ACM3_HUMAN
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
ELM instance | Name | Type | Start | End | Partner |
---|---|---|---|---|---|
ELMI004274 | TRG_DiLeu_BaEn_2 | TRG | 275 | 281 | - |
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ACM3_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 40.6250 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 40.6250 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 40.6250 | 4 | no |
GO:0046872 | metal ion binding | 34.3750 | 4 | no |
GO:0019900 | kinase binding | 28.1250 | 4 | no |
GO:0003924 | GTPase activity | 28.1250 | 7 | no |
GO:0016462 | pyrophosphatase activity | 28.1250 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 28.1250 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 28.1250 | 6 | no |
GO:0019901 | protein kinase binding | 21.8750 | 5 | no |
GO:0005525 | GTP binding | 21.8750 | 5 | no |
GO:0019001 | guanyl nucleotide binding | 21.8750 | 5 | no |
GO:0032561 | guanyl ribonucleotide binding | 21.8750 | 5 | no |
GO:0004930 | G protein-coupled receptor activity | 15.6250 | 4 | yes |
GO:0098960 | postsynaptic neurotransmitter receptor activity | 15.6250 | 4 | yes |
GO:0004435 | phosphatidylinositol phospholipase C activity | 12.5000 | 7 | yes |
GO:0004620 | phospholipase activity | 12.5000 | 5 | yes |
GO:0004629 | phospholipase C activity | 12.5000 | 6 | yes |
GO:0004993 | G protein-coupled serotonin receptor activity | 12.5000 | 5 | yes |
GO:0008081 | phosphoric diester hydrolase activity | 12.5000 | 5 | yes |
GO:0008227 | G protein-coupled amine receptor activity | 12.5000 | 5 | yes |
GO:0015464 | acetylcholine receptor activity | 12.5000 | 4 | yes |
GO:0016298 | lipase activity | 12.5000 | 4 | yes |
GO:0016907 | G protein-coupled acetylcholine receptor activity | 12.5000 | 5 | yes |
GO:0042578 | phosphoric ester hydrolase activity | 12.5000 | 4 | yes |
GO:0099528 | G protein-coupled neurotransmitter receptor activity | 12.5000 | 4 | yes |
GO:0099589 | serotonin receptor activity | 12.5000 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ACM3_HUMAN |
---|---|---|---|---|
GO:0060255 | regulation of macromolecule metabolic process | 43.7500 | 4 | no |
GO:0010646 | regulation of cell communication | 43.7500 | 4 | no |
GO:0048522 | positive regulation of cellular process | 43.7500 | 4 | no |
GO:0048523 | negative regulation of cellular process | 43.7500 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 40.6250 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 40.6250 | 4 | no |
GO:0051049 | regulation of transport | 37.5000 | 4 | yes |
GO:0009966 | regulation of signal transduction | 37.5000 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 37.5000 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 31.2500 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 31.2500 | 5 | no |
GO:0051336 | regulation of hydrolase activity | 31.2500 | 4 | no |
GO:0036211 | protein modification process | 28.1250 | 4 | yes |
GO:0043269 | regulation of ion transport | 28.1250 | 5 | yes |
GO:0043412 | macromolecule modification | 28.1250 | 4 | yes |
GO:0001932 | regulation of protein phosphorylation | 28.1250 | 7 | no |
GO:0009892 | negative regulation of metabolic process | 28.1250 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 28.1250 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 28.1250 | 5 | no |
GO:0031399 | regulation of protein modification process | 28.1250 | 6 | no |
GO:0042325 | regulation of phosphorylation | 28.1250 | 7 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 28.1250 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 28.1250 | 5 | no |
GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | no |
GO:0010563 | negative regulation of phosphorus metabolic process | 25.0000 | 6 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | no |
GO:0031400 | negative regulation of protein modification process | 25.0000 | 7 | no |
GO:0043085 | positive regulation of catalytic activity | 25.0000 | 4 | no |
GO:0045936 | negative regulation of phosphate metabolic process | 25.0000 | 7 | no |
GO:0051050 | positive regulation of transport | 25.0000 | 4 | no |
GO:0051248 | negative regulation of protein metabolic process | 25.0000 | 6 | no |
GO:0006996 | organelle organization | 25.0000 | 4 | no |
GO:0008104 | protein localization | 25.0000 | 4 | no |
GO:0007213 | G protein-coupled acetylcholine receptor signaling pathway | 21.8750 | 4 | yes |
GO:0019722 | calcium-mediated signaling | 21.8750 | 5 | yes |
GO:0019932 | second-messenger-mediated signaling | 21.8750 | 4 | yes |
GO:0034762 | regulation of transmembrane transport | 21.8750 | 4 | yes |
GO:0034765 | regulation of ion transmembrane transport | 21.8750 | 5 | yes |
GO:0095500 | acetylcholine receptor signaling pathway | 21.8750 | 4 | yes |
GO:0001933 | negative regulation of protein phosphorylation | 21.8750 | 8 | no |
GO:0042326 | negative regulation of phosphorylation | 21.8750 | 8 | no |
GO:0043549 | regulation of kinase activity | 21.8750 | 5 | no |
GO:0045859 | regulation of protein kinase activity | 21.8750 | 6 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 21.8750 | 5 | no |
GO:0051338 | regulation of transferase activity | 21.8750 | 4 | no |
GO:0051345 | positive regulation of hydrolase activity | 21.8750 | 5 | no |
GO:0010243 | response to organonitrogen compound | 21.8750 | 4 | no |
GO:0010468 | regulation of gene expression | 21.8750 | 5 | no |
GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 18.7500 | 4 | yes |
GO:0022898 | regulation of transmembrane transporter activity | 18.7500 | 4 | yes |
GO:0032412 | regulation of ion transmembrane transporter activity | 18.7500 | 5 | yes |
GO:0006937 | regulation of muscle contraction | 15.6250 | 6 | yes |
GO:0007268 | chemical synaptic transmission | 15.6250 | 6 | yes |
GO:0044057 | regulation of system process | 15.6250 | 4 | yes |
GO:0046903 | secretion | 15.6250 | 4 | yes |
GO:0051240 | positive regulation of multicellular organismal process | 15.6250 | 4 | yes |
GO:0090257 | regulation of muscle system process | 15.6250 | 5 | yes |
GO:0098916 | anterograde trans-synaptic signaling | 15.6250 | 5 | yes |
GO:0099537 | trans-synaptic signaling | 15.6250 | 4 | yes |
GO:1903522 | regulation of blood circulation | 15.6250 | 5 | yes |
GO:0007187 | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | 12.5000 | 4 | yes |
GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | 12.5000 | 5 | yes |
GO:0007197 | adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway | 12.5000 | 5 | yes |
GO:0007399 | nervous system development | 12.5000 | 4 | yes |
GO:0003018 | vascular process in circulatory system | 9.3750 | 4 | yes |
GO:0006936 | muscle contraction | 9.3750 | 4 | yes |
GO:0007589 | body fluid secretion | 9.3750 | 4 | yes |
GO:0003056 | regulation of vascular associated smooth muscle contraction | 6.2500 | 7 | yes |
GO:0006939 | smooth muscle contraction | 6.2500 | 5 | yes |
GO:0006940 | regulation of smooth muscle contraction | 6.2500 | 7 | yes |
GO:0019229 | regulation of vasoconstriction | 6.2500 | 6 | yes |
GO:0035150 | regulation of tube size | 6.2500 | 4 | yes |
GO:0035296 | regulation of tube diameter | 6.2500 | 5 | yes |
GO:0045933 | positive regulation of muscle contraction | 6.2500 | 5 | yes |
GO:0045987 | positive regulation of smooth muscle contraction | 6.2500 | 6 | yes |
GO:0097746 | blood vessel diameter maintenance | 6.2500 | 5 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in ACM3_HUMAN |
---|---|---|---|---|
DOID:0050700 | cardiomyopathy | 6.2500 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 6.2500 | 5 | no |
DOID:114 | heart disease | 6.2500 | 3 | no |
DOID:2843 | long QT syndrome | 6.2500 | 6 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ACM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SET_HUMAN | [view interactions] | Low throughput | no | yes |
KC1A_HUMAN | [view interactions] | Low throughput | no | yes |
RGS7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NALCN_HUMAN | [view interactions] | Low throughput | no | no |
RGS4_HUMAN | [view interactions] | Low throughput | no | no |
ACM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
NEB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
JKIP1_HUMAN | [view interactions] | High throughput | no | no |
MAGD2_HUMAN | [view interactions] | High throughput | no | yes |
P121C_HUMAN | [view interactions] | High throughput | no | yes |
SEPT3_HUMAN | [view interactions] | High throughput | no | no |
CC184_HUMAN | [view interactions] | High throughput | no | no |
SGSM3_HUMAN | [view interactions] | High throughput | no | yes |
TAP1_HUMAN | [view interactions] | High throughput | no | yes |
TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
YIPF3_HUMAN | [view interactions] | High throughput | no | yes |
MDM2_HUMAN | [view interactions] | High throughput | no | yes |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TBA3C_HUMAN | [view interactions] | High throughput | no | no |
TBA3D_HUMAN | [view interactions] | High throughput | no | no |
FARP2_HUMAN | [view interactions] | High throughput | no | yes |
DCP2_HUMAN | [view interactions] | High throughput | no | yes |
UBP46_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GPN3_HUMAN | [view interactions] | High throughput | no | yes |
DYM_HUMAN | [view interactions] | High throughput | no | yes |
HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
ATLA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FAKD1_HUMAN | [view interactions] | High throughput | no | yes |
DNJA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRM7_HUMAN | [view interactions] | High throughput | no | yes |
CAND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CA112_HUMAN | [view interactions] | High throughput | no | yes |
PIGX_HUMAN | [view interactions] | High throughput | no | yes |
PBIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
IPIL1_HUMAN | [view interactions] | High throughput | no | no |
P55G_HUMAN | [view interactions] | High throughput | no | yes |
PEX1_HUMAN | [view interactions] | High throughput | no | no |
CERS6_HUMAN | [view interactions] | High throughput | no | yes |
PRKDC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AT1A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RNBP6_HUMAN | [view interactions] | High throughput | no | yes |
IPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IPO13_HUMAN | [view interactions] | High throughput | no | yes |
TELO2_HUMAN | [view interactions] | High throughput | no | yes |
PTH2_HUMAN | [view interactions] | High throughput | no | yes |
PP6R1_HUMAN | [view interactions] | High throughput | no | no |
NOCT_HUMAN | [view interactions] | High throughput | no | no |
STX18_HUMAN | [view interactions] | High throughput | no | yes |
JPH1_HUMAN | [view interactions] | High throughput | no | no |
GTPB2_HUMAN | [view interactions] | High throughput | no | yes |
YIPF4_HUMAN | [view interactions] | High throughput | no | yes |
IPO9_HUMAN | [view interactions] | High throughput | no | no |
EXOC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SYNM_HUMAN | [view interactions] | High throughput | no | yes |
F241B_HUMAN | [view interactions] | High throughput | no | yes |
GBF1_HUMAN | [view interactions] | High throughput | no | yes |
ARL10_HUMAN | [view interactions] | High throughput | no | yes |
HEAT3_HUMAN | [view interactions] | High throughput | no | yes |
LRP10_HUMAN | [view interactions] | High throughput | no | no |
TBB8_HUMAN | [view interactions] | High throughput | no | no |
STAR3_HUMAN | [view interactions] | High throughput | no | yes |
AT1A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PI4KA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PK3CB_HUMAN | [view interactions] | High throughput | no | yes |
LTN1_HUMAN | [view interactions] | High throughput | no | no |
TTI1_HUMAN | [view interactions] | High throughput | no | yes |
PLD2_HUMAN | [view interactions] | High throughput | no | yes |
S4A7_HUMAN | [view interactions] | High throughput | no | no |
NEK4_HUMAN | [view interactions] | High throughput | no | yes |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CD2B2_HUMAN | [view interactions] | High throughput | no | yes |
RCAF1_HUMAN | [view interactions] | High throughput | no | yes |
COMD7_HUMAN | [view interactions] | High throughput | no | no |
GNA11_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GRM5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ACM1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GBG12_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GNAQ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
RGS8_HUMAN | [view entry] [view interactions] | Computational | yes | yes |