AT2B1_HUMAN
Evidence for PS localization
Functions
Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts . Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (PubMed). May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI004289 | TRG_DiLeu_BaLyEn_6 | TRG | 1157 | 1162 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AT2B1_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 40.7407 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 40.7407 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 40.7407 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 25.9259 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 25.9259 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 25.9259 | 6 | yes |
| GO:0019900 | kinase binding | 25.9259 | 4 | no |
| GO:0046872 | metal ion binding | 24.6914 | 4 | yes |
| GO:0019901 | protein kinase binding | 24.6914 | 5 | no |
| GO:0003924 | GTPase activity | 23.4568 | 7 | no |
| GO:0019001 | guanyl nucleotide binding | 23.4568 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 23.4568 | 5 | no |
| GO:0005525 | GTP binding | 22.2222 | 5 | no |
| GO:0005524 | ATP binding | 18.5185 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 18.5185 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 18.5185 | 5 | yes |
| GO:0008324 | cation transmembrane transporter activity | 11.1111 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 11.1111 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 11.1111 | 5 | yes |
| GO:0022853 | active ion transmembrane transporter activity | 9.8765 | 4 | yes |
| GO:0015399 | primary active transmembrane transporter activity | 8.6420 | 4 | yes |
| GO:0015662 | P-type ion transporter activity | 8.6420 | 4 | yes |
| GO:0005388 | P-type calcium transporter activity | 4.9383 | 4 | yes |
| GO:0015085 | calcium ion transmembrane transporter activity | 4.9383 | 6 | yes |
| GO:0030165 | PDZ domain binding | 4.9383 | 4 | yes |
| GO:0016887 | ATP hydrolysis activity | 2.4691 | 7 | yes |
| GO:1905056 | P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration | 2.4691 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AT2B1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 62.9630 | 4 | no |
| GO:0051049 | regulation of transport | 54.3210 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 49.3827 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 48.1481 | 4 | no |
| GO:0010646 | regulation of cell communication | 46.9136 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 44.4444 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 41.9753 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.7407 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.7407 | 4 | no |
| GO:0008104 | protein localization | 39.5062 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 39.5062 | 4 | no |
| GO:0009966 | regulation of signal transduction | 38.2716 | 4 | no |
| GO:0071702 | organic substance transport | 37.0370 | 4 | no |
| GO:0022607 | cellular component assembly | 37.0370 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.0370 | 5 | no |
| GO:0010468 | regulation of gene expression | 35.8025 | 5 | yes |
| GO:0006996 | organelle organization | 34.5679 | 4 | no |
| GO:0071705 | nitrogen compound transport | 33.3333 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | no |
| GO:0051050 | positive regulation of transport | 33.3333 | 4 | yes |
| GO:0071310 | cellular response to organic substance | 32.0988 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 30.8642 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 30.8642 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 29.6296 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.6296 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 28.3951 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 27.1605 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 27.1605 | 5 | no |
| GO:0023056 | positive regulation of signaling | 27.1605 | 4 | no |
| GO:0060341 | regulation of cellular localization | 27.1605 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.1605 | 5 | yes |
| GO:0015031 | protein transport | 25.9259 | 4 | no |
| GO:0030030 | cell projection organization | 25.9259 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 25.9259 | 4 | no |
| GO:0043269 | regulation of ion transport | 25.9259 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 25.9259 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 24.6914 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 24.6914 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.4568 | 6 | no |
| GO:0032880 | regulation of protein localization | 23.4568 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.4568 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.4568 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 23.4568 | 4 | no |
| GO:0030334 | regulation of cell migration | 23.4568 | 5 | no |
| GO:2000145 | regulation of cell motility | 23.4568 | 4 | no |
| GO:0010941 | regulation of cell death | 23.4568 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 23.4568 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 23.4568 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 22.2222 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 22.2222 | 4 | no |
| GO:0031399 | regulation of protein modification process | 22.2222 | 6 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 22.2222 | 6 | no |
| GO:1903829 | positive regulation of protein localization | 22.2222 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 22.2222 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 22.2222 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 22.2222 | 5 | no |
| GO:0010959 | regulation of metal ion transport | 22.2222 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 20.9877 | 7 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.9877 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.9877 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 20.9877 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.9877 | 5 | no |
| GO:0036211 | protein modification process | 20.9877 | 4 | no |
| GO:0043412 | macromolecule modification | 20.9877 | 4 | no |
| GO:0006811 | ion transport | 20.9877 | 4 | yes |
| GO:0044057 | regulation of system process | 20.9877 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 20.9877 | 4 | yes |
| GO:0048878 | chemical homeostasis | 19.7531 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 19.7531 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 19.7531 | 4 | yes |
| GO:0050801 | ion homeostasis | 18.5185 | 5 | yes |
| GO:0055080 | cation homeostasis | 18.5185 | 6 | yes |
| GO:0098771 | inorganic ion homeostasis | 18.5185 | 6 | yes |
| GO:0014070 | response to organic cyclic compound | 17.2840 | 4 | yes |
| GO:0055065 | metal ion homeostasis | 17.2840 | 7 | yes |
| GO:1903522 | regulation of blood circulation | 17.2840 | 5 | yes |
| GO:0001817 | regulation of cytokine production | 16.0494 | 4 | yes |
| GO:0006812 | cation transport | 16.0494 | 5 | yes |
| GO:0006873 | cellular ion homeostasis | 16.0494 | 4 | yes |
| GO:0008016 | regulation of heart contraction | 16.0494 | 6 | yes |
| GO:0030003 | cellular cation homeostasis | 16.0494 | 5 | yes |
| GO:0006875 | cellular metal ion homeostasis | 14.8148 | 6 | yes |
| GO:0033993 | response to lipid | 14.8148 | 4 | yes |
| GO:0051924 | regulation of calcium ion transport | 14.8148 | 7 | yes |
| GO:0090257 | regulation of muscle system process | 14.8148 | 5 | yes |
| GO:0006937 | regulation of muscle contraction | 13.5802 | 6 | yes |
| GO:0030001 | metal ion transport | 13.5802 | 6 | yes |
| GO:0098655 | cation transmembrane transport | 13.5802 | 4 | yes |
| GO:0098660 | inorganic ion transmembrane transport | 13.5802 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 13.5802 | 5 | yes |
| GO:0010629 | negative regulation of gene expression | 12.3457 | 6 | yes |
| GO:0043270 | positive regulation of ion transport | 12.3457 | 5 | yes |
| GO:0071407 | cellular response to organic cyclic compound | 12.3457 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 12.3457 | 4 | yes |
| GO:0071396 | cellular response to lipid | 11.1111 | 5 | yes |
| GO:0072507 | divalent inorganic cation homeostasis | 11.1111 | 7 | yes |
| GO:0003018 | vascular process in circulatory system | 9.8765 | 4 | yes |
| GO:0001818 | negative regulation of cytokine production | 8.6420 | 5 | yes |
| GO:0035150 | regulation of tube size | 8.6420 | 4 | yes |
| GO:0035296 | regulation of tube diameter | 8.6420 | 5 | yes |
| GO:0048545 | response to steroid hormone | 8.6420 | 4 | yes |
| GO:0072503 | cellular divalent inorganic cation homeostasis | 8.6420 | 6 | yes |
| GO:0097746 | blood vessel diameter maintenance | 8.6420 | 5 | yes |
| GO:0006874 | cellular calcium ion homeostasis | 7.4074 | 7 | yes |
| GO:0055074 | calcium ion homeostasis | 7.4074 | 8 | yes |
| GO:0006816 | calcium ion transport | 6.1728 | 7 | yes |
| GO:0051928 | positive regulation of calcium ion transport | 6.1728 | 6 | yes |
| GO:0070588 | calcium ion transmembrane transport | 6.1728 | 6 | yes |
| GO:0097305 | response to alcohol | 6.1728 | 4 | yes |
| GO:0019229 | regulation of vasoconstriction | 4.9383 | 6 | yes |
| GO:0031960 | response to corticosteroid | 4.9383 | 5 | yes |
| GO:0032870 | cellular response to hormone stimulus | 4.9383 | 4 | yes |
| GO:0051384 | response to glucocorticoid | 4.9383 | 6 | yes |
| GO:0071383 | cellular response to steroid hormone stimulus | 4.9383 | 5 | yes |
| GO:1901654 | response to ketone | 4.9383 | 4 | yes |
| GO:1903779 | regulation of cardiac conduction | 4.9383 | 4 | yes |
| GO:0006940 | regulation of smooth muscle contraction | 3.7037 | 7 | yes |
| GO:0051480 | regulation of cytosolic calcium ion concentration | 3.7037 | 8 | yes |
| GO:0003056 | regulation of vascular associated smooth muscle contraction | 2.4691 | 7 | yes |
| GO:0007420 | brain development | 2.4691 | 4 | yes |
| GO:0030278 | regulation of ossification | 2.4691 | 4 | yes |
| GO:0030500 | regulation of bone mineralization | 2.4691 | 5 | yes |
| GO:0031667 | response to nutrient levels | 2.4691 | 4 | yes |
| GO:0051385 | response to mineralocorticoid | 2.4691 | 6 | yes |
| GO:0051412 | response to corticosterone | 2.4691 | 5 | yes |
| GO:0070167 | regulation of biomineral tissue development | 2.4691 | 4 | yes |
| GO:0071384 | cellular response to corticosteroid stimulus | 2.4691 | 6 | yes |
| GO:0071385 | cellular response to glucocorticoid stimulus | 2.4691 | 7 | yes |
| GO:0097306 | cellular response to alcohol | 2.4691 | 5 | yes |
| GO:1901655 | cellular response to ketone | 2.4691 | 5 | yes |
| GO:1990034 | calcium ion export across plasma membrane | 2.4691 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in AT2B1_HUMAN |
|---|---|---|---|---|
| DOID:0050700 | cardiomyopathy | 4.9383 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 4.9383 | 5 | no |
| DOID:114 | heart disease | 4.9383 | 3 | no |
| DOID:2843 | long QT syndrome | 4.9383 | 6 | no |
| DOID:331 | central nervous system disease | 3.7037 | 3 | no |
| DOID:10273 | heart conduction disease | 2.4691 | 4 | no |
| DOID:0111962 | combined immunodeficiency | 2.4691 | 4 | no |
| DOID:612 | primary immunodeficiency disease | 2.4691 | 3 | no |
| DOID:1289 | neurodegenerative disease | 2.4691 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BCR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANPRA_HUMAN | [view interactions] | Low throughput | no | no |
| ITPR3_HUMAN | [view interactions] | Low throughput | no | yes |
| AT2A2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SNTA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NOS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NPTN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| BROMI_HUMAN | [view interactions] | High throughput | no | no |
| XPO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MBIP1_HUMAN | [view interactions] | High throughput | no | yes |
| HACD3_HUMAN | [view interactions] | High throughput | no | yes |
| S38A1_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| MD2L2_HUMAN | [view interactions] | High throughput | no | yes |
| CNR2_HUMAN | [view interactions] | High throughput | no | yes |
| MOT11_HUMAN | [view interactions] | High throughput | no | no |
| H2A1B_HUMAN | [view interactions] | High throughput | no | yes |
| H15_HUMAN | [view interactions] | High throughput | no | no |
| H12_HUMAN | [view interactions] | High throughput | no | yes |
| HACD1_HUMAN | [view interactions] | High throughput | no | no |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| UN93B_HUMAN | [view interactions] | High throughput | no | yes |
| APBB1_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| TYRO3_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| CD9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| CCR2_HUMAN | [view interactions] | High throughput | no | yes |
| PAR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETS1_HUMAN | [view interactions] | High throughput | no | no |
| NPHP1_HUMAN | [view interactions] | High throughput | no | yes |
| FTM_HUMAN | [view interactions] | High throughput | no | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTDSL_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| FLT3_HUMAN | [view interactions] | High throughput | no | no |
| NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCRIB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TERF2_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AT1A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| H17B6_HUMAN | [view interactions] | High throughput | no | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| CCND1_HUMAN | [view interactions] | High throughput | no | yes |
| SRPRA_HUMAN | [view interactions] | High throughput | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM40_HUMAN | [view interactions] | High throughput | no | yes |
| ATLA3_HUMAN | [view interactions] | High throughput | no | no |
| CSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| CENPO_HUMAN | [view interactions] | High throughput | no | no |
| TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
| ATP7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMR1A_HUMAN | [view interactions] | High throughput | no | no |
| ITB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZW10_HUMAN | [view interactions] | High throughput | no | yes |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ZN598_HUMAN | [view interactions] | High throughput | no | no |
| TPTE_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S15A3_HUMAN | [view interactions] | High throughput | no | yes |
| DUS2_HUMAN | [view interactions] | High throughput | no | no |
| DUS6_HUMAN | [view interactions] | High throughput | no | yes |
| DUS7_HUMAN | [view interactions] | High throughput | no | yes |
| PTN3_HUMAN | [view interactions] | High throughput | no | yes |
| PTPR2_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| EMC1_HUMAN | [view interactions] | High throughput | no | yes |
| EMC2_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF11_HUMAN | [view interactions] | High throughput | no | yes |
| AKT3_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| APR_HUMAN | [view interactions] | High throughput | no | yes |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| CQ078_HUMAN | [view interactions] | High throughput | no | no |
| NIPA3_HUMAN | [view interactions] | High throughput | no | no |
| CD27_HUMAN | [view interactions] | High throughput | no | no |
| GP182_HUMAN | [view interactions] | High throughput | no | no |
| OPALI_HUMAN | [view interactions] | High throughput | no | yes |
| P2RY8_HUMAN | [view interactions] | High throughput | no | no |
| FZD7_HUMAN | [view interactions] | High throughput | no | yes |
| F174A_HUMAN | [view interactions] | High throughput | no | yes |
| SNG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEG9C_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| PLPL4_HUMAN | [view interactions] | High throughput | no | yes |
| LIRB4_HUMAN | [view interactions] | High throughput | no | no |
| TPST2_HUMAN | [view interactions] | High throughput | no | yes |
| FPR2_HUMAN | [view interactions] | High throughput | no | yes |
| GP173_HUMAN | [view interactions] | High throughput | no | no |
| CLC2D_HUMAN | [view interactions] | High throughput | no | yes |
| S1PR4_HUMAN | [view interactions] | High throughput | no | no |
| P2RY2_HUMAN | [view interactions] | High throughput | no | no |
| ENTP7_HUMAN | [view interactions] | High throughput | no | no |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND1_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| RND3_HUMAN | [view interactions] | High throughput | no | no |
| RHOV_HUMAN | [view interactions] | High throughput | no | no |
| LIN41_HUMAN | [view interactions] | High throughput | no | no |
| AT2B3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACSL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HM13_HUMAN | [view interactions] | High throughput | no | yes |
| IDH3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLGN_HUMAN | [view interactions] | High throughput | no | no |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDS2_HUMAN | [view interactions] | High throughput | no | yes |
| NB5R1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCO1_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5E_HUMAN | [view interactions] | High throughput | no | no |
| ATP5I_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ADA12_HUMAN | [view interactions] | High throughput | no | no |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| DJC16_HUMAN | [view interactions] | High throughput | no | no |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| CP2C9_HUMAN | [view interactions] | High throughput | no | no |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| DYR2_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| E41LA_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI2_HUMAN | [view interactions] | High throughput | no | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LMAN1_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET7A_HUMAN | [view interactions] | High throughput | no | no |
| AFAD_HUMAN | [view interactions] | High throughput | no | yes |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PANX1_HUMAN | [view interactions] | High throughput | no | no |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| PEX3_HUMAN | [view interactions] | High throughput | no | yes |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3B_HUMAN | [view interactions] | High throughput | no | no |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| KGP1_HUMAN | [view interactions] | Computational | no | yes |
| KGP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |