AP1S1_HUMAN
Evidence for PS localization
Functions
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AP1S1_HUMAN |
|---|---|---|---|---|
| GO:0035615 | clathrin adaptor activity | 25.0000 | 4 | yes |
| GO:0003723 | RNA binding | 25.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AP1S1_HUMAN |
|---|---|---|---|---|
| GO:0071702 | organic substance transport | 70.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 70.0000 | 4 | yes |
| GO:0008104 | protein localization | 65.0000 | 4 | yes |
| GO:0015031 | protein transport | 65.0000 | 4 | yes |
| GO:0006886 | intracellular protein transport | 55.0000 | 4 | yes |
| GO:0006996 | organelle organization | 45.0000 | 4 | yes |
| GO:0022607 | cellular component assembly | 40.0000 | 4 | yes |
| GO:0098657 | import into cell | 35.0000 | 4 | yes |
| GO:0006898 | receptor-mediated endocytosis | 30.0000 | 4 | yes |
| GO:0046903 | secretion | 30.0000 | 4 | yes |
| GO:0016050 | vesicle organization | 25.0000 | 5 | yes |
| GO:0070925 | organelle assembly | 25.0000 | 5 | yes |
| GO:0072583 | clathrin-dependent endocytosis | 25.0000 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 25.0000 | 4 | no |
| GO:0051049 | regulation of transport | 25.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 25.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 25.0000 | 4 | no |
| GO:0009306 | protein secretion | 20.0000 | 4 | yes |
| GO:0032438 | melanosome organization | 20.0000 | 7 | yes |
| GO:0033363 | secretory granule organization | 20.0000 | 6 | yes |
| GO:0035592 | establishment of protein localization to extracellular region | 20.0000 | 4 | yes |
| GO:0048753 | pigment granule organization | 20.0000 | 6 | yes |
| GO:0060155 | platelet dense granule organization | 20.0000 | 7 | yes |
| GO:0071692 | protein localization to extracellular region | 20.0000 | 5 | yes |
| GO:1903232 | melanosome assembly | 20.0000 | 6 | yes |
| GO:0110010 | basolateral protein secretion | 15.0000 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AP1G2_HUMAN | [view interactions] | Low throughput | no | yes |
| AP1G1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP1M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BST2_HUMAN | [view interactions] | Low throughput | no | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EBLN2_HUMAN | [view interactions] | High throughput | no | no |
| ARMC6_HUMAN | [view interactions] | High throughput | no | yes |
| RAB10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S61A1_HUMAN | [view interactions] | High throughput | no | no |
| MOT1_HUMAN | [view interactions] | High throughput | no | no |
| AP1S2_HUMAN | [view interactions] | High throughput | no | no |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| PICK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| AP1M2_HUMAN | [view interactions] | High throughput | no | no |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MR1L1_HUMAN | [view interactions] | High throughput | no | no |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| SPT33_HUMAN | [view interactions] | High throughput | no | no |
| COMT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSUH2_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| E2F4_HUMAN | [view interactions] | High throughput | no | no |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| SPPL3_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| ELOB_HUMAN | [view interactions] | High throughput | no | no |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FRIH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX3_HUMAN | [view interactions] | High throughput | no | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCA3_HUMAN | [view interactions] | High throughput | no | yes |
| SC31A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCC1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AIMP2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| PEPL1_HUMAN | [view interactions] | High throughput | no | yes |
| TRM61_HUMAN | [view interactions] | High throughput | no | no |
| TRM1_HUMAN | [view interactions] | High throughput | no | yes |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| ARL4C_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |