Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

ACM5_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in ACM5_HUMAN
GO:0043169 cation binding 23.5294 4 no
GO:0004435 phosphatidylinositol phospholipase C activity 17.6471 7 yes
GO:0004620 phospholipase activity 17.6471 5 yes
GO:0004629 phospholipase C activity 17.6471 6 yes
GO:0004930 G protein-coupled receptor activity 17.6471 4 yes
GO:0004993 G protein-coupled serotonin receptor activity 17.6471 6 yes
GO:0008081 phosphoric diester hydrolase activity 17.6471 5 yes
GO:0008227 G protein-coupled amine receptor activity 17.6471 5 yes
GO:0015464 acetylcholine receptor activity 17.6471 4 yes
GO:0016298 lipase activity 17.6471 4 yes
GO:0016907 G protein-coupled acetylcholine receptor activity 17.6471 5 yes
GO:0042578 phosphoric ester hydrolase activity 17.6471 4 yes
GO:0098960 postsynaptic neurotransmitter receptor activity 17.6471 4 yes
GO:0099528 G protein-coupled neurotransmitter receptor activity 17.6471 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in ACM5_HUMAN
GO:0006996 organelle organization 58.8235 4 no
GO:0071702 organic substance transport 47.0588 4 yes
GO:0071705 nitrogen compound transport 47.0588 4 yes
GO:0048522 positive regulation of cellular process 47.0588 4 no
GO:0022607 cellular component assembly 41.1765 4 no
GO:0051049 regulation of transport 41.1765 4 no
GO:0060255 regulation of macromolecule metabolic process 35.2941 4 yes
GO:0080090 regulation of primary metabolic process 35.2941 4 yes
GO:0048523 negative regulation of cellular process 35.2941 4 no
GO:0010646 regulation of cell communication 35.2941 4 no
GO:0007268 chemical synaptic transmission 29.4118 7 yes
GO:0031323 regulation of cellular metabolic process 29.4118 4 yes
GO:0046903 secretion 29.4118 4 yes
GO:0098916 anterograde trans-synaptic signaling 29.4118 6 yes
GO:0099536 synaptic signaling 29.4118 4 yes
GO:0099537 trans-synaptic signaling 29.4118 5 yes
GO:0008104 protein localization 29.4118 4 no
GO:0051046 regulation of secretion 29.4118 5 no
GO:0051050 positive regulation of transport 29.4118 4 no
GO:1903530 regulation of secretion by cell 29.4118 4 no
GO:0051650 establishment of vesicle localization 29.4118 4 no
GO:0061024 membrane organization 29.4118 4 no
GO:0097479 synaptic vesicle localization 29.4118 4 no
GO:0019220 regulation of phosphate metabolic process 23.5294 6 yes
GO:0051174 regulation of phosphorus metabolic process 23.5294 5 yes
GO:0015031 protein transport 23.5294 4 no
GO:0060341 regulation of cellular localization 23.5294 4 no
GO:0051128 regulation of cellular component organization 23.5294 4 no
GO:0070925 organelle assembly 23.5294 5 no
GO:0051047 positive regulation of secretion 23.5294 5 no
GO:1903532 positive regulation of secretion by cell 23.5294 5 no
GO:0016050 vesicle organization 23.5294 5 no
GO:0017157 regulation of exocytosis 23.5294 5 no
GO:0046928 regulation of neurotransmitter secretion 23.5294 5 no
GO:0050804 modulation of chemical synaptic transmission 23.5294 5 no
GO:0051588 regulation of neurotransmitter transport 23.5294 5 no
GO:0060627 regulation of vesicle-mediated transport 23.5294 4 no
GO:0099177 regulation of trans-synaptic signaling 23.5294 4 no
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 17.6471 4 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 17.6471 4 yes
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 17.6471 5 yes
GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway 17.6471 5 yes
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 17.6471 4 yes
GO:0015844 monoamine transport 17.6471 5 yes
GO:0015850 organic hydroxy compound transport 17.6471 5 yes
GO:0015872 dopamine transport 17.6471 7 yes
GO:0019216 regulation of lipid metabolic process 17.6471 5 yes
GO:0051937 catecholamine transport 17.6471 6 yes
GO:0095500 acetylcholine receptor signaling pathway 17.6471 4 yes
GO:0001696 gastric acid secretion 11.7647 4 yes
GO:0019226 transmission of nerve impulse 11.7647 4 yes
GO:0035303 regulation of dephosphorylation 11.7647 7 yes
GO:0046717 acid secretion 11.7647 5 yes
GO:0060304 regulation of phosphatidylinositol dephosphorylation 11.7647 5 yes
GO:1903725 regulation of phospholipid metabolic process 11.7647 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ACM3_HUMAN [view entry] [view interactions] Low throughput yes yes
AP3M1_HUMAN [view entry] [view interactions] Low throughput yes yes
DTBP1_HUMAN [view entry] [view interactions] Low throughput yes yes
AP3D1_HUMAN [view entry] [view interactions] Low throughput yes no
ACM5_HUMAN [view entry] [view interactions] Low throughput yes no
RGS7_HUMAN [view entry] [view interactions] Low throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
T161A_HUMAN [view interactions] High throughput no yes
UBP33_HUMAN [view interactions] High throughput no yes
MSMO1_HUMAN [view interactions] High throughput no yes
GTR6_HUMAN [view interactions] High throughput no yes
SC5A6_HUMAN [view interactions] High throughput no no
SC6A8_HUMAN [view entry] [view interactions] High throughput yes no
SPNS1_HUMAN [view interactions] High throughput no yes
STR3N_HUMAN [view interactions] High throughput no yes
CXB6_HUMAN [view entry] [view interactions] High throughput yes no
SMAD6_HUMAN [view interactions] High throughput no no
REEP5_HUMAN [view entry] [view interactions] High throughput yes yes
TSSP_HUMAN [view interactions] High throughput no no
GOG8A_HUMAN [view interactions] High throughput no no
M3K1_HUMAN [view interactions] High throughput no yes
NPAS3_HUMAN [view interactions] High throughput no yes
NLE1_HUMAN [view interactions] High throughput no yes
RTN1_HUMAN [view entry] [view interactions] High throughput yes yes
MYH7_HUMAN [view interactions] High throughput no no
CD82_HUMAN [view interactions] High throughput no no
ATP9A_HUMAN [view interactions] High throughput no yes
AT2A2_HUMAN [view entry] [view interactions] High throughput yes yes
ASTN2_HUMAN [view entry] [view interactions] High throughput yes no
ASPH_HUMAN [view interactions] High throughput no yes
HLAF_HUMAN [view interactions] High throughput no no
ERCC1_HUMAN [view interactions] High throughput no yes
E41L1_HUMAN [view entry] [view interactions] High throughput yes yes
EPC1_HUMAN [view interactions] High throughput no no
PEBB_HUMAN [view interactions] High throughput no no
RAB3A_HUMAN [view entry] [view interactions] High throughput yes yes
CAV1_HUMAN [view interactions] High throughput no no
TM160_HUMAN [view interactions] High throughput no no
ARL10_HUMAN [view interactions] High throughput no yes
K0232_HUMAN [view interactions] High throughput no yes
TRI26_HUMAN [view interactions] High throughput no yes
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes