Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KS6B1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling. Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function. Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex. The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function. Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1. In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B. May be involved in cytoskeletal rearrangement through binding to neurabin. Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR (PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed). Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI001214 DOC_WD40_RPTOR_TOS_1 DOC 28 33 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KS6B1_HUMAN
GO:0017076 purine nucleotide binding 48.5714 4 yes
GO:0032555 purine ribonucleotide binding 48.5714 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 48.5714 4 yes
GO:0005524 ATP binding 44.2857 5 yes
GO:0030554 adenyl nucleotide binding 44.2857 5 yes
GO:0032559 adenyl ribonucleotide binding 44.2857 5 yes
GO:0016301 kinase activity 38.5714 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 38.5714 4 yes
GO:0019900 kinase binding 32.8571 4 no
GO:0004712 protein serine/threonine/tyrosine kinase activity 31.4286 4 yes
GO:0019901 protein kinase binding 31.4286 5 no
GO:0004674 protein serine/threonine kinase activity 28.5714 4 yes
GO:0106310 protein serine kinase activity 25.7143 4 yes
GO:0046872 metal ion binding 22.8571 4 no
GO:0003723 RNA binding 22.8571 4 no
GO:0019902 phosphatase binding 14.2857 4 yes
GO:0019903 protein phosphatase binding 10.0000 5 yes
GO:0030165 PDZ domain binding 5.7143 4 yes
GO:0051721 protein phosphatase 2A binding 5.7143 6 yes
GO:0004711 ribosomal protein S6 kinase activity 2.8571 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KS6B1_HUMAN
GO:0031323 regulation of cellular metabolic process 82.8571 4 yes
GO:0048522 positive regulation of cellular process 82.8571 4 yes
GO:0010646 regulation of cell communication 80.0000 4 yes
GO:0080090 regulation of primary metabolic process 80.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 78.5714 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 77.1429 4 yes
GO:0048523 negative regulation of cellular process 75.7143 4 yes
GO:0009966 regulation of signal transduction 74.2857 4 yes
GO:0051246 regulation of protein metabolic process 68.5714 5 yes
GO:0009893 positive regulation of metabolic process 62.8571 4 yes
GO:0031325 positive regulation of cellular metabolic process 60.0000 5 yes
GO:0010468 regulation of gene expression 57.1429 5 yes
GO:1902531 regulation of intracellular signal transduction 57.1429 5 no
GO:0010604 positive regulation of macromolecule metabolic process 55.7143 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 54.2857 5 yes
GO:0051128 regulation of cellular component organization 52.8571 4 no
GO:0036211 protein modification process 51.4286 4 yes
GO:0043412 macromolecule modification 51.4286 4 yes
GO:0019220 regulation of phosphate metabolic process 51.4286 6 no
GO:0051174 regulation of phosphorus metabolic process 51.4286 5 no
GO:0009889 regulation of biosynthetic process 50.0000 4 yes
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 yes
GO:0009892 negative regulation of metabolic process 50.0000 4 no
GO:0006796 phosphate-containing compound metabolic process 48.5714 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 48.5714 5 yes
GO:0051247 positive regulation of protein metabolic process 48.5714 6 yes
GO:0031399 regulation of protein modification process 48.5714 6 no
GO:0042325 regulation of phosphorylation 47.1429 7 no
GO:0010648 negative regulation of cell communication 45.7143 5 yes
GO:0010941 regulation of cell death 45.7143 4 yes
GO:0023057 negative regulation of signaling 45.7143 4 yes
GO:0048585 negative regulation of response to stimulus 45.7143 4 yes
GO:0031324 negative regulation of cellular metabolic process 45.7143 5 no
GO:0048584 positive regulation of response to stimulus 45.7143 4 no
GO:0010605 negative regulation of macromolecule metabolic process 44.2857 5 no
GO:0010647 positive regulation of cell communication 44.2857 5 no
GO:0023056 positive regulation of signaling 44.2857 4 no
GO:0009894 regulation of catabolic process 44.2857 4 no
GO:0009968 negative regulation of signal transduction 42.8571 5 yes
GO:0009967 positive regulation of signal transduction 42.8571 5 no
GO:0051049 regulation of transport 41.4286 4 yes
GO:0071310 cellular response to organic substance 41.4286 4 yes
GO:0001932 regulation of protein phosphorylation 41.4286 7 no
GO:0031329 regulation of cellular catabolic process 41.4286 5 no
GO:0010243 response to organonitrogen compound 40.0000 4 yes
GO:0042127 regulation of cell population proliferation 40.0000 4 yes
GO:0042981 regulation of apoptotic process 40.0000 6 yes
GO:0043067 regulation of programmed cell death 40.0000 5 yes
GO:0043085 positive regulation of catalytic activity 40.0000 4 no
GO:0045595 regulation of cell differentiation 40.0000 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 40.0000 5 no
GO:0016310 phosphorylation 38.5714 5 yes
GO:0006468 protein phosphorylation 37.1429 5 yes
GO:0051726 regulation of cell cycle 37.1429 4 yes
GO:1901701 cellular response to oxygen-containing compound 37.1429 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 37.1429 6 no
GO:0045937 positive regulation of phosphate metabolic process 37.1429 7 no
GO:0051338 regulation of transferase activity 37.1429 4 no
GO:0051094 positive regulation of developmental process 35.7143 4 yes
GO:0060548 negative regulation of cell death 35.7143 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 35.7143 5 no
GO:0031401 positive regulation of protein modification process 35.7143 7 no
GO:0042327 positive regulation of phosphorylation 35.7143 8 no
GO:0006996 organelle organization 35.7143 4 no
GO:0033043 regulation of organelle organization 34.2857 5 no
GO:0080134 regulation of response to stress 34.2857 4 no
GO:1902533 positive regulation of intracellular signal transduction 34.2857 6 no
GO:0008284 positive regulation of cell population proliferation 32.8571 5 yes
GO:0043549 regulation of kinase activity 32.8571 5 no
GO:0051130 positive regulation of cellular component organization 32.8571 5 no
GO:0044087 regulation of cellular component biogenesis 32.8571 4 no
GO:0009891 positive regulation of biosynthetic process 31.4286 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 31.4286 6 yes
GO:0030334 regulation of cell migration 31.4286 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 31.4286 6 yes
GO:0043066 negative regulation of apoptotic process 31.4286 7 yes
GO:0043069 negative regulation of programmed cell death 31.4286 6 yes
GO:1901699 cellular response to nitrogen compound 31.4286 4 yes
GO:2000145 regulation of cell motility 31.4286 4 yes
GO:0001934 positive regulation of protein phosphorylation 31.4286 8 no
GO:0071417 cellular response to organonitrogen compound 30.0000 4 yes
GO:0051248 negative regulation of protein metabolic process 30.0000 6 no
GO:0022607 cellular component assembly 30.0000 4 no
GO:0051336 regulation of hydrolase activity 30.0000 4 no
GO:0018193 peptidyl-amino acid modification 28.5714 5 yes
GO:0051252 regulation of RNA metabolic process 28.5714 5 no
GO:0051347 positive regulation of transferase activity 28.5714 5 no
GO:0007167 enzyme-linked receptor protein signaling pathway 28.5714 4 no
GO:0045597 positive regulation of cell differentiation 28.5714 5 no
GO:0010628 positive regulation of gene expression 27.1429 6 yes
GO:0030335 positive regulation of cell migration 27.1429 6 yes
GO:0040017 positive regulation of locomotion 27.1429 4 yes
GO:2000147 positive regulation of cell motility 27.1429 5 yes
GO:0045859 regulation of protein kinase activity 27.1429 6 no
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 27.1429 5 no
GO:0009896 positive regulation of catabolic process 27.1429 5 no
GO:0060341 regulation of cellular localization 27.1429 4 no
GO:0031344 regulation of cell projection organization 27.1429 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 27.1429 6 no
GO:0030030 cell projection organization 27.1429 4 no
GO:0022603 regulation of anatomical structure morphogenesis 27.1429 4 no
GO:0006915 apoptotic process 25.7143 4 yes
GO:1901652 response to peptide 25.7143 4 yes
GO:2000112 regulation of cellular macromolecule biosynthetic process 25.7143 6 yes
GO:0051050 positive regulation of transport 25.7143 4 no
GO:0051240 positive regulation of multicellular organismal process 25.7143 4 no
GO:0016192 vesicle-mediated transport 25.7143 4 no
GO:0044089 positive regulation of cellular component biogenesis 25.7143 5 no
GO:0006355 regulation of DNA-templated transcription 24.2857 6 no
GO:0030155 regulation of cell adhesion 24.2857 4 no
GO:0033674 positive regulation of kinase activity 24.2857 6 no
GO:1903506 regulation of nucleic acid-templated transcription 24.2857 7 no
GO:2001141 regulation of RNA biosynthetic process 24.2857 6 no
GO:0002684 positive regulation of immune system process 24.2857 4 no
GO:0010638 positive regulation of organelle organization 24.2857 6 no
GO:0032101 regulation of response to external stimulus 24.2857 4 no
GO:0043408 regulation of MAPK cascade 24.2857 6 no
GO:0010608 post-transcriptional regulation of gene expression 22.8571 6 yes
GO:0034248 regulation of cellular amide metabolic process 22.8571 5 yes
GO:0071702 organic substance transport 22.8571 4 yes
GO:0043933 protein-containing complex organization 22.8571 4 no
GO:0010629 negative regulation of gene expression 22.8571 6 no
GO:0031331 positive regulation of cellular catabolic process 22.8571 6 no
GO:0032880 regulation of protein localization 22.8571 5 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 22.8571 6 no
GO:2000026 regulation of multicellular organismal development 22.8571 4 no
GO:0008104 protein localization 22.8571 4 no
GO:0010506 regulation of autophagy 22.8571 6 no
GO:0007010 cytoskeleton organization 22.8571 5 no
GO:0050804 modulation of chemical synaptic transmission 22.8571 5 no
GO:0099177 regulation of trans-synaptic signaling 22.8571 4 no
GO:0006417 regulation of translation 21.4286 6 yes
GO:0014070 response to organic cyclic compound 21.4286 4 yes
GO:0043434 response to peptide hormone 21.4286 4 yes
GO:1901653 cellular response to peptide 21.4286 5 yes
GO:0065003 protein-containing complex assembly 21.4286 5 no
GO:0051345 positive regulation of hydrolase activity 21.4286 5 no
GO:0050776 regulation of immune response 21.4286 4 no
GO:0051493 regulation of cytoskeleton organization 21.4286 6 no
GO:0120036 plasma membrane bounded cell projection organization 21.4286 5 no
GO:0007346 regulation of mitotic cell cycle 20.0000 5 yes
GO:0018105 peptidyl-serine phosphorylation 20.0000 6 yes
GO:0018209 peptidyl-serine modification 20.0000 6 yes
GO:0032868 response to insulin 20.0000 5 yes
GO:0032870 cellular response to hormone stimulus 20.0000 4 yes
GO:0034762 regulation of transmembrane transport 20.0000 4 yes
GO:0050890 cognition 20.0000 4 yes
GO:0045787 positive regulation of cell cycle 18.5714 5 yes
GO:0070848 response to growth factor 18.5714 4 yes
GO:0033993 response to lipid 17.1429 4 yes
GO:0034097 response to cytokine 17.1429 4 yes
GO:0071375 cellular response to peptide hormone stimulus 17.1429 5 yes
GO:0071407 cellular response to organic cyclic compound 17.1429 5 yes
GO:0032869 cellular response to insulin stimulus 15.7143 6 yes
GO:0048638 regulation of developmental growth 15.7143 4 yes
GO:0071363 cellular response to growth factor stimulus 15.7143 5 yes
GO:0031667 response to nutrient levels 14.2857 4 yes
GO:0045927 positive regulation of growth 14.2857 4 yes
GO:0071396 cellular response to lipid 14.2857 5 yes
GO:2001233 regulation of apoptotic signaling pathway 14.2857 5 yes
GO:0045931 positive regulation of mitotic cell cycle 12.8571 6 yes
GO:0071345 cellular response to cytokine stimulus 12.8571 5 yes
GO:2001236 regulation of extrinsic apoptotic signaling pathway 12.8571 6 yes
GO:2001234 negative regulation of apoptotic signaling pathway 11.4286 6 yes
GO:0007613 memory 10.0000 4 yes
GO:0031929 TOR signaling 10.0000 4 yes
GO:0034250 positive regulation of cellular amide metabolic process 10.0000 6 yes
GO:0043491 protein kinase B signaling 10.0000 4 yes
GO:0045727 positive regulation of translation 10.0000 7 yes
GO:0046626 regulation of insulin receptor signaling pathway 10.0000 5 yes
GO:0048015 phosphatidylinositol-mediated signaling 10.0000 5 yes
GO:0048017 inositol lipid-mediated signaling 10.0000 4 yes
GO:0048660 regulation of smooth muscle cell proliferation 10.0000 5 yes
GO:1900076 regulation of cellular response to insulin stimulus 10.0000 4 yes
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 10.0000 7 yes
GO:0000082 G1/S transition of mitotic cell cycle 8.5714 5 yes
GO:0006446 regulation of translational initiation 8.5714 7 yes
GO:0010827 regulation of glucose transmembrane transport 8.5714 5 yes
GO:0043200 response to amino acid 8.5714 4 yes
GO:0044772 mitotic cell cycle phase transition 8.5714 4 yes
GO:0044843 cell cycle G1/S phase transition 8.5714 4 yes
GO:0046324 regulation of glucose import 8.5714 6 yes
GO:0046627 negative regulation of insulin receptor signaling pathway 8.5714 6 yes
GO:0048639 positive regulation of developmental growth 8.5714 5 yes
GO:0048661 positive regulation of smooth muscle cell proliferation 8.5714 6 yes
GO:1900077 negative regulation of cellular response to insulin stimulus 8.5714 5 yes
GO:1901654 response to ketone 8.5714 4 yes
GO:0002237 response to molecule of bacterial origin 7.1429 4 yes
GO:0009743 response to carbohydrate 7.1429 4 yes
GO:0014910 regulation of smooth muscle cell migration 7.1429 6 yes
GO:0014911 positive regulation of smooth muscle cell migration 7.1429 7 yes
GO:0031960 response to corticosteroid 7.1429 5 yes
GO:0032496 response to lipopolysaccharide 7.1429 4 yes
GO:0034612 response to tumor necrosis factor 7.1429 5 yes
GO:0048545 response to steroid hormone 7.1429 4 yes
GO:1901655 cellular response to ketone 7.1429 5 yes
GO:0001662 behavioral fear response 5.7143 4 yes
GO:0006936 muscle contraction 5.7143 4 yes
GO:0006941 striated muscle contraction 5.7143 5 yes
GO:0007616 long-term memory 5.7143 5 yes
GO:0009746 response to hexose 5.7143 6 yes
GO:0009749 response to glucose 5.7143 7 yes
GO:0034284 response to monosaccharide 5.7143 5 yes
GO:0034341 response to interferon-gamma 5.7143 5 yes
GO:0043201 response to leucine 5.7143 5 yes
GO:0051384 response to glucocorticoid 5.7143 6 yes
GO:0071346 cellular response to interferon-gamma 5.7143 6 yes
GO:0071383 cellular response to steroid hormone stimulus 5.7143 5 yes
GO:0071548 response to dexamethasone 5.7143 5 yes
GO:0006869 lipid transport 4.2857 5 yes
GO:0045948 positive regulation of translational initiation 4.2857 8 yes
GO:0071384 cellular response to corticosteroid stimulus 4.2857 6 yes
GO:0071385 cellular response to glucocorticoid stimulus 4.2857 7 yes
GO:0071549 cellular response to dexamethasone stimulus 4.2857 6 yes
GO:0097305 response to alcohol 4.2857 4 yes
GO:0003009 skeletal muscle contraction 2.8571 6 yes
GO:0014732 skeletal muscle atrophy 2.8571 5 yes
GO:0014891 striated muscle atrophy 2.8571 4 yes
GO:0015849 organic acid transport 2.8571 5 yes
GO:0015908 fatty acid transport 2.8571 6 yes
GO:0015909 long-chain fatty acid transport 2.8571 7 yes
GO:0033574 response to testosterone 2.8571 5 yes
GO:0033762 response to glucagon 2.8571 5 yes
GO:0043501 skeletal muscle adaptation 2.8571 4 yes
GO:0044539 long-chain fatty acid import into cell 2.8571 6 yes
GO:0045471 response to ethanol 2.8571 5 yes
GO:0048631 regulation of skeletal muscle tissue growth 2.8571 5 yes
GO:0048633 positive regulation of skeletal muscle tissue growth 2.8571 6 yes
GO:0048641 regulation of skeletal muscle tissue development 2.8571 5 yes
GO:0048643 positive regulation of skeletal muscle tissue development 2.8571 6 yes
GO:0098657 import into cell 2.8571 4 yes
GO:0140354 lipid import into cell 2.8571 5 yes
GO:1901861 regulation of muscle tissue development 2.8571 4 yes
GO:1901863 positive regulation of muscle tissue development 2.8571 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in KS6B1_HUMAN
DOID:0050686 organ system cancer 4.2857 3 no
DOID:4194 glucose metabolism disease 2.8571 4 no
DOID:9351 diabetes mellitus 2.8571 6 no
DOID:9352 type 2 diabetes mellitus 2.8571 7 no
DOID:1289 neurodegenerative disease 2.8571 4 no
DOID:331 central nervous system disease 2.8571 3 no
DOID:6457 Cowden syndrome 2.8571 3 no
DOID:0081062 diabetes 2.8571 5 no
DOID:2978 carbohydrate metabolic disorder 2.8571 3 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NEB1_HUMAN [view entry] [view interactions] Low throughput yes yes
RPTOR_HUMAN [view interactions] Low throughput no yes
2ABB_HUMAN [view interactions] Low throughput no yes
PYR1_HUMAN [view entry] [view interactions] Low throughput yes yes
COASY_HUMAN [view entry] [view interactions] Low throughput yes yes
IER5_HUMAN [view interactions] Low throughput no yes
RS6_HUMAN [view entry] [view interactions] Low throughput yes yes
PDPK1_HUMAN [view entry] [view interactions] Low throughput yes yes
AKT1_HUMAN [view entry] [view interactions] Low throughput yes yes
EIF3B_HUMAN [view interactions] Low throughput no yes
MDM2_HUMAN [view interactions] Low throughput no yes
GLI1_HUMAN [view interactions] Low throughput no no
PHLP1_HUMAN [view interactions] Low throughput no yes
PHLP2_HUMAN [view interactions] Low throughput no yes
PDK1_HUMAN [view interactions] Low throughput no yes
KS6B1_HUMAN [view entry] [view interactions] Low throughput yes yes
MTOR_HUMAN [view entry] [view interactions] Low throughput yes yes
MAD1_HUMAN [view interactions] Low throughput no yes
MK08_HUMAN [view interactions] Low throughput no yes
TSC1_HUMAN [view entry] [view interactions] Low throughput yes yes
TSC2_HUMAN [view entry] [view interactions] Low throughput yes yes
RICTR_HUMAN [view interactions] Low throughput no yes
CSK2B_HUMAN [view entry] [view interactions] Low throughput yes yes
PDIP3_HUMAN [view interactions] Low throughput no no
RBX1_HUMAN [view entry] [view interactions] Low throughput yes no
TRAF4_HUMAN [view interactions] Low throughput no yes
XPO1_HUMAN [view entry] [view interactions] Low throughput yes yes
EIF3F_HUMAN [view interactions] Low throughput no yes
2ABA_HUMAN [view interactions] Low throughput no yes
PLD2_HUMAN [view interactions] Low throughput no yes
TERT_HUMAN [view interactions] Low throughput no no
KPCZ_HUMAN [view entry] [view interactions] Low throughput yes yes
EP300_HUMAN [view interactions] Low throughput no yes
KAT2B_HUMAN [view interactions] Low throughput no yes
NFAC1_HUMAN [view interactions] Low throughput no no
TRIB2_HUMAN [view interactions] Low throughput no yes
DDT4L_HUMAN [view interactions] Low throughput no no
IRS2_HUMAN [view interactions] Low throughput no yes
MXI1_HUMAN [view interactions] Low throughput no yes
PGFRB_HUMAN [view interactions] Low throughput no yes
UBP11_HUMAN [view interactions] Low throughput no yes
TAU_HUMAN [view entry] [view interactions] Low throughput yes yes
TBK1_HUMAN [view entry] [view interactions] Low throughput yes yes
EF2K_HUMAN [view entry] [view interactions] Low throughput yes no
CSK21_HUMAN [view entry] [view interactions] Low throughput yes yes
ACTS_HUMAN [view interactions] Low throughput no no
MK14_HUMAN [view interactions] Low throughput no yes
MK01_HUMAN [view entry] [view interactions] Low throughput yes yes
MK03_HUMAN [view entry] [view interactions] Low throughput yes yes
MK09_HUMAN [view interactions] Low throughput no yes
IRS1_HUMAN [view entry] [view interactions] Low throughput yes yes
RMP_HUMAN [view interactions] Low throughput no yes
RHEB_HUMAN [view entry] [view interactions] Low throughput yes yes
NR1I2_HUMAN [view interactions] Low throughput no no
DPTOR_HUMAN [view interactions] Low throughput no no
PI42A_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
HD_HUMAN [view entry] [view interactions] Low throughput yes yes
SIN1_HUMAN [view interactions] Low throughput no yes
STAT1_HUMAN [view entry] [view interactions] Low throughput yes no
ASTRA_HUMAN [view interactions] High throughput no no
TETN_HUMAN [view interactions] High throughput no no
DPPA4_HUMAN [view interactions] High throughput no no
NCBP1_HUMAN [view interactions] High throughput no yes
PPP5_HUMAN [view entry] [view interactions] High throughput yes yes
PAK1_HUMAN [view entry] [view interactions] High throughput yes yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
4EBP1_HUMAN [view entry] [view interactions] High throughput yes yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
IF4E_HUMAN [view entry] [view interactions] High throughput yes yes
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
KI3L1_HUMAN [view interactions] High throughput no no
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
STK11_HUMAN [view interactions] High throughput no yes
HOOK2_HUMAN [view interactions] High throughput no yes
EIF3C_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3H_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
SQSTM_HUMAN [view interactions] High throughput no yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
UBL4A_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
AGR2_HUMAN [view interactions] High throughput no no
APEX1_HUMAN [view interactions] High throughput no yes
GUAD_HUMAN [view interactions] High throughput no yes
TBB4A_HUMAN [view interactions] High throughput no yes
KIT_HUMAN [view interactions] High throughput no no
RIR2_HUMAN [view interactions] High throughput no no
VHL_HUMAN [view entry] [view interactions] High throughput yes yes
ABL1_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
BTK_HUMAN [view interactions] High throughput no no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
SRC_HUMAN [view entry] [view interactions] High throughput yes no
KSYK_HUMAN [view interactions] High throughput no no
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
FBX7_HUMAN [view interactions] High throughput no yes
DC1L1_HUMAN [view entry] [view interactions] High throughput yes yes
BICD1_HUMAN [view interactions] High throughput no yes
BICD2_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] Computational no yes
GRB2_HUMAN [view entry] [view interactions] Computational yes yes
NCOA3_HUMAN [view interactions] Computational no yes
KAPCB_HUMAN [view entry] [view interactions] Computational yes yes
FAK1_HUMAN [view entry] [view interactions] Computational yes yes
PP2AB_HUMAN [view interactions] Computational no yes
P85A_HUMAN [view interactions] Computational no yes
PDCD4_HUMAN [view interactions] Computational no yes
IF4A1_HUMAN [view interactions] Computational no no
2AAB_HUMAN [view interactions] Computational no yes
2A5D_HUMAN [view entry] [view interactions] Computational yes yes
S38A9_HUMAN [view interactions] Computational no yes
CARM1_HUMAN [view interactions] Computational no yes
LTOR1_HUMAN [view entry] [view interactions] Computational yes yes
BCAR1_HUMAN [view interactions] Computational no yes
PRS6B_HUMAN [view interactions] Computational no yes
4EBP2_HUMAN [view entry] [view interactions] Computational yes yes
MED1_HUMAN [view interactions] Computational no no
RRAGD_HUMAN [view interactions] Computational no yes
FOS_HUMAN [view interactions] Computational no yes
RRAGC_HUMAN [view interactions] Computational no yes
E2F1_HUMAN [view interactions] Computational no yes
AKT3_HUMAN [view interactions] Computational no yes
TGFR1_HUMAN [view interactions] Computational no no
RAC1_HUMAN [view entry] [view interactions] Computational yes no
PTEN_HUMAN [view entry] [view interactions] Computational yes yes
TGFR2_HUMAN [view interactions] Computational no no
RXRG_HUMAN [view interactions] Computational no no
SHC1_HUMAN [view entry] [view interactions] Computational yes yes
PP2AA_HUMAN [view entry] [view interactions] Computational yes yes
IGF1_HUMAN [view entry] [view interactions] Computational yes no
2AAA_HUMAN [view entry] [view interactions] Computational yes no
LTOR3_HUMAN [view interactions] Computational no yes
HMGA1_HUMAN [view interactions] Computational no yes
DKC1_HUMAN [view interactions] Computational no yes
FOXO3_HUMAN [view interactions] Computational no yes
ITA6_HUMAN [view interactions] Computational no yes
INSR_HUMAN [view interactions] Computational no yes
IF4G1_HUMAN [view entry] [view interactions] Computational yes yes
PDK2_HUMAN [view interactions] Computational no yes
INS_HUMAN [view interactions] Computational no no
AKTS1_HUMAN [view interactions] Computational no yes
CRK_HUMAN [view entry] [view interactions] Computational yes no
CD79B_HUMAN [view interactions] Computational no no
PAXI_HUMAN [view interactions] Computational no yes
KS6B2_HUMAN [view interactions] Computational no yes
FKB1A_HUMAN [view interactions] Computational no yes
ITB1_HUMAN [view entry] [view interactions] Computational yes no
KAPCG_HUMAN [view interactions] Computational no no
PABP1_HUMAN [view entry] [view interactions] Computational yes yes
LTOR4_HUMAN [view interactions] Computational no yes
PK3CA_HUMAN [view entry] [view interactions] Computational yes yes
AKT2_HUMAN [view entry] [view interactions] Computational yes yes
KAPCA_HUMAN [view entry] [view interactions] Computational yes yes
TGFB3_HUMAN [view interactions] Computational no no
SP1_HUMAN [view interactions] Computational no yes
EIF3A_HUMAN [view entry] [view interactions] Computational yes yes
GSK3B_HUMAN [view entry] [view interactions] Computational yes yes
BECN1_HUMAN [view interactions] Computational no yes
IL2_HUMAN [view interactions] Computational no no
RXRB_HUMAN [view interactions] Computational no yes
RXRA_HUMAN [view interactions] Computational no yes
LST8_HUMAN [view interactions] Computational no yes
KPCA_HUMAN [view entry] [view interactions] Computational yes yes
ESR1_HUMAN [view interactions] Computational no no
CD79A_HUMAN [view interactions] Computational no no
RRAGB_HUMAN [view interactions] Computational no yes
FOXA2_HUMAN [view interactions] Computational no no
LTOR2_HUMAN [view interactions] Computational no yes
CTCF_HUMAN [view interactions] Computational no yes
MITF_HUMAN [view interactions] Computational no no
RRAGA_HUMAN [view interactions] Computational no yes
1433B_HUMAN [view entry] [view interactions] Computational yes yes
BCR_HUMAN [view entry] [view interactions] Computational yes yes