5862 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.5862 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 24.1379 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 24.1379 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 24.1379 | 6 | no |
| GO:0003924 | GTPase activity | 20.6897 | 7 | no |
| GO:0005525 | GTP binding | 20.6897 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 20.6897 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 20.6897 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TBC17_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 51.7241 | 4 | yes |
| GO:0071702 | organic substance transport | 51.7241 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 51.7241 | 4 | yes |
| GO:0015031 | protein transport | 44.8276 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 44.8276 | 4 | no |
| GO:0006886 | intracellular protein transport | 41.3793 | 4 | yes |
| GO:0006996 | organelle organization | 41.3793 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 41.3793 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 41.3793 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 41.3793 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 37.9310 | 4 | no |
| GO:0051049 | regulation of transport | 37.9310 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 37.9310 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 34.4828 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 31.0345 | 4 | yes |
| GO:0022607 | cellular component assembly | 31.0345 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 31.0345 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 31.0345 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.5862 | 5 | no |
| GO:0010646 | regulation of cell communication | 27.5862 | 4 | no |
| GO:0033365 | protein localization to organelle | 27.5862 | 5 | no |
| GO:0033043 | regulation of organelle organization | 27.5862 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 27.5862 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 24.1379 | 5 | no |
| GO:0070925 | organelle assembly | 20.6897 | 5 | no |
| GO:0032880 | regulation of protein localization | 20.6897 | 5 | no |
| GO:0060341 | regulation of cellular localization | 20.6897 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 20.6897 | 4 | no |
| GO:0009894 | regulation of catabolic process | 20.6897 | 4 | no |
| GO:0016197 | endosomal transport | 13.7931 | 4 | yes |
| GO:0016482 | cytosolic transport | 10.3448 | 4 | yes |
| GO:0042147 | retrograde transport, endosome to Golgi | 6.8966 | 5 | yes |
| GO:0043085 | positive regulation of catalytic activity | 6.8966 | 4 | yes |
| GO:0051336 | regulation of hydrolase activity | 6.8966 | 4 | yes |
| GO:0051345 | positive regulation of hydrolase activity | 6.8966 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| OPTN_HUMAN | [view interactions] | Low throughput | no | yes |
| RAB8A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TFR1_HUMAN | [view interactions] | Low throughput | no | yes |
| MLP3B_HUMAN | [view interactions] | Low throughput | no | yes |
| STX12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC121_HUMAN | [view interactions] | High throughput | no | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBAC2_HUMAN | [view interactions] | High throughput | no | yes |
| ASCC2_HUMAN | [view interactions] | High throughput | no | yes |
| TF3C1_HUMAN | [view interactions] | High throughput | no | yes |
| TCPE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBRL_HUMAN | [view interactions] | High throughput | no | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CACO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| DHX29_HUMAN | [view interactions] | High throughput | no | yes |
| CSN1_HUMAN | [view interactions] | High throughput | no | no |
| NIPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAAT_HUMAN | [view interactions] | High throughput | no | no |
| CDN2D_HUMAN | [view interactions] | High throughput | no | no |
| CUL2_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN8_HUMAN | [view interactions] | High throughput | no | yes |
| TBC15_HUMAN | [view interactions] | High throughput | no | yes |
| ZBBX_HUMAN | [view interactions] | High throughput | no | no |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| RS16_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BNIP5_HUMAN | [view interactions] | High throughput | no | no |
| HIDE1_HUMAN | [view interactions] | High throughput | no | no |
| CXCR4_HUMAN | [view interactions] | High throughput | no | no |
| FIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYS1_HUMAN | [view interactions] | High throughput | no | no |
| ADT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLRG2_HUMAN | [view interactions] | High throughput | no | no |
| ADT4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARVA_HUMAN | [view interactions] | High throughput | no | yes |
| COR1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| OSBP1_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAB2_HUMAN | [view interactions] | High throughput | no | yes |
| LICH_HUMAN | [view interactions] | High throughput | no | yes |
| MECR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEMO1_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD9_HUMAN | [view interactions] | High throughput | no | yes |
| SELO_HUMAN | [view interactions] | High throughput | no | yes |
| GGA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCAB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AOFA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AOFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLAP_HUMAN | [view interactions] | High throughput | no | yes |
| PP1R7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP2BA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBXN7_HUMAN | [view interactions] | High throughput | no | yes |
| TWF2_HUMAN | [view interactions] | High throughput | no | no |
| AHSA2_HUMAN | [view interactions] | High throughput | no | no |
| HAOX1_HUMAN | [view interactions] | High throughput | no | no |
| CARME_HUMAN | [view interactions] | High throughput | no | yes |
| TBC25_HUMAN | [view interactions] | High throughput | no | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DJB13_HUMAN | [view interactions] | High throughput | no | no |
| GBRL2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB7B_HUMAN | [view interactions] | Computational | no | no |
| GBRAP_HUMAN | [view interactions] | Computational | no | no |