Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

AT1A4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in AT1A4_HUMAN
GO:0017076 purine nucleotide binding 46.1538 4 yes
GO:0030554 adenyl nucleotide binding 46.1538 5 yes
GO:0032555 purine ribonucleotide binding 46.1538 4 yes
GO:0032559 adenyl ribonucleotide binding 46.1538 5 yes
GO:0046872 metal ion binding 46.1538 4 yes
GO:0005391 P-type sodium:potassium-exchanging transporter activity 38.4615 5 yes
GO:0005524 ATP binding 38.4615 5 yes
GO:0008324 cation transmembrane transporter activity 38.4615 4 yes
GO:0008554 P-type sodium transporter activity 38.4615 4 yes
GO:0008556 P-type potassium transmembrane transporter activity 38.4615 4 yes
GO:0015079 potassium ion transmembrane transporter activity 38.4615 6 yes
GO:0015081 sodium ion transmembrane transporter activity 38.4615 6 yes
GO:0015399 primary active transmembrane transporter activity 38.4615 4 yes
GO:0015662 P-type ion transporter activity 38.4615 4 yes
GO:0022853 active ion transmembrane transporter activity 38.4615 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 38.4615 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 38.4615 4 yes
GO:0046873 metal ion transmembrane transporter activity 38.4615 5 yes
GO:0019900 kinase binding 30.7692 4 yes
GO:0046982 protein heterodimerization activity 30.7692 4 no
GO:0019901 protein kinase binding 23.0769 5 no
GO:0042578 phosphoric ester hydrolase activity 23.0769 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in AT1A4_HUMAN
GO:0006811 ion transport 53.8462 4 yes
GO:0006812 cation transport 53.8462 5 yes
GO:0030001 metal ion transport 53.8462 6 yes
GO:0051049 regulation of transport 53.8462 4 no
GO:0006813 potassium ion transport 46.1538 7 yes
GO:0006814 sodium ion transport 46.1538 7 yes
GO:0006873 cellular ion homeostasis 46.1538 4 yes
GO:0006875 cellular metal ion homeostasis 46.1538 6 yes
GO:0006883 cellular sodium ion homeostasis 46.1538 7 yes
GO:0030003 cellular cation homeostasis 46.1538 5 yes
GO:0030004 cellular monovalent inorganic cation homeostasis 46.1538 6 yes
GO:0030007 cellular potassium ion homeostasis 46.1538 7 yes
GO:0035725 sodium ion transmembrane transport 46.1538 6 yes
GO:0036376 sodium ion export across plasma membrane 46.1538 4 yes
GO:0048878 chemical homeostasis 46.1538 4 yes
GO:0050801 ion homeostasis 46.1538 5 yes
GO:0055065 metal ion homeostasis 46.1538 7 yes
GO:0055067 monovalent inorganic cation homeostasis 46.1538 7 yes
GO:0055075 potassium ion homeostasis 46.1538 8 yes
GO:0055078 sodium ion homeostasis 46.1538 8 yes
GO:0055080 cation homeostasis 46.1538 6 yes
GO:0071805 potassium ion transmembrane transport 46.1538 6 yes
GO:0098655 cation transmembrane transport 46.1538 4 yes
GO:0098657 import into cell 46.1538 4 yes
GO:0098659 inorganic cation import across plasma membrane 46.1538 5 yes
GO:0098660 inorganic ion transmembrane transport 46.1538 4 yes
GO:0098662 inorganic cation transmembrane transport 46.1538 5 yes
GO:0098771 inorganic ion homeostasis 46.1538 6 yes
GO:0099587 inorganic ion import across plasma membrane 46.1538 4 yes
GO:1990573 potassium ion import across plasma membrane 46.1538 6 yes
GO:0043269 regulation of ion transport 46.1538 5 no
GO:0048522 positive regulation of cellular process 46.1538 4 no
GO:0048523 negative regulation of cellular process 46.1538 4 no
GO:0031323 regulation of cellular metabolic process 46.1538 4 no
GO:0036211 protein modification process 46.1538 4 no
GO:0043412 macromolecule modification 46.1538 4 no
GO:0060255 regulation of macromolecule metabolic process 46.1538 4 no
GO:0080090 regulation of primary metabolic process 46.1538 4 no
GO:0010959 regulation of metal ion transport 38.4615 6 no
GO:0086064 cell communication by electrical coupling involved in cardiac conduction 38.4615 4 no
GO:0009889 regulation of biosynthetic process 38.4615 4 no
GO:0010468 regulation of gene expression 38.4615 5 no
GO:0031326 regulation of cellular biosynthetic process 38.4615 5 no
GO:0051171 regulation of nitrogen compound metabolic process 38.4615 4 no
GO:0010646 regulation of cell communication 38.4615 4 no
GO:0003018 vascular process in circulatory system 30.7692 4 yes
GO:1902600 proton transmembrane transport 30.7692 6 yes
GO:0002028 regulation of sodium ion transport 30.7692 7 no
GO:0022898 regulation of transmembrane transporter activity 30.7692 4 no
GO:0032412 regulation of ion transmembrane transporter activity 30.7692 5 no
GO:0034762 regulation of transmembrane transport 30.7692 4 no
GO:0034765 regulation of ion transmembrane transport 30.7692 5 no
GO:0051128 regulation of cellular component organization 30.7692 4 no
GO:0086009 membrane repolarization 30.7692 4 no
GO:0006355 regulation of DNA-templated transcription 30.7692 6 no
GO:0010556 regulation of macromolecule biosynthetic process 30.7692 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 30.7692 5 no
GO:0051252 regulation of RNA metabolic process 30.7692 5 no
GO:1903506 regulation of nucleic acid-templated transcription 30.7692 7 no
GO:2001141 regulation of RNA biosynthetic process 30.7692 6 no
GO:0006796 phosphate-containing compound metabolic process 30.7692 4 no
GO:0009892 negative regulation of metabolic process 30.7692 4 no
GO:0006937 regulation of muscle contraction 30.7692 6 no
GO:0044057 regulation of system process 30.7692 4 no
GO:0090257 regulation of muscle system process 30.7692 5 no
GO:1903522 regulation of blood circulation 30.7692 5 no
GO:0010232 vascular transport 23.0769 4 yes
GO:0150104 transport across blood-brain barrier 23.0769 5 yes
GO:0030030 cell projection organization 23.0769 4 no
GO:0043270 positive regulation of ion transport 23.0769 5 no
GO:0051050 positive regulation of transport 23.0769 4 no
GO:0051130 positive regulation of cellular component organization 23.0769 5 no
GO:1902305 regulation of sodium ion transmembrane transport 23.0769 7 no
GO:1904062 regulation of cation transmembrane transport 23.0769 6 no
GO:0050890 cognition 23.0769 4 no
GO:0043086 negative regulation of catalytic activity 23.0769 4 no
GO:0070647 protein modification by small protein conjugation or removal 23.0769 5 no
GO:0010605 negative regulation of macromolecule metabolic process 23.0769 5 no
GO:0031324 negative regulation of cellular metabolic process 23.0769 5 no
GO:0050804 modulation of chemical synaptic transmission 23.0769 5 no
GO:0099177 regulation of trans-synaptic signaling 23.0769 4 no
GO:0009966 regulation of signal transduction 23.0769 4 no
GO:0006942 regulation of striated muscle contraction 23.0769 7 no
GO:0008016 regulation of heart contraction 23.0769 6 no
GO:0014070 response to organic cyclic compound 23.0769 4 no
GO:0032870 cellular response to hormone stimulus 23.0769 4 no
GO:0033993 response to lipid 23.0769 4 no
GO:0048545 response to steroid hormone 23.0769 4 no
GO:0051240 positive regulation of multicellular organismal process 23.0769 4 no
GO:0051241 negative regulation of multicellular organismal process 23.0769 4 no
GO:0055119 relaxation of cardiac muscle 23.0769 5 no
GO:0071310 cellular response to organic substance 23.0769 4 no
GO:0071383 cellular response to steroid hormone stimulus 23.0769 5 no
GO:0071396 cellular response to lipid 23.0769 5 no
GO:0071407 cellular response to organic cyclic compound 23.0769 5 no
GO:0090075 relaxation of muscle 23.0769 4 no
GO:1903416 response to glycoside 23.0769 4 no
GO:0006936 muscle contraction 23.0769 4 no
GO:0019722 calcium-mediated signaling 23.0769 5 no
GO:0019932 second-messenger-mediated signaling 23.0769 4 no
GO:0051924 regulation of calcium ion transport 23.0769 7 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ACM3_HUMAN [view entry] [view interactions] High throughput yes yes
H4_HUMAN [view interactions] High throughput no yes
P2RY8_HUMAN [view interactions] High throughput no no
TP4A3_HUMAN [view interactions] High throughput no no
B9D1_HUMAN [view interactions] High throughput no yes
RIC8A_HUMAN [view entry] [view interactions] High throughput yes no
CTG1B_HUMAN [view interactions] High throughput no no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
CSN5_HUMAN [view interactions] High throughput no yes
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
AT1B4_HUMAN [view interactions] High throughput no no
RPGR_HUMAN [view interactions] High throughput no yes
LRCC1_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
HEXI1_HUMAN [view interactions] High throughput no yes
UBE3A_HUMAN [view interactions] High throughput no yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
KLHL9_HUMAN [view interactions] High throughput no no
KIBRA_HUMAN [view interactions] High throughput no yes
CD244_HUMAN [view interactions] High throughput no no
CE024_HUMAN [view interactions] High throughput no yes
KAP1_HUMAN [view entry] [view interactions] High throughput yes yes
IZUM1_HUMAN [view interactions] High throughput no no
CHTOP_HUMAN [view interactions] High throughput no yes
CSK_HUMAN [view interactions] High throughput no yes
AT1B2_HUMAN [view entry] [view interactions] Computational yes no
AT1B1_HUMAN [view entry] [view interactions] Computational yes no
AT1B3_HUMAN [view interactions] Computational no yes
PLM_HUMAN [view interactions] Computational no no
KCNJ5_HUMAN [view interactions] Computational no yes
AT1A3_HUMAN [view entry] [view interactions] Computational yes no
ATNG_HUMAN [view interactions] Computational no no
AT1A1_HUMAN [view entry] [view interactions] Computational yes no
AT1A2_HUMAN [view entry] [view interactions] Computational yes yes