UBE2N_HUMAN
Evidence for PS localization
Functions
The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical Lys-63-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the Lys-63-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the Lys-63-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate Lys-63-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the viral RNA-dependent Lys-63-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (PubMed, PubMed). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate Lys-63-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in UBE2N_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 37.0370 | 4 | no |
| GO:0046872 | metal ion binding | 37.0370 | 5 | no |
| GO:0000166 | nucleotide binding | 33.3333 | 4 | yes |
| GO:0043168 | anion binding | 33.3333 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 31.4815 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 27.7778 | 6 | yes |
| GO:0032555 | purine ribonucleotide binding | 26.8519 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.8519 | 4 | yes |
| GO:0003723 | RNA binding | 24.0741 | 4 | yes |
| GO:0005524 | ATP binding | 23.1481 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 23.1481 | 5 | yes |
| GO:0019900 | kinase binding | 22.2222 | 4 | no |
| GO:0044389 | ubiquitin-like protein ligase binding | 20.3704 | 4 | yes |
| GO:0004842 | ubiquitin-protein transferase activity | 19.4444 | 4 | yes |
| GO:0016755 | aminoacyltransferase activity | 19.4444 | 4 | yes |
| GO:0031625 | ubiquitin protein ligase binding | 19.4444 | 5 | yes |
| GO:0043130 | ubiquitin binding | 8.3333 | 4 | yes |
| GO:0061631 | ubiquitin conjugating enzyme activity | 1.8519 | 5 | yes |
| GO:0061650 | ubiquitin-like protein conjugating enzyme activity | 1.8519 | 4 | yes |
| GO:0097027 | ubiquitin-protein transferase activator activity | 1.8519 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in UBE2N_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.3333 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 56.4815 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 56.4815 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 51.8519 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 50.9259 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 47.2222 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 45.3704 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 44.4444 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 42.5926 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 40.7407 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 40.7407 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 39.8148 | 4 | no |
| GO:0010468 | regulation of gene expression | 39.8148 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 39.8148 | 5 | yes |
| GO:0036211 | protein modification process | 38.8889 | 4 | yes |
| GO:0043412 | macromolecule modification | 38.8889 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 36.1111 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 35.1852 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 35.1852 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 34.2593 | 6 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 34.2593 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 31.4815 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.4815 | 5 | yes |
| GO:0022607 | cellular component assembly | 30.5556 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 29.6296 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 29.6296 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 28.7037 | 4 | no |
| GO:0009057 | macromolecule catabolic process | 28.7037 | 4 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 27.7778 | 6 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 27.7778 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 27.7778 | 6 | no |
| GO:0009894 | regulation of catabolic process | 27.7778 | 4 | no |
| GO:0008104 | protein localization | 27.7778 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 27.7778 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 27.7778 | 4 | yes |
| GO:0043687 | post-translational protein modification | 27.7778 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 26.8519 | 5 | yes |
| GO:0016567 | protein ubiquitination | 26.8519 | 8 | yes |
| GO:0031399 | regulation of protein modification process | 26.8519 | 6 | yes |
| GO:0032446 | protein modification by small protein conjugation | 26.8519 | 7 | yes |
| GO:0051252 | regulation of RNA metabolic process | 25.9259 | 5 | yes |
| GO:0051130 | positive regulation of cellular component organization | 25.9259 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0009968 | negative regulation of signal transduction | 25.0000 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 25.0000 | 4 | yes |
| GO:0080134 | regulation of response to stress | 24.0741 | 4 | yes |
| GO:0043066 | negative regulation of apoptotic process | 24.0741 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 24.0741 | 5 | no |
| GO:0051049 | regulation of transport | 24.0741 | 4 | no |
| GO:0006996 | organelle organization | 24.0741 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.0741 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 24.0741 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 23.1481 | 6 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 23.1481 | 7 | yes |
| GO:0006508 | proteolysis | 23.1481 | 4 | yes |
| GO:0051603 | proteolysis involved in protein catabolic process | 22.2222 | 5 | yes |
| GO:1901565 | organonitrogen compound catabolic process | 22.2222 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 22.2222 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 22.2222 | 7 | yes |
| GO:0071310 | cellular response to organic substance | 21.2963 | 4 | no |
| GO:0043933 | protein-containing complex organization | 21.2963 | 4 | no |
| GO:0019941 | modification-dependent protein catabolic process | 21.2963 | 6 | yes |
| GO:0043632 | modification-dependent macromolecule catabolic process | 21.2963 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 20.3704 | 4 | no |
| GO:0030163 | protein catabolic process | 19.4444 | 4 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 19.4444 | 5 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 18.5185 | 6 | yes |
| GO:0006511 | ubiquitin-dependent protein catabolic process | 18.5185 | 7 | yes |
| GO:1902532 | negative regulation of intracellular signal transduction | 17.5926 | 6 | yes |
| GO:1901873 | regulation of post-translational protein modification | 15.7407 | 7 | yes |
| GO:1903320 | regulation of protein modification by small protein conjugation or removal | 15.7407 | 8 | yes |
| GO:0010498 | proteasomal protein catabolic process | 15.7407 | 5 | yes |
| GO:0031396 | regulation of protein ubiquitination | 15.7407 | 9 | yes |
| GO:0080135 | regulation of cellular response to stress | 14.8148 | 4 | yes |
| GO:0090304 | nucleic acid metabolic process | 14.8148 | 4 | yes |
| GO:0000209 | protein polyubiquitination | 14.8148 | 9 | yes |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 14.8148 | 6 | yes |
| GO:0002684 | positive regulation of immune system process | 12.0370 | 4 | yes |
| GO:1901875 | positive regulation of post-translational protein modification | 11.1111 | 8 | yes |
| GO:1903322 | positive regulation of protein modification by small protein conjugation or removal | 11.1111 | 9 | yes |
| GO:0031398 | positive regulation of protein ubiquitination | 11.1111 | 10 | yes |
| GO:0050776 | regulation of immune response | 10.1852 | 4 | yes |
| GO:0006974 | DNA damage response | 9.2593 | 4 | yes |
| GO:0050778 | positive regulation of immune response | 9.2593 | 5 | yes |
| GO:0051052 | regulation of DNA metabolic process | 9.2593 | 5 | yes |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity | 9.2593 | 4 | yes |
| GO:0043122 | regulation of canonical NF-kappaB signal transduction | 8.3333 | 6 | yes |
| GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 8.3333 | 5 | yes |
| GO:0006259 | DNA metabolic process | 7.4074 | 5 | yes |
| GO:0043123 | positive regulation of canonical NF-kappaB signal transduction | 7.4074 | 7 | yes |
| GO:0051054 | positive regulation of DNA metabolic process | 7.4074 | 6 | yes |
| GO:0070534 | protein K63-linked ubiquitination | 6.4815 | 10 | yes |
| GO:0140546 | defense response to symbiont | 6.4815 | 4 | yes |
| GO:0006281 | DNA repair | 6.4815 | 5 | yes |
| GO:1902914 | regulation of protein polyubiquitination | 5.5556 | 10 | yes |
| GO:1903432 | regulation of TORC1 signaling | 5.5556 | 7 | yes |
| GO:0006282 | regulation of DNA repair | 5.5556 | 5 | yes |
| GO:0032006 | regulation of TOR signaling | 5.5556 | 6 | yes |
| GO:1902916 | positive regulation of protein polyubiquitination | 4.6296 | 11 | yes |
| GO:1904262 | negative regulation of TORC1 signaling | 4.6296 | 8 | yes |
| GO:2000779 | regulation of double-strand break repair | 4.6296 | 6 | yes |
| GO:2000781 | positive regulation of double-strand break repair | 4.6296 | 6 | yes |
| GO:0032007 | negative regulation of TOR signaling | 4.6296 | 7 | yes |
| GO:0045739 | positive regulation of DNA repair | 4.6296 | 5 | yes |
| GO:0051607 | defense response to virus | 3.7037 | 4 | yes |
| GO:1900044 | regulation of protein K63-linked ubiquitination | 3.7037 | 11 | yes |
| GO:1902523 | positive regulation of protein K63-linked ubiquitination | 3.7037 | 12 | yes |
| GO:0000729 | DNA double-strand break processing | 3.7037 | 6 | yes |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | 3.7037 | 4 | yes |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 3.7037 | 4 | yes |
| GO:0006301 | postreplication repair | 3.7037 | 6 | yes |
| GO:0050851 | antigen receptor-mediated signaling pathway | 3.7037 | 5 | yes |
| GO:0050852 | T cell receptor signaling pathway | 3.7037 | 6 | yes |
| GO:0140374 | antiviral innate immune response | 2.7778 | 4 | yes |
| GO:0000724 | double-strand break repair via homologous recombination | 2.7778 | 7 | yes |
| GO:0000725 | recombinational repair | 2.7778 | 6 | yes |
| GO:0006302 | double-strand break repair | 2.7778 | 6 | yes |
| GO:0006310 | DNA recombination | 2.7778 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RIPK1_HUMAN | [view interactions] | Low throughput | no | yes |
| CCNB1_HUMAN | [view interactions] | Low throughput | no | no |
| RO52_HUMAN | [view interactions] | Low throughput | no | yes |
| PTTG1_HUMAN | [view interactions] | Low throughput | no | no |
| TRI23_HUMAN | [view interactions] | Low throughput | no | yes |
| H2A1B_HUMAN | [view interactions] | Low throughput | no | yes |
| RNF4_HUMAN | [view interactions] | Low throughput | no | yes |
| RN111_HUMAN | [view interactions] | Low throughput | no | yes |
| RN135_HUMAN | [view interactions] | Low throughput | no | yes |
| PELI1_HUMAN | [view interactions] | Low throughput | no | yes |
| RN122_HUMAN | [view interactions] | Low throughput | no | yes |
| UBB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LNX1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RS27A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PDES1_HUMAN | [view interactions] | Low throughput | no | no |
| BRCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| ARI2_HUMAN | [view interactions] | Low throughput | no | no |
| NEPR1_HUMAN | [view interactions] | Low throughput | no | yes |
| BIRC2_HUMAN | [view interactions] | Low throughput | no | yes |
| RN213_HUMAN | [view interactions] | Low throughput | no | yes |
| AURKA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HERC2_HUMAN | [view interactions] | Low throughput | no | yes |
| TNAP3_HUMAN | [view interactions] | Low throughput | no | yes |
| ISG15_HUMAN | [view interactions] | Low throughput | no | no |
| PYC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PCCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACACA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PCCB_HUMAN | [view interactions] | Low throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARI1_HUMAN | [view interactions] | Low throughput | no | yes |
| MFN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TNFA_HUMAN | [view interactions] | Low throughput | no | no |
| NHLC1_HUMAN | [view interactions] | Low throughput | no | no |
| RHDF2_HUMAN | [view interactions] | Low throughput | no | yes |
| RNF11_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2V2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CHFR_HUMAN | [view interactions] | Low throughput | no | no |
| SIR1_HUMAN | [view interactions] | Low throughput | no | yes |
| ZNRF1_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2V1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| M3K1_HUMAN | [view interactions] | Low throughput | no | yes |
| TRAF6_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| OTUB1_HUMAN | [view interactions] | Low throughput | no | yes |
| CDK6_HUMAN | [view interactions] | Low throughput | no | yes |
| CHIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SHPRH_HUMAN | [view interactions] | Low throughput | no | yes |
| HLTF_HUMAN | [view interactions] | Low throughput | no | no |
| HS90A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RN168_HUMAN | [view interactions] | Low throughput | no | no |
| IL1B_HUMAN | [view interactions] | Low throughput | no | no |
| TRAF2_HUMAN | [view interactions] | Low throughput | no | yes |
| RN128_HUMAN | [view interactions] | Low throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | Low throughput | no | no |
| OTUB2_HUMAN | [view interactions] | Low throughput | no | no |
| SH3R1_HUMAN | [view interactions] | Low throughput | no | yes |
| RN103_HUMAN | [view interactions] | Low throughput | no | no |
| MYLIP_HUMAN | [view interactions] | Low throughput | no | no |
| LRSM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRI17_HUMAN | [view interactions] | Low throughput | no | yes |
| TRI39_HUMAN | [view interactions] | Low throughput | no | no |
| RNF5_HUMAN | [view interactions] | Low throughput | no | yes |
| NBN_HUMAN | [view interactions] | Low throughput | no | yes |
| RN126_HUMAN | [view interactions] | Low throughput | no | yes |
| RN152_HUMAN | [view interactions] | Low throughput | no | no |
| RN115_HUMAN | [view interactions] | Low throughput | no | yes |
| ARK2C_HUMAN | [view interactions] | Low throughput | no | no |
| PELI3_HUMAN | [view interactions] | Low throughput | no | yes |
| TRI72_HUMAN | [view interactions] | Low throughput | no | no |
| NED4L_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRI33_HUMAN | [view interactions] | Low throughput | no | yes |
| BCL10_HUMAN | [view interactions] | Low throughput | no | yes |
| TRI32_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MALT1_HUMAN | [view interactions] | Low throughput | no | no |
| DTL_HUMAN | [view interactions] | Low throughput | no | no |
| RNF41_HUMAN | [view interactions] | Low throughput | no | yes |
| RN181_HUMAN | [view interactions] | Low throughput | no | no |
| FA12_HUMAN | [view interactions] | Low throughput | no | no |
| TRI69_HUMAN | [view interactions] | Low throughput | no | no |
| RNF8_HUMAN | [view interactions] | Low throughput | no | yes |
| TRI63_HUMAN | [view interactions] | Low throughput | no | no |
| MUL1_HUMAN | [view interactions] | Low throughput | no | no |
| TRI25_HUMAN | [view interactions] | Low throughput | no | yes |
| UHRF1_HUMAN | [view interactions] | Low throughput | no | yes |
| TRIM5_HUMAN | [view interactions] | Low throughput | no | yes |
| CBL_HUMAN | [view interactions] | Low throughput | no | yes |
| MARH7_HUMAN | [view interactions] | Low throughput | no | yes |
| RNF38_HUMAN | [view interactions] | Low throughput | no | yes |
| TRI65_HUMAN | [view interactions] | Low throughput | no | yes |
| TREX2_HUMAN | [view interactions] | Low throughput | no | no |
| TRI15_HUMAN | [view interactions] | Low throughput | no | no |
| TRI34_HUMAN | [view interactions] | Low throughput | no | no |
| UBA1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRIM7_HUMAN | [view interactions] | Low throughput | no | yes |
| ZNRF2_HUMAN | [view interactions] | Low throughput | no | yes |
| RN138_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| IKKA_HUMAN | [view interactions] | Low throughput | no | yes |
| RIOK3_HUMAN | [view interactions] | High throughput | no | yes |
| THA_HUMAN | [view interactions] | High throughput | no | yes |
| RET2_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2E1_HUMAN | [view interactions] | High throughput | no | yes |
| VATH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDT6_HUMAN | [view interactions] | High throughput | no | yes |
| VP33B_HUMAN | [view interactions] | High throughput | no | yes |
| UB2D3_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXD17_HUMAN | [view interactions] | High throughput | no | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SARDH_HUMAN | [view interactions] | High throughput | no | yes |
| CBLB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFD1_HUMAN | [view interactions] | High throughput | no | no |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| VASP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INT3_HUMAN | [view interactions] | High throughput | no | yes |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2B3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MFSD6_HUMAN | [view interactions] | High throughput | no | yes |
| GNA1_HUMAN | [view interactions] | High throughput | no | no |
| AN13D_HUMAN | [view interactions] | High throughput | no | yes |
| ACO13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2R2_HUMAN | [view interactions] | High throughput | no | no |
| ARF4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SL9B2_HUMAN | [view interactions] | High throughput | no | yes |
| ASPDH_HUMAN | [view interactions] | High throughput | no | yes |
| CAB39_HUMAN | [view interactions] | High throughput | no | yes |
| AN13A_HUMAN | [view interactions] | High throughput | no | yes |
| FUMH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DBF4B_HUMAN | [view interactions] | High throughput | no | yes |
| HCDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| ROA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF34_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI52_HUMAN | [view interactions] | High throughput | no | yes |
| IDH3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC7_HUMAN | [view interactions] | High throughput | no | no |
| LDH6A_HUMAN | [view interactions] | High throughput | no | no |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TSN17_HUMAN | [view interactions] | High throughput | no | yes |
| LDHC_HUMAN | [view interactions] | High throughput | no | no |
| UB2E2_HUMAN | [view interactions] | High throughput | no | yes |
| LEG1_HUMAN | [view interactions] | High throughput | no | yes |
| SERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PELI2_HUMAN | [view interactions] | High throughput | no | yes |
| RD23B_HUMAN | [view interactions] | High throughput | no | yes |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| SF01_HUMAN | [view interactions] | High throughput | no | yes |
| POLI_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2K_HUMAN | [view interactions] | High throughput | no | yes |
| CCD69_HUMAN | [view interactions] | High throughput | no | yes |
| UBL5_HUMAN | [view interactions] | High throughput | no | no |
| HIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACBP_HUMAN | [view interactions] | High throughput | no | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THTR_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP6_HUMAN | [view interactions] | High throughput | no | no |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KRT36_HUMAN | [view interactions] | High throughput | no | no |
| TM1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HG2A_HUMAN | [view interactions] | High throughput | no | yes |
| TOM1_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2D2_HUMAN | [view interactions] | High throughput | no | yes |
| GRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2D1_HUMAN | [view interactions] | High throughput | no | yes |
| CEP85_HUMAN | [view interactions] | High throughput | no | no |
| ZFAN5_HUMAN | [view interactions] | High throughput | no | yes |
| DCNL2_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F184A_HUMAN | [view interactions] | High throughput | no | no |
| BRE1B_HUMAN | [view interactions] | High throughput | no | yes |
| DEN6B_HUMAN | [view interactions] | High throughput | no | no |
| RB11B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TDRKH_HUMAN | [view interactions] | High throughput | no | no |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCNL1_HUMAN | [view interactions] | High throughput | no | yes |
| DJC21_HUMAN | [view interactions] | High throughput | no | yes |
| CREL1_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA4_HUMAN | [view interactions] | High throughput | no | yes |
| CAR14_HUMAN | [view interactions] | High throughput | no | no |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| ASCC2_HUMAN | [view interactions] | High throughput | no | yes |
| NRX1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ILRUN_HUMAN | [view interactions] | High throughput | no | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| CUED1_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IMPCT_HUMAN | [view interactions] | High throughput | no | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| APEX2_HUMAN | [view interactions] | High throughput | no | no |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| GGA2_HUMAN | [view interactions] | High throughput | no | yes |
| HBS1L_HUMAN | [view interactions] | High throughput | no | yes |
| EPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ST38L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| DDR1_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| EPHA6_HUMAN | [view interactions] | High throughput | no | no |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VGFR2_HUMAN | [view interactions] | High throughput | no | no |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| LMTK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMTK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MERTK_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROR1_HUMAN | [view interactions] | High throughput | no | no |
| ROS1_HUMAN | [view interactions] | High throughput | no | no |
| TIE2_HUMAN | [view interactions] | High throughput | no | no |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| IF2P_HUMAN | [view interactions] | High throughput | no | yes |
| CPNE3_HUMAN | [view interactions] | High throughput | no | yes |
| HPRT_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PYGL_HUMAN | [view interactions] | High throughput | no | yes |
| G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBS_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5E_HUMAN | [view interactions] | High throughput | no | no |
| ML12B_HUMAN | [view interactions] | High throughput | no | no |
| ZN207_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC8_HUMAN | [view interactions] | High throughput | no | yes |
| RU2B_HUMAN | [view interactions] | High throughput | no | yes |
| HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GARS_HUMAN | [view interactions] | High throughput | no | yes |
| IDHP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM12_HUMAN | [view interactions] | High throughput | no | yes |
| ARPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IPYR_HUMAN | [view interactions] | High throughput | no | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| ADRM1_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3M_HUMAN | [view interactions] | High throughput | no | yes |
| PRP31_HUMAN | [view interactions] | High throughput | no | yes |
| SIAS_HUMAN | [view interactions] | High throughput | no | yes |
| PA2G4_HUMAN | [view interactions] | High throughput | no | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| CYC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SF3A3_HUMAN | [view interactions] | High throughput | no | yes |
| AIMP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SF3A1_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF6_HUMAN | [view interactions] | High throughput | no | yes |
| SND1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRNN_HUMAN | [view interactions] | High throughput | no | no |
| SRP68_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM1_HUMAN | [view interactions] | High throughput | no | no |
| TRI50_HUMAN | [view interactions] | High throughput | no | no |
| TRI27_HUMAN | [view interactions] | High throughput | no | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| TLR4_HUMAN | [view interactions] | High throughput | no | yes |
| M3K7_HUMAN | [view interactions] | High throughput | no | yes |
| TNR5_HUMAN | [view interactions] | High throughput | no | no |
| NEMO_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RD23A_HUMAN | [view interactions] | High throughput | no | yes |
| TFE2_HUMAN | [view interactions] | High throughput | no | no |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHNO1_HUMAN | [view interactions] | High throughput | no | no |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| DZIP3_HUMAN | [view interactions] | High throughput | no | yes |
| RN123_HUMAN | [view interactions] | High throughput | no | yes |
| PPT1_HUMAN | [view interactions] | High throughput | no | yes |
| BFAR_HUMAN | [view interactions] | High throughput | no | no |
| SUZ12_HUMAN | [view interactions] | High throughput | no | no |
| TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| MEX3C_HUMAN | [view interactions] | High throughput | no | yes |
| MRP6_HUMAN | [view interactions] | High throughput | no | no |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HELLS_HUMAN | [view interactions] | High throughput | no | yes |
| STALP_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| DJC14_HUMAN | [view interactions] | High throughput | no | yes |
| APR_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| FOXA1_HUMAN | [view interactions] | High throughput | no | no |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| E2F4_HUMAN | [view interactions] | High throughput | no | no |
| HERC5_HUMAN | [view interactions] | High throughput | no | yes |
| PHOP1_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA4_HUMAN | [view interactions] | High throughput | no | no |
| LOXL2_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEK7_HUMAN | [view interactions] | High throughput | no | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LTK_HUMAN | [view interactions] | High throughput | no | no |
| ATAD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| PINX1_HUMAN | [view interactions] | High throughput | no | yes |
| STIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP48_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| FEN1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| ATG12_HUMAN | [view interactions] | High throughput | no | yes |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| DLGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBE2S_HUMAN | [view interactions] | High throughput | no | no |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2T_HUMAN | [view interactions] | High throughput | no | no |
| AMFR_HUMAN | [view interactions] | High throughput | no | yes |
| CAPS2_HUMAN | [view interactions] | High throughput | no | no |
| CNOT4_HUMAN | [view interactions] | High throughput | no | yes |
| MIB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DTX1_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| MIB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEUL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFX1_HUMAN | [view interactions] | High throughput | no | yes |
| BARD1_HUMAN | [view interactions] | High throughput | no | yes |
| PJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF13_HUMAN | [view interactions] | High throughput | no | yes |
| GOLI_HUMAN | [view interactions] | High throughput | no | yes |
| RN167_HUMAN | [view interactions] | High throughput | no | yes |
| RN182_HUMAN | [view interactions] | High throughput | no | no |
| RNF43_HUMAN | [view interactions] | High throughput | no | yes |
| SH3R2_HUMAN | [view interactions] | High throughput | no | yes |
| TOPRS_HUMAN | [view interactions] | High throughput | no | yes |
| ZNRF3_HUMAN | [view interactions] | High throughput | no | no |
| ZNRF4_HUMAN | [view interactions] | High throughput | no | no |
| XIAP_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI18_HUMAN | [view interactions] | High throughput | no | no |
| SIAH1_HUMAN | [view interactions] | High throughput | no | yes |
| MKRN3_HUMAN | [view interactions] | High throughput | no | yes |
| HOIL1_HUMAN | [view interactions] | High throughput | no | no |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| TRI54_HUMAN | [view interactions] | High throughput | no | no |
| MARH5_HUMAN | [view interactions] | High throughput | no | no |
| RFFL_HUMAN | [view interactions] | High throughput | no | yes |
| SIAH2_HUMAN | [view interactions] | High throughput | no | no |
| RN125_HUMAN | [view interactions] | High throughput | no | yes |
| UBE3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFWD3_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC8_HUMAN | [view interactions] | High throughput | no | no |
| MNS1_HUMAN | [view interactions] | High throughput | no | no |
| SDCG8_HUMAN | [view interactions] | High throughput | no | yes |
| CHIC2_HUMAN | [view interactions] | High throughput | no | no |
| TRIM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI11_HUMAN | [view interactions] | High throughput | no | yes |
| MED15_HUMAN | [view interactions] | High throughput | no | yes |