SSDH_HUMAN
Evidence for PS localization
Functions
Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SSDH_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 39.1304 | 4 | no |
| GO:0046872 | metal ion binding | 34.7826 | 5 | no |
| GO:0043168 | anion binding | 30.4348 | 4 | no |
| GO:0000166 | nucleotide binding | 26.0870 | 4 | no |
| GO:0017076 | purine nucleotide binding | 26.0870 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 26.0870 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.0870 | 4 | no |
| GO:0046914 | transition metal ion binding | 26.0870 | 6 | no |
| GO:0016462 | pyrophosphatase activity | 21.7391 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 21.7391 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 21.7391 | 6 | no |
| GO:0001664 | G protein-coupled receptor binding | 21.7391 | 4 | no |
| GO:0019900 | kinase binding | 21.7391 | 4 | no |
| GO:0004777 | succinate-semialdehyde dehydrogenase (NAD+) activity | 8.6957 | 6 | yes |
| GO:0009013 | succinate-semialdehyde dehydrogenase [NAD(P)+] activity | 8.6957 | 5 | yes |
| GO:0016620 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | 8.6957 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SSDH_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 60.8696 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 56.5217 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 52.1739 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 52.1739 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 52.1739 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 47.8261 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 43.4783 | 4 | no |
| GO:0043933 | protein-containing complex organization | 43.4783 | 4 | no |
| GO:0008104 | protein localization | 43.4783 | 4 | no |
| GO:0010646 | regulation of cell communication | 43.4783 | 4 | no |
| GO:0006996 | organelle organization | 39.1304 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 39.1304 | 5 | no |
| GO:0009966 | regulation of signal transduction | 39.1304 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 39.1304 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.7826 | 5 | no |
| GO:0022607 | cellular component assembly | 34.7826 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 34.7826 | 5 | no |
| GO:0051049 | regulation of transport | 34.7826 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 34.7826 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 34.7826 | 5 | no |
| GO:0050890 | cognition | 30.4348 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 30.4348 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.4348 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.4348 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 30.4348 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.4348 | 5 | no |
| GO:0071310 | cellular response to organic substance | 30.4348 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 30.4348 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.4348 | 4 | no |
| GO:0007268 | chemical synaptic transmission | 26.0870 | 7 | yes |
| GO:0098916 | anterograde trans-synaptic signaling | 26.0870 | 6 | yes |
| GO:0099536 | synaptic signaling | 26.0870 | 4 | yes |
| GO:0099537 | trans-synaptic signaling | 26.0870 | 5 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 26.0870 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.0870 | 5 | no |
| GO:0007612 | learning | 26.0870 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 26.0870 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 26.0870 | 5 | no |
| GO:0023057 | negative regulation of signaling | 26.0870 | 4 | no |
| GO:0043523 | regulation of neuron apoptotic process | 26.0870 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 26.0870 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 26.0870 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 26.0870 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 26.0870 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.0870 | 4 | no |
| GO:0071702 | organic substance transport | 26.0870 | 4 | no |
| GO:0071705 | nitrogen compound transport | 26.0870 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 26.0870 | 7 | no |
| GO:0009890 | negative regulation of biosynthetic process | 26.0870 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 26.0870 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.0870 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.0870 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 26.0870 | 6 | no |
| GO:0031399 | regulation of protein modification process | 26.0870 | 6 | no |
| GO:0032880 | regulation of protein localization | 26.0870 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.0870 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 26.0870 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 26.0870 | 5 | no |
| GO:0060341 | regulation of cellular localization | 26.0870 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 26.0870 | 6 | no |
| GO:0051094 | positive regulation of developmental process | 26.0870 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 21.7391 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 21.7391 | 4 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 21.7391 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 21.7391 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 21.7391 | 5 | no |
| GO:0090304 | nucleic acid metabolic process | 21.7391 | 4 | no |
| GO:0030030 | cell projection organization | 21.7391 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 21.7391 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 21.7391 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 21.7391 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.7391 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.7391 | 5 | no |
| GO:0006886 | intracellular protein transport | 21.7391 | 4 | no |
| GO:0015031 | protein transport | 21.7391 | 4 | no |
| GO:0010038 | response to metal ion | 21.7391 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 21.7391 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 21.7391 | 6 | no |
| GO:0014070 | response to organic cyclic compound | 21.7391 | 4 | no |
| GO:0022411 | cellular component disassembly | 21.7391 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 21.7391 | 5 | no |
| GO:0062012 | regulation of small molecule metabolic process | 21.7391 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 21.7391 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 21.7391 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.7391 | 4 | no |
| GO:0007417 | central nervous system development | 13.0435 | 4 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 13.0435 | 6 | yes |
| GO:0043648 | dicarboxylic acid metabolic process | 13.0435 | 6 | yes |
| GO:0006105 | succinate metabolic process | 8.6957 | 7 | yes |
| GO:0006536 | glutamate metabolic process | 8.6957 | 6 | yes |
| GO:0009063 | amino acid catabolic process | 8.6957 | 4 | yes |
| GO:0009064 | glutamine family amino acid metabolic process | 8.6957 | 5 | yes |
| GO:0009448 | gamma-aminobutyric acid metabolic process | 8.6957 | 5 | yes |
| GO:0009450 | gamma-aminobutyric acid catabolic process | 8.6957 | 5 | yes |
| GO:0016054 | organic acid catabolic process | 8.6957 | 4 | yes |
| GO:0046395 | carboxylic acid catabolic process | 8.6957 | 5 | yes |
| GO:0051932 | synaptic transmission, GABAergic | 8.6957 | 8 | yes |
| GO:0170033 | L-amino acid metabolic process | 8.6957 | 5 | yes |
| GO:0170039 | proteinogenic amino acid metabolic process | 8.6957 | 4 | yes |
| GO:0170041 | non-proteinogenic amino acid metabolic process | 8.6957 | 4 | yes |
| GO:0170044 | non-proteinogenic amino acid catabolic process | 8.6957 | 5 | yes |
| GO:1901605 | alpha-amino acid metabolic process | 8.6957 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SSDH_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTND_HUMAN | [view interactions] | High throughput | no | yes |
| AL1B1_HUMAN | [view interactions] | High throughput | no | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AL8A1_HUMAN | [view interactions] | High throughput | no | no |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| RPE_HUMAN | [view interactions] | High throughput | no | yes |
| UMPS_HUMAN | [view interactions] | High throughput | no | no |
| ARF5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC31A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC31B_HUMAN | [view interactions] | High throughput | no | yes |
| AT2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPDM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCO1_HUMAN | [view interactions] | High throughput | no | yes |
| CYGB_HUMAN | [view interactions] | High throughput | no | yes |
| GDPD1_HUMAN | [view interactions] | High throughput | no | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SELO_HUMAN | [view interactions] | High throughput | no | yes |
| GABT_HUMAN | [view interactions] | High throughput | no | yes |
| RT4I1_HUMAN | [view interactions] | High throughput | no | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM50_HUMAN | [view interactions] | High throughput | no | yes |
| OXLD1_HUMAN | [view interactions] | High throughput | no | no |
| FGL1_HUMAN | [view interactions] | High throughput | no | no |
| GATC_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KEAP1_HUMAN | [view interactions] | High throughput | no | yes |
| KPCD3_HUMAN | [view interactions] | High throughput | no | yes |
| IRAK4_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| CP135_HUMAN | [view interactions] | High throughput | no | no |
| MAGAB_HUMAN | [view interactions] | High throughput | no | no |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| CLIC6_HUMAN | [view interactions] | High throughput | no | no |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| GLMP_HUMAN | [view interactions] | High throughput | no | no |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAGE4_HUMAN | [view interactions] | High throughput | no | no |
| MAP2_HUMAN | [view interactions] | High throughput | no | yes |
| AHI1_HUMAN | [view interactions] | High throughput | no | yes |
| MSRB2_HUMAN | [view interactions] | High throughput | no | no |
| RM23_HUMAN | [view interactions] | High throughput | no | yes |
| GPR55_HUMAN | [view interactions] | High throughput | no | no |
| SRP54_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| KLF3_HUMAN | [view interactions] | High throughput | no | yes |
| TRPC6_HUMAN | [view interactions] | High throughput | no | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SSBP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| TIAR_HUMAN | [view interactions] | High throughput | no | no |