ACM5_HUMAN
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. [View more on UniProt]
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No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ACM5_HUMAN |
---|---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | 23.8095 | 4 | yes |
GO:0098960 | postsynaptic neurotransmitter receptor activity | 23.8095 | 4 | yes |
GO:0046872 | metal ion binding | 23.8095 | 4 | no |
GO:0004435 | phosphatidylinositol phospholipase C activity | 19.0476 | 7 | yes |
GO:0004620 | phospholipase activity | 19.0476 | 5 | yes |
GO:0004629 | phospholipase C activity | 19.0476 | 6 | yes |
GO:0004993 | G protein-coupled serotonin receptor activity | 19.0476 | 5 | yes |
GO:0008081 | phosphoric diester hydrolase activity | 19.0476 | 5 | yes |
GO:0008227 | G protein-coupled amine receptor activity | 19.0476 | 5 | yes |
GO:0015464 | acetylcholine receptor activity | 19.0476 | 4 | yes |
GO:0016298 | lipase activity | 19.0476 | 4 | yes |
GO:0016907 | G protein-coupled acetylcholine receptor activity | 19.0476 | 5 | yes |
GO:0042578 | phosphoric ester hydrolase activity | 19.0476 | 4 | yes |
GO:0099528 | G protein-coupled neurotransmitter receptor activity | 19.0476 | 4 | yes |
GO:0099589 | serotonin receptor activity | 19.0476 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ACM5_HUMAN |
---|---|---|---|---|
GO:0051049 | regulation of transport | 42.8571 | 4 | no |
GO:0048523 | negative regulation of cellular process | 42.8571 | 4 | no |
GO:0048522 | positive regulation of cellular process | 38.0952 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 38.0952 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 38.0952 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 38.0952 | 4 | yes |
GO:0006996 | organelle organization | 38.0952 | 4 | no |
GO:0043269 | regulation of ion transport | 33.3333 | 5 | no |
GO:0007268 | chemical synaptic transmission | 33.3333 | 6 | yes |
GO:0071702 | organic substance transport | 33.3333 | 4 | yes |
GO:0071705 | nitrogen compound transport | 33.3333 | 4 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 33.3333 | 5 | yes |
GO:0099537 | trans-synaptic signaling | 33.3333 | 4 | yes |
GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 28.5714 | 4 | no |
GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 28.5714 | 4 | yes |
GO:0007213 | G protein-coupled acetylcholine receptor signaling pathway | 28.5714 | 4 | yes |
GO:0019220 | regulation of phosphate metabolic process | 28.5714 | 6 | yes |
GO:0046903 | secretion | 28.5714 | 4 | yes |
GO:0051174 | regulation of phosphorus metabolic process | 28.5714 | 5 | yes |
GO:0095500 | acetylcholine receptor signaling pathway | 28.5714 | 4 | yes |
GO:0061024 | membrane organization | 23.8095 | 4 | no |
GO:0099177 | regulation of trans-synaptic signaling | 23.8095 | 4 | no |
GO:0008104 | protein localization | 23.8095 | 4 | no |
GO:0051050 | positive regulation of transport | 23.8095 | 4 | no |
GO:0009966 | regulation of signal transduction | 23.8095 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 23.8095 | 5 | no |
GO:0006811 | ion transport | 23.8095 | 4 | yes |
GO:0006812 | cation transport | 23.8095 | 5 | yes |
GO:0022607 | cellular component assembly | 23.8095 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 23.8095 | 5 | no |
GO:0007187 | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | 19.0476 | 4 | yes |
GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | 19.0476 | 5 | yes |
GO:0007197 | adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway | 19.0476 | 5 | yes |
GO:0015844 | monoamine transport | 14.2857 | 5 | yes |
GO:0015850 | organic hydroxy compound transport | 14.2857 | 5 | yes |
GO:0015872 | dopamine transport | 14.2857 | 6 | yes |
GO:0019216 | regulation of lipid metabolic process | 14.2857 | 5 | yes |
GO:0051937 | catecholamine transport | 14.2857 | 6 | yes |
GO:0001696 | gastric acid secretion | 9.5238 | 4 | yes |
GO:0035303 | regulation of dephosphorylation | 9.5238 | 7 | yes |
GO:0046717 | acid secretion | 9.5238 | 5 | yes |
GO:0060304 | regulation of phosphatidylinositol dephosphorylation | 9.5238 | 5 | yes |
GO:1903725 | regulation of phospholipid metabolic process | 9.5238 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
ACM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AP3M1_HUMAN | [view interactions] | Low throughput | no | yes |
DTBP1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
AP3D1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ACM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
RGS7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
T161A_HUMAN | [view interactions] | High throughput | no | yes |
UBP33_HUMAN | [view interactions] | High throughput | no | yes |
GTR6_HUMAN | [view interactions] | High throughput | no | yes |
SC5A6_HUMAN | [view interactions] | High throughput | no | no |
SC6A8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MSMO1_HUMAN | [view interactions] | High throughput | no | yes |
SPNS1_HUMAN | [view interactions] | High throughput | no | yes |
STR3N_HUMAN | [view interactions] | High throughput | no | yes |
CXB6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GOG8A_HUMAN | [view interactions] | High throughput | no | no |
M3K1_HUMAN | [view interactions] | High throughput | no | yes |
MYH7_HUMAN | [view interactions] | High throughput | no | no |
NPAS3_HUMAN | [view interactions] | High throughput | no | yes |
TSSP_HUMAN | [view interactions] | High throughput | no | no |
NLE1_HUMAN | [view interactions] | High throughput | no | yes |
RTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SMAD6_HUMAN | [view interactions] | High throughput | no | no |
HLAF_HUMAN | [view interactions] | High throughput | no | no |
CD82_HUMAN | [view interactions] | High throughput | no | no |
PEBB_HUMAN | [view interactions] | High throughput | no | no |
EPC1_HUMAN | [view interactions] | High throughput | no | no |
ATP9A_HUMAN | [view interactions] | High throughput | no | yes |
ERCC1_HUMAN | [view interactions] | High throughput | no | yes |
ASPH_HUMAN | [view interactions] | High throughput | no | yes |
ASTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
AT2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
E41L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
TM160_HUMAN | [view interactions] | High throughput | no | no |
ARL10_HUMAN | [view interactions] | High throughput | no | yes |
K0232_HUMAN | [view interactions] | High throughput | no | yes |
TRI26_HUMAN | [view interactions] | High throughput | no | yes |
MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GBG12_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GNAQ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ACM1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GRM5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
GNA11_HUMAN | [view entry] [view interactions] | Computational | yes | yes |