UBP46_HUMAN
Evidence for PS localization
Functions
Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 . Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed, PubMed). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in UBP46_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 35.7143 | 4 | no |
| GO:0045296 | cadherin binding | 28.5714 | 4 | no |
| GO:0031625 | ubiquitin protein ligase binding | 25.0000 | 5 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 25.0000 | 4 | no |
| GO:0019900 | kinase binding | 25.0000 | 4 | no |
| GO:0046872 | metal ion binding | 21.4286 | 4 | yes |
| GO:0019901 | protein kinase binding | 21.4286 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in UBP46_HUMAN |
|---|---|---|---|---|
| GO:0051171 | regulation of nitrogen compound metabolic process | 50.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 46.4286 | 4 | no |
| GO:0010646 | regulation of cell communication | 42.8571 | 4 | yes |
| GO:0008104 | protein localization | 39.2857 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 39.2857 | 4 | no |
| GO:0036211 | protein modification process | 35.7143 | 4 | yes |
| GO:0043412 | macromolecule modification | 35.7143 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 35.7143 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 35.7143 | 4 | no |
| GO:0006886 | intracellular protein transport | 32.1429 | 4 | no |
| GO:0009966 | regulation of signal transduction | 32.1429 | 4 | no |
| GO:0015031 | protein transport | 32.1429 | 4 | no |
| GO:0031399 | regulation of protein modification process | 32.1429 | 6 | no |
| GO:0071702 | organic substance transport | 32.1429 | 4 | no |
| GO:0071705 | nitrogen compound transport | 32.1429 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 28.5714 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 28.5714 | 5 | no |
| GO:0070647 | protein modification by small protein conjugation or removal | 25.0000 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.0000 | 6 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.0000 | 5 | no |
| GO:0051049 | regulation of transport | 25.0000 | 4 | no |
| GO:0006508 | proteolysis | 21.4286 | 4 | yes |
| GO:0009057 | macromolecule catabolic process | 21.4286 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 21.4286 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 21.4286 | 4 | yes |
| GO:0010468 | regulation of gene expression | 21.4286 | 5 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 21.4286 | 6 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 21.4286 | 7 | no |
| GO:0071310 | cellular response to organic substance | 21.4286 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 21.4286 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 21.4286 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 21.4286 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 21.4286 | 5 | no |
| GO:0051726 | regulation of cell cycle | 21.4286 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.4286 | 4 | no |
| GO:0019941 | modification-dependent protein catabolic process | 17.8571 | 6 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 17.8571 | 5 | yes |
| GO:0044265 | cellular macromolecule catabolic process | 17.8571 | 4 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 17.8571 | 5 | yes |
| GO:0001662 | behavioral fear response | 7.1429 | 4 | yes |
| GO:0016579 | protein deubiquitination | 7.1429 | 6 | yes |
| GO:0070646 | protein modification by small protein removal | 7.1429 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PHLP1_HUMAN | [view interactions] | Low throughput | no | yes |
| WDR48_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WDR20_HUMAN | [view interactions] | Low throughput | no | no |
| UBP12_HUMAN | [view interactions] | Low throughput | no | yes |
| DMWD_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| WDR26_HUMAN | [view interactions] | Low throughput | no | yes |
| MEP50_HUMAN | [view interactions] | Low throughput | no | yes |
| STK4_HUMAN | [view interactions] | Low throughput | no | yes |
| H2A2C_HUMAN | [view interactions] | Low throughput | no | yes |
| H2B2E_HUMAN | [view interactions] | Low throughput | no | yes |
| RL40_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GRIA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| E2AK4_HUMAN | [view interactions] | High throughput | no | yes |
| AL9A1_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| R51A1_HUMAN | [view interactions] | High throughput | no | no |
| MYL6B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PHLP2_HUMAN | [view interactions] | High throughput | no | yes |
| SET_HUMAN | [view interactions] | High throughput | no | yes |
| ERP44_HUMAN | [view interactions] | High throughput | no | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2B1H_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VSX1_HUMAN | [view interactions] | High throughput | no | no |
| JIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| USH1C_HUMAN | [view interactions] | High throughput | no | yes |
| MYL6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNX6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNX2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PE2R3_HUMAN | [view interactions] | High throughput | no | no |
| GILT_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSYL6_HUMAN | [view interactions] | High throughput | no | no |
| GORS1_HUMAN | [view interactions] | High throughput | no | yes |
| RN19B_HUMAN | [view interactions] | High throughput | no | yes |
| THUM3_HUMAN | [view interactions] | High throughput | no | yes |
| ACM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IBP1_HUMAN | [view interactions] | High throughput | no | no |
| MAVS_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| UBP1_HUMAN | [view interactions] | High throughput | no | yes |
| CIRBP_HUMAN | [view interactions] | High throughput | no | no |
| FAXC_HUMAN | [view interactions] | High throughput | no | no |
| ANKE1_HUMAN | [view interactions] | High throughput | no | yes |
| SGO1_HUMAN | [view interactions] | High throughput | no | no |
| IGDC4_HUMAN | [view interactions] | High throughput | no | yes |
| OPALI_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS27A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |