SC6A8_HUMAN
Evidence for PS localization
Functions
Required for the uptake of creatine in muscles and brain. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SC6A8_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 50.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 47.5000 | 5 | no |
| GO:0043168 | anion binding | 47.5000 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 45.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 45.0000 | 4 | no |
| GO:0003924 | GTPase activity | 40.0000 | 7 | no |
| GO:0005525 | GTP binding | 40.0000 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 40.0000 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 40.0000 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 40.0000 | 6 | no |
| GO:0019001 | guanyl nucleotide binding | 40.0000 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 40.0000 | 5 | no |
| GO:0019900 | kinase binding | 25.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 25.0000 | 5 | no |
| GO:0019003 | GDP binding | 22.5000 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SC6A8_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.0000 | 4 | no |
| GO:0008104 | protein localization | 50.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 47.5000 | 4 | no |
| GO:0071702 | organic substance transport | 45.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 45.0000 | 4 | yes |
| GO:0006996 | organelle organization | 42.5000 | 4 | no |
| GO:0022607 | cellular component assembly | 40.0000 | 4 | no |
| GO:0051049 | regulation of transport | 37.5000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 37.5000 | 4 | no |
| GO:0010646 | regulation of cell communication | 35.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 35.0000 | 4 | no |
| GO:0060341 | regulation of cellular localization | 35.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 32.5000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 32.5000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 32.5000 | 4 | no |
| GO:0015031 | protein transport | 32.5000 | 4 | no |
| GO:0032880 | regulation of protein localization | 32.5000 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 30.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.0000 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.0000 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.0000 | 5 | no |
| GO:0030334 | regulation of cell migration | 30.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.0000 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.0000 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 30.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.0000 | 5 | no |
| GO:2000145 | regulation of cell motility | 30.0000 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 30.0000 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 30.0000 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 27.5000 | 4 | no |
| GO:0030030 | cell projection organization | 27.5000 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 27.5000 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 27.5000 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 27.5000 | 6 | no |
| GO:0033043 | regulation of organelle organization | 27.5000 | 5 | no |
| GO:0007264 | small GTPase-mediated signal transduction | 27.5000 | 5 | no |
| GO:0007010 | cytoskeleton organization | 27.5000 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0007015 | actin filament organization | 22.5000 | 5 | no |
| GO:0030155 | regulation of cell adhesion | 22.5000 | 4 | no |
| GO:0030335 | positive regulation of cell migration | 22.5000 | 6 | no |
| GO:0040017 | positive regulation of locomotion | 22.5000 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 22.5000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.5000 | 5 | no |
| GO:0071310 | cellular response to organic substance | 22.5000 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.5000 | 5 | no |
| GO:2000147 | positive regulation of cell motility | 22.5000 | 5 | no |
| GO:1903829 | positive regulation of protein localization | 22.5000 | 5 | no |
| GO:0019752 | carboxylic acid metabolic process | 7.5000 | 5 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 7.5000 | 6 | yes |
| GO:0043436 | oxoacid metabolic process | 7.5000 | 4 | yes |
| GO:0006811 | monoatomic ion transport | 5.0000 | 4 | yes |
| GO:0006836 | neurotransmitter transport | 5.0000 | 4 | yes |
| GO:0015711 | organic anion transport | 5.0000 | 5 | yes |
| GO:0015849 | organic acid transport | 5.0000 | 5 | yes |
| GO:0046942 | carboxylic acid transport | 5.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NTR1_HUMAN | [view interactions] | High throughput | no | no |
| S22A4_HUMAN | [view interactions] | High throughput | no | yes |
| FPR2_HUMAN | [view interactions] | High throughput | no | yes |
| HACL2_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDS2_HUMAN | [view interactions] | High throughput | no | yes |
| PTSS1_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| T161A_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC2_HUMAN | [view interactions] | High throughput | no | yes |
| UBIA1_HUMAN | [view interactions] | High throughput | no | no |
| AL3A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PREB_HUMAN | [view interactions] | High throughput | no | yes |
| TRAM1_HUMAN | [view interactions] | High throughput | no | yes |
| CLGN_HUMAN | [view interactions] | High throughput | no | no |
| AUP1_HUMAN | [view interactions] | High throughput | no | yes |
| LEG3_HUMAN | [view interactions] | High throughput | no | yes |
| CHP1_HUMAN | [view interactions] | High throughput | no | yes |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| CDS1_HUMAN | [view interactions] | High throughput | no | yes |
| QSOX2_HUMAN | [view interactions] | High throughput | no | yes |
| MA1B1_HUMAN | [view interactions] | High throughput | no | yes |
| LMBR1_HUMAN | [view interactions] | High throughput | no | yes |
| FADS2_HUMAN | [view interactions] | High throughput | no | yes |
| S27A3_HUMAN | [view interactions] | High throughput | no | no |
| LMBD2_HUMAN | [view interactions] | High throughput | no | yes |
| KDSR_HUMAN | [view interactions] | High throughput | no | yes |
| SYEM_HUMAN | [view interactions] | High throughput | no | yes |
| NCPR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| G6PC3_HUMAN | [view interactions] | High throughput | no | no |
| SCAM3_HUMAN | [view interactions] | High throughput | no | no |
| EPDR1_HUMAN | [view interactions] | High throughput | no | yes |
| PIGS_HUMAN | [view interactions] | High throughput | no | yes |
| T161B_HUMAN | [view interactions] | High throughput | no | no |
| OS9_HUMAN | [view interactions] | High throughput | no | yes |
| RFT1_HUMAN | [view interactions] | High throughput | no | yes |
| S39A6_HUMAN | [view interactions] | High throughput | no | yes |
| SNX19_HUMAN | [view interactions] | High throughput | no | yes |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| FZD8_HUMAN | [view interactions] | High throughput | no | yes |
| SORT_HUMAN | [view interactions] | High throughput | no | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPPL3_HUMAN | [view interactions] | High throughput | no | no |
| KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| DNJ5B_HUMAN | [view interactions] | High throughput | no | no |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX8A_HUMAN | [view interactions] | High throughput | no | yes |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| DYR2_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMT1A_HUMAN | [view interactions] | High throughput | no | no |
| AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PANX1_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3B_HUMAN | [view interactions] | High throughput | no | no |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MUC18_HUMAN | [view interactions] | High throughput | no | yes |
| PPIL3_HUMAN | [view interactions] | High throughput | no | yes |
| MAGD2_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| YIPF3_HUMAN | [view interactions] | High throughput | no | yes |
| GRPR_HUMAN | [view interactions] | High throughput | no | no |
| 5NTD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PI2R_HUMAN | [view interactions] | High throughput | no | no |
| AGTR1_HUMAN | [view interactions] | High throughput | no | no |
| BKRB1_HUMAN | [view interactions] | High throughput | no | yes |
| ACM5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MKS3_HUMAN | [view interactions] | High throughput | no | no |
| TECT3_HUMAN | [view interactions] | High throughput | no | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| TM216_HUMAN | [view interactions] | High throughput | no | no |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| KCNK3_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSRG_HUMAN | [view interactions] | High throughput | no | yes |
| SCYL1_HUMAN | [view interactions] | High throughput | no | yes |
| TPRA1_HUMAN | [view interactions] | High throughput | no | yes |
| TM41B_HUMAN | [view interactions] | High throughput | no | yes |
| COPT2_HUMAN | [view interactions] | High throughput | no | yes |
| GLR_HUMAN | [view interactions] | High throughput | no | no |
| TLCD5_HUMAN | [view interactions] | High throughput | no | no |
| CKLF5_HUMAN | [view interactions] | High throughput | no | yes |
| FPR1_HUMAN | [view interactions] | High throughput | no | no |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| C5AR1_HUMAN | [view interactions] | High throughput | no | yes |
| S26A6_HUMAN | [view interactions] | High throughput | no | yes |
| TR10C_HUMAN | [view interactions] | High throughput | no | no |
| GPR17_HUMAN | [view interactions] | High throughput | no | no |