ACM3_HUMAN
Evidence for PS localization
Functions
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI004274 | TRG_DiLeu_BaEn_2 | TRG | 275 | 281 | - |
| ELMI004274 | TRG_DiLeu_BaEn_2 | TRG | 275 | 281 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ACM3_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 46.6667 | 4 | yes |
| GO:0046872 | metal ion binding | 40.0000 | 5 | no |
| GO:0000166 | nucleotide binding | 36.6667 | 4 | no |
| GO:0017076 | purine nucleotide binding | 36.6667 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 36.6667 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 36.6667 | 4 | no |
| GO:0043168 | anion binding | 36.6667 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 30.0000 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 30.0000 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 30.0000 | 6 | no |
| GO:0019900 | kinase binding | 30.0000 | 4 | no |
| GO:0003924 | GTPase activity | 23.3333 | 7 | no |
| GO:0019901 | protein kinase binding | 23.3333 | 5 | no |
| GO:0004435 | phosphatidylinositol phospholipase C activity | 10.0000 | 7 | yes |
| GO:0004620 | phospholipase activity | 10.0000 | 5 | yes |
| GO:0004629 | phospholipase C activity | 10.0000 | 6 | yes |
| GO:0004930 | G protein-coupled receptor activity | 10.0000 | 4 | yes |
| GO:0004993 | G protein-coupled serotonin receptor activity | 10.0000 | 6 | yes |
| GO:0008081 | phosphoric diester hydrolase activity | 10.0000 | 5 | yes |
| GO:0008227 | G protein-coupled amine receptor activity | 10.0000 | 5 | yes |
| GO:0015464 | acetylcholine receptor activity | 10.0000 | 4 | yes |
| GO:0016298 | lipase activity | 10.0000 | 4 | yes |
| GO:0016907 | G protein-coupled acetylcholine receptor activity | 10.0000 | 5 | yes |
| GO:0042578 | phosphoric ester hydrolase activity | 10.0000 | 4 | yes |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 10.0000 | 4 | yes |
| GO:0099528 | G protein-coupled neurotransmitter receptor activity | 10.0000 | 4 | yes |
| GO:0042166 | acetylcholine binding | 6.6667 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ACM3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 56.6667 | 4 | yes |
| GO:0010646 | regulation of cell communication | 53.3333 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 43.3333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 43.3333 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 43.3333 | 4 | no |
| GO:0051049 | regulation of transport | 40.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 40.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
| GO:0051050 | positive regulation of transport | 33.3333 | 4 | yes |
| GO:0010243 | response to organonitrogen compound | 30.0000 | 4 | no |
| GO:0141124 | intracellular signaling cassette | 26.6667 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 26.6667 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.6667 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.6667 | 5 | no |
| GO:0008104 | protein localization | 26.6667 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 26.6667 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 26.6667 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.6667 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.6667 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 26.6667 | 5 | no |
| GO:0071310 | cellular response to organic substance | 26.6667 | 4 | no |
| GO:0032880 | regulation of protein localization | 23.3333 | 5 | yes |
| GO:0034762 | regulation of transmembrane transport | 23.3333 | 4 | yes |
| GO:0036211 | protein modification process | 23.3333 | 4 | yes |
| GO:0043412 | macromolecule modification | 23.3333 | 4 | yes |
| GO:0044057 | regulation of system process | 23.3333 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 23.3333 | 4 | yes |
| GO:1903522 | regulation of blood circulation | 23.3333 | 5 | yes |
| GO:1903829 | positive regulation of protein localization | 23.3333 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 23.3333 | 4 | no |
| GO:0010468 | regulation of gene expression | 23.3333 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.3333 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 23.3333 | 5 | no |
| GO:0006996 | organelle organization | 23.3333 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 23.3333 | 7 | no |
| GO:0031399 | regulation of protein modification process | 23.3333 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 23.3333 | 7 | no |
| GO:0051248 | negative regulation of protein metabolic process | 23.3333 | 6 | no |
| GO:0014070 | response to organic cyclic compound | 23.3333 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.3333 | 5 | no |
| GO:0051726 | regulation of cell cycle | 23.3333 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 20.0000 | 5 | yes |
| GO:0019722 | calcium-mediated signaling | 20.0000 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 20.0000 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 20.0000 | 4 | yes |
| GO:0090257 | regulation of muscle system process | 20.0000 | 5 | yes |
| GO:0006937 | regulation of muscle contraction | 16.6667 | 6 | yes |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 16.6667 | 4 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 16.6667 | 4 | yes |
| GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 16.6667 | 5 | yes |
| GO:0051046 | regulation of secretion | 16.6667 | 5 | yes |
| GO:0051222 | positive regulation of protein transport | 16.6667 | 5 | yes |
| GO:0051223 | regulation of protein transport | 16.6667 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 16.6667 | 6 | yes |
| GO:1903530 | regulation of secretion by cell | 16.6667 | 4 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 16.6667 | 6 | yes |
| GO:0007213 | G protein-coupled acetylcholine receptor signaling pathway | 13.3333 | 4 | yes |
| GO:0046903 | secretion | 13.3333 | 4 | yes |
| GO:0050708 | regulation of protein secretion | 13.3333 | 5 | yes |
| GO:0050714 | positive regulation of protein secretion | 13.3333 | 6 | yes |
| GO:0051047 | positive regulation of secretion | 13.3333 | 5 | yes |
| GO:0095500 | acetylcholine receptor signaling pathway | 13.3333 | 4 | yes |
| GO:1903532 | positive regulation of secretion by cell | 13.3333 | 5 | yes |
| GO:0003018 | vascular process in circulatory system | 10.0000 | 4 | yes |
| GO:0006936 | muscle contraction | 10.0000 | 4 | yes |
| GO:0007187 | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | 10.0000 | 4 | yes |
| GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | 10.0000 | 5 | yes |
| GO:0007197 | adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway | 10.0000 | 5 | yes |
| GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway | 10.0000 | 4 | yes |
| GO:0007268 | chemical synaptic transmission | 10.0000 | 7 | yes |
| GO:0007399 | nervous system development | 10.0000 | 4 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 10.0000 | 6 | yes |
| GO:0099536 | synaptic signaling | 10.0000 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 10.0000 | 5 | yes |
| GO:0002791 | regulation of peptide secretion | 6.6667 | 6 | yes |
| GO:0002793 | positive regulation of peptide secretion | 6.6667 | 6 | yes |
| GO:0003056 | regulation of vascular associated smooth muscle contraction | 6.6667 | 7 | yes |
| GO:0006939 | smooth muscle contraction | 6.6667 | 5 | yes |
| GO:0006940 | regulation of smooth muscle contraction | 6.6667 | 7 | yes |
| GO:0007207 | phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway | 6.6667 | 5 | yes |
| GO:0007589 | body fluid secretion | 6.6667 | 4 | yes |
| GO:0019229 | regulation of vasoconstriction | 6.6667 | 6 | yes |
| GO:0032024 | positive regulation of insulin secretion | 6.6667 | 7 | yes |
| GO:0035150 | regulation of tube size | 6.6667 | 4 | yes |
| GO:0035296 | regulation of tube diameter | 6.6667 | 5 | yes |
| GO:0045933 | positive regulation of muscle contraction | 6.6667 | 5 | yes |
| GO:0045987 | positive regulation of smooth muscle contraction | 6.6667 | 6 | yes |
| GO:0046883 | regulation of hormone secretion | 6.6667 | 4 | yes |
| GO:0046887 | positive regulation of hormone secretion | 6.6667 | 5 | yes |
| GO:0050796 | regulation of insulin secretion | 6.6667 | 6 | yes |
| GO:0090087 | regulation of peptide transport | 6.6667 | 5 | yes |
| GO:0090276 | regulation of peptide hormone secretion | 6.6667 | 5 | yes |
| GO:0090277 | positive regulation of peptide hormone secretion | 6.6667 | 6 | yes |
| GO:0097746 | blood vessel diameter maintenance | 6.6667 | 5 | yes |
| GO:0099105 | ion channel modulating, G protein-coupled receptor signaling pathway | 6.6667 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NALCN_HUMAN | [view interactions] | Low throughput | no | no |
| RGS4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ACM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NEB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SET_HUMAN | [view interactions] | Low throughput | no | yes |
| KC1A_HUMAN | [view interactions] | Low throughput | no | yes |
| RGS7_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| S4A7_HUMAN | [view interactions] | High throughput | no | no |
| PLD2_HUMAN | [view interactions] | High throughput | no | yes |
| TTI1_HUMAN | [view interactions] | High throughput | no | yes |
| LTN1_HUMAN | [view interactions] | High throughput | no | no |
| PK3CB_HUMAN | [view interactions] | High throughput | no | yes |
| PI4KA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| TBB3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT1A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STAR3_HUMAN | [view interactions] | High throughput | no | yes |
| TBB8_HUMAN | [view interactions] | High throughput | no | no |
| LRP10_HUMAN | [view interactions] | High throughput | no | no |
| HEAT3_HUMAN | [view interactions] | High throughput | no | yes |
| ARL10_HUMAN | [view interactions] | High throughput | no | yes |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| F241B_HUMAN | [view interactions] | High throughput | no | yes |
| SYNM_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IPO9_HUMAN | [view interactions] | High throughput | no | no |
| YIPF4_HUMAN | [view interactions] | High throughput | no | yes |
| GTPB2_HUMAN | [view interactions] | High throughput | no | yes |
| JPH1_HUMAN | [view interactions] | High throughput | no | no |
| STX18_HUMAN | [view interactions] | High throughput | no | yes |
| NOCT_HUMAN | [view interactions] | High throughput | no | no |
| PP6R1_HUMAN | [view interactions] | High throughput | no | no |
| PTH2_HUMAN | [view interactions] | High throughput | no | yes |
| TELO2_HUMAN | [view interactions] | High throughput | no | yes |
| IPO13_HUMAN | [view interactions] | High throughput | no | yes |
| IPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| CD2B2_HUMAN | [view interactions] | High throughput | no | yes |
| JKIP1_HUMAN | [view interactions] | High throughput | no | no |
| RCAF1_HUMAN | [view interactions] | High throughput | no | yes |
| COMD7_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| YIPF3_HUMAN | [view interactions] | High throughput | no | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAP1_HUMAN | [view interactions] | High throughput | no | yes |
| SGSM3_HUMAN | [view interactions] | High throughput | no | yes |
| CC184_HUMAN | [view interactions] | High throughput | no | no |
| SEPT3_HUMAN | [view interactions] | High throughput | no | no |
| P121C_HUMAN | [view interactions] | High throughput | no | yes |
| MAGD2_HUMAN | [view interactions] | High throughput | no | yes |
| MDM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA3C_HUMAN | [view interactions] | High throughput | no | no |
| TBA3D_HUMAN | [view interactions] | High throughput | no | no |
| FARP2_HUMAN | [view interactions] | High throughput | no | yes |
| DCP2_HUMAN | [view interactions] | High throughput | no | yes |
| UBP46_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPN3_HUMAN | [view interactions] | High throughput | no | yes |
| DYM_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| ATLA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD1_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRM7_HUMAN | [view interactions] | High throughput | no | yes |
| CAND2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FIRRM_HUMAN | [view interactions] | High throughput | no | yes |
| PIGX_HUMAN | [view interactions] | High throughput | no | yes |
| PBIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| IPIL1_HUMAN | [view interactions] | High throughput | no | no |
| P55G_HUMAN | [view interactions] | High throughput | no | yes |
| PEX1_HUMAN | [view interactions] | High throughput | no | no |
| CERS6_HUMAN | [view interactions] | High throughput | no | yes |
| PRKDC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT1A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RNBP6_HUMAN | [view interactions] | High throughput | no | yes |