PUR9_HUMAN
Evidence for PS localization
Functions
Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed, PubMed). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed, PubMed, PubMed). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed). Also catalyzes the cyclization of FAICAR to IMP (PubMed, PubMed). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PUR9_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 26.1905 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 26.1905 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.1905 | 4 | no |
| GO:0045296 | cadherin binding | 23.8095 | 4 | yes |
| GO:0003723 | RNA binding | 23.8095 | 4 | no |
| GO:0046872 | metal ion binding | 21.4286 | 4 | no |
| GO:0042803 | protein homodimerization activity | 16.6667 | 4 | yes |
| GO:0016742 | hydroxymethyl-, formyl- and related transferase activity | 7.1429 | 4 | yes |
| GO:0003937 | IMP cyclohydrolase activity | 4.7619 | 6 | yes |
| GO:0004643 | phosphoribosylaminoimidazolecarboxamide formyltransferase activity | 4.7619 | 5 | yes |
| GO:0016814 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines | 4.7619 | 4 | yes |
| GO:0019238 | cyclohydrolase activity | 4.7619 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PUR9_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 61.9048 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 50.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 47.6190 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 47.6190 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 38.0952 | 5 | no |
| GO:0010468 | regulation of gene expression | 38.0952 | 5 | no |
| GO:0010646 | regulation of cell communication | 38.0952 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 35.7143 | 4 | no |
| GO:0060341 | regulation of cellular localization | 33.3333 | 4 | no |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0032880 | regulation of protein localization | 33.3333 | 5 | no |
| GO:0071310 | cellular response to organic substance | 30.9524 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 30.9524 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 28.5714 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 28.5714 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 28.5714 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 28.5714 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 28.5714 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 28.5714 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.5714 | 5 | no |
| GO:0051049 | regulation of transport | 28.5714 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 26.1905 | 6 | no |
| GO:1903829 | positive regulation of protein localization | 26.1905 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.1905 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.1905 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.1905 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 26.1905 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.1905 | 5 | no |
| GO:0031399 | regulation of protein modification process | 26.1905 | 6 | no |
| GO:0010941 | regulation of cell death | 23.8095 | 4 | no |
| GO:0036211 | protein modification process | 23.8095 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 23.8095 | 5 | no |
| GO:0043412 | macromolecule modification | 23.8095 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 23.8095 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 23.8095 | 4 | no |
| GO:0022607 | cellular component assembly | 23.8095 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.8095 | 4 | no |
| GO:0031400 | negative regulation of protein modification process | 23.8095 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.4286 | 5 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 21.4286 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.4286 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 21.4286 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.4286 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 21.4286 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.4286 | 6 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.4286 | 4 | no |
| GO:0008104 | protein localization | 21.4286 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 21.4286 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.4286 | 6 | no |
| GO:0051050 | positive regulation of transport | 21.4286 | 4 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 19.0476 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 19.0476 | 5 | yes |
| GO:0072521 | purine-containing compound metabolic process | 19.0476 | 4 | yes |
| GO:0006163 | purine nucleotide metabolic process | 16.6667 | 5 | yes |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 16.6667 | 4 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 16.6667 | 4 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 14.2857 | 6 | yes |
| GO:0009259 | ribonucleotide metabolic process | 14.2857 | 5 | yes |
| GO:0018130 | heterocycle biosynthetic process | 14.2857 | 4 | yes |
| GO:0019438 | aromatic compound biosynthetic process | 14.2857 | 4 | yes |
| GO:0019693 | ribose phosphate metabolic process | 14.2857 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 14.2857 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 14.2857 | 4 | yes |
| GO:0072522 | purine-containing compound biosynthetic process | 14.2857 | 5 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 14.2857 | 4 | yes |
| GO:0034097 | response to cytokine | 11.9048 | 4 | yes |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 11.9048 | 4 | yes |
| GO:1901137 | carbohydrate derivative biosynthetic process | 11.9048 | 4 | yes |
| GO:0006164 | purine nucleotide biosynthetic process | 9.5238 | 6 | yes |
| GO:0009116 | nucleoside metabolic process | 9.5238 | 4 | yes |
| GO:0009123 | nucleoside monophosphate metabolic process | 9.5238 | 5 | yes |
| GO:0009126 | purine nucleoside monophosphate metabolic process | 9.5238 | 6 | yes |
| GO:0009152 | purine ribonucleotide biosynthetic process | 9.5238 | 7 | yes |
| GO:0009161 | ribonucleoside monophosphate metabolic process | 9.5238 | 6 | yes |
| GO:0009165 | nucleotide biosynthetic process | 9.5238 | 6 | yes |
| GO:0009167 | purine ribonucleoside monophosphate metabolic process | 9.5238 | 7 | yes |
| GO:0009260 | ribonucleotide biosynthetic process | 9.5238 | 6 | yes |
| GO:0043648 | dicarboxylic acid metabolic process | 9.5238 | 6 | yes |
| GO:0046033 | AMP metabolic process | 9.5238 | 7 | yes |
| GO:0046390 | ribose phosphate biosynthetic process | 9.5238 | 5 | yes |
| GO:0071345 | cellular response to cytokine stimulus | 9.5238 | 5 | yes |
| GO:0090407 | organophosphate biosynthetic process | 9.5238 | 4 | yes |
| GO:1901293 | nucleoside phosphate biosynthetic process | 9.5238 | 5 | yes |
| GO:1901657 | glycosyl compound metabolic process | 9.5238 | 4 | yes |
| GO:0006167 | AMP biosynthetic process | 7.1429 | 8 | yes |
| GO:0006177 | GMP biosynthetic process | 7.1429 | 8 | yes |
| GO:0006188 | IMP biosynthetic process | 7.1429 | 8 | yes |
| GO:0006189 | de novo IMP biosynthetic process | 7.1429 | 9 | yes |
| GO:0006760 | folic acid-containing compound metabolic process | 7.1429 | 4 | yes |
| GO:0009124 | nucleoside monophosphate biosynthetic process | 7.1429 | 6 | yes |
| GO:0009127 | purine nucleoside monophosphate biosynthetic process | 7.1429 | 7 | yes |
| GO:0009156 | ribonucleoside monophosphate biosynthetic process | 7.1429 | 7 | yes |
| GO:0009168 | purine ribonucleoside monophosphate biosynthetic process | 7.1429 | 8 | yes |
| GO:0042558 | pteridine-containing compound metabolic process | 7.1429 | 4 | yes |
| GO:0044208 | de novo AMP biosynthetic process | 7.1429 | 9 | yes |
| GO:0046037 | GMP metabolic process | 7.1429 | 7 | yes |
| GO:0046040 | IMP metabolic process | 7.1429 | 7 | yes |
| GO:0046653 | tetrahydrofolate metabolic process | 7.1429 | 5 | yes |
| GO:0097292 | XMP metabolic process | 7.1429 | 7 | yes |
| GO:0097293 | XMP biosynthetic process | 7.1429 | 8 | yes |
| GO:0097294 | de novo XMP biosynthetic process | 7.1429 | 9 | yes |
| GO:0009396 | folic acid-containing compound biosynthetic process | 4.7619 | 5 | yes |
| GO:0031100 | animal organ regeneration | 4.7619 | 4 | yes |
| GO:0042398 | cellular modified amino acid biosynthetic process | 4.7619 | 4 | yes |
| GO:0042559 | pteridine-containing compound biosynthetic process | 4.7619 | 5 | yes |
| GO:0046452 | dihydrofolate metabolic process | 4.7619 | 5 | yes |
| GO:0046654 | tetrahydrofolate biosynthetic process | 4.7619 | 6 | yes |
| GO:0098760 | response to interleukin-7 | 4.7619 | 5 | yes |
| GO:0098761 | cellular response to interleukin-7 | 4.7619 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in PUR9_HUMAN |
|---|---|---|---|---|
| DOID:12377 | spinal muscular atrophy | 4.7619 | 6 | no |
| DOID:1289 | neurodegenerative disease | 4.7619 | 4 | no |
| DOID:231 | motor neuron disease | 4.7619 | 5 | no |
| DOID:331 | central nervous system disease | 4.7619 | 3 | no |
| DOID:574 | peripheral nervous system disease | 4.7619 | 3 | no |
| DOID:870 | neuropathy | 4.7619 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PUR9_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| PPIP1_HUMAN | [view interactions] | High throughput | no | no |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| SPB5_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JAK1_HUMAN | [view interactions] | High throughput | no | yes |
| SIR7_HUMAN | [view interactions] | High throughput | no | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| TFE3_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| IF16_HUMAN | [view interactions] | High throughput | no | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| KAT6A_HUMAN | [view interactions] | High throughput | no | yes |
| CATL1_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| FBX43_HUMAN | [view interactions] | High throughput | no | no |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARL3_HUMAN | [view interactions] | High throughput | no | yes |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ICLN_HUMAN | [view interactions] | High throughput | no | yes |
| TYSY_HUMAN | [view interactions] | High throughput | no | yes |
| SCOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBBP6_HUMAN | [view interactions] | High throughput | no | yes |
| CRK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| ASB6_HUMAN | [view interactions] | High throughput | no | yes |
| SAHH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAN2_HUMAN | [view interactions] | High throughput | no | no |
| CGL_HUMAN | [view interactions] | High throughput | no | yes |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GMDS_HUMAN | [view interactions] | High throughput | no | yes |
| MCTS1_HUMAN | [view interactions] | High throughput | no | no |
| STK26_HUMAN | [view interactions] | High throughput | no | no |
| MYO1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGFD1_HUMAN | [view interactions] | High throughput | no | yes |
| PAPS1_HUMAN | [view interactions] | High throughput | no | yes |
| PTMA_HUMAN | [view interactions] | High throughput | no | yes |
| TATD1_HUMAN | [view interactions] | High throughput | no | yes |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IPO5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ISOC1_HUMAN | [view interactions] | High throughput | no | no |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ULA1_HUMAN | [view interactions] | High throughput | no | yes |
| NSF1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PLPHP_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A16A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACO13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUR8_HUMAN | [view interactions] | High throughput | no | yes |
| ARMT1_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DEOC_HUMAN | [view interactions] | High throughput | no | no |
| DNM1L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LGUL_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCAB1_HUMAN | [view interactions] | High throughput | no | no |
| KCAB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUR6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGM1_HUMAN | [view interactions] | High throughput | no | no |
| PLIN3_HUMAN | [view interactions] | High throughput | no | yes |
| GLYC_HUMAN | [view interactions] | High throughput | no | no |
| SPRE_HUMAN | [view interactions] | High throughput | no | yes |
| EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNZ2_HUMAN | [view interactions] | High throughput | no | yes |
| PUR2_HUMAN | [view interactions] | High throughput | no | yes |
| RTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRNT1_HUMAN | [view interactions] | High throughput | no | yes |
| BCAT1_HUMAN | [view interactions] | High throughput | no | no |
| DBLOH_HUMAN | [view interactions] | High throughput | no | no |
| ECH1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CPNS1_HUMAN | [view interactions] | High throughput | no | yes |
| LDHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| NECD_HUMAN | [view interactions] | High throughput | no | no |
| MK11_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| IFIX_HUMAN | [view interactions] | High throughput | no | no |
| OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
| SH3G3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHOC2_HUMAN | [view interactions] | High throughput | no | yes |
| KPCE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| MYLK_HUMAN | [view interactions] | High throughput | no | no |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELF3_HUMAN | [view interactions] | High throughput | no | no |
| CIA30_HUMAN | [view interactions] | High throughput | no | yes |
| SNRPA_HUMAN | [view interactions] | High throughput | no | yes |
| RADIL_HUMAN | [view interactions] | High throughput | no | no |
| STOM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRDL_HUMAN | [view interactions] | High throughput | no | yes |
| MAOM_HUMAN | [view interactions] | High throughput | no | yes |
| CMBL_HUMAN | [view interactions] | High throughput | no | no |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| GMPR1_HUMAN | [view interactions] | Computational | no | yes |
| METH_HUMAN | [view interactions] | Computational | no | yes |
| IMDH1_HUMAN | [view interactions] | Computational | no | yes |
| ENTP5_HUMAN | [view interactions] | Computational | no | yes |
| PURA2_HUMAN | [view interactions] | Computational | no | yes |
| ENTP8_HUMAN | [view interactions] | Computational | no | no |
| FTCD_HUMAN | [view interactions] | Computational | no | no |
| MTDC_HUMAN | [view interactions] | Computational | no | yes |
| PUR4_HUMAN | [view interactions] | Computational | no | yes |
| ENTP4_HUMAN | [view interactions] | Computational | no | yes |
| GLYM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ENTP1_HUMAN | [view interactions] | Computational | no | yes |
| APT_HUMAN | [view interactions] | Computational | no | yes |
| IMDH2_HUMAN | [view interactions] | Computational | no | yes |
| 5NT3B_HUMAN | [view interactions] | Computational | no | yes |
| CANT1_HUMAN | [view interactions] | Computational | no | yes |
| NT5M_HUMAN | [view interactions] | Computational | no | yes |
| 5NT1A_HUMAN | [view interactions] | Computational | no | yes |
| NUD16_HUMAN | [view interactions] | Computational | no | yes |
| AMPD1_HUMAN | [view interactions] | Computational | no | yes |
| DYR_HUMAN | [view interactions] | Computational | no | yes |
| ENTP6_HUMAN | [view interactions] | Computational | no | yes |
| 5NT1B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PUR1_HUMAN | [view interactions] | Computational | no | yes |
| ENTP3_HUMAN | [view interactions] | Computational | no | no |
| AMPD3_HUMAN | [view interactions] | Computational | no | no |
| PURA1_HUMAN | [view interactions] | Computational | no | no |
| GCST_HUMAN | [view interactions] | Computational | no | yes |
| NT5C_HUMAN | [view interactions] | Computational | no | yes |
| DYR2_HUMAN | [view interactions] | Computational | no | yes |
| GUAA_HUMAN | [view interactions] | Computational | no | no |
| MTHR_HUMAN | [view interactions] | Computational | no | yes |
| HPRT_HUMAN | [view interactions] | Computational | no | yes |
| 5NTC_HUMAN | [view interactions] | Computational | no | yes |
| 5NTD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MTD2L_HUMAN | [view interactions] | Computational | no | no |
| ITPA_HUMAN | [view interactions] | Computational | no | yes |