SC31A_HUMAN
Evidence for PS localization
Functions
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002659 | LIG_EF_ALG2_ABM_1 | LIG | 870 | 879 | - |
| ELMI002660 | LIG_EF_ALG2_ABM_2 | LIG | 839 | 843 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SC31A_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 30.9091 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 30.9091 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 30.9091 | 4 | no |
| GO:0046872 | metal ion binding | 27.2727 | 4 | no |
| GO:0003723 | RNA binding | 27.2727 | 4 | no |
| GO:0005524 | ATP binding | 21.8182 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 21.8182 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 21.8182 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SC31A_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 50.9091 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 49.0909 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 49.0909 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 49.0909 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 47.2727 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 45.4545 | 4 | no |
| GO:0008104 | protein localization | 43.6364 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 41.8182 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
| GO:0071702 | organic substance transport | 40.0000 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 40.0000 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 38.1818 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 36.3636 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 34.5455 | 4 | no |
| GO:0010646 | regulation of cell communication | 34.5455 | 4 | no |
| GO:0015031 | protein transport | 34.5455 | 4 | yes |
| GO:0010468 | regulation of gene expression | 34.5455 | 5 | no |
| GO:0009966 | regulation of signal transduction | 32.7273 | 4 | no |
| GO:0006996 | organelle organization | 32.7273 | 4 | yes |
| GO:0043412 | macromolecule modification | 30.9091 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.9091 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 30.9091 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.9091 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 30.9091 | 4 | yes |
| GO:0036211 | protein modification process | 29.0909 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 29.0909 | 5 | no |
| GO:0006886 | intracellular protein transport | 29.0909 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 29.0909 | 4 | no |
| GO:0022607 | cellular component assembly | 27.2727 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 27.2727 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 27.2727 | 4 | no |
| GO:0032880 | regulation of protein localization | 25.4545 | 5 | no |
| GO:0033043 | regulation of organelle organization | 25.4545 | 5 | no |
| GO:0060341 | regulation of cellular localization | 25.4545 | 4 | no |
| GO:0023056 | positive regulation of signaling | 25.4545 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.6364 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.6364 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 23.6364 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 23.6364 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.6364 | 4 | no |
| GO:0031399 | regulation of protein modification process | 21.8182 | 6 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.8182 | 5 | no |
| GO:0043933 | protein-containing complex organization | 21.8182 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.8182 | 4 | no |
| GO:0071310 | cellular response to organic substance | 21.8182 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 21.8182 | 5 | no |
| GO:0051049 | regulation of transport | 21.8182 | 4 | no |
| GO:0010941 | regulation of cell death | 21.8182 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 21.8182 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 21.8182 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.8182 | 5 | no |
| GO:0048193 | Golgi vesicle transport | 20.0000 | 5 | yes |
| GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport | 16.3636 | 4 | yes |
| GO:0035459 | vesicle cargo loading | 10.9091 | 4 | yes |
| GO:0090110 | COPII-coated vesicle cargo loading | 10.9091 | 4 | yes |
| GO:0010038 | response to metal ion | 9.0909 | 4 | yes |
| GO:0051592 | response to calcium ion | 5.4545 | 5 | yes |
| GO:0007029 | endoplasmic reticulum organization | 3.6364 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SC31A_HUMAN |
|---|---|---|---|---|
| DOID:0050686 | organ system cancer | 3.6364 | 3 | no |
| DOID:10534 | stomach cancer | 3.6364 | 5 | no |
| DOID:3119 | gastrointestinal system cancer | 3.6364 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PDCD6_HUMAN | [view interactions] | Low throughput | no | no |
| SEC13_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SC23A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ALG2_HUMAN | [view interactions] | Low throughput | no | yes |
| STAM1_HUMAN | [view interactions] | Low throughput | no | yes |
| STAM2_HUMAN | [view interactions] | Low throughput | no | yes |
| KLH12_HUMAN | [view interactions] | Low throughput | no | no |
| ARI1_HUMAN | [view interactions] | Low throughput | no | yes |
| UBP8_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SC31A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PFD1_HUMAN | [view interactions] | High throughput | no | yes |
| TNNT1_HUMAN | [view interactions] | High throughput | no | no |
| MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| TFG_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| LUZP1_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCYL1_HUMAN | [view interactions] | High throughput | no | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| REL_HUMAN | [view interactions] | High throughput | no | yes |
| APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYOM2_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBAC1_HUMAN | [view interactions] | High throughput | no | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA8_HUMAN | [view interactions] | High throughput | no | no |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| MUSK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGFRA_HUMAN | [view interactions] | High throughput | no | no |
| RET_HUMAN | [view interactions] | High throughput | no | yes |
| T22D2_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FHL5_HUMAN | [view interactions] | High throughput | no | no |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| STB5L_HUMAN | [view interactions] | High throughput | no | no |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NOP14_HUMAN | [view interactions] | High throughput | no | yes |
| S23IP_HUMAN | [view interactions] | High throughput | no | yes |
| NOC4L_HUMAN | [view interactions] | High throughput | no | no |
| GNPI1_HUMAN | [view interactions] | High throughput | no | yes |
| GRDN_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| PEF1_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC23B_HUMAN | [view interactions] | High throughput | no | yes |
| SC24C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC24D_HUMAN | [view interactions] | High throughput | no | yes |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| MRP6_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| LMBRL_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| AKT3_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| GORS1_HUMAN | [view interactions] | High throughput | no | yes |
| RPA49_HUMAN | [view interactions] | High throughput | no | yes |
| RAB14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOES_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PGTA_HUMAN | [view interactions] | High throughput | no | yes |
| SPTC1_HUMAN | [view interactions] | High throughput | no | yes |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| ARF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPOE3_HUMAN | [view interactions] | High throughput | no | yes |
| TBL1R_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B1_HUMAN | [view interactions] | High throughput | no | no |
| DEPD5_HUMAN | [view interactions] | High throughput | no | yes |
| BAZ1A_HUMAN | [view interactions] | High throughput | no | no |
| ARL5A_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTF2_HUMAN | [view interactions] | High throughput | no | no |
| MA1A1_HUMAN | [view interactions] | High throughput | no | yes |
| NCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| MA2A1_HUMAN | [view interactions] | High throughput | no | no |
| S39A9_HUMAN | [view interactions] | High throughput | no | yes |
| TPC12_HUMAN | [view interactions] | High throughput | no | yes |
| TPC10_HUMAN | [view interactions] | High throughput | no | no |
| GNT2A_HUMAN | [view interactions] | High throughput | no | yes |
| CARM1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARFG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC24B_HUMAN | [view interactions] | High throughput | no | yes |
| ZNT5_HUMAN | [view interactions] | High throughput | no | yes |
| UB2J1_HUMAN | [view interactions] | High throughput | no | yes |
| TPC13_HUMAN | [view interactions] | High throughput | no | yes |
| VPS51_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC8_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| ACATN_HUMAN | [view interactions] | High throughput | no | yes |
| VPS45_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPRI_HUMAN | [view interactions] | High throughput | no | yes |
| RAB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPC11_HUMAN | [view interactions] | High throughput | no | no |
| VPS53_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPPC5_HUMAN | [view interactions] | High throughput | no | yes |
| RABX5_HUMAN | [view interactions] | High throughput | no | no |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFE2_HUMAN | [view interactions] | High throughput | no | no |
| MA1B1_HUMAN | [view interactions] | High throughput | no | yes |
| B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
| RICTR_HUMAN | [view interactions] | High throughput | no | yes |
| SC24A_HUMAN | [view interactions] | High throughput | no | no |
| S39A7_HUMAN | [view interactions] | High throughput | no | yes |
| MOGS_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| TPC2A_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPC2L_HUMAN | [view interactions] | High throughput | no | yes |
| SAR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACACA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARMT1_HUMAN | [view interactions] | High throughput | no | yes |
| VATC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FPPS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUD13_HUMAN | [view interactions] | High throughput | no | no |
| SSDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VATD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBS_HUMAN | [view interactions] | High throughput | no | yes |
| CGL_HUMAN | [view interactions] | High throughput | no | yes |
| CYB5B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHX15_HUMAN | [view interactions] | High throughput | no | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PNCB_HUMAN | [view interactions] | High throughput | no | no |
| NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBCA_HUMAN | [view interactions] | High throughput | no | yes |
| TPD54_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| FCL_HUMAN | [view interactions] | High throughput | no | yes |
| ELOB_HUMAN | [view interactions] | High throughput | no | no |
| RT15_HUMAN | [view interactions] | High throughput | no | yes |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RLA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI2_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| NU155_HUMAN | [view interactions] | High throughput | no | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| USO1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SC22B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| XBP1_HUMAN | [view interactions] | Computational | no | no |
| PREB_HUMAN | [view interactions] | Computational | no | yes |
| SAR1B_HUMAN | [view interactions] | Computational | no | yes |
| TPC2B_HUMAN | [view interactions] | Computational | no | no |
| LMAN1_HUMAN | [view interactions] | Computational | no | yes |
| TMED7_HUMAN | [view interactions] | Computational | no | yes |
| SC16B_HUMAN | [view interactions] | Computational | no | no |
| STX5_HUMAN | [view interactions] | Computational | no | yes |
| SC16A_HUMAN | [view interactions] | Computational | no | yes |
| SC31B_HUMAN | [view interactions] | Computational | no | yes |