AT2B3_HUMAN
Evidence for PS localization
Functions
ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels at the presynaptic terminals (PubMed, PubMed, PubMed, PubMed). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed, PubMed). May counter-transport protons, but the mechanism and the stoichiometry of this Ca(2+)/H(+) exchange remains to be established . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in AT2B3_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 50.0000 | 4 | yes |
| GO:0005524 | ATP binding | 35.0000 | 5 | yes |
| GO:0017076 | purine nucleotide binding | 35.0000 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 35.0000 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 35.0000 | 4 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 35.0000 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 35.0000 | 4 | yes |
| GO:0008324 | cation transmembrane transporter activity | 30.0000 | 4 | yes |
| GO:0022890 | inorganic cation transmembrane transporter activity | 30.0000 | 4 | yes |
| GO:0015399 | primary active transmembrane transporter activity | 25.0000 | 4 | yes |
| GO:0022853 | active ion transmembrane transporter activity | 25.0000 | 4 | yes |
| GO:0003723 | RNA binding | 25.0000 | 4 | no |
| GO:0005509 | calcium ion binding | 25.0000 | 5 | no |
| GO:0019900 | kinase binding | 25.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 25.0000 | 5 | no |
| GO:0015085 | calcium ion transmembrane transporter activity | 20.0000 | 6 | yes |
| GO:0030165 | PDZ domain binding | 20.0000 | 4 | yes |
| GO:0046873 | metal ion transmembrane transporter activity | 20.0000 | 5 | yes |
| GO:0005388 | P-type calcium transporter activity | 15.0000 | 4 | yes |
| GO:0015662 | P-type ion transporter activity | 15.0000 | 4 | yes |
| GO:1905056 | P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration | 15.0000 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in AT2B3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 55.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 45.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 45.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 45.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 40.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 40.0000 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 40.0000 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 40.0000 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 40.0000 | 5 | no |
| GO:0051049 | regulation of transport | 40.0000 | 4 | no |
| GO:0055080 | cation homeostasis | 35.0000 | 6 | yes |
| GO:0098771 | inorganic ion homeostasis | 35.0000 | 6 | yes |
| GO:1903522 | regulation of blood circulation | 35.0000 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 35.0000 | 6 | no |
| GO:0031399 | regulation of protein modification process | 35.0000 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 35.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 35.0000 | 5 | no |
| GO:0043269 | regulation of ion transport | 35.0000 | 5 | no |
| GO:0051050 | positive regulation of transport | 35.0000 | 4 | no |
| GO:0008104 | protein localization | 35.0000 | 4 | no |
| GO:0008016 | regulation of heart contraction | 35.0000 | 6 | yes |
| GO:0044057 | regulation of system process | 35.0000 | 4 | yes |
| GO:0048878 | chemical homeostasis | 35.0000 | 4 | yes |
| GO:0050801 | ion homeostasis | 35.0000 | 5 | yes |
| GO:0055065 | metal ion homeostasis | 35.0000 | 7 | yes |
| GO:0072507 | divalent inorganic cation homeostasis | 30.0000 | 7 | yes |
| GO:0009966 | regulation of signal transduction | 30.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.0000 | 5 | no |
| GO:0010646 | regulation of cell communication | 30.0000 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 30.0000 | 7 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.0000 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.0000 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 30.0000 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 30.0000 | 4 | no |
| GO:0051051 | negative regulation of transport | 30.0000 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 30.0000 | 5 | no |
| GO:0006811 | ion transport | 30.0000 | 4 | yes |
| GO:0006812 | cation transport | 30.0000 | 5 | yes |
| GO:0006873 | cellular ion homeostasis | 30.0000 | 4 | yes |
| GO:0006875 | cellular metal ion homeostasis | 30.0000 | 6 | yes |
| GO:0030003 | cellular cation homeostasis | 30.0000 | 5 | yes |
| GO:0072503 | cellular divalent inorganic cation homeostasis | 25.0000 | 6 | yes |
| GO:0001932 | regulation of protein phosphorylation | 25.0000 | 7 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 25.0000 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 25.0000 | 7 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 25.0000 | 7 | no |
| GO:0036211 | protein modification process | 25.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 25.0000 | 4 | no |
| GO:0010038 | response to metal ion | 25.0000 | 4 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 25.0000 | 6 | no |
| GO:0010959 | regulation of metal ion transport | 25.0000 | 6 | no |
| GO:0031400 | negative regulation of protein modification process | 25.0000 | 7 | no |
| GO:0043271 | negative regulation of ion transport | 25.0000 | 5 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 25.0000 | 7 | no |
| GO:0051248 | negative regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0051338 | regulation of transferase activity | 25.0000 | 4 | no |
| GO:0051924 | regulation of calcium ion transport | 25.0000 | 7 | no |
| GO:0014070 | response to organic cyclic compound | 25.0000 | 4 | no |
| GO:0006874 | cellular calcium ion homeostasis | 25.0000 | 7 | yes |
| GO:0055074 | calcium ion homeostasis | 25.0000 | 8 | yes |
| GO:0098655 | cation transmembrane transport | 20.0000 | 4 | yes |
| GO:0098660 | inorganic ion transmembrane transport | 20.0000 | 4 | yes |
| GO:0098662 | inorganic cation transmembrane transport | 20.0000 | 5 | yes |
| GO:0030001 | metal ion transport | 20.0000 | 6 | yes |
| GO:0051480 | regulation of cytosolic calcium ion concentration | 20.0000 | 8 | yes |
| GO:1903779 | regulation of cardiac conduction | 15.0000 | 4 | yes |
| GO:0006816 | calcium ion transport | 15.0000 | 7 | yes |
| GO:0070588 | calcium ion transmembrane transport | 10.0000 | 6 | yes |
| GO:1990034 | calcium ion export across plasma membrane | 10.0000 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in AT2B3_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 10.0000 | 3 | no |
| DOID:2843 | long QT syndrome | 10.0000 | 6 | no |
| DOID:0050700 | cardiomyopathy | 10.0000 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 10.0000 | 5 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| 1433E_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1H_HUMAN | [view interactions] | High throughput | no | yes |
| H2A1B_HUMAN | [view interactions] | High throughput | no | yes |
| VATA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| 5HT2C_HUMAN | [view interactions] | High throughput | no | no |
| FOXR1_HUMAN | [view interactions] | High throughput | no | no |
| TERF2_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| PLPL4_HUMAN | [view interactions] | High throughput | no | yes |
| CD27_HUMAN | [view interactions] | High throughput | no | no |
| CTDS2_HUMAN | [view interactions] | High throughput | no | yes |
| CD1B_HUMAN | [view interactions] | High throughput | no | yes |
| TSN5_HUMAN | [view interactions] | High throughput | no | no |
| DGUOK_HUMAN | [view interactions] | High throughput | no | yes |
| LEG8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AAKG1_HUMAN | [view interactions] | High throughput | no | no |
| CGAT1_HUMAN | [view interactions] | High throughput | no | no |
| H17B6_HUMAN | [view interactions] | High throughput | no | yes |
| AGTR1_HUMAN | [view interactions] | High throughput | no | no |
| PF2R_HUMAN | [view interactions] | High throughput | no | no |
| TXD15_HUMAN | [view interactions] | High throughput | no | yes |
| SLAF1_HUMAN | [view interactions] | High throughput | no | no |
| P2RY8_HUMAN | [view interactions] | High throughput | no | no |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| AT2B2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNBP6_HUMAN | [view interactions] | High throughput | no | yes |
| LIRB4_HUMAN | [view interactions] | High throughput | no | no |
| FPR2_HUMAN | [view interactions] | High throughput | no | yes |
| GALT6_HUMAN | [view interactions] | High throughput | no | yes |
| IPPK_HUMAN | [view interactions] | High throughput | no | yes |
| CP2B6_HUMAN | [view interactions] | High throughput | no | no |
| C3AR_HUMAN | [view interactions] | High throughput | no | no |
| S1PR1_HUMAN | [view interactions] | High throughput | no | no |
| AGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| S19A1_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| S26A4_HUMAN | [view interactions] | High throughput | no | no |
| TPST2_HUMAN | [view interactions] | High throughput | no | yes |
| IDD_HUMAN | [view interactions] | High throughput | no | no |
| TMM59_HUMAN | [view interactions] | High throughput | no | yes |
| O13J1_HUMAN | [view interactions] | High throughput | no | no |
| V2R_HUMAN | [view interactions] | High throughput | no | no |
| LEG9B_HUMAN | [view interactions] | High throughput | no | no |
| CXCR4_HUMAN | [view interactions] | High throughput | no | no |
| OPRX_HUMAN | [view interactions] | High throughput | no | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C5AR1_HUMAN | [view interactions] | High throughput | no | yes |
| NPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IFT27_HUMAN | [view interactions] | High throughput | no | yes |
| GPM6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CLC4A_HUMAN | [view interactions] | High throughput | no | no |
| IL2RA_HUMAN | [view interactions] | High throughput | no | no |
| CQ078_HUMAN | [view interactions] | High throughput | no | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| GLR_HUMAN | [view interactions] | High throughput | no | no |
| OX2R_HUMAN | [view interactions] | High throughput | no | no |
| ADAM7_HUMAN | [view interactions] | High throughput | no | no |
| CC018_HUMAN | [view interactions] | High throughput | no | yes |
| CD226_HUMAN | [view interactions] | High throughput | no | yes |
| OPALI_HUMAN | [view interactions] | High throughput | no | yes |
| NIPA3_HUMAN | [view interactions] | High throughput | no | no |
| LRC55_HUMAN | [view interactions] | High throughput | no | yes |
| TR13C_HUMAN | [view interactions] | High throughput | no | no |
| P2RY2_HUMAN | [view interactions] | High throughput | no | no |
| F174A_HUMAN | [view interactions] | High throughput | no | yes |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ENTP7_HUMAN | [view interactions] | High throughput | no | no |
| AT2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HM13_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLGN_HUMAN | [view interactions] | High throughput | no | no |
| COX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| KGP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAC1D_HUMAN | [view interactions] | Computational | no | yes |
| KCNJ5_HUMAN | [view interactions] | Computational | no | yes |
| KGP1_HUMAN | [view interactions] | Computational | no | yes |