Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

STAT1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus (PubMed). ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated (PubMed). It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
600 Leu Pro Immunodeficiency31B(IMD31B) -
706 Leu Ser Immunodeficiency31A(IMD31A) -
201 Lys Asn Immunodeficiency31B(IMD31B) -
320 Glu Gln Immunodeficiency31A(IMD31A) -
463 Gln His Immunodeficiency31A(IMD31A) -
165 Asp Gly Immunodeficiency31C(IMD31C) -
165 Asp His Immunodeficiency31C(IMD31C) -
170 Tyr Asn Immunodeficiency31C(IMD31C) -
174 Cys Arg Immunodeficiency31C(IMD31C) -
202 Met Ile Immunodeficiency31C(IMD31C) -
202 Met Val Immunodeficiency31C(IMD31C) -
267 Ala Val Immunodeficiency31C(IMD31C) -
271 Gln Pro Immunodeficiency31C(IMD31C) -
274 Arg Gln Immunodeficiency31C(IMD31C) -
274 Arg Trp Immunodeficiency31C(IMD31C) -
286 Lys Ile Immunodeficiency31C(IMD31C) -
288 Thr Ala Immunodeficiency31C(IMD31C) -
637 Lys Glu Immunodeficiency31A(IMD31A) -
673 Lys Arg Immunodeficiency31A(IMD31A) -
179 Asn Lys Immunodeficiency31C(IMD31C) -
278 Lys Glu Immunodeficiency31C(IMD31C) -
285 Gln Arg Immunodeficiency31C(IMD31C) -
298 Lys Asn Immunodeficiency31C(IMD31C) -
384 Gly Asp Immunodeficiency31C(IMD31C) -
385 Thr Met Immunodeficiency31C(IMD31C) -
701 Tyr Cys Immunodeficiency31B(IMD31B) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in STAT1_HUMAN
GO:0000166 nucleotide binding 34.2657 4 no
GO:0017076 purine nucleotide binding 34.2657 5 no
GO:0043168 anion binding 33.5664 4 no
GO:0030554 adenyl nucleotide binding 32.1678 6 no
GO:0032555 purine ribonucleotide binding 30.7692 4 no
GO:0035639 purine ribonucleoside triphosphate binding 30.7692 4 no
GO:0003723 RNA binding 30.7692 4 no
GO:0005524 ATP binding 28.6713 5 no
GO:0032559 adenyl ribonucleotide binding 28.6713 5 no
GO:0043169 cation binding 21.6783 4 no
GO:0046872 metal ion binding 20.9790 5 no
GO:0045296 cadherin binding 19.5804 4 yes
GO:0044389 ubiquitin-like protein ligase binding 11.1888 4 yes
GO:0042803 protein homodimerization activity 10.4895 4 yes
GO:0019902 phosphatase binding 9.0909 4 yes
GO:0019903 protein phosphatase binding 8.3916 5 yes
GO:0003677 DNA binding 7.6923 4 yes
GO:0140297 DNA-binding transcription factor binding 7.6923 4 yes
GO:0001664 G protein-coupled receptor binding 6.9930 4 yes
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 6.9930 5 yes
GO:0003690 double-stranded DNA binding 6.2937 5 yes
GO:0043565 sequence-specific DNA binding 6.2937 5 yes
GO:0000976 transcription cis-regulatory region binding 5.5944 5 yes
GO:0001067 transcription regulatory region nucleic acid binding 5.5944 4 yes
GO:1990837 sequence-specific double-stranded DNA binding 5.5944 6 yes
GO:0016922 nuclear receptor binding 4.8951 6 yes
GO:0005126 cytokine receptor binding 4.1958 4 yes
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding 3.4965 6 yes
GO:0000987 cis-regulatory region sequence-specific DNA binding 3.4965 6 yes
GO:0001221 transcription coregulator binding 3.4965 4 yes
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding 2.7972 7 yes
GO:0051721 protein phosphatase 2A binding 2.7972 6 yes
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 2.0979 7 yes
GO:0001046 core promoter sequence-specific DNA binding 2.0979 6 yes
GO:0001222 transcription corepressor binding 2.0979 5 yes
GO:0001223 transcription coactivator binding 2.0979 5 yes
GO:0032813 tumor necrosis factor receptor superfamily binding 2.0979 5 yes
GO:0005164 tumor necrosis factor receptor binding 1.3986 6 yes
GO:0031730 CCR5 chemokine receptor binding 1.3986 7 yes
GO:0035035 histone acetyltransferase binding 1.3986 4 yes
GO:0042379 chemokine receptor binding 1.3986 5 yes
GO:0048020 CCR chemokine receptor binding 1.3986 6 yes
GO:1990841 promoter-specific chromatin binding 1.3986 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in STAT1_HUMAN
GO:0031323 regulation of cellular metabolic process 46.1538 4 yes
GO:0060255 regulation of macromolecule metabolic process 46.1538 4 yes
GO:0048522 positive regulation of cellular process 45.4545 4 yes
GO:0080090 regulation of primary metabolic process 44.0559 4 yes
GO:0048523 negative regulation of cellular process 43.3566 4 yes
GO:0009889 regulation of biosynthetic process 37.7622 4 yes
GO:0010646 regulation of cell communication 37.7622 4 yes
GO:0031326 regulation of cellular biosynthetic process 37.0629 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 36.3636 5 yes
GO:0010468 regulation of gene expression 35.6643 6 yes
GO:0051128 regulation of cellular component organization 35.6643 4 no
GO:0051246 regulation of protein metabolic process 34.2657 5 no
GO:0009966 regulation of signal transduction 32.1678 4 yes
GO:0022607 cellular component assembly 32.1678 4 no
GO:0009893 positive regulation of metabolic process 31.4685 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 29.3706 5 yes
GO:0008104 protein localization 29.3706 4 no
GO:0009892 negative regulation of metabolic process 27.2727 4 yes
GO:0031325 positive regulation of cellular metabolic process 27.2727 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 26.5734 5 yes
GO:0006996 organelle organization 26.5734 4 no
GO:0044087 regulation of cellular component biogenesis 26.5734 4 no
GO:0010605 negative regulation of macromolecule metabolic process 25.8741 5 yes
GO:0031324 negative regulation of cellular metabolic process 24.4755 5 yes
GO:0042981 regulation of apoptotic process 24.4755 5 yes
GO:0043067 regulation of programmed cell death 24.4755 4 yes
GO:0023056 positive regulation of signaling 24.4755 4 no
GO:0031399 regulation of protein modification process 24.4755 6 no
GO:0043933 protein-containing complex organization 24.4755 4 no
GO:0009059 macromolecule biosynthetic process 24.4755 4 no
GO:0071310 cellular response to organic substance 23.7762 4 yes
GO:0010647 positive regulation of cell communication 23.7762 5 no
GO:0051252 regulation of RNA metabolic process 23.0769 5 yes
GO:0048584 positive regulation of response to stimulus 23.0769 4 no
GO:0071702 organic substance transport 23.0769 4 no
GO:0051049 regulation of transport 23.0769 4 no
GO:0009891 positive regulation of biosynthetic process 22.3776 5 yes
GO:1902531 regulation of intracellular signal transduction 22.3776 5 yes
GO:0031328 positive regulation of cellular biosynthetic process 21.6783 6 yes
GO:0009967 positive regulation of signal transduction 21.6783 5 no
GO:0051247 positive regulation of protein metabolic process 21.6783 6 no
GO:0009894 regulation of catabolic process 21.6783 4 no
GO:0006355 regulation of DNA-templated transcription 20.9790 7 yes
GO:0051240 positive regulation of multicellular organismal process 20.9790 4 yes
GO:2001141 regulation of RNA biosynthetic process 20.9790 6 yes
GO:0071705 nitrogen compound transport 20.9790 4 no
GO:0009890 negative regulation of biosynthetic process 20.2797 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 20.2797 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 20.2797 6 yes
GO:0006796 phosphate-containing compound metabolic process 20.2797 4 no
GO:0015031 protein transport 20.2797 4 no
GO:0036211 protein modification process 20.2797 4 no
GO:0043412 macromolecule modification 20.2797 4 no
GO:1901566 organonitrogen compound biosynthetic process 20.2797 4 no
GO:0010558 negative regulation of macromolecule biosynthetic process 19.5804 6 yes
GO:0010648 negative regulation of cell communication 18.8811 5 yes
GO:0023057 negative regulation of signaling 18.8811 4 yes
GO:0048585 negative regulation of response to stimulus 18.8811 4 yes
GO:0042127 regulation of cell population proliferation 18.1818 4 yes
GO:0045595 regulation of cell differentiation 18.1818 4 yes
GO:0009968 negative regulation of signal transduction 16.7832 5 yes
GO:0080134 regulation of response to stress 16.7832 4 yes
GO:1901701 cellular response to oxygen-containing compound 16.0839 4 yes
GO:0034097 response to cytokine 15.3846 4 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 15.3846 5 yes
GO:0051094 positive regulation of developmental process 15.3846 4 yes
GO:0010243 response to organonitrogen compound 14.6853 4 yes
GO:0010628 positive regulation of gene expression 13.9860 7 yes
GO:0014070 response to organic cyclic compound 13.9860 4 yes
GO:0032101 regulation of response to external stimulus 13.9860 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 13.2867 4 yes
GO:0031347 regulation of defense response 13.2867 5 yes
GO:2000026 regulation of multicellular organismal development 13.2867 4 yes
GO:0006357 regulation of transcription by RNA polymerase II 12.5874 8 yes
GO:0051254 positive regulation of RNA metabolic process 12.5874 6 yes
GO:0008284 positive regulation of cell population proliferation 11.8881 5 yes
GO:0045597 positive regulation of cell differentiation 11.8881 5 yes
GO:0051241 negative regulation of multicellular organismal process 11.8881 4 yes
GO:0001817 regulation of cytokine production 11.8881 4 yes
GO:0008285 negative regulation of cell population proliferation 11.1888 5 yes
GO:0045893 positive regulation of DNA-templated transcription 11.1888 8 yes
GO:0060284 regulation of cell development 11.1888 5 yes
GO:0071345 cellular response to cytokine stimulus 11.1888 5 yes
GO:1902680 positive regulation of RNA biosynthetic process 11.1888 7 yes
GO:0032870 cellular response to hormone stimulus 10.4895 4 yes
GO:0071407 cellular response to organic cyclic compound 10.4895 5 yes
GO:1902532 negative regulation of intracellular signal transduction 10.4895 6 yes
GO:0071417 cellular response to organonitrogen compound 9.7902 4 yes
GO:1901699 cellular response to nitrogen compound 9.7902 4 yes
GO:0002831 regulation of response to biotic stimulus 9.0909 4 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 9.0909 5 yes
GO:0034341 response to type II interferon 8.3916 5 yes
GO:0045892 negative regulation of DNA-templated transcription 8.3916 8 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 8.3916 9 yes
GO:0051253 negative regulation of RNA metabolic process 8.3916 6 yes
GO:1902679 negative regulation of RNA biosynthetic process 8.3916 7 yes
GO:0051093 negative regulation of developmental process 7.6923 4 yes
GO:0001819 positive regulation of cytokine production 7.6923 5 yes
GO:0043434 response to peptide hormone 6.9930 4 yes
GO:0071346 cellular response to type II interferon 6.9930 6 yes
GO:0000122 negative regulation of transcription by RNA polymerase II 6.9930 9 yes
GO:0000302 response to reactive oxygen species 6.9930 4 yes
GO:0019221 cytokine-mediated signaling pathway 6.2937 4 yes
GO:0045596 negative regulation of cell differentiation 6.2937 5 yes
GO:0048660 regulation of smooth muscle cell proliferation 6.2937 5 yes
GO:1903706 regulation of hemopoiesis 6.2937 4 yes
GO:0032868 response to insulin 5.5944 5 yes
GO:0043122 regulation of canonical NF-kappaB signal transduction 5.5944 6 yes
GO:0045637 regulation of myeloid cell differentiation 5.5944 5 yes
GO:0045765 regulation of angiogenesis 5.5944 5 yes
GO:0060429 epithelium development 5.5944 4 yes
GO:0071375 cellular response to peptide hormone stimulus 5.5944 5 yes
GO:0140546 defense response to symbiont 5.5944 4 yes
GO:1901342 regulation of vasculature development 5.5944 5 yes
GO:0042542 response to hydrogen peroxide 4.8951 4 yes
GO:0048661 positive regulation of smooth muscle cell proliferation 4.8951 6 yes
GO:0050678 regulation of epithelial cell proliferation 4.8951 5 yes
GO:0032869 cellular response to insulin stimulus 4.1958 6 yes
GO:0007259 cell surface receptor signaling pathway via JAK-STAT 3.4965 5 yes
GO:0016525 negative regulation of angiogenesis 3.4965 6 yes
GO:0032479 regulation of type I interferon production 3.4965 5 yes
GO:0033209 tumor necrosis factor-mediated signaling pathway 3.4965 5 yes
GO:0045639 positive regulation of myeloid cell differentiation 3.4965 6 yes
GO:0045646 regulation of erythrocyte differentiation 3.4965 6 yes
GO:0045648 positive regulation of erythrocyte differentiation 3.4965 7 yes
GO:0051607 defense response to virus 3.4965 4 yes
GO:0097696 cell surface receptor signaling pathway via STAT 3.4965 4 yes
GO:1901343 negative regulation of vasculature development 3.4965 5 yes
GO:2000181 negative regulation of blood vessel morphogenesis 3.4965 5 yes
GO:0001936 regulation of endothelial cell proliferation 2.7972 6 yes
GO:0014074 response to purine-containing compound 2.7972 5 yes
GO:0043124 negative regulation of canonical NF-kappaB signal transduction 2.7972 7 yes
GO:0046683 response to organophosphorus 2.7972 4 yes
GO:0060333 type II interferon-mediated signaling pathway 2.7972 6 yes
GO:0140888 interferon-mediated signaling pathway 2.7972 5 yes
GO:0001937 negative regulation of endothelial cell proliferation 2.0979 7 yes
GO:0002053 positive regulation of mesenchymal cell proliferation 2.0979 6 yes
GO:0003339 regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis 2.0979 7 yes
GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis 2.0979 8 yes
GO:0010464 regulation of mesenchymal cell proliferation 2.0979 5 yes
GO:0030856 regulation of epithelial cell differentiation 2.0979 5 yes
GO:0030857 negative regulation of epithelial cell differentiation 2.0979 6 yes
GO:0032481 positive regulation of type I interferon production 2.0979 6 yes
GO:0035456 response to interferon-beta 2.0979 5 yes
GO:0035458 cellular response to interferon-beta 2.0979 6 yes
GO:0038113 interleukin-9-mediated signaling pathway 2.0979 5 yes
GO:0048525 negative regulation of viral process 2.0979 4 yes
GO:0048762 mesenchymal cell differentiation 2.0979 4 yes
GO:0050680 negative regulation of epithelial cell proliferation 2.0979 6 yes
GO:0050688 regulation of defense response to virus 2.0979 5 yes
GO:0051591 response to cAMP 2.0979 4 yes
GO:0051769 regulation of nitric-oxide synthase biosynthetic process 2.0979 6 yes
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process 2.0979 7 yes
GO:0072182 regulation of nephron tubule epithelial cell differentiation 2.0979 7 yes
GO:2000696 regulation of epithelial cell differentiation involved in kidney development 2.0979 6 yes
GO:2000697 negative regulation of epithelial cell differentiation involved in kidney development 2.0979 7 yes
GO:0002230 positive regulation of defense response to virus by host 1.3986 7 yes
GO:0008015 blood circulation 1.3986 4 yes
GO:0010742 macrophage derived foam cell differentiation 1.3986 5 yes
GO:0032647 regulation of interferon-alpha production 1.3986 6 yes
GO:0032727 positive regulation of interferon-alpha production 1.3986 7 yes
GO:0046725 negative regulation by virus of viral protein levels in host cell 1.3986 4 yes
GO:0050691 regulation of defense response to virus by host 1.3986 6 yes
GO:0060337 type I interferon-mediated signaling pathway 1.3986 6 yes
GO:0061005 cell differentiation involved in kidney development 1.3986 4 yes
GO:0061326 renal tubule development 1.3986 4 yes
GO:0070106 interleukin-27-mediated signaling pathway 1.3986 5 yes
GO:0072135 kidney mesenchymal cell proliferation 1.3986 4 yes
GO:0072136 metanephric mesenchymal cell proliferation involved in metanephros development 1.3986 5 yes
GO:0072161 mesenchymal cell differentiation involved in kidney development 1.3986 5 yes
GO:0072162 metanephric mesenchymal cell differentiation 1.3986 6 yes
GO:0072183 negative regulation of nephron tubule epithelial cell differentiation 1.3986 6 yes
GO:0072202 cell differentiation involved in metanephros development 1.3986 5 yes
GO:0072203 cell proliferation involved in metanephros development 1.3986 4 yes
GO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation 1.3986 8 yes
GO:0072308 negative regulation of metanephric nephron tubule epithelial cell differentiation 1.3986 7 yes
GO:0090077 foam cell differentiation 1.3986 4 yes
GO:0090183 regulation of kidney development 1.3986 4 yes
GO:0090185 negative regulation of kidney development 1.3986 5 yes
GO:2001012 mesenchymal cell differentiation involved in renal system development 1.3986 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KS6B1_HUMAN [view entry] [view interactions] Low throughput yes yes
CNOT7_HUMAN [view interactions] Low throughput no no
STAT4_HUMAN [view interactions] Low throughput no yes
USF1_HUMAN [view interactions] Low throughput no yes
TBP_HUMAN [view interactions] Low throughput no yes
NF1_HUMAN [view entry] [view interactions] Low throughput yes no
NFE2_HUMAN [view interactions] Low throughput no no
RIGI_HUMAN [view interactions] Low throughput no yes
PTN6_HUMAN [view interactions] Low throughput no no
FOS_HUMAN [view interactions] Low throughput no yes
PML_HUMAN [view interactions] Low throughput no yes
AHR_HUMAN [view interactions] Low throughput no yes
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
JAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
PTN11_HUMAN [view entry] [view interactions] Low throughput yes yes
CBP_HUMAN [view interactions] Low throughput no yes
IL6RB_HUMAN [view interactions] Low throughput no no
KIT_HUMAN [view interactions] Low throughput no no
MTOR_HUMAN [view entry] [view interactions] Low throughput yes yes
PIAS1_HUMAN [view entry] [view interactions] Low throughput yes yes
FANCC_HUMAN [view interactions] Low throughput no yes
BRCA1_HUMAN [view interactions] Low throughput no yes
RACK1_HUMAN [view interactions] Low throughput no yes
I27RA_HUMAN [view interactions] Low throughput no no
EP300_HUMAN [view interactions] Low throughput no yes
E2AK2_HUMAN [view entry] [view interactions] Low throughput yes yes
MCM5_HUMAN [view interactions] Low throughput no no
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
VDR_HUMAN [view interactions] Low throughput no no
HSF1_HUMAN [view interactions] Low throughput no yes
TNR1A_HUMAN [view interactions] Low throughput no yes
TRADD_HUMAN [view interactions] Low throughput no yes
KPCD_HUMAN [view entry] [view interactions] Low throughput yes yes
IRF1_HUMAN [view interactions] Low throughput no yes
JUN_HUMAN [view interactions] Low throughput no yes
RNF11_HUMAN [view interactions] Low throughput no yes
PTN2_HUMAN [view interactions] Low throughput no yes
MBD1_HUMAN [view interactions] Low throughput no yes
BCL3_HUMAN [view interactions] Low throughput no yes
TIF1B_HUMAN [view interactions] Low throughput no yes
SMCA4_HUMAN [view interactions] Low throughput no yes
ATF3_HUMAN [view interactions] Low throughput no yes
SMCA2_HUMAN [view interactions] Low throughput no yes
DOT1L_HUMAN [view interactions] Low throughput no yes
SMUF1_HUMAN [view interactions] Low throughput no yes
PRS6A_HUMAN [view entry] [view interactions] Low throughput yes yes
H32_HUMAN [view interactions] Low throughput no yes
HDAC4_HUMAN [view interactions] Low throughput no yes
IRAK1_HUMAN [view interactions] Low throughput no yes
ANM1_HUMAN [view interactions] Low throughput no yes
IKBA_HUMAN [view interactions] Low throughput no yes
HDAC1_HUMAN [view interactions] Low throughput no no
HDAC3_HUMAN [view interactions] Low throughput no yes
IGBP1_HUMAN [view interactions] Low throughput no yes
PTPA_HUMAN [view interactions] Low throughput no yes
UBP13_HUMAN [view interactions] Low throughput no yes
DTX3L_HUMAN [view interactions] Low throughput no yes
PARP9_HUMAN [view interactions] Low throughput no no
PPARA_HUMAN [view interactions] Low throughput no yes
PPARD_HUMAN [view interactions] Low throughput no yes
PPARG_HUMAN [view interactions] Low throughput no yes
FANCE_HUMAN [view interactions] Low throughput no yes
ITAV_HUMAN [view interactions] Low throughput no yes
ENPL_HUMAN [view entry] [view interactions] Low throughput yes yes
UBP2_HUMAN [view interactions] Low throughput no yes
MAGA3_HUMAN [view interactions] Low throughput no no
MAVS_HUMAN [view interactions] Low throughput no yes
EGFR_HUMAN [view interactions] Low throughput no no
KDM3A_HUMAN [view interactions] Low throughput no no
RN220_HUMAN [view entry] [view interactions] Low throughput yes yes
UBP39_HUMAN [view interactions] Low throughput no yes
CO6A1_HUMAN [view interactions] Low throughput no no
SOCS5_HUMAN [view interactions] Low throughput no yes
STAT3_HUMAN [view entry] [view interactions] Low throughput yes yes
IMA5_HUMAN [view entry] [view interactions] Low throughput yes yes
JAK1_HUMAN [view interactions] Low throughput no yes
INGR1_HUMAN [view interactions] Low throughput no no
STAT1_HUMAN [view entry] [view interactions] Low throughput yes no
STAT2_HUMAN [view interactions] Low throughput no yes
IRF9_HUMAN [view interactions] Low throughput no yes
NMI_HUMAN [view interactions] Low throughput no yes
INAR1_HUMAN [view interactions] Low throughput no yes
INAR2_HUMAN [view interactions] Low throughput no no
USF2_HUMAN [view interactions] Low throughput no no
UBP22_HUMAN [view interactions] Low throughput no yes
CUL4A_HUMAN [view interactions] Low throughput no no
SQSTM_HUMAN [view interactions] Low throughput no yes
RN168_HUMAN [view interactions] Low throughput no no
RO52_HUMAN [view interactions] Low throughput no yes
IL2RB_HUMAN [view interactions] Low throughput no no
ELP2_HUMAN [view interactions] Low throughput no yes
GTF2I_HUMAN [view interactions] Low throughput no yes
KCC2A_HUMAN [view entry] [view interactions] Low throughput yes yes
TYK2_HUMAN [view interactions] Low throughput no no
UBC9_HUMAN [view entry] [view interactions] Low throughput yes yes
ANM3_HUMAN [view interactions] Low throughput no yes
PK3CA_HUMAN [view entry] [view interactions] Low throughput yes yes
DUS2_HUMAN [view interactions] Low throughput no no
LST8_HUMAN [view interactions] Low throughput no yes
RL23A_HUMAN [view entry] [view interactions] High throughput yes yes
SC23B_HUMAN [view interactions] High throughput no yes
ACPH_HUMAN [view interactions] High throughput no yes
RL39_HUMAN [view interactions] High throughput no no
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
H15_HUMAN [view interactions] High throughput no no
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
RLA0_HUMAN [view entry] [view interactions] High throughput yes yes
ERF3B_HUMAN [view interactions] High throughput no yes
RL18_HUMAN [view entry] [view interactions] High throughput yes yes
HIRP3_HUMAN [view interactions] High throughput no no
RL13_HUMAN [view entry] [view interactions] High throughput yes yes
HS74L_HUMAN [view entry] [view interactions] High throughput yes no
RL27A_HUMAN [view entry] [view interactions] High throughput yes yes
IDE_HUMAN [view interactions] High throughput no yes
TIM44_HUMAN [view interactions] High throughput no yes
JMJD6_HUMAN [view interactions] High throughput no yes
TM223_HUMAN [view interactions] High throughput no yes
SYK_HUMAN [view interactions] High throughput no yes
RS8_HUMAN [view entry] [view interactions] High throughput yes no
NAA10_HUMAN [view interactions] High throughput no yes
RL3_HUMAN [view entry] [view interactions] High throughput yes yes
SYSC_HUMAN [view interactions] High throughput no yes
RIN3_HUMAN [view interactions] High throughput no yes
GLYM_HUMAN [view entry] [view interactions] High throughput yes yes
NOP58_HUMAN [view interactions] High throughput no yes
SNX2_HUMAN [view entry] [view interactions] High throughput yes no
RM46_HUMAN [view interactions] High throughput no yes
SNX6_HUMAN [view entry] [view interactions] High throughput yes no
RL35A_HUMAN [view entry] [view interactions] High throughput yes no
ATG7_HUMAN [view interactions] High throughput no yes
RL5_HUMAN [view entry] [view interactions] High throughput yes yes
VATC1_HUMAN [view entry] [view interactions] High throughput yes yes
RL35_HUMAN [view entry] [view interactions] High throughput yes yes
NAA15_HUMAN [view interactions] High throughput no yes
RLA2_HUMAN [view entry] [view interactions] High throughput yes yes
PAWR_HUMAN [view interactions] High throughput no yes
COQ8B_HUMAN [view interactions] High throughput no yes
RTF1_HUMAN [view interactions] High throughput no yes
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
GLYC_HUMAN [view interactions] High throughput no no
RS15_HUMAN [view entry] [view interactions] High throughput yes yes
SNX1_HUMAN [view entry] [view interactions] High throughput yes yes
RS24_HUMAN [view entry] [view interactions] High throughput yes yes
TSNAX_HUMAN [view interactions] High throughput no yes
RL13A_HUMAN [view entry] [view interactions] High throughput yes yes
VPS29_HUMAN [view entry] [view interactions] High throughput yes yes
SARNP_HUMAN [view interactions] High throughput no yes
TBCD_HUMAN [view entry] [view interactions] High throughput yes no
RS2_HUMAN [view entry] [view interactions] High throughput yes yes
VP26A_HUMAN [view entry] [view interactions] High throughput yes no
PRPS1_HUMAN [view entry] [view interactions] High throughput yes no
SYAC_HUMAN [view interactions] High throughput no yes
AK17A_HUMAN [view interactions] High throughput no no
AHSA1_HUMAN [view entry] [view interactions] High throughput yes yes
CPIN1_HUMAN [view interactions] High throughput no no
LAT_HUMAN [view interactions] High throughput no no
PAK2_HUMAN [view entry] [view interactions] High throughput yes no
PHAG1_HUMAN [view interactions] High throughput no yes
RB_HUMAN [view interactions] High throughput no yes
CBL_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
CASPC_HUMAN [view interactions] High throughput no no
TAF6_HUMAN [view interactions] High throughput no no
TP4A3_HUMAN [view interactions] High throughput no no
AP1S1_HUMAN [view entry] [view interactions] High throughput yes yes
BPIB3_HUMAN [view interactions] High throughput no no
FKBP4_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2F_HUMAN [view interactions] High throughput no yes
MA7D3_HUMAN [view interactions] High throughput no no
GSTK1_HUMAN [view entry] [view interactions] High throughput yes yes
PEPL1_HUMAN [view interactions] High throughput no yes
DNJA3_HUMAN [view entry] [view interactions] High throughput yes yes
RPP25_HUMAN [view interactions] High throughput no yes
MLP3B_HUMAN [view interactions] High throughput no yes
CIAO3_HUMAN [view interactions] High throughput no yes
CNO10_HUMAN [view interactions] High throughput no yes
TRM1_HUMAN [view interactions] High throughput no yes
PPM1H_HUMAN [view interactions] High throughput no yes
CD2AP_HUMAN [view interactions] High throughput no no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
DPPA3_HUMAN [view interactions] High throughput no no
HSC20_HUMAN [view interactions] High throughput no yes
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
NAA40_HUMAN [view interactions] High throughput no no
CCNF_HUMAN [view interactions] High throughput no no
INSR_HUMAN [view interactions] High throughput no yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
TX101_HUMAN [view interactions] High throughput no no
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
SPTB1_HUMAN [view entry] [view interactions] High throughput yes yes
RFA3_HUMAN [view interactions] High throughput no yes
OTUD4_HUMAN [view interactions] High throughput no yes
WWTR1_HUMAN [view interactions] High throughput no yes
EIF1A_HUMAN [view interactions] High throughput no no
LZTR1_HUMAN [view interactions] High throughput no no
RBTN2_HUMAN [view interactions] High throughput no yes
ACTN4_HUMAN [view entry] [view interactions] High throughput yes yes
DCTN1_HUMAN [view entry] [view interactions] High throughput yes yes
GFAP_HUMAN [view entry] [view interactions] High throughput yes no
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN1_HUMAN [view entry] [view interactions] High throughput yes yes
SPTB2_HUMAN [view entry] [view interactions] High throughput yes yes
E2F1_HUMAN [view interactions] High throughput no yes
STK4_HUMAN [view interactions] High throughput no yes
FOXA3_HUMAN [view interactions] High throughput no yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
PKNX1_HUMAN [view interactions] High throughput no yes
GATA3_HUMAN [view interactions] High throughput no no
PGFRA_HUMAN [view interactions] High throughput no no
TF65_HUMAN [view entry] [view interactions] High throughput yes yes
STA5A_HUMAN [view interactions] High throughput no no
PGFRB_HUMAN [view interactions] High throughput no yes
MOES_HUMAN [view entry] [view interactions] High throughput yes no
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1B_HUMAN [view entry] [view interactions] High throughput yes no
WDR1_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1D_HUMAN [view entry] [view interactions] High throughput yes yes
TPM1_HUMAN [view entry] [view interactions] High throughput yes no
MYL6B_HUMAN [view entry] [view interactions] High throughput yes no
ARPC4_HUMAN [view entry] [view interactions] High throughput yes no
ARP3_HUMAN [view entry] [view interactions] High throughput yes yes
SEPT6_HUMAN [view interactions] High throughput no yes
LASP1_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
MYH14_HUMAN [view entry] [view interactions] High throughput yes no
TMOD3_HUMAN [view interactions] High throughput no yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
MYO6_HUMAN [view entry] [view interactions] High throughput yes no
CFTR_HUMAN [view interactions] High throughput no no
TNAP3_HUMAN [view interactions] High throughput no yes
CTBL1_HUMAN [view interactions] High throughput no yes
KPCE_HUMAN [view entry] [view interactions] High throughput yes yes
ISG15_HUMAN [view interactions] High throughput no no
GBB2_HUMAN [view entry] [view interactions] High throughput yes yes
HUWE1_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
DRB5_HUMAN [view interactions] High throughput no no
SACA1_HUMAN [view interactions] High throughput no no
TX264_HUMAN [view interactions] High throughput no no
NTRK1_HUMAN [view interactions] High throughput no yes
H2B1J_HUMAN [view interactions] High throughput no yes
U2AF2_HUMAN [view interactions] High throughput no yes
DOCK4_HUMAN [view entry] [view interactions] High throughput yes no
G3BP1_HUMAN [view interactions] High throughput no yes
ACK1_HUMAN [view entry] [view interactions] High throughput yes yes
NR1H3_HUMAN [view interactions] High throughput no yes
NR1H2_HUMAN [view interactions] High throughput no yes
TES_HUMAN [view interactions] High throughput no yes
GSK3A_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
TGFB1_HUMAN [view interactions] High throughput no no
YAP1_HUMAN [view interactions] High throughput no yes
KC1A_HUMAN [view interactions] High throughput no yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
YAF2_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
TRI11_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
CDK9_HUMAN [view interactions] High throughput no yes
SHPS1_HUMAN [view entry] [view interactions] High throughput yes yes
DCA13_HUMAN [view interactions] High throughput no yes
A16L1_HUMAN [view entry] [view interactions] High throughput yes yes
ACTC_HUMAN [view interactions] High throughput no no
ELL_HUMAN [view interactions] High throughput no no
TGFR2_HUMAN [view interactions] High throughput no no
RBCC1_HUMAN [view interactions] High throughput no no
NR2C2_HUMAN [view interactions] High throughput no yes
RUFY1_HUMAN [view interactions] High throughput no yes
DDB1_HUMAN [view interactions] High throughput no yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
HCDH_HUMAN [view entry] [view interactions] High throughput yes yes
WWP2_HUMAN [view interactions] High throughput no no
HLAB_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
NU4LM_HUMAN [view interactions] High throughput no no
BRD4_HUMAN [view interactions] High throughput no yes
NCPR_HUMAN [view entry] [view interactions] High throughput yes yes
RNF31_HUMAN [view interactions] High throughput no yes
RXRA_HUMAN [view interactions] High throughput no yes
UNK_HUMAN [view interactions] High throughput no yes
NOMO1_HUMAN [view entry] [view interactions] High throughput yes yes
AUXI_HUMAN [view entry] [view interactions] High throughput yes yes
NOMO2_HUMAN [view interactions] High throughput no yes
SLIK5_HUMAN [view entry] [view interactions] High throughput yes no
ARRB2_HUMAN [view entry] [view interactions] High throughput yes no
AGAP3_HUMAN [view entry] [view interactions] High throughput yes yes
KPCD3_HUMAN [view interactions] High throughput no yes
MA7D1_HUMAN [view entry] [view interactions] High throughput yes no
RARA_HUMAN [view interactions] High throughput no no
ANM9_HUMAN [view interactions] High throughput no no
ESR1_HUMAN [view interactions] High throughput no no
OTUL_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
RRP1B_HUMAN [view interactions] High throughput no yes
CDC73_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
GRN_HUMAN [view interactions] High throughput no no
I13R2_HUMAN [view interactions] High throughput no no
KPCB_HUMAN [view entry] [view interactions] High throughput yes yes
B3GA1_HUMAN [view interactions] High throughput no yes
GLPA_HUMAN [view interactions] High throughput no no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
CC018_HUMAN [view interactions] High throughput no yes
GPR45_HUMAN [view interactions] High throughput no no
CUL4B_HUMAN [view interactions] High throughput no yes
EFMT3_HUMAN [view interactions] High throughput no no
UBXN6_HUMAN [view entry] [view interactions] High throughput yes yes
GGH_HUMAN [view interactions] High throughput no yes
DHC24_HUMAN [view interactions] High throughput no yes
IFNL1_HUMAN [view interactions] High throughput no no
CEL3A_HUMAN [view interactions] High throughput no no
IFN14_HUMAN [view interactions] High throughput no no
AQP3_HUMAN [view interactions] High throughput no no
IFNL3_HUMAN [view interactions] High throughput no no
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
IFNA5_HUMAN [view interactions] High throughput no no
MIC19_HUMAN [view entry] [view interactions] High throughput yes yes
NPAS1_HUMAN [view interactions] High throughput no no
ETFB_HUMAN [view entry] [view interactions] High throughput yes yes
MFD4A_HUMAN [view interactions] High throughput no yes
NDUS3_HUMAN [view entry] [view interactions] High throughput yes yes
UBC12_HUMAN [view entry] [view interactions] High throughput yes yes
UCHL1_HUMAN [view entry] [view interactions] High throughput yes yes
AT1A1_HUMAN [view entry] [view interactions] High throughput yes no
PFKAL_HUMAN [view entry] [view interactions] High throughput yes yes
OVOL2_HUMAN [view interactions] High throughput no no
6PGD_HUMAN [view entry] [view interactions] High throughput yes no
ZRAN1_HUMAN [view interactions] High throughput no yes
ERP44_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
PYGL_HUMAN [view interactions] High throughput no yes
QCR1_HUMAN [view entry] [view interactions] High throughput yes yes
PARPT_HUMAN [view interactions] High throughput no no
LGUL_HUMAN [view interactions] High throughput no yes
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
DHB4_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
SYFB_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
ACTG_HUMAN [view entry] [view interactions] High throughput yes yes
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
TBCA_HUMAN [view interactions] High throughput no yes
RHG24_HUMAN [view interactions] High throughput no yes
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
LDHB_HUMAN [view entry] [view interactions] High throughput yes yes
STMN1_HUMAN [view interactions] High throughput no yes
EZH2_HUMAN [view interactions] High throughput no no
PABP3_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
CAPR1_HUMAN [view entry] [view interactions] High throughput yes yes
CL16A_HUMAN [view interactions] High throughput no yes
PTBP2_HUMAN [view interactions] High throughput no no
RICTR_HUMAN [view interactions] High throughput no yes
DESM_HUMAN [view entry] [view interactions] High throughput yes no
MOK_HUMAN [view interactions] High throughput no no
PLEC_HUMAN [view entry] [view interactions] High throughput yes yes
SPPL3_HUMAN [view interactions] High throughput no no
AINX_HUMAN [view entry] [view interactions] High throughput yes yes
IMA7_HUMAN [view interactions] High throughput no yes
DDR1_HUMAN [view interactions] High throughput no yes
ZAP70_HUMAN [view interactions] High throughput no no
FRIH_HUMAN [view entry] [view interactions] High throughput yes yes
MVP_HUMAN [view entry] [view interactions] High throughput yes yes
DDX6_HUMAN [view entry] [view interactions] High throughput yes yes
LMOD1_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RL6_HUMAN [view entry] [view interactions] High throughput yes yes
TERA_HUMAN [view entry] [view interactions] High throughput yes yes
RL8_HUMAN [view entry] [view interactions] High throughput yes yes
RS9_HUMAN [view entry] [view interactions] High throughput yes yes
UAP1L_HUMAN [view interactions] High throughput no yes
RL24_HUMAN [view entry] [view interactions] High throughput yes yes
CASP3_HUMAN [view entry] [view interactions] High throughput yes yes
PLOD3_HUMAN [view interactions] High throughput no yes
CASP7_HUMAN [view interactions] High throughput no no
RL7A_HUMAN [view entry] [view interactions] High throughput yes no
GRB7_HUMAN [view interactions] High throughput no no
NMD3_HUMAN [view interactions] High throughput no no
RL18A_HUMAN [view entry] [view interactions] High throughput yes yes
NSF_HUMAN [view entry] [view interactions] High throughput yes yes
IF2G_HUMAN [view interactions] High throughput no yes
SERA_HUMAN [view entry] [view interactions] High throughput yes yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes