SSDH_HUMAN
Evidence for PS localization
Functions
Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SSDH_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 50.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 26.6667 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 26.6667 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.6667 | 4 | no |
| GO:0016620 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | 10.0000 | 4 | yes |
| GO:0004777 | succinate-semialdehyde dehydrogenase (NAD+) activity | 6.6667 | 6 | yes |
| GO:0009013 | succinate-semialdehyde dehydrogenase [NAD(P)+] activity | 6.6667 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SSDH_HUMAN |
|---|---|---|---|---|
| GO:0019752 | carboxylic acid metabolic process | 50.0000 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 50.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 43.3333 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 36.6667 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 33.3333 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 30.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 30.0000 | 4 | no |
| GO:0043648 | dicarboxylic acid metabolic process | 30.0000 | 6 | yes |
| GO:0009893 | positive regulation of metabolic process | 30.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 30.0000 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 26.6667 | 5 | no |
| GO:0010646 | regulation of cell communication | 26.6667 | 4 | no |
| GO:0032787 | monocarboxylic acid metabolic process | 26.6667 | 6 | yes |
| GO:0051128 | regulation of cellular component organization | 26.6667 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 23.3333 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.3333 | 5 | no |
| GO:0008104 | protein localization | 23.3333 | 4 | no |
| GO:0009966 | regulation of signal transduction | 23.3333 | 4 | no |
| GO:0072350 | tricarboxylic acid metabolic process | 23.3333 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 23.3333 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 23.3333 | 5 | no |
| GO:0022607 | cellular component assembly | 23.3333 | 4 | no |
| GO:1901565 | organonitrogen compound catabolic process | 10.0000 | 4 | yes |
| GO:0006105 | succinate metabolic process | 6.6667 | 7 | yes |
| GO:0006536 | glutamate metabolic process | 6.6667 | 6 | yes |
| GO:0007417 | central nervous system development | 6.6667 | 4 | yes |
| GO:0009063 | cellular amino acid catabolic process | 6.6667 | 4 | yes |
| GO:0009064 | glutamine family amino acid metabolic process | 6.6667 | 5 | yes |
| GO:0009448 | gamma-aminobutyric acid metabolic process | 6.6667 | 4 | yes |
| GO:0009450 | gamma-aminobutyric acid catabolic process | 6.6667 | 5 | yes |
| GO:0016054 | organic acid catabolic process | 6.6667 | 4 | yes |
| GO:0042135 | neurotransmitter catabolic process | 6.6667 | 4 | yes |
| GO:0046395 | carboxylic acid catabolic process | 6.6667 | 5 | yes |
| GO:1901605 | alpha-amino acid metabolic process | 6.6667 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SSDH_HUMAN |
|---|---|---|---|---|
| DOID:0050155 | sensory system disease | 6.6667 | 3 | no |
| DOID:10584 | retinitis pigmentosa | 6.6667 | 7 | no |
| DOID:5614 | eye disease | 6.6667 | 4 | no |
| DOID:8466 | retinal degeneration | 6.6667 | 6 | no |
| DOID:9799 | eye degenerative disease | 6.6667 | 5 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SSDH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM50_HUMAN | [view interactions] | High throughput | no | yes |
| OXLD1_HUMAN | [view interactions] | High throughput | no | no |
| FGL1_HUMAN | [view interactions] | High throughput | no | no |
| GATC_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KPCD3_HUMAN | [view interactions] | High throughput | no | yes |
| IRAK4_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| MAGAB_HUMAN | [view interactions] | High throughput | no | no |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| GLMP_HUMAN | [view interactions] | High throughput | no | no |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAGE4_HUMAN | [view interactions] | High throughput | no | no |
| MAP2_HUMAN | [view interactions] | High throughput | no | yes |
| AHI1_HUMAN | [view interactions] | High throughput | no | yes |
| MSRB2_HUMAN | [view interactions] | High throughput | no | no |
| RM23_HUMAN | [view interactions] | High throughput | no | yes |
| GPR55_HUMAN | [view interactions] | High throughput | no | no |
| SRP54_HUMAN | [view interactions] | High throughput | no | yes |
| TRPC6_HUMAN | [view interactions] | High throughput | no | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| TIAR_HUMAN | [view interactions] | High throughput | no | no |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTND_HUMAN | [view interactions] | High throughput | no | yes |
| AL1B1_HUMAN | [view interactions] | High throughput | no | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL8A1_HUMAN | [view interactions] | High throughput | no | no |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| RPE_HUMAN | [view interactions] | High throughput | no | yes |
| UMPS_HUMAN | [view interactions] | High throughput | no | no |
| ARF5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC31A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC31B_HUMAN | [view interactions] | High throughput | no | yes |
| AT2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPDM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCO1_HUMAN | [view interactions] | High throughput | no | yes |
| CYGB_HUMAN | [view interactions] | High throughput | no | yes |
| GDPD1_HUMAN | [view interactions] | High throughput | no | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SELO_HUMAN | [view interactions] | High throughput | no | yes |
| GABT_HUMAN | [view interactions] | High throughput | no | yes |
| RT4I1_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| OGDHL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| IDH3G_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ODO1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ACLY_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PYC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| P5CS_HUMAN | [view interactions] | Computational | no | yes |
| IDH3B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PCKGC_HUMAN | [view interactions] | Computational | no | no |
| IDHC_HUMAN | [view interactions] | Computational | no | no |
| PCKGM_HUMAN | [view interactions] | Computational | no | no |
| MDHM_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| IDH3A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| IDHP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |