Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

EF2K_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI003210 MOD_CDK_SPxxK_3 MOD 356 363 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in EF2K_HUMAN
GO:0017076 purine nucleotide binding 45.4545 4 yes
GO:0030554 adenyl nucleotide binding 40.9091 5 yes
GO:0032555 purine ribonucleotide binding 40.9091 4 yes
GO:0032559 adenyl ribonucleotide binding 36.3636 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 36.3636 4 yes
GO:0005524 ATP binding 31.8182 5 yes
GO:0046872 metal ion binding 31.8182 4 yes
GO:0003723 RNA binding 31.8182 4 no
GO:0019900 kinase binding 31.8182 4 no
GO:0019901 protein kinase binding 31.8182 5 no
GO:0003779 actin binding 27.2727 4 no
GO:0004674 protein serine/threonine kinase activity 18.1818 4 yes
GO:0005509 calcium ion binding 18.1818 5 yes
GO:0016301 kinase activity 18.1818 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 18.1818 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in EF2K_HUMAN
GO:0051171 regulation of nitrogen compound metabolic process 68.1818 4 yes
GO:0060255 regulation of macromolecule metabolic process 68.1818 4 yes
GO:0080090 regulation of primary metabolic process 68.1818 4 yes
GO:0031323 regulation of cellular metabolic process 68.1818 4 yes
GO:0048522 positive regulation of cellular process 63.6364 4 yes
GO:0048523 negative regulation of cellular process 59.0909 4 yes
GO:0051246 regulation of protein metabolic process 54.5455 5 yes
GO:0051049 regulation of transport 50.0000 4 yes
GO:0009893 positive regulation of metabolic process 45.4545 4 no
GO:0010604 positive regulation of macromolecule metabolic process 45.4545 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 45.4545 5 no
GO:0010646 regulation of cell communication 40.9091 4 no
GO:0031325 positive regulation of cellular metabolic process 40.9091 5 no
GO:0036211 protein modification process 36.3636 4 yes
GO:0043412 macromolecule modification 36.3636 4 yes
GO:0009892 negative regulation of metabolic process 36.3636 4 no
GO:0010605 negative regulation of macromolecule metabolic process 36.3636 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 36.3636 5 no
GO:0010468 regulation of gene expression 36.3636 5 no
GO:0051247 positive regulation of protein metabolic process 36.3636 6 no
GO:0051128 regulation of cellular component organization 31.8182 4 yes
GO:0071310 cellular response to organic substance 31.8182 4 yes
GO:0006996 organelle organization 31.8182 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 31.8182 5 no
GO:0009889 regulation of biosynthetic process 31.8182 4 no
GO:0010556 regulation of macromolecule biosynthetic process 31.8182 5 no
GO:0031326 regulation of cellular biosynthetic process 31.8182 5 no
GO:0009966 regulation of signal transduction 31.8182 4 no
GO:0031324 negative regulation of cellular metabolic process 31.8182 5 no
GO:0006796 phosphate-containing compound metabolic process 31.8182 4 yes
GO:0010243 response to organonitrogen compound 31.8182 4 yes
GO:0014070 response to organic cyclic compound 31.8182 4 yes
GO:1901701 cellular response to oxygen-containing compound 27.2727 4 yes
GO:0008104 protein localization 27.2727 4 no
GO:0071702 organic substance transport 27.2727 4 no
GO:0009894 regulation of catabolic process 27.2727 4 no
GO:0051248 negative regulation of protein metabolic process 27.2727 6 no
GO:0051252 regulation of RNA metabolic process 27.2727 5 no
GO:0044057 regulation of system process 27.2727 4 no
GO:0051726 regulation of cell cycle 27.2727 4 no
GO:0022607 cellular component assembly 27.2727 4 no
GO:0006468 protein phosphorylation 27.2727 5 yes
GO:0016310 phosphorylation 27.2727 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 27.2727 4 yes
GO:0031399 regulation of protein modification process 27.2727 6 yes
GO:0042325 regulation of phosphorylation 22.7273 7 yes
GO:0042981 regulation of apoptotic process 22.7273 6 yes
GO:0043067 regulation of programmed cell death 22.7273 5 yes
GO:0044087 regulation of cellular component biogenesis 22.7273 4 yes
GO:0051050 positive regulation of transport 22.7273 4 yes
GO:0051094 positive regulation of developmental process 22.7273 4 yes
GO:0051174 regulation of phosphorus metabolic process 22.7273 5 yes
GO:0060627 regulation of vesicle-mediated transport 22.7273 4 yes
GO:0071417 cellular response to organonitrogen compound 22.7273 4 yes
GO:1901699 cellular response to nitrogen compound 22.7273 4 yes
GO:0007010 cytoskeleton organization 22.7273 5 no
GO:0031400 negative regulation of protein modification process 22.7273 7 no
GO:0050890 cognition 22.7273 4 no
GO:1902531 regulation of intracellular signal transduction 22.7273 5 no
GO:0009891 positive regulation of biosynthetic process 22.7273 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.7273 6 no
GO:0010608 post-transcriptional regulation of gene expression 22.7273 6 no
GO:0010628 positive regulation of gene expression 22.7273 6 no
GO:0031328 positive regulation of cellular biosynthetic process 22.7273 6 no
GO:0001932 regulation of protein phosphorylation 22.7273 7 yes
GO:0010941 regulation of cell death 22.7273 4 yes
GO:0019220 regulation of phosphate metabolic process 22.7273 6 yes
GO:0022604 regulation of cell morphogenesis 22.7273 5 yes
GO:0032870 cellular response to hormone stimulus 18.1818 4 yes
GO:0043066 negative regulation of apoptotic process 18.1818 7 yes
GO:0043069 negative regulation of programmed cell death 18.1818 6 yes
GO:0044089 positive regulation of cellular component biogenesis 18.1818 5 yes
GO:0051240 positive regulation of multicellular organismal process 18.1818 4 yes
GO:0051592 response to calcium ion 18.1818 5 yes
GO:0060548 negative regulation of cell death 18.1818 5 yes
GO:0071407 cellular response to organic cyclic compound 18.1818 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 18.1818 6 yes
GO:0010038 response to metal ion 18.1818 4 yes
GO:0031344 regulation of cell projection organization 18.1818 5 yes
GO:0031952 regulation of protein autophosphorylation 18.1818 8 yes
GO:0043434 response to peptide hormone 13.6364 4 yes
GO:0045595 regulation of cell differentiation 13.6364 4 yes
GO:0045597 positive regulation of cell differentiation 13.6364 5 yes
GO:0046777 protein autophosphorylation 13.6364 6 yes
GO:0051130 positive regulation of cellular component organization 13.6364 5 yes
GO:0070848 response to growth factor 13.6364 4 yes
GO:0071363 cellular response to growth factor stimulus 13.6364 5 yes
GO:0071375 cellular response to peptide hormone stimulus 13.6364 5 yes
GO:1901652 response to peptide 13.6364 4 yes
GO:1901653 cellular response to peptide 13.6364 5 yes
GO:2000026 regulation of multicellular organismal development 13.6364 4 yes
GO:0031346 positive regulation of cell projection organization 13.6364 6 yes
GO:0032868 response to insulin 9.0909 5 yes
GO:0032869 cellular response to insulin stimulus 9.0909 6 yes
GO:0034645 cellular macromolecule biosynthetic process 9.0909 4 yes
GO:0046683 response to organophosphorus 9.0909 4 yes
GO:0048814 regulation of dendrite morphogenesis 9.0909 5 yes
GO:0050767 regulation of neurogenesis 9.0909 6 yes
GO:0050769 positive regulation of neurogenesis 9.0909 6 yes
GO:0050773 regulation of dendrite development 9.0909 4 yes
GO:0050775 positive regulation of dendrite morphogenesis 9.0909 6 yes
GO:0050807 regulation of synapse organization 9.0909 5 yes
GO:0051591 response to cAMP 9.0909 4 yes
GO:0051960 regulation of nervous system development 9.0909 5 yes
GO:0051962 positive regulation of nervous system development 9.0909 5 yes
GO:0060284 regulation of cell development 9.0909 5 yes
GO:0060998 regulation of dendritic spine development 9.0909 4 yes
GO:0060999 positive regulation of dendritic spine development 9.0909 5 yes
GO:0061001 regulation of dendritic spine morphogenesis 9.0909 5 yes
GO:0061003 positive regulation of dendritic spine morphogenesis 9.0909 6 yes
GO:0071241 cellular response to inorganic substance 9.0909 4 yes
GO:0071320 cellular response to cAMP 9.0909 5 yes
GO:0099175 regulation of postsynapse organization 9.0909 6 yes
GO:1990090 cellular response to nerve growth factor stimulus 9.0909 4 yes
GO:1990416 cellular response to brain-derived neurotrophic factor stimulus 9.0909 5 yes
GO:0006414 translational elongation 9.0909 5 yes
GO:0009059 macromolecule biosynthetic process 9.0909 4 yes
GO:0010720 positive regulation of cell development 9.0909 6 yes
GO:0010769 regulation of cell morphogenesis involved in differentiation 9.0909 6 yes
GO:0010770 positive regulation of cell morphogenesis involved in differentiation 9.0909 7 yes
GO:0010975 regulation of neuron projection development 9.0909 7 yes
GO:0010976 positive regulation of neuron projection development 9.0909 7 yes
GO:0014074 response to purine-containing compound 9.0909 5 yes
GO:0030100 regulation of endocytosis 9.0909 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in EF2K_HUMAN
DOID:0050700 cardiomyopathy 9.0909 4 no
DOID:0060036 intrinsic cardiomyopathy 9.0909 5 no
DOID:114 heart disease 9.0909 3 no
DOID:2843 long QT syndrome 9.0909 6 no

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FBW1B_HUMAN [view interactions] Low throughput no yes
KS6B2_HUMAN [view interactions] Low throughput no yes
KS6A1_HUMAN [view interactions] Low throughput no yes
CDK1_HUMAN [view interactions] Low throughput no no
ACADV_HUMAN [view interactions] Low throughput no yes
CCNB1_HUMAN [view interactions] Low throughput no no
FBW1A_HUMAN [view interactions] Low throughput no yes
SKP1_HUMAN [view interactions] Low throughput no yes
DENR_HUMAN [view interactions] Low throughput no yes
ALBU_HUMAN [view interactions] Low throughput no no
MAP2_HUMAN [view interactions] Low throughput no yes
PA2G4_HUMAN [view interactions] Low throughput no yes
IF4A3_HUMAN [view entry] [view interactions] Low throughput yes yes
KS6B1_HUMAN [view entry] [view interactions] Low throughput yes yes
EF2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
FKBP6_HUMAN [view interactions] High throughput no no
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
E41L3_HUMAN [view entry] [view interactions] High throughput yes yes
E41L1_HUMAN [view entry] [view interactions] High throughput yes yes
PTPRA_HUMAN [view interactions] High throughput no yes
EPB41_HUMAN [view entry] [view interactions] High throughput yes no
NSMA_HUMAN [view interactions] High throughput no yes
CNOT1_HUMAN [view interactions] High throughput no yes
RAE1L_HUMAN [view interactions] High throughput no no
SRP14_HUMAN [view interactions] High throughput no no
ACACA_HUMAN [view entry] [view interactions] High throughput yes yes
SRP09_HUMAN [view interactions] High throughput no no
WDFY3_HUMAN [view interactions] High throughput no yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
AGO2_HUMAN [view interactions] High throughput no yes
HS12B_HUMAN [view interactions] High throughput no yes
TULP3_HUMAN [view interactions] High throughput no yes
CLH2_HUMAN [view interactions] High throughput no no
RET1_HUMAN [view interactions] High throughput no no
SPR1B_HUMAN [view interactions] High throughput no no
SLN11_HUMAN [view interactions] High throughput no yes
ARP2_HUMAN [view entry] [view interactions] High throughput yes yes
CALR_HUMAN [view interactions] High throughput no yes
DPP9_HUMAN [view interactions] High throughput no yes
DUS3L_HUMAN [view interactions] High throughput no yes
SYAC_HUMAN [view interactions] High throughput no yes
CALU_HUMAN [view interactions] High throughput no yes
OSGEP_HUMAN [view interactions] High throughput no yes
THG1_HUMAN [view interactions] High throughput no yes
PANK4_HUMAN [view interactions] High throughput no no
KAP1_HUMAN [view entry] [view interactions] High throughput yes yes
RAGP1_HUMAN [view entry] [view interactions] High throughput yes yes
PRPK_HUMAN [view interactions] High throughput no yes
UBE3C_HUMAN [view entry] [view interactions] High throughput yes yes
BICD1_HUMAN [view interactions] High throughput no yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
MK13_HUMAN [view interactions] Computational no yes
AAKG1_HUMAN [view interactions] Computational no no
CALM2_HUMAN [view entry] [view interactions] Computational yes yes
CALM3_HUMAN [view entry] [view interactions] Computational yes yes
KPCG_HUMAN [view entry] [view interactions] Computational yes yes
AAPK1_HUMAN [view interactions] Computational no no
AAPK2_HUMAN [view interactions] Computational no yes
AAKG3_HUMAN [view interactions] Computational no no
KPCA_HUMAN [view entry] [view interactions] Computational yes yes
AAKB1_HUMAN [view interactions] Computational no yes
AAKB2_HUMAN [view interactions] Computational no yes
AAKG2_HUMAN [view interactions] Computational no yes