RGS4_HUMAN
Evidence for PS localization
Functions
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RGS4_HUMAN |
|---|---|---|---|---|
| GO:0003924 | GTPase activity | 50.0000 | 7 | yes |
| GO:0016462 | pyrophosphatase activity | 50.0000 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 50.0000 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 50.0000 | 6 | yes |
| GO:0000166 | nucleotide binding | 50.0000 | 4 | no |
| GO:0001664 | G protein-coupled receptor binding | 50.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 50.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 50.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 50.0000 | 4 | no |
| GO:0043168 | anion binding | 50.0000 | 4 | no |
| GO:0043169 | cation binding | 50.0000 | 4 | no |
| GO:0005525 | GTP binding | 40.0000 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 40.0000 | 6 | no |
| GO:0032561 | guanyl ribonucleotide binding | 40.0000 | 5 | no |
| GO:0046872 | metal ion binding | 40.0000 | 5 | no |
| GO:0019900 | kinase binding | 30.0000 | 4 | yes |
| GO:0019901 | protein kinase binding | 30.0000 | 5 | yes |
| GO:0004930 | G protein-coupled receptor activity | 30.0000 | 4 | no |
| GO:0098960 | postsynaptic neurotransmitter receptor activity | 30.0000 | 4 | no |
| GO:0005096 | GTPase activator activity | 20.0000 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 20.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RGS4_HUMAN |
|---|---|---|---|---|
| GO:0010646 | regulation of cell communication | 80.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 70.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 60.0000 | 4 | yes |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 60.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 60.0000 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 60.0000 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 60.0000 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 40.0000 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 40.0000 | 5 | yes |
| GO:0051049 | regulation of transport | 40.0000 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 40.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 40.0000 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 40.0000 | 5 | no |
| GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | 40.0000 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 40.0000 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 40.0000 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 40.0000 | 4 | yes |
| GO:0045744 | negative regulation of G protein-coupled receptor signaling pathway | 30.0000 | 6 | yes |
| GO:0048585 | negative regulation of response to stimulus | 30.0000 | 4 | yes |
| GO:0051051 | negative regulation of transport | 30.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 30.0000 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 30.0000 | 4 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 30.0000 | 6 | yes |
| GO:0097305 | response to alcohol | 30.0000 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 30.0000 | 7 | no |
| GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway | 30.0000 | 4 | no |
| GO:0007213 | G protein-coupled acetylcholine receptor signaling pathway | 30.0000 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.0000 | 6 | no |
| GO:0031399 | regulation of protein modification process | 30.0000 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 30.0000 | 7 | no |
| GO:0043086 | negative regulation of catalytic activity | 30.0000 | 4 | no |
| GO:0043549 | regulation of kinase activity | 30.0000 | 5 | no |
| GO:0045859 | regulation of protein kinase activity | 30.0000 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 30.0000 | 5 | no |
| GO:0051338 | regulation of transferase activity | 30.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 30.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 30.0000 | 4 | no |
| GO:0095500 | acetylcholine receptor signaling pathway | 30.0000 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 30.0000 | 7 | no |
| GO:0009893 | positive regulation of metabolic process | 30.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.0000 | 5 | no |
| GO:0043408 | regulation of MAPK cascade | 30.0000 | 6 | no |
| GO:0071310 | cellular response to organic substance | 30.0000 | 4 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 30.0000 | 6 | no |
| GO:0099536 | synaptic signaling | 30.0000 | 4 | no |
| GO:0099537 | trans-synaptic signaling | 30.0000 | 5 | no |
| GO:0051046 | regulation of secretion | 30.0000 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 30.0000 | 4 | no |
| GO:0008277 | regulation of G protein-coupled receptor signaling pathway | 30.0000 | 5 | yes |
| GO:0009968 | negative regulation of signal transduction | 30.0000 | 5 | yes |
| GO:0010243 | response to organonitrogen compound | 30.0000 | 4 | yes |
| GO:0014070 | response to organic cyclic compound | 30.0000 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 30.0000 | 5 | yes |
| GO:0044057 | regulation of system process | 20.0000 | 4 | yes |
| GO:0045471 | response to ethanol | 20.0000 | 5 | yes |
| GO:0045595 | regulation of cell differentiation | 20.0000 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 20.0000 | 4 | yes |
| GO:0051924 | regulation of calcium ion transport | 20.0000 | 7 | yes |
| GO:0051952 | regulation of amine transport | 20.0000 | 5 | yes |
| GO:0051953 | negative regulation of amine transport | 20.0000 | 5 | yes |
| GO:0051955 | regulation of amino acid transport | 20.0000 | 6 | yes |
| GO:0051956 | negative regulation of amino acid transport | 20.0000 | 6 | yes |
| GO:0090257 | regulation of muscle system process | 20.0000 | 5 | yes |
| GO:0110053 | regulation of actin filament organization | 20.0000 | 6 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 20.0000 | 5 | yes |
| GO:1903522 | regulation of blood circulation | 20.0000 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 20.0000 | 4 | yes |
| GO:0010959 | regulation of metal ion transport | 20.0000 | 6 | yes |
| GO:0032890 | regulation of organic acid transport | 20.0000 | 5 | yes |
| GO:0032891 | negative regulation of organic acid transport | 20.0000 | 5 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 20.0000 | 5 | yes |
| GO:0032970 | regulation of actin filament-based process | 20.0000 | 4 | yes |
| GO:0034762 | regulation of transmembrane transport | 20.0000 | 4 | yes |
| GO:0043269 | regulation of monoatomic ion transport | 20.0000 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ZDHC3_HUMAN | [view interactions] | Low throughput | no | yes |
| ACM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAO_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAI1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| AEDO_HUMAN | [view interactions] | Low throughput | no | yes |
| COPB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAQ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ERBB3_HUMAN | [view interactions] | Low throughput | no | yes |
| GRM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KCMF1_HUMAN | [view interactions] | Low throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | Low throughput | no | yes |
| GNAI2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KRIT1_HUMAN | [view interactions] | Low throughput | no | no |
| GABR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBR1_HUMAN | [view interactions] | Low throughput | no | yes |
| PPCEL_HUMAN | [view interactions] | High throughput | no | yes |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MTHFS_HUMAN | [view interactions] | High throughput | no | yes |