Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AT1A4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AT1A4_HUMAN
GO:0043169 cation binding 46.1538 4 yes
GO:0046872 metal ion binding 38.4615 5 yes
GO:0019900 kinase binding 30.7692 4 yes
GO:0000166 nucleotide binding 23.0769 4 yes
GO:0017076 purine nucleotide binding 23.0769 5 yes
GO:0030554 adenyl nucleotide binding 23.0769 6 yes
GO:0032555 purine ribonucleotide binding 23.0769 4 yes
GO:0032559 adenyl ribonucleotide binding 23.0769 5 yes
GO:0043168 anion binding 23.0769 4 yes
GO:0005524 ATP binding 15.3846 5 yes
GO:0008324 monoatomic cation transmembrane transporter activity 15.3846 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 15.3846 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 15.3846 4 yes
GO:0046873 metal ion transmembrane transporter activity 15.3846 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in AT1A4_HUMAN
GO:0010646 regulation of cell communication 69.2308 4 no
GO:0048522 positive regulation of cellular process 69.2308 4 no
GO:0051049 regulation of transport 53.8462 4 no
GO:0048523 negative regulation of cellular process 53.8462 4 no
GO:0031323 regulation of cellular metabolic process 53.8462 4 no
GO:0036211 protein modification process 53.8462 4 no
GO:0043412 macromolecule modification 53.8462 4 no
GO:0060255 regulation of macromolecule metabolic process 53.8462 4 no
GO:0080090 regulation of primary metabolic process 53.8462 4 no
GO:0010647 positive regulation of cell communication 53.8462 5 no
GO:0023056 positive regulation of signaling 53.8462 4 no
GO:0051128 regulation of cellular component organization 46.1538 4 no
GO:0006355 regulation of DNA-templated transcription 46.1538 7 no
GO:0009889 regulation of biosynthetic process 46.1538 4 no
GO:0010468 regulation of gene expression 46.1538 6 no
GO:0010556 regulation of macromolecule biosynthetic process 46.1538 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 46.1538 5 no
GO:0031326 regulation of cellular biosynthetic process 46.1538 5 no
GO:0051252 regulation of RNA metabolic process 46.1538 5 no
GO:2001141 regulation of RNA biosynthetic process 46.1538 6 no
GO:0009966 regulation of signal transduction 46.1538 4 no
GO:0009967 positive regulation of signal transduction 46.1538 5 no
GO:0048584 positive regulation of response to stimulus 46.1538 4 no
GO:0050804 modulation of chemical synaptic transmission 38.4615 5 no
GO:0099177 regulation of trans-synaptic signaling 38.4615 4 no
GO:0006996 organelle organization 30.7692 4 no
GO:0022607 cellular component assembly 30.7692 4 no
GO:0033043 regulation of organelle organization 30.7692 5 no
GO:0044087 regulation of cellular component biogenesis 30.7692 4 no
GO:0051240 positive regulation of multicellular organismal process 30.7692 4 no
GO:0060341 regulation of cellular localization 30.7692 4 no
GO:0006357 regulation of transcription by RNA polymerase II 30.7692 8 no
GO:0043687 post-translational protein modification 30.7692 5 no
GO:0070647 protein modification by small protein conjugation or removal 30.7692 6 no
GO:0009892 negative regulation of metabolic process 30.7692 4 no
GO:0010605 negative regulation of macromolecule metabolic process 30.7692 5 no
GO:0031324 negative regulation of cellular metabolic process 30.7692 5 no
GO:0009968 negative regulation of signal transduction 30.7692 5 no
GO:0010648 negative regulation of cell communication 30.7692 5 no
GO:0023057 negative regulation of signaling 30.7692 4 no
GO:0048585 negative regulation of response to stimulus 30.7692 4 no
GO:1902531 regulation of intracellular signal transduction 30.7692 5 no
GO:1902532 negative regulation of intracellular signal transduction 30.7692 6 no
GO:0006811 monoatomic ion transport 23.0769 4 yes
GO:0006812 monoatomic cation transport 23.0769 5 yes
GO:0030001 metal ion transport 23.0769 6 yes
GO:0098657 import into cell 23.0769 4 yes
GO:0044057 regulation of system process 23.0769 4 no
GO:0031344 regulation of cell projection organization 23.0769 5 no
GO:0043254 regulation of protein-containing complex assembly 23.0769 5 no
GO:0051129 negative regulation of cellular component organization 23.0769 5 no
GO:0051130 positive regulation of cellular component organization 23.0769 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 23.0769 6 no
GO:0009893 positive regulation of metabolic process 23.0769 4 no
GO:0010604 positive regulation of macromolecule metabolic process 23.0769 5 no
GO:0016567 protein ubiquitination 23.0769 8 no
GO:0032446 protein modification by small protein conjugation 23.0769 7 no
GO:0043086 negative regulation of catalytic activity 23.0769 4 no
GO:0043933 protein-containing complex organization 23.0769 4 no
GO:0065003 protein-containing complex assembly 23.0769 5 no
GO:0031399 regulation of protein modification process 23.0769 6 no
GO:0050890 cognition 23.0769 4 no
GO:0051246 regulation of protein metabolic process 23.0769 5 no
GO:0006508 proteolysis 23.0769 4 no
GO:0009890 negative regulation of biosynthetic process 23.0769 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 23.0769 6 no
GO:0031327 negative regulation of cellular biosynthetic process 23.0769 6 no
GO:0051241 negative regulation of multicellular organismal process 23.0769 4 no
GO:1902533 positive regulation of intracellular signal transduction 23.0769 6 no
GO:0003018 vascular process in circulatory system 15.3846 4 yes
GO:0006873 intracellular monoatomic ion homeostasis 15.3846 4 yes
GO:0030003 intracellular monoatomic cation homeostasis 15.3846 5 yes
GO:0055080 monoatomic cation homeostasis 15.3846 4 yes
GO:0098655 monoatomic cation transmembrane transport 15.3846 4 yes
GO:0098659 inorganic cation import across plasma membrane 15.3846 5 yes
GO:0098662 inorganic cation transmembrane transport 15.3846 4 yes
GO:0099587 inorganic ion import across plasma membrane 15.3846 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ACM3_HUMAN [view entry] [view interactions] High throughput yes yes
H4_HUMAN [view interactions] High throughput no yes
P2RY8_HUMAN [view interactions] High throughput no no
TP4A3_HUMAN [view interactions] High throughput no no
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
B9D1_HUMAN [view interactions] High throughput no yes
RIC8A_HUMAN [view entry] [view interactions] High throughput yes no
CTG1B_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
CSN5_HUMAN [view interactions] High throughput no yes
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
AT1B4_HUMAN [view interactions] High throughput no no
RPGR_HUMAN [view interactions] High throughput no yes
LRCC1_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
HEXI1_HUMAN [view interactions] High throughput no yes
UBE3A_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
KLHL9_HUMAN [view interactions] High throughput no no
KIBRA_HUMAN [view entry] [view interactions] High throughput yes yes
CD244_HUMAN [view interactions] High throughput no no
CE024_HUMAN [view interactions] High throughput no yes
KAP1_HUMAN [view entry] [view interactions] High throughput yes yes
IZUM1_HUMAN [view interactions] High throughput no no
CHTOP_HUMAN [view interactions] High throughput no yes
MAP1B_HUMAN [view entry] [view interactions] High throughput yes yes
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
CSK_HUMAN [view interactions] High throughput no yes
RED1_HUMAN [view interactions] High throughput no no