Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KCAB2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed, PubMed). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability . Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity . Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed, PubMed). Promotes KCNA4 channel closure (PubMed, PubMed). Modulates the functional properties of KCNA5 . Enhances KCNB2 channel activity . Binds NADPH and has NADPH-dependent aldoketoreductase activity . Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KCAB2_HUMAN
GO:0005216 monoatomic ion channel activity 23.5294 4 yes
GO:0015267 channel activity 23.5294 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 23.5294 4 yes
GO:0005261 monoatomic cation channel activity 20.5882 5 yes
GO:0008324 monoatomic cation transmembrane transporter activity 20.5882 4 yes
GO:0022836 gated channel activity 20.5882 5 yes
GO:0046873 metal ion transmembrane transporter activity 20.5882 5 yes
GO:0005244 voltage-gated monoatomic ion channel activity 17.6471 5 yes
GO:0005249 voltage-gated potassium channel activity 17.6471 7 yes
GO:0005267 potassium channel activity 17.6471 6 yes
GO:0015079 potassium ion transmembrane transporter activity 17.6471 6 yes
GO:0022832 voltage-gated channel activity 17.6471 6 yes
GO:0022843 voltage-gated monoatomic cation channel activity 17.6471 6 yes
GO:0099106 ion channel regulator activity 17.6471 4 yes
GO:0015459 potassium channel regulator activity 14.7059 5 yes
GO:0004033 aldo-keto reductase (NADPH) activity 5.8824 5 yes
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 5.8824 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KCAB2_HUMAN
GO:0051049 regulation of transport 52.9412 4 yes
GO:0051128 regulation of cellular component organization 50.0000 4 no
GO:0010646 regulation of cell communication 50.0000 4 no
GO:0048522 positive regulation of cellular process 47.0588 4 no
GO:0048523 negative regulation of cellular process 47.0588 4 no
GO:0060255 regulation of macromolecule metabolic process 44.1176 4 no
GO:0006996 organelle organization 44.1176 4 no
GO:0080090 regulation of primary metabolic process 41.1765 4 no
GO:0009966 regulation of signal transduction 41.1765 4 no
GO:0051246 regulation of protein metabolic process 38.2353 5 no
GO:0022607 cellular component assembly 38.2353 4 no
GO:0009893 positive regulation of metabolic process 35.2941 4 no
GO:0008104 protein localization 35.2941 4 no
GO:0050804 modulation of chemical synaptic transmission 35.2941 5 no
GO:0099177 regulation of trans-synaptic signaling 35.2941 4 no
GO:0010604 positive regulation of macromolecule metabolic process 32.3529 5 no
GO:0031323 regulation of cellular metabolic process 32.3529 4 no
GO:0060341 regulation of cellular localization 29.4118 4 yes
GO:0009894 regulation of catabolic process 29.4118 4 no
GO:0050890 cognition 29.4118 4 no
GO:1902531 regulation of intracellular signal transduction 29.4118 5 no
GO:0010647 positive regulation of cell communication 29.4118 5 no
GO:0023056 positive regulation of signaling 29.4118 4 no
GO:0048584 positive regulation of response to stimulus 29.4118 4 no
GO:0009892 negative regulation of metabolic process 29.4118 4 no
GO:0010605 negative regulation of macromolecule metabolic process 29.4118 5 no
GO:0006796 phosphate-containing compound metabolic process 26.4706 4 yes
GO:0032880 regulation of protein localization 26.4706 5 yes
GO:0034762 regulation of transmembrane transport 26.4706 4 yes
GO:0031344 regulation of cell projection organization 26.4706 5 no
GO:0036211 protein modification process 26.4706 4 no
GO:0043412 macromolecule modification 26.4706 4 no
GO:0051130 positive regulation of cellular component organization 26.4706 5 no
GO:0051247 positive regulation of protein metabolic process 26.4706 6 no
GO:0010648 negative regulation of cell communication 26.4706 5 no
GO:0023057 negative regulation of signaling 26.4706 4 no
GO:0030030 cell projection organization 26.4706 4 no
GO:0048585 negative regulation of response to stimulus 26.4706 4 no
GO:0120036 plasma membrane bounded cell projection organization 26.4706 5 no
GO:0043933 protein-containing complex organization 26.4706 4 no
GO:0043269 regulation of monoatomic ion transport 23.5294 5 yes
GO:0009896 positive regulation of catabolic process 23.5294 5 no
GO:0022603 regulation of anatomical structure morphogenesis 23.5294 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.5294 6 no
GO:0009968 negative regulation of signal transduction 23.5294 5 no
GO:0031175 neuron projection development 23.5294 6 no
GO:0045595 regulation of cell differentiation 23.5294 4 no
GO:0051129 negative regulation of cellular component organization 23.5294 5 no
GO:0009967 positive regulation of signal transduction 23.5294 5 no
GO:0009889 regulation of biosynthetic process 23.5294 4 no
GO:0010468 regulation of gene expression 23.5294 6 no
GO:0010556 regulation of macromolecule biosynthetic process 23.5294 5 no
GO:0019220 regulation of phosphate metabolic process 23.5294 6 no
GO:0031324 negative regulation of cellular metabolic process 23.5294 5 no
GO:0031326 regulation of cellular biosynthetic process 23.5294 5 no
GO:0031399 regulation of protein modification process 23.5294 6 no
GO:0042325 regulation of phosphorylation 23.5294 7 no
GO:0044087 regulation of cellular component biogenesis 23.5294 4 no
GO:0051174 regulation of phosphorus metabolic process 23.5294 5 no
GO:0065003 protein-containing complex assembly 23.5294 5 no
GO:0010959 regulation of metal ion transport 20.5882 6 yes
GO:0034765 regulation of monoatomic ion transmembrane transport 20.5882 5 yes
GO:1904062 regulation of monoatomic cation transmembrane transport 20.5882 6 yes
GO:0010975 regulation of neuron projection development 20.5882 7 no
GO:0051051 negative regulation of transport 20.5882 4 no
GO:0060627 regulation of vesicle-mediated transport 20.5882 4 no
GO:2000026 regulation of multicellular organismal development 20.5882 4 no
GO:0007010 cytoskeleton organization 20.5882 5 no
GO:0001932 regulation of protein phosphorylation 20.5882 7 no
GO:0031325 positive regulation of cellular metabolic process 20.5882 5 no
GO:0051248 negative regulation of protein metabolic process 20.5882 6 no
GO:0051259 protein complex oligomerization 20.5882 6 no
GO:0043549 regulation of kinase activity 20.5882 5 no
GO:0051338 regulation of transferase activity 20.5882 4 no
GO:0043266 regulation of potassium ion transport 14.7059 7 yes
GO:1901379 regulation of potassium ion transmembrane transport 14.7059 7 yes
GO:0006163 purine nucleotide metabolic process 11.7647 5 yes
GO:0006753 nucleoside phosphate metabolic process 11.7647 4 yes
GO:0009117 nucleotide metabolic process 11.7647 5 yes
GO:0072521 purine-containing compound metabolic process 11.7647 4 yes
GO:0019362 pyridine nucleotide metabolic process 8.8235 5 yes
GO:0046496 nicotinamide nucleotide metabolic process 8.8235 6 yes
GO:0072524 pyridine-containing compound metabolic process 8.8235 4 yes
GO:2000008 regulation of protein localization to cell surface 8.8235 6 yes
GO:0006739 NADP metabolic process 5.8824 6 yes
GO:0070995 NADPH oxidation 5.8824 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KCNA2_HUMAN [view entry] [view interactions] Low throughput yes yes
KCNA1_HUMAN [view entry] [view interactions] Low throughput yes yes
KCAB2_HUMAN [view entry] [view interactions] Low throughput yes yes
S40A1_HUMAN [view interactions] Low throughput no no
KPCZ_HUMAN [view entry] [view interactions] Low throughput yes yes
KHDR1_HUMAN [view interactions] Low throughput no yes
KCNA5_HUMAN [view interactions] Low throughput no no
KCNA4_HUMAN [view entry] [view interactions] Low throughput yes yes
SIR1_HUMAN [view interactions] Low throughput no yes
SQSTM_HUMAN [view interactions] Low throughput no yes
KCNA3_HUMAN [view entry] [view interactions] Low throughput yes no
ATX1_HUMAN [view interactions] High throughput no yes
SPTCS_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SAP_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
MIME_HUMAN [view interactions] High throughput no no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
LCOR_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
HAOX1_HUMAN [view interactions] High throughput no no
KCAB1_HUMAN [view interactions] High throughput no no
GAPD1_HUMAN [view entry] [view interactions] High throughput yes yes
CCAR2_HUMAN [view interactions] High throughput no yes
KCNA6_HUMAN [view interactions] High throughput no no
KCAB3_HUMAN [view interactions] High throughput no no
GRIA2_HUMAN [view entry] [view interactions] High throughput yes yes
NASP_HUMAN [view interactions] High throughput no yes
SNX3_HUMAN [view entry] [view interactions] High throughput yes no
ZN281_HUMAN [view interactions] High throughput no no
RM50_HUMAN [view interactions] High throughput no yes
BCOR_HUMAN [view interactions] High throughput no no
BAG6_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5B_HUMAN [view entry] [view interactions] High throughput yes yes
SNW1_HUMAN [view interactions] High throughput no yes
UBR5_HUMAN [view interactions] High throughput no no
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
TNNC2_HUMAN [view interactions] High throughput no no
KCA10_HUMAN [view interactions] High throughput no no
KPCD2_HUMAN [view interactions] High throughput no yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
F16P1_HUMAN [view interactions] High throughput no no
RIGI_HUMAN [view interactions] High throughput no yes
MFAP4_HUMAN [view interactions] High throughput no no
PEX19_HUMAN [view interactions] High throughput no yes
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
HSF1_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
NED4L_HUMAN [view entry] [view interactions] High throughput yes yes
PUR9_HUMAN [view entry] [view interactions] High throughput yes yes
ALDOA_HUMAN [view entry] [view interactions] High throughput yes no
PPCE_HUMAN [view interactions] High throughput no yes
NTF2_HUMAN [view interactions] High throughput no yes
DPP6_HUMAN [view entry] [view interactions] High throughput yes no
TBC17_HUMAN [view entry] [view interactions] High throughput yes yes
CNTP2_HUMAN [view entry] [view interactions] High throughput yes yes
HDHD3_HUMAN [view interactions] High throughput no yes