Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KCAB2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed, PubMed). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability . Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity . Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed, PubMed). Promotes KCNA4 channel closure (PubMed, PubMed). Modulates the functional properties of KCNA5 . Enhances KCNB2 channel activity . Binds NADPH and has NADPH-dependent aldoketoreductase activity . Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KCAB2_HUMAN
GO:0008324 cation transmembrane transporter activity 43.9024 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 43.9024 4 yes
GO:0005216 ion channel activity 41.4634 4 yes
GO:0005261 cation channel activity 41.4634 5 yes
GO:0015267 channel activity 41.4634 4 yes
GO:0022836 gated channel activity 41.4634 5 yes
GO:0046873 metal ion transmembrane transporter activity 41.4634 5 yes
GO:0005244 voltage-gated ion channel activity 39.0244 4 yes
GO:0005249 voltage-gated potassium channel activity 39.0244 6 yes
GO:0005267 potassium channel activity 39.0244 6 yes
GO:0015079 potassium ion transmembrane transporter activity 39.0244 6 yes
GO:0022832 voltage-gated channel activity 39.0244 6 yes
GO:0022843 voltage-gated cation channel activity 39.0244 5 yes
GO:0005251 delayed rectifier potassium channel activity 26.8293 7 no
GO:0015459 potassium channel regulator activity 9.7561 4 yes
GO:0004033 aldo-keto reductase (NADP) activity 4.8780 5 yes
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4.8780 4 yes
GO:0047834 D-threo-aldose 1-dehydrogenase activity 4.8780 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KCAB2_HUMAN
GO:0051049 regulation of transport 68.2927 4 yes
GO:0043269 regulation of ion transport 56.0976 5 yes
GO:0034762 regulation of transmembrane transport 53.6585 4 yes
GO:0034765 regulation of ion transmembrane transport 53.6585 5 yes
GO:0022607 cellular component assembly 48.7805 4 no
GO:0048522 positive regulation of cellular process 43.9024 4 no
GO:0006811 ion transport 39.0244 4 no
GO:0006812 cation transport 39.0244 5 no
GO:0043933 protein-containing complex organization 39.0244 4 no
GO:0065003 protein-containing complex assembly 39.0244 5 no
GO:0030001 metal ion transport 36.5854 6 no
GO:0051259 protein complex oligomerization 36.5854 6 no
GO:0098655 cation transmembrane transport 36.5854 4 no
GO:0098660 inorganic ion transmembrane transport 36.5854 4 no
GO:0098662 inorganic cation transmembrane transport 36.5854 5 no
GO:0010646 regulation of cell communication 36.5854 4 no
GO:0006813 potassium ion transport 34.1463 7 no
GO:0051260 protein homooligomerization 34.1463 7 no
GO:0071805 potassium ion transmembrane transport 34.1463 6 no
GO:0008104 protein localization 34.1463 4 no
GO:0048523 negative regulation of cellular process 34.1463 4 no
GO:0051128 regulation of cellular component organization 34.1463 4 no
GO:0006996 organelle organization 31.7073 4 no
GO:0009966 regulation of signal transduction 31.7073 4 no
GO:0060255 regulation of macromolecule metabolic process 31.7073 4 no
GO:0051171 regulation of nitrogen compound metabolic process 29.2683 4 no
GO:0080090 regulation of primary metabolic process 29.2683 4 no
GO:1904062 regulation of cation transmembrane transport 26.8293 6 yes
GO:0031323 regulation of cellular metabolic process 26.8293 4 no
GO:0051246 regulation of protein metabolic process 26.8293 5 no
GO:0010648 negative regulation of cell communication 24.3902 5 no
GO:0023057 negative regulation of signaling 24.3902 4 no
GO:0050804 modulation of chemical synaptic transmission 24.3902 5 no
GO:0051050 positive regulation of transport 24.3902 4 no
GO:0099177 regulation of trans-synaptic signaling 24.3902 4 no
GO:0010647 positive regulation of cell communication 24.3902 5 no
GO:0023056 positive regulation of signaling 24.3902 4 no
GO:0009893 positive regulation of metabolic process 24.3902 4 no
GO:0048584 positive regulation of response to stimulus 24.3902 4 no
GO:0006796 phosphate-containing compound metabolic process 21.9512 4 yes
GO:0010959 regulation of metal ion transport 21.9512 6 yes
GO:0060341 regulation of cellular localization 21.9512 4 yes
GO:0010941 regulation of cell death 21.9512 4 no
GO:0042981 regulation of apoptotic process 21.9512 6 no
GO:0043067 regulation of programmed cell death 21.9512 5 no
GO:0009892 negative regulation of metabolic process 21.9512 4 no
GO:0010605 negative regulation of macromolecule metabolic process 21.9512 5 no
GO:0050890 cognition 21.9512 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 21.9512 5 no
GO:1902531 regulation of intracellular signal transduction 21.9512 5 no
GO:0010604 positive regulation of macromolecule metabolic process 21.9512 5 no
GO:0032880 regulation of protein localization 19.5122 5 yes
GO:0043266 regulation of potassium ion transport 17.0732 7 yes
GO:1901379 regulation of potassium ion transmembrane transport 17.0732 7 yes
GO:0006753 nucleoside phosphate metabolic process 9.7561 4 yes
GO:0009117 nucleotide metabolic process 9.7561 5 yes
GO:0006739 NADP metabolic process 4.8780 7 yes
GO:0019362 pyridine nucleotide metabolic process 4.8780 5 yes
GO:0046496 nicotinamide nucleotide metabolic process 4.8780 6 yes
GO:0070995 NADPH oxidation 4.8780 8 yes
GO:0072524 pyridine-containing compound metabolic process 4.8780 4 yes
GO:2000008 regulation of protein localization to cell surface 4.8780 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in KCAB2_HUMAN
DOID:331 central nervous system disease 17.0732 3 no
DOID:0050701 electroclinical syndrome 9.7561 6 no
DOID:1826 epilepsy 9.7561 5 no
DOID:936 brain disease 9.7561 4 no
DOID:0050951 hereditary ataxia 7.3171 5 no
DOID:1289 neurodegenerative disease 7.3171 4 no
DOID:0112202 developmental and epileptic encephalopathy 7.3171 7 no
DOID:0050753 cerebellar ataxia 4.8780 6 no
DOID:1441 autosomal dominant cerebellar ataxia 4.8780 7 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
SQSTM_HUMAN [view interactions] Low throughput no yes
KCNA3_HUMAN [view entry] [view interactions] Low throughput yes no
KCNA2_HUMAN [view entry] [view interactions] Low throughput yes yes
KCNA1_HUMAN [view entry] [view interactions] Low throughput yes yes
KCAB2_HUMAN [view entry] [view interactions] Low throughput yes yes
S40A1_HUMAN [view interactions] Low throughput no no
KPCZ_HUMAN [view entry] [view interactions] Low throughput yes yes
KHDR1_HUMAN [view interactions] Low throughput no yes
KCNA5_HUMAN [view interactions] Low throughput no no
KCNA4_HUMAN [view entry] [view interactions] Low throughput yes yes
SIR1_HUMAN [view interactions] Low throughput no yes
KCAB3_HUMAN [view interactions] High throughput no no
GRIA2_HUMAN [view entry] [view interactions] High throughput yes yes
NASP_HUMAN [view interactions] High throughput no yes
SNX3_HUMAN [view entry] [view interactions] High throughput yes no
ZN281_HUMAN [view interactions] High throughput no no
RM50_HUMAN [view interactions] High throughput no yes
BCOR_HUMAN [view interactions] High throughput no no
BAG6_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5B_HUMAN [view entry] [view interactions] High throughput yes yes
SNW1_HUMAN [view interactions] High throughput no yes
UBR5_HUMAN [view interactions] High throughput no no
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
TNNC2_HUMAN [view interactions] High throughput no no
KCA10_HUMAN [view interactions] High throughput no no
KPCD2_HUMAN [view interactions] High throughput no yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
F16P1_HUMAN [view interactions] High throughput no no
DDX58_HUMAN [view interactions] High throughput no yes
MFAP4_HUMAN [view interactions] High throughput no no
PEX19_HUMAN [view interactions] High throughput no yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
NED4L_HUMAN [view interactions] High throughput no yes
PUR9_HUMAN [view entry] [view interactions] High throughput yes yes
ALDOA_HUMAN [view entry] [view interactions] High throughput yes no
PPCE_HUMAN [view interactions] High throughput no yes
NTF2_HUMAN [view interactions] High throughput no yes
DPP6_HUMAN [view entry] [view interactions] High throughput yes no
TBC17_HUMAN [view entry] [view interactions] High throughput yes yes
CNTP2_HUMAN [view entry] [view interactions] High throughput yes yes
ATX1_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SAP_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
MIME_HUMAN [view interactions] High throughput no no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
HAOX1_HUMAN [view interactions] High throughput no no
KCAB1_HUMAN [view interactions] High throughput no no
GAPD1_HUMAN [view entry] [view interactions] High throughput yes yes
CCAR2_HUMAN [view interactions] High throughput no yes
KCNA6_HUMAN [view interactions] High throughput no no
KCNH5_HUMAN [view interactions] Computational no no
KCNQ2_HUMAN [view entry] [view interactions] Computational yes yes
KCNB1_HUMAN [view entry] [view interactions] Computational yes yes
KCNH1_HUMAN [view entry] [view interactions] Computational yes yes
KCND3_HUMAN [view entry] [view interactions] Computational yes yes
KCNC2_HUMAN [view entry] [view interactions] Computational yes no
KCNS3_HUMAN [view interactions] Computational no yes
KCNV1_HUMAN [view interactions] Computational no no
KCNC4_HUMAN [view entry] [view interactions] Computational yes no
KCNF1_HUMAN [view interactions] Computational no no
RAB28_HUMAN [view interactions] Computational no yes
KCND1_HUMAN [view entry] [view interactions] Computational yes yes
KCNQ4_HUMAN [view interactions] Computational no yes
KCND2_HUMAN [view entry] [view interactions] Computational yes yes
KCNQ3_HUMAN [view interactions] Computational no no
KCNC1_HUMAN [view entry] [view interactions] Computational yes yes
KCNC3_HUMAN [view entry] [view interactions] Computational yes yes
KCNB2_HUMAN [view interactions] Computational no no