ULA1_HUMAN
Evidence for PS localization
Functions
Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. The covalent attachment of NEDD8 to target proteins is known as neddylation and the process is involved in the regulation of cell growth, viability and development. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ULA1_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 34.4828 | 4 | no |
| GO:0000166 | nucleotide binding | 27.5862 | 4 | no |
| GO:0017076 | purine nucleotide binding | 27.5862 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 27.5862 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.5862 | 4 | no |
| GO:0003723 | RNA binding | 24.1379 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 20.6897 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 20.6897 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 20.6897 | 6 | no |
| GO:0005524 | ATP binding | 20.6897 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 20.6897 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 20.6897 | 5 | no |
| GO:0031625 | ubiquitin protein ligase binding | 17.2414 | 5 | yes |
| GO:0044389 | ubiquitin-like protein ligase binding | 17.2414 | 4 | yes |
| GO:0046982 | protein heterodimerization activity | 6.8966 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ULA1_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 58.6207 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 58.6207 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 58.6207 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 55.1724 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 51.7241 | 4 | no |
| GO:0010468 | regulation of gene expression | 51.7241 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 51.7241 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 51.7241 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 51.7241 | 4 | no |
| GO:0010646 | regulation of cell communication | 48.2759 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 44.8276 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 44.8276 | 4 | no |
| GO:0009966 | regulation of signal transduction | 44.8276 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 41.3793 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 41.3793 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 37.9310 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.9310 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 37.9310 | 6 | no |
| GO:0006996 | organelle organization | 37.9310 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 34.4828 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 34.4828 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 34.4828 | 6 | no |
| GO:0071310 | cellular response to organic substance | 34.4828 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 34.4828 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 34.4828 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 34.4828 | 5 | no |
| GO:0023056 | positive regulation of signaling | 34.4828 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 34.4828 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 31.0345 | 7 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.0345 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 31.0345 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 31.0345 | 6 | no |
| GO:0051049 | regulation of transport | 31.0345 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 31.0345 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 31.0345 | 4 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 31.0345 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 31.0345 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 31.0345 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 31.0345 | 6 | no |
| GO:0031399 | regulation of protein modification process | 31.0345 | 6 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 31.0345 | 6 | no |
| GO:0010628 | positive regulation of gene expression | 31.0345 | 7 | no |
| GO:0036211 | protein modification process | 27.5862 | 4 | yes |
| GO:0043412 | macromolecule modification | 27.5862 | 4 | yes |
| GO:0051726 | regulation of cell cycle | 27.5862 | 4 | yes |
| GO:0008104 | protein localization | 27.5862 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 27.5862 | 6 | no |
| GO:0033043 | regulation of organelle organization | 27.5862 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 27.5862 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 27.5862 | 5 | no |
| GO:0032880 | regulation of protein localization | 27.5862 | 5 | no |
| GO:0060341 | regulation of cellular localization | 27.5862 | 4 | no |
| GO:0010629 | negative regulation of gene expression | 27.5862 | 7 | no |
| GO:0043933 | protein-containing complex organization | 27.5862 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 27.5862 | 4 | no |
| GO:0009057 | macromolecule catabolic process | 24.1379 | 4 | yes |
| GO:0030162 | regulation of proteolysis | 24.1379 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.1379 | 5 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 24.1379 | 4 | no |
| GO:0009894 | regulation of catabolic process | 24.1379 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 24.1379 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 24.1379 | 5 | no |
| GO:0022607 | cellular component assembly | 24.1379 | 4 | no |
| GO:0023057 | negative regulation of signaling | 24.1379 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 24.1379 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 24.1379 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 24.1379 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 24.1379 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 24.1379 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 24.1379 | 6 | no |
| GO:0006508 | proteolysis | 20.6897 | 4 | yes |
| GO:0010564 | regulation of cell cycle process | 20.6897 | 5 | yes |
| GO:0006357 | regulation of transcription by RNA polymerase II | 20.6897 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 20.6897 | 6 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 20.6897 | 7 | no |
| GO:0051493 | regulation of cytoskeleton organization | 20.6897 | 6 | no |
| GO:0033365 | protein localization to organelle | 20.6897 | 5 | no |
| GO:0042176 | regulation of protein catabolic process | 20.6897 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 20.6897 | 7 | no |
| GO:0031401 | positive regulation of protein modification process | 20.6897 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 20.6897 | 7 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 20.6897 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.6897 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 20.6897 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 20.6897 | 4 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 20.6897 | 5 | no |
| GO:0007010 | cytoskeleton organization | 20.6897 | 5 | no |
| GO:0006915 | apoptotic process | 17.2414 | 4 | yes |
| GO:0043523 | regulation of neuron apoptotic process | 17.2414 | 6 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 17.2414 | 5 | yes |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 13.7931 | 7 | yes |
| GO:0019941 | modification-dependent protein catabolic process | 13.7931 | 6 | yes |
| GO:0032446 | protein modification by small protein conjugation | 13.7931 | 7 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 13.7931 | 5 | yes |
| GO:0043687 | post-translational protein modification | 13.7931 | 5 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 13.7931 | 6 | yes |
| GO:0007346 | regulation of mitotic cell cycle | 10.3448 | 5 | yes |
| GO:0045116 | protein neddylation | 10.3448 | 8 | yes |
| GO:0051402 | neuron apoptotic process | 10.3448 | 5 | yes |
| GO:0010389 | regulation of G2/M transition of mitotic cell cycle | 6.8966 | 7 | yes |
| GO:0016567 | protein ubiquitination | 6.8966 | 8 | yes |
| GO:1901987 | regulation of cell cycle phase transition | 6.8966 | 6 | yes |
| GO:1901990 | regulation of mitotic cell cycle phase transition | 6.8966 | 6 | yes |
| GO:1902749 | regulation of cell cycle G2/M phase transition | 6.8966 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| UBC12_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NEDD8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBA3_HUMAN | [view interactions] | Low throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| FBX11_HUMAN | [view interactions] | Low throughput | no | no |
| TRIPC_HUMAN | [view interactions] | Low throughput | no | yes |
| ASPP2_HUMAN | [view interactions] | Low throughput | no | yes |
| PINK1_HUMAN | [view interactions] | Low throughput | no | yes |
| GARS_HUMAN | [view interactions] | Low throughput | no | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UIMC1_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRBP2_HUMAN | [view interactions] | High throughput | no | yes |
| ALG8_HUMAN | [view interactions] | High throughput | no | yes |
| HEXB_HUMAN | [view interactions] | High throughput | no | no |
| UBQL4_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT44_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT7B_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| ANR39_HUMAN | [view interactions] | High throughput | no | no |
| WIF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SERB1_HUMAN | [view interactions] | High throughput | no | yes |
| TGS1_HUMAN | [view interactions] | High throughput | no | yes |
| R144A_HUMAN | [view interactions] | High throughput | no | yes |
| ZN684_HUMAN | [view interactions] | High throughput | no | no |
| NTNG1_HUMAN | [view interactions] | High throughput | no | no |
| T183A_HUMAN | [view interactions] | High throughput | no | no |
| LRTM1_HUMAN | [view interactions] | High throughput | no | no |
| RIPP1_HUMAN | [view interactions] | High throughput | no | no |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HERC5_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| CAVN3_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| DCAF6_HUMAN | [view interactions] | High throughput | no | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2F_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| CAN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DCPS_HUMAN | [view interactions] | High throughput | no | yes |
| MCTS1_HUMAN | [view interactions] | High throughput | no | no |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PUR9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC1D_HUMAN | [view interactions] | High throughput | no | yes |
| NUCB2_HUMAN | [view interactions] | High throughput | no | yes |
| PA1B2_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| PLPHP_HUMAN | [view interactions] | High throughput | no | yes |
| GDS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TATD1_HUMAN | [view interactions] | High throughput | no | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NSF1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAPS1_HUMAN | [view interactions] | High throughput | no | yes |
| PCY2_HUMAN | [view interactions] | High throughput | no | yes |
| IPP2_HUMAN | [view interactions] | High throughput | no | no |
| TRXR1_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDC3_HUMAN | [view interactions] | High throughput | no | yes |
| PLOD1_HUMAN | [view interactions] | High throughput | no | yes |
| UBA5_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| HARS1_HUMAN | [view interactions] | High throughput | no | yes |
| IPP2B_HUMAN | [view interactions] | High throughput | no | no |
| DIAP1_HUMAN | [view interactions] | High throughput | no | yes |
| CSDE1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNLI1_HUMAN | [view interactions] | High throughput | no | yes |
| LMNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KS6B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| PROF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LICH_HUMAN | [view interactions] | High throughput | no | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GTF2I_HUMAN | [view interactions] | High throughput | no | yes |
| LMNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| NAA15_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RFA4_HUMAN | [view interactions] | High throughput | no | yes |