Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

EF2K_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI003210 MOD_CDK_SPxxK_3 MOD 356 363 -
ELMI003210 MOD_CDK_SPxxK_3 MOD 356 363 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in EF2K_HUMAN
GO:0043168 anion binding 42.8571 4 yes
GO:0003723 RNA binding 42.8571 4 no
GO:0000166 nucleotide binding 38.0952 4 yes
GO:0017076 purine nucleotide binding 38.0952 5 yes
GO:0032555 purine ribonucleotide binding 38.0952 4 yes
GO:0030554 adenyl nucleotide binding 33.3333 6 yes
GO:0032559 adenyl ribonucleotide binding 33.3333 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 33.3333 4 yes
GO:0005524 ATP binding 28.5714 5 yes
GO:0043169 cation binding 28.5714 4 yes
GO:0046872 metal ion binding 28.5714 5 yes
GO:0003779 actin binding 28.5714 4 no
GO:0019900 kinase binding 23.8095 4 no
GO:0019901 protein kinase binding 23.8095 5 no
GO:0004674 protein serine/threonine kinase activity 14.2857 4 yes
GO:0005509 calcium ion binding 14.2857 6 yes
GO:0016301 kinase activity 14.2857 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 14.2857 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in EF2K_HUMAN
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 yes
GO:0080090 regulation of primary metabolic process 66.6667 4 yes
GO:0031323 regulation of cellular metabolic process 61.9048 4 yes
GO:0048523 negative regulation of cellular process 57.1429 4 yes
GO:0051246 regulation of protein metabolic process 57.1429 5 yes
GO:0009889 regulation of biosynthetic process 52.3810 4 yes
GO:0010468 regulation of gene expression 52.3810 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 52.3810 5 yes
GO:0031326 regulation of cellular biosynthetic process 52.3810 5 yes
GO:0009893 positive regulation of metabolic process 47.6190 4 no
GO:0010604 positive regulation of macromolecule metabolic process 47.6190 5 no
GO:0031325 positive regulation of cellular metabolic process 47.6190 5 no
GO:0051049 regulation of transport 42.8571 4 yes
GO:0009891 positive regulation of biosynthetic process 42.8571 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 42.8571 6 no
GO:0031328 positive regulation of cellular biosynthetic process 42.8571 6 no
GO:0006417 regulation of translation 38.0952 6 yes
GO:0006996 organelle organization 38.0952 4 yes
GO:0010608 post-transcriptional regulation of gene expression 38.0952 7 yes
GO:0009892 negative regulation of metabolic process 38.0952 4 no
GO:0010605 negative regulation of macromolecule metabolic process 38.0952 5 no
GO:0010646 regulation of cell communication 38.0952 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 38.0952 5 no
GO:0051252 regulation of RNA metabolic process 38.0952 5 no
GO:0022607 cellular component assembly 38.0952 4 no
GO:0007010 cytoskeleton organization 33.3333 5 yes
GO:0051128 regulation of cellular component organization 33.3333 4 yes
GO:0071310 cellular response to organic substance 33.3333 4 yes
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0010628 positive regulation of gene expression 33.3333 7 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0036211 protein modification process 28.5714 4 yes
GO:0043412 macromolecule modification 28.5714 4 yes
GO:0043933 protein-containing complex organization 28.5714 4 yes
GO:0006355 regulation of DNA-templated transcription 28.5714 7 no
GO:0006357 regulation of transcription by RNA polymerase II 28.5714 8 no
GO:0051248 negative regulation of protein metabolic process 28.5714 6 no
GO:2001141 regulation of RNA biosynthetic process 28.5714 6 no
GO:0006913 nucleocytoplasmic transport 28.5714 5 no
GO:0008104 protein localization 28.5714 4 no
GO:0051169 nuclear transport 28.5714 4 no
GO:0071702 organic substance transport 28.5714 4 no
GO:0006796 phosphate-containing compound metabolic process 23.8095 4 yes
GO:0014070 response to organic cyclic compound 23.8095 4 yes
GO:0051094 positive regulation of developmental process 23.8095 4 yes
GO:0051240 positive regulation of multicellular organismal process 23.8095 4 yes
GO:1901701 cellular response to oxygen-containing compound 23.8095 4 yes
GO:1902531 regulation of intracellular signal transduction 23.8095 5 no
GO:0048584 positive regulation of response to stimulus 23.8095 4 no
GO:0009894 regulation of catabolic process 23.8095 4 no
GO:0051168 nuclear export 23.8095 6 no
GO:0071705 nitrogen compound transport 23.8095 4 no
GO:0009890 negative regulation of biosynthetic process 23.8095 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 23.8095 6 no
GO:0010629 negative regulation of gene expression 23.8095 7 no
GO:0030865 cortical cytoskeleton organization 23.8095 6 no
GO:0030866 cortical actin cytoskeleton organization 23.8095 4 no
GO:0031327 negative regulation of cellular biosynthetic process 23.8095 6 no
GO:0065003 protein-containing complex assembly 23.8095 5 no
GO:0045727 positive regulation of translation 23.8095 7 no
GO:0006468 protein phosphorylation 19.0476 5 yes
GO:0010243 response to organonitrogen compound 19.0476 4 yes
GO:0016310 phosphorylation 19.0476 5 yes
GO:0022603 regulation of anatomical structure morphogenesis 19.0476 4 yes
GO:0031344 regulation of cell projection organization 19.0476 5 yes
GO:0032870 cellular response to hormone stimulus 19.0476 4 yes
GO:0042981 regulation of apoptotic process 19.0476 5 yes
GO:0043067 regulation of programmed cell death 19.0476 4 yes
GO:0044087 regulation of cellular component biogenesis 19.0476 4 yes
GO:0051050 positive regulation of transport 19.0476 4 yes
GO:0051130 positive regulation of cellular component organization 19.0476 5 yes
GO:0060627 regulation of vesicle-mediated transport 19.0476 4 yes
GO:0071417 cellular response to organonitrogen compound 19.0476 4 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 19.0476 6 yes
GO:1901699 cellular response to nitrogen compound 19.0476 4 yes
GO:0001932 regulation of protein phosphorylation 14.2857 7 yes
GO:0009059 macromolecule biosynthetic process 14.2857 4 yes
GO:0010038 response to metal ion 14.2857 4 yes
GO:0019220 regulation of phosphate metabolic process 14.2857 6 yes
GO:0022604 regulation of cell morphogenesis 14.2857 5 yes
GO:0031346 positive regulation of cell projection organization 14.2857 6 yes
GO:0031399 regulation of protein modification process 14.2857 6 yes
GO:0042325 regulation of phosphorylation 14.2857 7 yes
GO:0043066 negative regulation of apoptotic process 14.2857 6 yes
GO:0043069 negative regulation of programmed cell death 14.2857 5 yes
GO:0043434 response to peptide hormone 14.2857 4 yes
GO:0044089 positive regulation of cellular component biogenesis 14.2857 5 yes
GO:0045595 regulation of cell differentiation 14.2857 4 yes
GO:0051174 regulation of phosphorus metabolic process 14.2857 5 yes
GO:0071241 cellular response to inorganic substance 14.2857 4 yes
GO:0071363 cellular response to growth factor stimulus 14.2857 4 yes
GO:0071375 cellular response to peptide hormone stimulus 14.2857 5 yes
GO:0071407 cellular response to organic cyclic compound 14.2857 5 yes
GO:0097435 supramolecular fiber organization 14.2857 4 yes
GO:0006414 translational elongation 9.5238 5 yes
GO:0014074 response to purine-containing compound 9.5238 5 yes
GO:0030100 regulation of endocytosis 9.5238 5 yes
GO:0031952 regulation of protein autophosphorylation 9.5238 8 yes
GO:0032868 response to insulin 9.5238 5 yes
GO:0032869 cellular response to insulin stimulus 9.5238 6 yes
GO:0045597 positive regulation of cell differentiation 9.5238 5 yes
GO:0045807 positive regulation of endocytosis 9.5238 5 yes
GO:0046683 response to organophosphorus 9.5238 4 yes
GO:0051591 response to cAMP 9.5238 4 yes
GO:0051592 response to calcium ion 9.5238 5 yes
GO:0071248 cellular response to metal ion 9.5238 5 yes
GO:0071320 cellular response to cAMP 9.5238 5 yes
GO:0140243 regulation of translation at synapse 9.5238 7 yes
GO:0140245 regulation of translation at postsynapse 9.5238 8 yes
GO:1990089 response to nerve growth factor 9.5238 4 yes
GO:1990090 cellular response to nerve growth factor stimulus 9.5238 5 yes
GO:1990416 cellular response to brain-derived neurotrophic factor stimulus 9.5238 6 yes
GO:2000026 regulation of multicellular organismal development 9.5238 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FBW1B_HUMAN [view interactions] Low throughput no yes
KS6B2_HUMAN [view interactions] Low throughput no yes
KS6A1_HUMAN [view entry] [view interactions] Low throughput yes yes
CDK1_HUMAN [view interactions] Low throughput no no
ACADV_HUMAN [view interactions] Low throughput no yes
CCNB1_HUMAN [view interactions] Low throughput no no
FBW1A_HUMAN [view interactions] Low throughput no yes
SKP1_HUMAN [view interactions] Low throughput no yes
DENR_HUMAN [view interactions] Low throughput no yes
ALBU_HUMAN [view interactions] Low throughput no no
MAP2_HUMAN [view interactions] Low throughput no yes
PA2G4_HUMAN [view interactions] Low throughput no yes
IF4A3_HUMAN [view entry] [view interactions] Low throughput yes yes
KS6B1_HUMAN [view entry] [view interactions] Low throughput yes yes
EF2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
FKBP6_HUMAN [view interactions] High throughput no no
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
CNOT1_HUMAN [view interactions] High throughput no yes
NSMA_HUMAN [view interactions] High throughput no yes
EPB41_HUMAN [view entry] [view interactions] High throughput yes no
PTPRA_HUMAN [view interactions] High throughput no yes
E41L1_HUMAN [view entry] [view interactions] High throughput yes yes
E41L3_HUMAN [view entry] [view interactions] High throughput yes yes
WDFY3_HUMAN [view interactions] High throughput no yes
SRP09_HUMAN [view interactions] High throughput no no
ACACA_HUMAN [view entry] [view interactions] High throughput yes yes
SRP14_HUMAN [view interactions] High throughput no no
RAE1L_HUMAN [view interactions] High throughput no no
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
AGO2_HUMAN [view entry] [view interactions] High throughput yes yes
HS12B_HUMAN [view interactions] High throughput no yes
TULP3_HUMAN [view interactions] High throughput no yes
CLH2_HUMAN [view interactions] High throughput no no
RET1_HUMAN [view interactions] High throughput no no
SPR1B_HUMAN [view interactions] High throughput no no
SLN11_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
ARP2_HUMAN [view entry] [view interactions] High throughput yes yes
CALR_HUMAN [view entry] [view interactions] High throughput yes yes
DPP9_HUMAN [view interactions] High throughput no yes
DUS3L_HUMAN [view interactions] High throughput no yes
SYAC_HUMAN [view interactions] High throughput no yes
CALU_HUMAN [view interactions] High throughput no yes
OSGEP_HUMAN [view interactions] High throughput no yes
THG1_HUMAN [view interactions] High throughput no yes
PANK4_HUMAN [view interactions] High throughput no no
KAP1_HUMAN [view entry] [view interactions] High throughput yes yes
RAGP1_HUMAN [view entry] [view interactions] High throughput yes yes
PRPK_HUMAN [view interactions] High throughput no yes
UBE3C_HUMAN [view entry] [view interactions] High throughput yes yes
LRRF1_HUMAN [view interactions] High throughput no yes
BICD1_HUMAN [view interactions] High throughput no yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
ARL8B_HUMAN [view interactions] High throughput no yes