Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

PUR9_HUMAN

Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed, PubMed). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed, PubMed, PubMed). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed). Also catalyzes the cyclization of FAICAR to IMP (PubMed, PubMed). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in PUR9_HUMAN
GO:0000166 nucleotide binding 32.6531 4 no
GO:0017076 purine nucleotide binding 32.6531 5 no
GO:0043168 anion binding 32.6531 4 no
GO:0032555 purine ribonucleotide binding 30.6122 4 no
GO:0035639 purine ribonucleoside triphosphate binding 30.6122 4 no
GO:0030554 adenyl nucleotide binding 26.5306 6 no
GO:0019900 kinase binding 26.5306 4 no
GO:0019901 protein kinase binding 26.5306 5 no
GO:0005524 ATP binding 24.4898 5 no
GO:0032559 adenyl ribonucleotide binding 24.4898 5 no
GO:0031625 ubiquitin protein ligase binding 24.4898 5 no
GO:0043169 cation binding 24.4898 4 no
GO:0044389 ubiquitin-like protein ligase binding 24.4898 4 no
GO:0046872 metal ion binding 24.4898 5 no
GO:0045296 cadherin binding 22.4490 4 yes
GO:0003723 RNA binding 22.4490 4 no
GO:0042803 protein homodimerization activity 14.2857 4 yes
GO:0003937 IMP cyclohydrolase activity 4.0816 6 yes
GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity 4.0816 5 yes
GO:0016742 hydroxymethyl-, formyl- and related transferase activity 4.0816 4 yes
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 4.0816 4 yes
GO:0019238 cyclohydrolase activity 4.0816 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in PUR9_HUMAN
GO:0048522 positive regulation of cellular process 67.3469 4 no
GO:0031323 regulation of cellular metabolic process 57.1429 4 no
GO:0060255 regulation of macromolecule metabolic process 57.1429 4 no
GO:0080090 regulation of primary metabolic process 55.1020 4 no
GO:0048523 negative regulation of cellular process 53.0612 4 no
GO:0009889 regulation of biosynthetic process 46.9388 4 no
GO:0010468 regulation of gene expression 46.9388 6 no
GO:0010556 regulation of macromolecule biosynthetic process 46.9388 5 no
GO:0031326 regulation of cellular biosynthetic process 46.9388 5 no
GO:0009893 positive regulation of metabolic process 40.8163 4 no
GO:0010646 regulation of cell communication 40.8163 4 no
GO:0051128 regulation of cellular component organization 38.7755 4 no
GO:0032880 regulation of protein localization 38.7755 5 no
GO:0060341 regulation of cellular localization 38.7755 4 no
GO:0009966 regulation of signal transduction 38.7755 4 no
GO:0071310 cellular response to organic substance 36.7347 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 36.7347 5 no
GO:0031325 positive regulation of cellular metabolic process 36.7347 5 no
GO:0048584 positive regulation of response to stimulus 36.7347 4 no
GO:0009892 negative regulation of metabolic process 36.7347 4 no
GO:0051246 regulation of protein metabolic process 36.7347 5 no
GO:0010605 negative regulation of macromolecule metabolic process 34.6939 5 no
GO:1902531 regulation of intracellular signal transduction 34.6939 5 no
GO:0009891 positive regulation of biosynthetic process 32.6531 5 no
GO:0031328 positive regulation of cellular biosynthetic process 32.6531 6 no
GO:0036211 protein modification process 32.6531 4 no
GO:0043067 regulation of programmed cell death 32.6531 4 no
GO:0043412 macromolecule modification 32.6531 4 no
GO:0006796 phosphate-containing compound metabolic process 30.6122 4 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 30.6122 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.6122 5 no
GO:0022607 cellular component assembly 30.6122 4 no
GO:0008104 protein localization 30.6122 4 no
GO:0031324 negative regulation of cellular metabolic process 30.6122 5 no
GO:0051049 regulation of transport 30.6122 4 no
GO:0042981 regulation of apoptotic process 30.6122 5 no
GO:0051094 positive regulation of developmental process 30.6122 4 no
GO:0006355 regulation of DNA-templated transcription 26.5306 7 no
GO:0051252 regulation of RNA metabolic process 26.5306 5 no
GO:0080134 regulation of response to stress 26.5306 4 no
GO:2001141 regulation of RNA biosynthetic process 26.5306 6 no
GO:0019220 regulation of phosphate metabolic process 26.5306 6 no
GO:0051174 regulation of phosphorus metabolic process 26.5306 5 no
GO:1903829 positive regulation of protein localization 26.5306 5 no
GO:1901701 cellular response to oxygen-containing compound 26.5306 4 no
GO:0006996 organelle organization 24.4898 4 no
GO:0031399 regulation of protein modification process 24.4898 6 no
GO:0045595 regulation of cell differentiation 24.4898 4 no
GO:0051130 positive regulation of cellular component organization 22.4490 5 no
GO:0051248 negative regulation of protein metabolic process 22.4490 6 no
GO:0051726 regulation of cell cycle 22.4490 4 no
GO:0009890 negative regulation of biosynthetic process 22.4490 5 no
GO:0009967 positive regulation of signal transduction 22.4490 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 22.4490 6 no
GO:0010647 positive regulation of cell communication 22.4490 5 no
GO:0023056 positive regulation of signaling 22.4490 4 no
GO:0031327 negative regulation of cellular biosynthetic process 22.4490 6 no
GO:0051247 positive regulation of protein metabolic process 22.4490 6 no
GO:0006508 proteolysis 22.4490 4 no
GO:0009894 regulation of catabolic process 22.4490 4 no
GO:0022603 regulation of anatomical structure morphogenesis 22.4490 4 no
GO:0048585 negative regulation of response to stimulus 22.4490 4 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 20.4082 5 no
GO:0031400 negative regulation of protein modification process 20.4082 7 no
GO:0032101 regulation of response to external stimulus 20.4082 4 no
GO:0070201 regulation of establishment of protein localization 20.4082 6 no
GO:0010628 positive regulation of gene expression 20.4082 7 no
GO:0051240 positive regulation of multicellular organismal process 20.4082 4 no
GO:0009057 macromolecule catabolic process 20.4082 4 no
GO:0009968 negative regulation of signal transduction 20.4082 5 no
GO:0010243 response to organonitrogen compound 20.4082 4 no
GO:0010648 negative regulation of cell communication 20.4082 5 no
GO:0023057 negative regulation of signaling 20.4082 4 no
GO:0033043 regulation of organelle organization 20.4082 5 no
GO:0043933 protein-containing complex organization 20.4082 4 no
GO:0030334 regulation of cell migration 20.4082 5 no
GO:2000145 regulation of cell motility 20.4082 4 no
GO:0034097 response to cytokine 16.3265 4 yes
GO:0006163 purine nucleotide metabolic process 14.2857 5 yes
GO:0006753 nucleoside phosphate metabolic process 14.2857 4 yes
GO:0009117 nucleotide metabolic process 14.2857 5 yes
GO:0071345 cellular response to cytokine stimulus 14.2857 5 yes
GO:0072521 purine-containing compound metabolic process 14.2857 4 yes
GO:0009150 purine ribonucleotide metabolic process 12.2449 6 yes
GO:0009259 ribonucleotide metabolic process 12.2449 5 yes
GO:0019693 ribose phosphate metabolic process 12.2449 4 yes
GO:0019752 carboxylic acid metabolic process 10.2041 5 yes
GO:0034654 nucleobase-containing compound biosynthetic process 10.2041 4 yes
GO:0043436 oxoacid metabolic process 10.2041 4 yes
GO:1901362 organic cyclic compound biosynthetic process 10.2041 4 yes
GO:1901566 organonitrogen compound biosynthetic process 10.2041 4 yes
GO:0006164 purine nucleotide biosynthetic process 8.1633 6 yes
GO:0009152 purine ribonucleotide biosynthetic process 8.1633 7 yes
GO:0009165 nucleotide biosynthetic process 8.1633 6 yes
GO:0009260 ribonucleotide biosynthetic process 8.1633 6 yes
GO:0046390 ribose phosphate biosynthetic process 8.1633 5 yes
GO:0072522 purine-containing compound biosynthetic process 8.1633 5 yes
GO:0090407 organophosphate biosynthetic process 8.1633 4 yes
GO:1901137 carbohydrate derivative biosynthetic process 8.1633 4 yes
GO:1901293 nucleoside phosphate biosynthetic process 8.1633 5 yes
GO:0006167 AMP biosynthetic process 6.1224 8 yes
GO:0006177 GMP biosynthetic process 6.1224 8 yes
GO:0006188 IMP biosynthetic process 6.1224 8 yes
GO:0006189 de novo IMP biosynthetic process 6.1224 9 yes
GO:0009123 nucleoside monophosphate metabolic process 6.1224 5 yes
GO:0009124 nucleoside monophosphate biosynthetic process 6.1224 6 yes
GO:0009126 purine nucleoside monophosphate metabolic process 6.1224 6 yes
GO:0009127 purine nucleoside monophosphate biosynthetic process 6.1224 7 yes
GO:0009156 ribonucleoside monophosphate biosynthetic process 6.1224 7 yes
GO:0009161 ribonucleoside monophosphate metabolic process 6.1224 6 yes
GO:0009167 purine ribonucleoside monophosphate metabolic process 6.1224 7 yes
GO:0009168 purine ribonucleoside monophosphate biosynthetic process 6.1224 8 yes
GO:0031100 animal organ regeneration 6.1224 4 yes
GO:0043648 dicarboxylic acid metabolic process 6.1224 6 yes
GO:0044208 de novo AMP biosynthetic process 6.1224 9 yes
GO:0046033 AMP metabolic process 6.1224 7 yes
GO:0046037 GMP metabolic process 6.1224 7 yes
GO:0046040 IMP metabolic process 6.1224 7 yes
GO:0097292 XMP metabolic process 6.1224 7 yes
GO:0097293 XMP biosynthetic process 6.1224 8 yes
GO:0097294 de novo XMP biosynthetic process 6.1224 9 yes
GO:0006760 folic acid-containing compound metabolic process 4.0816 4 yes
GO:0009396 folic acid-containing compound biosynthetic process 4.0816 5 yes
GO:0042398 cellular modified amino acid biosynthetic process 4.0816 4 yes
GO:0042558 pteridine-containing compound metabolic process 4.0816 4 yes
GO:0042559 pteridine-containing compound biosynthetic process 4.0816 5 yes
GO:0046452 dihydrofolate metabolic process 4.0816 5 yes
GO:0046653 tetrahydrofolate metabolic process 4.0816 5 yes
GO:0046654 tetrahydrofolate biosynthetic process 4.0816 6 yes
GO:0098760 response to interleukin-7 4.0816 5 yes
GO:0098761 cellular response to interleukin-7 4.0816 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PUR9_HUMAN [view entry] [view interactions] Low throughput yes yes
MTR1A_HUMAN [view interactions] High throughput no no
IFIX_HUMAN [view interactions] High throughput no no
OTUB1_HUMAN [view interactions] High throughput no yes
SH3G3_HUMAN [view entry] [view interactions] High throughput yes no
SHOC2_HUMAN [view interactions] High throughput no yes
KPCE_HUMAN [view entry] [view interactions] High throughput yes yes
CAV1_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
P53_HUMAN [view interactions] High throughput no no
NF2L2_HUMAN [view interactions] High throughput no yes
HMGA2_HUMAN [view interactions] High throughput no yes
TRI63_HUMAN [view interactions] High throughput no no
M3K7_HUMAN [view interactions] High throughput no yes
MYLK_HUMAN [view entry] [view interactions] High throughput yes no
VHL_HUMAN [view entry] [view interactions] High throughput yes yes
ELF3_HUMAN [view interactions] High throughput no no
CIA30_HUMAN [view interactions] High throughput no yes
SNRPA_HUMAN [view interactions] High throughput no yes
RADIL_HUMAN [view interactions] High throughput no no
STOM_HUMAN [view entry] [view interactions] High throughput yes yes
HNRDL_HUMAN [view interactions] High throughput no yes
MAOM_HUMAN [view interactions] High throughput no yes
CMBL_HUMAN [view interactions] High throughput no no
CDK2_HUMAN [view interactions] High throughput no yes
TRAF6_HUMAN [view entry] [view interactions] High throughput yes yes
PPIP1_HUMAN [view interactions] High throughput no no
IKKE_HUMAN [view interactions] High throughput no yes
NDKB_HUMAN [view entry] [view interactions] High throughput yes yes
TX101_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
RBM11_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
SPB5_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
JAK1_HUMAN [view interactions] High throughput no yes
SIR7_HUMAN [view interactions] High throughput no yes
ISG15_HUMAN [view interactions] High throughput no no
CUL7_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
INSR_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
U2AF2_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
RN123_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
TFE3_HUMAN [view interactions] High throughput no yes
BIRC3_HUMAN [view interactions] High throughput no no
LMBRL_HUMAN [view interactions] High throughput no no
PINK1_HUMAN [view interactions] High throughput no yes
EMC2_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
PRC1_HUMAN [view interactions] High throughput no yes
IF16_HUMAN [view interactions] High throughput no no
BRD4_HUMAN [view interactions] High throughput no yes
RIGI_HUMAN [view interactions] High throughput no yes
KAT6A_HUMAN [view interactions] High throughput no yes
CATL1_HUMAN [view interactions] High throughput no yes
IFM1_HUMAN [view interactions] High throughput no no
IFM3_HUMAN [view interactions] High throughput no yes
CLC4D_HUMAN [view interactions] High throughput no no
CLC4E_HUMAN [view interactions] High throughput no no
BAG1_HUMAN [view interactions] High throughput no yes
FBX43_HUMAN [view interactions] High throughput no no
ARP2_HUMAN [view entry] [view interactions] High throughput yes yes
ARL3_HUMAN [view interactions] High throughput no yes
SAR1B_HUMAN [view interactions] High throughput no yes
AURKA_HUMAN [view entry] [view interactions] High throughput yes no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC6_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
HAPR1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
RHG24_HUMAN [view interactions] High throughput no yes
MYO10_HUMAN [view interactions] High throughput no no
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
GSK3A_HUMAN [view interactions] High throughput no yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
TET5C_HUMAN [view interactions] High throughput no yes
CYTN_HUMAN [view interactions] High throughput no no
EZH2_HUMAN [view interactions] High throughput no no
UBE2H_HUMAN [view interactions] High throughput no yes
FAS_HUMAN [view entry] [view interactions] High throughput yes no
SRBP2_HUMAN [view interactions] High throughput no yes
ATG7_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RIT1_HUMAN [view interactions] High throughput no yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
ICLN_HUMAN [view interactions] High throughput no yes
TYSY_HUMAN [view interactions] High throughput no yes
SCOT1_HUMAN [view entry] [view interactions] High throughput yes yes
RBBP6_HUMAN [view interactions] High throughput no yes
CRK_HUMAN [view entry] [view interactions] High throughput yes no
TADBP_HUMAN [view interactions] High throughput no yes
SUMO2_HUMAN [view entry] [view interactions] High throughput yes yes
THIO_HUMAN [view interactions] High throughput no yes
ASB6_HUMAN [view interactions] High throughput no yes
SAHH_HUMAN [view entry] [view interactions] High throughput yes yes
CAN2_HUMAN [view entry] [view interactions] High throughput yes no
CGL_HUMAN [view interactions] High throughput no yes
FUMH_HUMAN [view entry] [view interactions] High throughput yes yes
GMDS_HUMAN [view interactions] High throughput no yes
MCTS1_HUMAN [view interactions] High throughput no no
STK26_HUMAN [view interactions] High throughput no no
MYO1E_HUMAN [view entry] [view interactions] High throughput yes yes
OGFD1_HUMAN [view interactions] High throughput no yes
PAPS1_HUMAN [view interactions] High throughput no yes
PTMA_HUMAN [view interactions] High throughput no yes
TATD1_HUMAN [view interactions] High throughput no yes
UBA1_HUMAN [view entry] [view interactions] High throughput yes yes
IPO5_HUMAN [view entry] [view interactions] High throughput yes yes
ISOC1_HUMAN [view interactions] High throughput no no
MOES_HUMAN [view entry] [view interactions] High throughput yes no
ULA1_HUMAN [view entry] [view interactions] High throughput yes yes
NSF1C_HUMAN [view entry] [view interactions] High throughput yes yes
LIS1_HUMAN [view entry] [view interactions] High throughput yes yes
PLPHP_HUMAN [view interactions] High throughput no yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
A16A1_HUMAN [view entry] [view interactions] High throughput yes no
ACO13_HUMAN [view entry] [view interactions] High throughput yes yes
PUR8_HUMAN [view interactions] High throughput no yes
ARMT1_HUMAN [view interactions] High throughput no yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
DEOC_HUMAN [view interactions] High throughput no no
DNM1L_HUMAN [view entry] [view interactions] High throughput yes yes
LGUL_HUMAN [view interactions] High throughput no yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
KCAB1_HUMAN [view interactions] High throughput no no
KCAB2_HUMAN [view entry] [view interactions] High throughput yes yes
PUR6_HUMAN [view entry] [view interactions] High throughput yes yes
PGM1_HUMAN [view interactions] High throughput no no
PLIN3_HUMAN [view interactions] High throughput no yes
GLYC_HUMAN [view interactions] High throughput no no
SPRE_HUMAN [view interactions] High throughput no yes
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
RNZ2_HUMAN [view interactions] High throughput no yes
PUR2_HUMAN [view interactions] High throughput no yes
RTN4_HUMAN [view entry] [view interactions] High throughput yes yes
TRNT1_HUMAN [view interactions] High throughput no yes
BCAT1_HUMAN [view interactions] High throughput no no
DBLOH_HUMAN [view interactions] High throughput no no
ECH1_HUMAN [view interactions] High throughput no yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
CPNS1_HUMAN [view interactions] High throughput no yes
LDHA_HUMAN [view entry] [view interactions] High throughput yes yes
GNPI1_HUMAN [view interactions] High throughput no yes
SDSL_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
AGR2_HUMAN [view interactions] High throughput no no
NECD_HUMAN [view interactions] High throughput no no
MK11_HUMAN [view interactions] High throughput no yes
NAA40_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
STING_HUMAN [view interactions] High throughput no yes
KBTB4_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes