AP1S1_HUMAN
Evidence for PS localization
Functions
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AP1S1_HUMAN |
|---|---|---|---|---|
| GO:0035615 | clathrin adaptor activity | 28.0000 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AP1S1_HUMAN |
|---|---|---|---|---|
| GO:0016192 | vesicle-mediated transport | 80.0000 | 4 | yes |
| GO:0008104 | protein localization | 76.0000 | 4 | yes |
| GO:0015031 | protein transport | 76.0000 | 4 | yes |
| GO:0071702 | organic substance transport | 76.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 76.0000 | 4 | yes |
| GO:0006886 | intracellular protein transport | 68.0000 | 4 | yes |
| GO:0006897 | endocytosis | 48.0000 | 5 | yes |
| GO:0006898 | receptor-mediated endocytosis | 44.0000 | 6 | yes |
| GO:0051049 | regulation of transport | 40.0000 | 4 | no |
| GO:0072583 | clathrin-dependent endocytosis | 36.0000 | 7 | no |
| GO:0051128 | regulation of cellular component organization | 32.0000 | 4 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 28.0000 | 4 | no |
| GO:0043933 | protein-containing complex organization | 28.0000 | 4 | no |
| GO:0048193 | Golgi vesicle transport | 24.0000 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 24.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 24.0000 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| AP1G2_HUMAN | [view interactions] | Low throughput | no | yes |
| AP1G1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| AP1M1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BST2_HUMAN | [view interactions] | Low throughput | no | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EBLN2_HUMAN | [view interactions] | High throughput | no | no |
| ARMC6_HUMAN | [view interactions] | High throughput | no | yes |
| RAB10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S61A1_HUMAN | [view interactions] | High throughput | no | no |
| MOT1_HUMAN | [view interactions] | High throughput | no | no |
| AP1S2_HUMAN | [view interactions] | High throughput | no | no |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| PICK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| AP1M2_HUMAN | [view interactions] | High throughput | no | no |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MR1L1_HUMAN | [view interactions] | High throughput | no | no |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| SPT33_HUMAN | [view interactions] | High throughput | no | no |
| COMT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSUH2_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| ELOB_HUMAN | [view interactions] | High throughput | no | no |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FRIH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX3_HUMAN | [view interactions] | High throughput | no | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP4E1_HUMAN | [view interactions] | Computational | no | no |
| SYNRG_HUMAN | [view interactions] | Computational | no | yes |
| AP3S2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| AP1S3_HUMAN | [view interactions] | Computational | no | yes |
| AUXI_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AFTIN_HUMAN | [view interactions] | Computational | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP4M1_HUMAN | [view interactions] | Computational | no | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP4B1_HUMAN | [view interactions] | Computational | no | yes |
| CLCB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP2S1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| NCALD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP5S1_HUMAN | [view interactions] | Computational | no | yes |
| KCNQ5_HUMAN | [view interactions] | Computational | no | yes |
| AP3S1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| AP3M2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AP5B1_HUMAN | [view interactions] | Computational | no | yes |
| AP5M1_HUMAN | [view interactions] | Computational | no | no |