E41L1_HUMAN
Evidence for PS localization
Functions
May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in E41L1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 32.9412 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 32.9412 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 32.9412 | 4 | no |
| GO:0019900 | kinase binding | 24.7059 | 4 | no |
| GO:0019901 | protein kinase binding | 23.5294 | 5 | no |
| GO:0003779 | actin binding | 16.4706 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in E41L1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 71.7647 | 4 | no |
| GO:0010646 | regulation of cell communication | 54.1176 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 51.7647 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 50.5882 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 49.4118 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 48.2353 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 45.8824 | 4 | no |
| GO:0009966 | regulation of signal transduction | 45.8824 | 4 | no |
| GO:0051049 | regulation of transport | 42.3529 | 4 | no |
| GO:0008104 | protein localization | 41.1765 | 4 | no |
| GO:0010468 | regulation of gene expression | 41.1765 | 5 | no |
| GO:0006996 | organelle organization | 40.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 40.0000 | 4 | no |
| GO:0071702 | organic substance transport | 38.8235 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 37.6471 | 4 | no |
| GO:0022607 | cellular component assembly | 35.2941 | 4 | no |
| GO:0071705 | nitrogen compound transport | 35.2941 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.2941 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 32.9412 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 32.9412 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 31.7647 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 30.5882 | 5 | no |
| GO:0023056 | positive regulation of signaling | 30.5882 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.5882 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.5882 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 29.4118 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 29.4118 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 29.4118 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.4118 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 29.4118 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 29.4118 | 5 | no |
| GO:0015031 | protein transport | 28.2353 | 4 | no |
| GO:0030030 | cell projection organization | 28.2353 | 4 | no |
| GO:0051050 | positive regulation of transport | 28.2353 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 28.2353 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 28.2353 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.0588 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 27.0588 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.0588 | 4 | no |
| GO:0010941 | regulation of cell death | 27.0588 | 4 | no |
| GO:0007010 | cytoskeleton organization | 25.8824 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 25.8824 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 25.8824 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.8824 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.8824 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 25.8824 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 25.8824 | 5 | no |
| GO:0043269 | regulation of ion transport | 24.7059 | 5 | no |
| GO:0071310 | cellular response to organic substance | 24.7059 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 24.7059 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 24.7059 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 24.7059 | 4 | no |
| GO:0031399 | regulation of protein modification process | 24.7059 | 6 | no |
| GO:0006886 | intracellular protein transport | 23.5294 | 4 | no |
| GO:0032880 | regulation of protein localization | 23.5294 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 23.5294 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 23.5294 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 23.5294 | 6 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.5294 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 23.5294 | 5 | no |
| GO:0033043 | regulation of organelle organization | 23.5294 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 23.5294 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.3529 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.3529 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 22.3529 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 22.3529 | 7 | no |
| GO:0042127 | regulation of cell population proliferation | 22.3529 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 21.1765 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 21.1765 | 5 | no |
| GO:0030865 | cortical cytoskeleton organization | 16.4706 | 6 | yes |
| GO:0030866 | cortical actin cytoskeleton organization | 9.4118 | 4 | yes |
| GO:0031032 | actomyosin structure organization | 7.0588 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in E41L1_HUMAN |
|---|---|---|---|---|
| DOID:0060038 | specific developmental disorder | 2.3529 | 3 | no |
| DOID:1059 | intellectual disability | 2.3529 | 4 | no |
| DOID:0111962 | combined immunodeficiency | 2.3529 | 4 | no |
| DOID:612 | primary immunodeficiency disease | 2.3529 | 3 | no |
| DOID:1289 | neurodegenerative disease | 2.3529 | 4 | no |
| DOID:331 | central nervous system disease | 2.3529 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| STA13_HUMAN | [view interactions] | Low throughput | no | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PP1B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NUMA1_HUMAN | [view interactions] | Low throughput | no | yes |
| ITPR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DRD2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DRD3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SDC2_HUMAN | [view interactions] | Low throughput | no | yes |
| CADM3_HUMAN | [view interactions] | Low throughput | no | no |
| GRIA4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MEIKN_HUMAN | [view interactions] | High throughput | no | no |
| E41L3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARGL1_HUMAN | [view interactions] | High throughput | no | yes |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| EF2K_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACM5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| POTE1_HUMAN | [view interactions] | High throughput | no | no |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARMC1_HUMAN | [view interactions] | High throughput | no | yes |
| HAX1_HUMAN | [view interactions] | High throughput | no | no |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| KTU_HUMAN | [view interactions] | High throughput | no | yes |
| DDAH2_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3I_HUMAN | [view interactions] | High throughput | no | yes |
| BRD2_HUMAN | [view interactions] | High throughput | no | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCTD5_HUMAN | [view interactions] | High throughput | no | no |
| E41L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MISP_HUMAN | [view interactions] | High throughput | no | no |
| PRIC3_HUMAN | [view interactions] | High throughput | no | yes |
| ISG20_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| EPB41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANKE1_HUMAN | [view interactions] | High throughput | no | yes |
| ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TNC18_HUMAN | [view interactions] | High throughput | no | yes |
| ICLN_HUMAN | [view interactions] | High throughput | no | yes |
| AFF4_HUMAN | [view interactions] | High throughput | no | yes |
| TRI41_HUMAN | [view interactions] | High throughput | no | yes |
| SET1A_HUMAN | [view interactions] | High throughput | no | yes |
| SRRM2_HUMAN | [view interactions] | High throughput | no | yes |
| MEP50_HUMAN | [view interactions] | High throughput | no | yes |
| ENL_HUMAN | [view interactions] | High throughput | no | yes |
| AFF1_HUMAN | [view interactions] | High throughput | no | no |
| SMD3_HUMAN | [view interactions] | High throughput | no | yes |
| CWC22_HUMAN | [view interactions] | High throughput | no | yes |
| VANG1_HUMAN | [view interactions] | High throughput | no | no |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACINU_HUMAN | [view interactions] | High throughput | no | yes |
| VANG2_HUMAN | [view interactions] | High throughput | no | no |
| CWC27_HUMAN | [view interactions] | High throughput | no | yes |
| SAP18_HUMAN | [view interactions] | High throughput | no | yes |
| MYH4_HUMAN | [view interactions] | High throughput | no | no |
| AF9_HUMAN | [view interactions] | High throughput | no | yes |
| CD6_HUMAN | [view interactions] | High throughput | no | no |
| SCML1_HUMAN | [view interactions] | High throughput | no | no |
| CLK2_HUMAN | [view interactions] | High throughput | no | yes |
| CLK3_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KT222_HUMAN | [view interactions] | High throughput | no | no |
| AP3M1_HUMAN | [view interactions] | High throughput | no | yes |
| GPTC8_HUMAN | [view interactions] | High throughput | no | yes |
| PININ_HUMAN | [view interactions] | High throughput | no | yes |
| ZCH10_HUMAN | [view interactions] | High throughput | no | yes |
| NAF1_HUMAN | [view interactions] | High throughput | no | yes |
| RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
| AP3B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXXC1_HUMAN | [view interactions] | High throughput | no | yes |
| CB39L_HUMAN | [view interactions] | High throughput | no | yes |
| MMTA2_HUMAN | [view interactions] | High throughput | no | yes |
| KBP_HUMAN | [view interactions] | High throughput | no | yes |
| AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
| MED17_HUMAN | [view interactions] | High throughput | no | no |
| MILR1_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOP16_HUMAN | [view interactions] | High throughput | no | yes |
| HNRL1_HUMAN | [view interactions] | High throughput | no | yes |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ICAL_HUMAN | [view interactions] | High throughput | no | yes |
| CSN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSN4_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CSN2_HUMAN | [view interactions] | High throughput | no | yes |
| CSN7A_HUMAN | [view interactions] | High throughput | no | yes |
| GCN1_HUMAN | [view interactions] | High throughput | no | yes |
| SHIP2_HUMAN | [view interactions] | High throughput | no | yes |
| NUP50_HUMAN | [view interactions] | High throughput | no | yes |
| DPOA2_HUMAN | [view interactions] | High throughput | no | yes |
| POP7_HUMAN | [view interactions] | High throughput | no | yes |
| RPP30_HUMAN | [view interactions] | High throughput | no | yes |
| KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PSA4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA5_HUMAN | [view interactions] | High throughput | no | yes |
| PSB3_HUMAN | [view interactions] | High throughput | no | yes |
| PSB4_HUMAN | [view interactions] | High throughput | no | yes |
| PSB5_HUMAN | [view interactions] | High throughput | no | yes |
| PSB7_HUMAN | [view interactions] | High throughput | no | yes |
| PI42C_HUMAN | [view interactions] | High throughput | no | yes |
| AP3D1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP3S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHG01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DPY30_HUMAN | [view interactions] | High throughput | no | yes |
| ENY2_HUMAN | [view interactions] | High throughput | no | yes |
| HS12A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PI42B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SCOC_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTPRA_HUMAN | [view interactions] | High throughput | no | yes |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LMAN1_HUMAN | [view interactions] | High throughput | no | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NGF_HUMAN | [view interactions] | Computational | no | no |
| CCG8_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| DLG1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KCC2D_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AKAP5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MYO6_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NTRK1_HUMAN | [view interactions] | Computational | no | yes |
| GRIA3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCG2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CCG4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| KCC2B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GRIK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCG3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MDM2_HUMAN | [view interactions] | Computational | no | yes |
| S12A5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| P85A_HUMAN | [view interactions] | Computational | no | yes |