MYL6B_HUMAN
Evidence for PS localization
Functions
Regulatory light chain of myosin. Does not bind calcium. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in MYL6B_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 39.4737 | 4 | no |
| GO:0017076 | purine nucleotide binding | 39.4737 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 39.4737 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 39.4737 | 4 | no |
| GO:0019900 | kinase binding | 34.2105 | 4 | no |
| GO:0019901 | protein kinase binding | 34.2105 | 5 | no |
| GO:0046872 | metal ion binding | 31.5789 | 4 | yes |
| GO:0005524 | ATP binding | 31.5789 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 31.5789 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 31.5789 | 5 | no |
| GO:0005509 | calcium ion binding | 18.4211 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in MYL6B_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.5263 | 4 | no |
| GO:0006996 | organelle organization | 57.8947 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 50.0000 | 4 | no |
| GO:0007010 | cytoskeleton organization | 47.3684 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 44.7368 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 42.1053 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 42.1053 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 42.1053 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 39.4737 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 39.4737 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 36.8421 | 5 | no |
| GO:0010646 | regulation of cell communication | 36.8421 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 34.2105 | 5 | no |
| GO:0051049 | regulation of transport | 34.2105 | 4 | no |
| GO:0022607 | cellular component assembly | 34.2105 | 4 | no |
| GO:0010468 | regulation of gene expression | 31.5789 | 5 | no |
| GO:0009966 | regulation of signal transduction | 31.5789 | 4 | no |
| GO:0033043 | regulation of organelle organization | 31.5789 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 31.5789 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.9474 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 28.9474 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 28.9474 | 4 | no |
| GO:0008104 | protein localization | 26.3158 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.3158 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 26.3158 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.3158 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 26.3158 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.3158 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 26.3158 | 5 | no |
| GO:0051726 | regulation of cell cycle | 26.3158 | 4 | no |
| GO:0032970 | regulation of actin filament-based process | 26.3158 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 23.6842 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 23.6842 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 23.6842 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 23.6842 | 5 | no |
| GO:0031399 | regulation of protein modification process | 23.6842 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 23.6842 | 7 | no |
| GO:0051336 | regulation of hydrolase activity | 23.6842 | 4 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 23.6842 | 5 | no |
| GO:0022604 | regulation of cell morphogenesis | 23.6842 | 5 | no |
| GO:0006936 | muscle contraction | 21.0526 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 21.0526 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.0526 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 21.0526 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 21.0526 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.0526 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 21.0526 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.0526 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 21.0526 | 7 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 21.0526 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 21.0526 | 5 | no |
| GO:0010941 | regulation of cell death | 21.0526 | 4 | no |
| GO:0036211 | protein modification process | 21.0526 | 4 | no |
| GO:0043412 | macromolecule modification | 21.0526 | 4 | no |
| GO:0043549 | regulation of kinase activity | 21.0526 | 5 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 21.0526 | 7 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.0526 | 6 | no |
| GO:0051338 | regulation of transferase activity | 21.0526 | 4 | no |
| GO:0051345 | positive regulation of hydrolase activity | 21.0526 | 5 | no |
| GO:0051050 | positive regulation of transport | 21.0526 | 4 | no |
| GO:0031032 | actomyosin structure organization | 21.0526 | 4 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 21.0526 | 5 | no |
| GO:0030030 | cell projection organization | 21.0526 | 4 | no |
| GO:0030049 | muscle filament sliding | 13.1579 | 6 | yes |
| GO:0033275 | actin-myosin filament sliding | 13.1579 | 5 | yes |
| GO:0060537 | muscle tissue development | 13.1579 | 4 | yes |
| GO:0070252 | actin-mediated cell contraction | 13.1579 | 4 | yes |
| GO:0007519 | skeletal muscle tissue development | 10.5263 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in MYL6B_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 10.5263 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 10.5263 | 5 | no |
| DOID:114 | heart disease | 10.5263 | 3 | no |
| DOID:0050155 | sensory system disease | 7.8947 | 3 | no |
| DOID:0050563 | nonsyndromic deafness | 7.8947 | 5 | no |
| DOID:0050564 | autosomal dominant nonsyndromic deafness | 7.8947 | 6 | no |
| DOID:2742 | auditory system disease | 7.8947 | 4 | no |
| DOID:2843 | long QT syndrome | 5.2632 | 6 | no |
| DOID:0080326 | familial hypertrophic cardiomyopathy | 5.2632 | 7 | no |
| DOID:11984 | hypertrophic cardiomyopathy | 5.2632 | 6 | no |
| DOID:12930 | dilated cardiomyopathy | 5.2632 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| IQGA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| MDM2_HUMAN | [view interactions] | Low throughput | no | yes |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| MYL6B_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| UBP46_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| ML12B_HUMAN | [view interactions] | High throughput | no | no |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SP17_HUMAN | [view interactions] | High throughput | no | no |
| MYO9B_HUMAN | [view interactions] | High throughput | no | yes |
| TAGL_HUMAN | [view interactions] | High throughput | no | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| DUX4_HUMAN | [view interactions] | High throughput | no | no |
| ATF3_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK3_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| FOS_HUMAN | [view interactions] | High throughput | no | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFE2_HUMAN | [view interactions] | High throughput | no | no |
| SP1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| CEP57_HUMAN | [view interactions] | High throughput | no | yes |
| CEP76_HUMAN | [view interactions] | High throughput | no | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| MYL6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| UBE2A_HUMAN | [view interactions] | High throughput | no | no |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| MEP50_HUMAN | [view interactions] | High throughput | no | yes |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| R144A_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT7B_HUMAN | [view interactions] | High throughput | no | no |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| NGB_HUMAN | [view interactions] | High throughput | no | yes |
| EMC5_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO9A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARHG8_HUMAN | [view interactions] | High throughput | no | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DTX3_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| FGD5_HUMAN | [view interactions] | High throughput | no | yes |
| BRD3_HUMAN | [view interactions] | High throughput | no | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| RHBT2_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ML12A_HUMAN | [view interactions] | High throughput | no | no |
| MYL9_HUMAN | [view interactions] | High throughput | no | no |
| IQGA3_HUMAN | [view interactions] | High throughput | no | no |
| MYH14_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NCKP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMAP_HUMAN | [view interactions] | High throughput | no | yes |
| EIPR1_HUMAN | [view interactions] | High throughput | no | yes |
| EI2BE_HUMAN | [view interactions] | High throughput | no | yes |
| IRF3_HUMAN | [view interactions] | High throughput | no | yes |
| DC1I2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SLN11_HUMAN | [view interactions] | High throughput | no | yes |
| MLRS_HUMAN | [view interactions] | Computational | no | no |
| TPM2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MYH6_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MYL10_HUMAN | [view interactions] | Computational | no | no |
| MYH8_HUMAN | [view interactions] | Computational | no | no |
| MYH1_HUMAN | [view interactions] | Computational | no | no |
| MYH13_HUMAN | [view interactions] | Computational | no | no |
| MYLK3_HUMAN | [view interactions] | Computational | no | no |
| ACTG_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MYH2_HUMAN | [view interactions] | Computational | no | yes |
| MLRV_HUMAN | [view interactions] | Computational | no | no |
| MYH4_HUMAN | [view interactions] | Computational | no | no |
| TPM1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MLRA_HUMAN | [view interactions] | Computational | no | no |
| MYLK_HUMAN | [view interactions] | Computational | no | no |
| MYH3_HUMAN | [view interactions] | Computational | no | no |
| MYPT1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MYL5_HUMAN | [view interactions] | Computational | no | no |
| MYH7_HUMAN | [view interactions] | Computational | no | no |
| MYH11_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| MYH15_HUMAN | [view interactions] | Computational | no | yes |