Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

UBE2N_HUMAN

The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical Lys-63-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the Lys-63-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the Lys-63-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate Lys-63-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UB2V1, catalyzes the viral RNA-dependent Lys-63-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (PubMed, PubMed). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate Lys-63-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway. [View more on UniProt]

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in UBE2N_HUMAN
GO:0046872 metal ion binding 33.0000 4 no
GO:0017076 purine nucleotide binding 31.0000 4 yes
GO:0032555 purine ribonucleotide binding 30.0000 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 30.0000 4 yes
GO:0030554 adenyl nucleotide binding 28.0000 5 yes
GO:0005524 ATP binding 27.0000 5 yes
GO:0032559 adenyl ribonucleotide binding 27.0000 5 yes
GO:0003723 RNA binding 25.0000 4 yes
GO:0019900 kinase binding 23.0000 4 no
GO:0019901 protein kinase binding 22.0000 5 no
GO:0044389 ubiquitin-like protein ligase binding 19.0000 4 yes
GO:0031625 ubiquitin protein ligase binding 18.0000 5 yes
GO:0004842 ubiquitin-protein transferase activity 13.0000 4 yes
GO:0043130 ubiquitin binding 8.0000 4 yes
GO:0061631 ubiquitin conjugating enzyme activity 2.0000 5 yes
GO:0061650 ubiquitin-like protein conjugating enzyme activity 2.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in UBE2N_HUMAN
GO:0048522 positive regulation of cellular process 62.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 59.0000 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 55.0000 4 yes
GO:0080090 regulation of primary metabolic process 55.0000 4 yes
GO:0009893 positive regulation of metabolic process 54.0000 4 yes
GO:0031323 regulation of cellular metabolic process 54.0000 4 yes
GO:0048523 negative regulation of cellular process 51.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 48.0000 5 yes
GO:0010646 regulation of cell communication 48.0000 4 yes
GO:0009966 regulation of signal transduction 46.0000 4 yes
GO:0031325 positive regulation of cellular metabolic process 43.0000 5 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 43.0000 5 yes
GO:0051246 regulation of protein metabolic process 42.0000 5 yes
GO:0036211 protein modification process 41.0000 4 yes
GO:0043412 macromolecule modification 41.0000 4 yes
GO:0010468 regulation of gene expression 40.0000 5 yes
GO:0051128 regulation of cellular component organization 37.0000 4 no
GO:0048584 positive regulation of response to stimulus 36.0000 4 yes
GO:0010941 regulation of cell death 36.0000 4 no
GO:0042981 regulation of apoptotic process 35.0000 6 no
GO:0043067 regulation of programmed cell death 35.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.0000 5 yes
GO:0051247 positive regulation of protein metabolic process 33.0000 6 yes
GO:1902531 regulation of intracellular signal transduction 33.0000 5 yes
GO:0009889 regulation of biosynthetic process 32.0000 4 yes
GO:0031326 regulation of cellular biosynthetic process 32.0000 5 yes
GO:0010647 positive regulation of cell communication 30.0000 5 yes
GO:0023056 positive regulation of signaling 30.0000 4 yes
GO:0009967 positive regulation of signal transduction 29.0000 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 29.0000 5 yes
GO:0031399 regulation of protein modification process 28.0000 6 yes
GO:0009892 negative regulation of metabolic process 28.0000 4 no
GO:0051252 regulation of RNA metabolic process 27.0000 5 yes
GO:0022607 cellular component assembly 27.0000 4 no
GO:0043085 positive regulation of catalytic activity 26.0000 4 yes
GO:0080134 regulation of response to stress 26.0000 4 yes
GO:0031401 positive regulation of protein modification process 25.0000 7 yes
GO:0010605 negative regulation of macromolecule metabolic process 25.0000 5 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:0006355 regulation of DNA-templated transcription 24.0000 6 yes
GO:0070647 protein modification by small protein conjugation or removal 24.0000 5 yes
GO:1903506 regulation of nucleic acid-templated transcription 24.0000 7 yes
GO:2001141 regulation of RNA biosynthetic process 24.0000 6 yes
GO:0008104 protein localization 24.0000 4 no
GO:0006996 organelle organization 24.0000 4 no
GO:0032446 protein modification by small protein conjugation 23.0000 6 yes
GO:0051338 regulation of transferase activity 23.0000 4 yes
GO:0080135 regulation of cellular response to stress 23.0000 4 yes
GO:0010648 negative regulation of cell communication 23.0000 5 no
GO:0023057 negative regulation of signaling 23.0000 4 no
GO:0048585 negative regulation of response to stimulus 23.0000 4 no
GO:0016567 protein ubiquitination 22.0000 7 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 22.0000 6 yes
GO:1902533 positive regulation of intracellular signal transduction 22.0000 6 yes
GO:0009894 regulation of catabolic process 22.0000 4 no
GO:0051130 positive regulation of cellular component organization 22.0000 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 22.0000 5 no
GO:0060548 negative regulation of cell death 22.0000 5 no
GO:0019220 regulation of phosphate metabolic process 22.0000 6 no
GO:0051174 regulation of phosphorus metabolic process 22.0000 5 no
GO:0006508 proteolysis 21.0000 4 yes
GO:0009057 macromolecule catabolic process 21.0000 4 yes
GO:0051049 regulation of transport 21.0000 4 no
GO:0009891 positive regulation of biosynthetic process 21.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 21.0000 6 no
GO:0044087 regulation of cellular component biogenesis 21.0000 4 no
GO:0009968 negative regulation of signal transduction 21.0000 5 no
GO:0031324 negative regulation of cellular metabolic process 21.0000 5 no
GO:0010243 response to organonitrogen compound 21.0000 4 no
GO:0051347 positive regulation of transferase activity 20.0000 5 yes
GO:0090304 nucleic acid metabolic process 18.0000 4 yes
GO:0044265 cellular macromolecule catabolic process 17.0000 4 yes
GO:0051603 proteolysis involved in protein catabolic process 17.0000 5 yes
GO:0019941 modification-dependent protein catabolic process 16.0000 6 yes
GO:0043632 modification-dependent macromolecule catabolic process 16.0000 5 yes
GO:0006259 DNA metabolic process 13.0000 4 yes
GO:0006974 cellular response to DNA damage stimulus 13.0000 4 yes
GO:0050776 regulation of immune response 13.0000 4 yes
GO:0051052 regulation of DNA metabolic process 13.0000 5 yes
GO:1903320 regulation of protein modification by small protein conjugation or removal 13.0000 7 yes
GO:0006281 DNA repair 12.0000 5 yes
GO:0006511 ubiquitin-dependent protein catabolic process 12.0000 7 yes
GO:0000209 protein polyubiquitination 11.0000 8 yes
GO:0031396 regulation of protein ubiquitination 11.0000 8 yes
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 11.0000 6 yes
GO:0051054 positive regulation of DNA metabolic process 11.0000 6 yes
GO:0051091 positive regulation of DNA-binding transcription factor activity 10.0000 4 yes
GO:1903322 positive regulation of protein modification by small protein conjugation or removal 10.0000 8 yes
GO:2001020 regulation of response to DNA damage stimulus 10.0000 5 yes
GO:0002684 positive regulation of immune system process 9.0000 4 yes
GO:0031398 positive regulation of protein ubiquitination 9.0000 9 yes
GO:0006282 regulation of DNA repair 8.0000 6 yes
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 8.0000 7 yes
GO:0051092 positive regulation of NF-kappaB transcription factor activity 8.0000 5 yes
GO:0006302 double-strand break repair 7.0000 6 yes
GO:0070534 protein K63-linked ubiquitination 7.0000 9 yes
GO:2000779 regulation of double-strand break repair 7.0000 7 yes
GO:0006301 postreplication repair 6.0000 6 yes
GO:0045739 positive regulation of DNA repair 6.0000 6 yes
GO:1902914 regulation of protein polyubiquitination 6.0000 9 yes
GO:2000781 positive regulation of double-strand break repair 6.0000 7 yes
GO:2001022 positive regulation of response to DNA damage stimulus 6.0000 5 yes
GO:0031056 regulation of histone modification 5.0000 7 yes
GO:0050778 positive regulation of immune response 5.0000 5 yes
GO:1902916 positive regulation of protein polyubiquitination 5.0000 10 yes
GO:0031058 positive regulation of histone modification 4.0000 8 yes
GO:1900044 regulation of protein K63-linked ubiquitination 4.0000 10 yes
GO:1902523 positive regulation of protein K63-linked ubiquitination 4.0000 11 yes
GO:0000724 double-strand break repair via homologous recombination 3.0000 7 yes
GO:0000725 recombinational repair 3.0000 6 yes
GO:0000729 DNA double-strand break processing 3.0000 5 yes
GO:0002768 immune response-regulating cell surface receptor signaling pathway 3.0000 4 yes
GO:0006310 DNA recombination 3.0000 5 yes
GO:0051438 regulation of ubiquitin-protein transferase activity 3.0000 5 yes
GO:0051443 positive regulation of ubiquitin-protein transferase activity 3.0000 6 yes
GO:0002429 immune response-activating cell surface receptor signaling pathway 2.0000 4 yes
GO:0016570 histone modification 2.0000 5 yes
GO:0016574 histone ubiquitination 2.0000 6 yes
GO:0033182 regulation of histone ubiquitination 2.0000 8 yes
GO:0050851 antigen receptor-mediated signaling pathway 2.0000 5 yes
GO:0050852 T cell receptor signaling pathway 2.0000 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in UBE2N_HUMAN
DOID:0050686 organ system cancer 3.0000 3 no
DOID:0050700 cardiomyopathy 3.0000 4 no
DOID:0060036 intrinsic cardiomyopathy 3.0000 5 no
DOID:114 heart disease 3.0000 3 no
DOID:1289 neurodegenerative disease 3.0000 4 no
DOID:331 central nervous system disease 3.0000 3 no
DOID:10595 Charcot-Marie-Tooth disease 3.0000 6 no
DOID:440 neuromuscular disease 3.0000 5 no
DOID:574 peripheral nervous system disease 3.0000 3 no
DOID:870 neuropathy 3.0000 4 no
DOID:2843 long QT syndrome 2.0000 6 no
DOID:12377 spinal muscular atrophy 2.0000 6 no
DOID:231 motor neuron disease 2.0000 5 no
DOID:0050539 Charcot-Marie-Tooth disease type 2 2.0000 7 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ZNRF2_HUMAN [view interactions] Low throughput no yes
UBA1_HUMAN [view entry] [view interactions] Low throughput yes yes
RO52_HUMAN [view interactions] Low throughput no yes
TRI23_HUMAN [view interactions] Low throughput no yes
RNF4_HUMAN [view interactions] Low throughput no yes
RN111_HUMAN [view interactions] Low throughput no yes
RN135_HUMAN [view interactions] Low throughput no yes
PELI1_HUMAN [view interactions] Low throughput no yes
RN122_HUMAN [view interactions] Low throughput no yes
RS27A_HUMAN [view entry] [view interactions] Low throughput yes yes
UBB_HUMAN [view entry] [view interactions] Low throughput yes yes
LNX1_HUMAN [view interactions] Low throughput no yes
PDES1_HUMAN [view interactions] Low throughput no no
BRCA1_HUMAN [view interactions] Low throughput no yes
ARI2_HUMAN [view interactions] Low throughput no no
NEPR1_HUMAN [view interactions] Low throughput no yes
BIRC2_HUMAN [view interactions] Low throughput no yes
RN213_HUMAN [view interactions] Low throughput no yes
AURKA_HUMAN [view entry] [view interactions] Low throughput yes no
P53_HUMAN [view interactions] Low throughput no no
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
HERC2_HUMAN [view interactions] Low throughput no yes
TNAP3_HUMAN [view interactions] Low throughput no yes
ISG15_HUMAN [view interactions] Low throughput no no
PYC_HUMAN [view entry] [view interactions] Low throughput yes yes
PCCA_HUMAN [view entry] [view interactions] Low throughput yes yes
ACACA_HUMAN [view entry] [view interactions] Low throughput yes yes
PCCB_HUMAN [view interactions] Low throughput no yes
PRKN_HUMAN [view entry] [view interactions] Low throughput yes yes
ARI1_HUMAN [view interactions] Low throughput no yes
MFN2_HUMAN [view entry] [view interactions] Low throughput yes yes
TNFA_HUMAN [view interactions] Low throughput no no
NHLC1_HUMAN [view interactions] Low throughput no no
RHDF2_HUMAN [view interactions] Low throughput no yes
RNF11_HUMAN [view interactions] Low throughput no yes
UB2V2_HUMAN [view entry] [view interactions] Low throughput yes no
SIR1_HUMAN [view interactions] Low throughput no yes
CHFR_HUMAN [view interactions] Low throughput no no
ZNRF1_HUMAN [view interactions] Low throughput no yes
UB2V1_HUMAN [view entry] [view interactions] Low throughput yes no
M3K1_HUMAN [view interactions] Low throughput no yes
TRAF6_HUMAN [view interactions] Low throughput no yes
CDK6_HUMAN [view interactions] Low throughput no yes
OTUB1_HUMAN [view interactions] Low throughput no yes
CHIP_HUMAN [view entry] [view interactions] Low throughput yes yes
SHPRH_HUMAN [view interactions] Low throughput no yes
HLTF_HUMAN [view interactions] Low throughput no no
IL1B_HUMAN [view interactions] Low throughput no no
HS90A_HUMAN [view entry] [view interactions] Low throughput yes yes
RN128_HUMAN [view interactions] Low throughput no yes
OTUB2_HUMAN [view interactions] Low throughput no no
SH3R1_HUMAN [view interactions] Low throughput no yes
MYLIP_HUMAN [view interactions] Low throughput no no
TRI17_HUMAN [view interactions] Low throughput no yes
TRI39_HUMAN [view interactions] Low throughput no no
RNF5_HUMAN [view interactions] Low throughput no yes
NBN_HUMAN [view interactions] Low throughput no yes
RN168_HUMAN [view interactions] Low throughput no no
RN126_HUMAN [view interactions] Low throughput no yes
RN115_HUMAN [view interactions] Low throughput no yes
PELI3_HUMAN [view interactions] Low throughput no yes
TRAF2_HUMAN [view interactions] Low throughput no yes
TRI72_HUMAN [view interactions] Low throughput no no
NED4L_HUMAN [view interactions] Low throughput no yes
BIRC3_HUMAN [view interactions] Low throughput no no
UBE2N_HUMAN [view entry] [view interactions] Low throughput yes yes
TRI33_HUMAN [view interactions] Low throughput no yes
BCL10_HUMAN [view interactions] Low throughput no yes
MALT1_HUMAN [view interactions] Low throughput no no
DTL_HUMAN [view interactions] Low throughput no no
RNF41_HUMAN [view interactions] Low throughput no yes
LRSM1_HUMAN [view entry] [view interactions] Low throughput yes yes
RN103_HUMAN [view interactions] Low throughput no no
RN181_HUMAN [view interactions] Low throughput no no
FA12_HUMAN [view interactions] Low throughput no no
TRI69_HUMAN [view interactions] Low throughput no no
TRI63_HUMAN [view interactions] Low throughput no no
MUL1_HUMAN [view interactions] Low throughput no no
RN152_HUMAN [view interactions] Low throughput no no
RN165_HUMAN [view interactions] Low throughput no no
UHRF1_HUMAN [view interactions] Low throughput no yes
CBL_HUMAN [view interactions] Low throughput no yes
RNF38_HUMAN [view interactions] Low throughput no yes
TRI65_HUMAN [view interactions] Low throughput no yes
TRI32_HUMAN [view entry] [view interactions] Low throughput yes yes
TREX2_HUMAN [view interactions] Low throughput no no
TRI15_HUMAN [view interactions] Low throughput no no
IKKA_HUMAN [view interactions] Low throughput no yes
RIPK1_HUMAN [view interactions] Low throughput no yes
CCNB1_HUMAN [view interactions] Low throughput no no
PTTG1_HUMAN [view interactions] Low throughput no no
H2A1B_HUMAN [view interactions] Low throughput no yes
RNF8_HUMAN [view interactions] Low throughput no yes
TRI25_HUMAN [view interactions] Low throughput no yes
TRIM5_HUMAN [view interactions] Low throughput no yes
MARH7_HUMAN [view interactions] Low throughput no yes
MED15_HUMAN [view interactions] High throughput no yes
ARF4_HUMAN [view entry] [view interactions] High throughput yes no
TRI11_HUMAN [view interactions] High throughput no yes
ASPD_HUMAN [view interactions] High throughput no yes
CAB39_HUMAN [view interactions] High throughput no yes
FUMH_HUMAN [view entry] [view interactions] High throughput yes yes
CHIC2_HUMAN [view interactions] High throughput no no
HCDH_HUMAN [view entry] [view interactions] High throughput yes yes
RIOK3_HUMAN [view interactions] High throughput no yes
ROA3_HUMAN [view entry] [view interactions] High throughput yes yes
THA_HUMAN [view interactions] High throughput no yes
HSPB1_HUMAN [view entry] [view interactions] High throughput yes no
IDH3A_HUMAN [view entry] [view interactions] High throughput yes yes
RET2_HUMAN [view interactions] High throughput no no
LDH6A_HUMAN [view interactions] High throughput no no
LDHB_HUMAN [view entry] [view interactions] High throughput yes yes
UB2E1_HUMAN [view interactions] High throughput no yes
LDHC_HUMAN [view interactions] High throughput no no
UB2D3_HUMAN [view interactions] High throughput no yes
LEG1_HUMAN [view interactions] High throughput no yes
NUDT6_HUMAN [view interactions] High throughput no yes
SERA_HUMAN [view entry] [view interactions] High throughput yes yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
RD23B_HUMAN [view interactions] High throughput no yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
SF01_HUMAN [view interactions] High throughput no yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2K_HUMAN [view interactions] High throughput no yes
UBL5_HUMAN [view interactions] High throughput no no
CBLB_HUMAN [view interactions] High throughput no yes
STXB1_HUMAN [view entry] [view interactions] High throughput yes yes
ACOX1_HUMAN [view interactions] High throughput no yes
ACBP_HUMAN [view interactions] High throughput no yes
INT3_HUMAN [view interactions] High throughput no yes
PEBP1_HUMAN [view entry] [view interactions] High throughput yes yes
MFSD6_HUMAN [view interactions] High throughput no yes
THTR_HUMAN [view interactions] High throughput no yes
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
UB2R2_HUMAN [view interactions] High throughput no no
TM1L2_HUMAN [view entry] [view interactions] High throughput yes yes
SL9B2_HUMAN [view interactions] High throughput no yes
TOM1_HUMAN [view interactions] High throughput no yes
AN13D_HUMAN [view interactions] High throughput no yes
FBX7_HUMAN [view interactions] High throughput no yes
AN13A_HUMAN [view interactions] High throughput no yes
UB2D2_HUMAN [view interactions] High throughput no yes
UB2D1_HUMAN [view interactions] High throughput no yes
DBF4B_HUMAN [view interactions] High throughput no yes
ZFAN5_HUMAN [view interactions] High throughput no yes
RHBL4_HUMAN [view interactions] High throughput no no
UBXN6_HUMAN [view entry] [view interactions] High throughput yes yes
RNF34_HUMAN [view interactions] High throughput no no
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
TRI52_HUMAN [view interactions] High throughput no yes
DJC21_HUMAN [view interactions] High throughput no yes
BIRC7_HUMAN [view interactions] High throughput no no
PDIA4_HUMAN [view interactions] High throughput no yes
MLP3B_HUMAN [view interactions] High throughput no yes
UB2E2_HUMAN [view interactions] High throughput no yes
TSN17_HUMAN [view interactions] High throughput no yes
PELI2_HUMAN [view interactions] High throughput no yes
SMUF1_HUMAN [view interactions] High throughput no yes
POLI_HUMAN [view interactions] High throughput no yes
CCD69_HUMAN [view interactions] High throughput no yes
HIP1_HUMAN [view entry] [view interactions] High throughput yes yes
HGS_HUMAN [view entry] [view interactions] High throughput yes yes
DNJB6_HUMAN [view entry] [view interactions] High throughput yes yes
HIP1R_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP6_HUMAN [view interactions] High throughput no no
KRT36_HUMAN [view interactions] High throughput no no
HG2A_HUMAN [view interactions] High throughput no yes
DNJB2_HUMAN [view entry] [view interactions] High throughput yes yes
EPHA1_HUMAN [view interactions] High throughput no yes
GRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
CEP85_HUMAN [view interactions] High throughput no no
DCNL2_HUMAN [view interactions] High throughput no yes
F184A_HUMAN [view interactions] High throughput no no
DEN6B_HUMAN [view interactions] High throughput no no
BAP1_HUMAN [view interactions] High throughput no yes
FAF2_HUMAN [view interactions] High throughput no yes
CREL1_HUMAN [view interactions] High throughput no yes
DCNL1_HUMAN [view interactions] High throughput no yes
CAR14_HUMAN [view interactions] High throughput no no
ASCC2_HUMAN [view interactions] High throughput no yes
ILRUN_HUMAN [view interactions] High throughput no yes
CUED1_HUMAN [view interactions] High throughput no yes
IMPCT_HUMAN [view interactions] High throughput no yes
APEX2_HUMAN [view interactions] High throughput no no
DP13A_HUMAN [view entry] [view interactions] High throughput yes yes
GGA2_HUMAN [view interactions] High throughput no yes
HBS1L_HUMAN [view interactions] High throughput no yes
EPN1_HUMAN [view entry] [view interactions] High throughput yes yes
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
ST38L_HUMAN [view entry] [view interactions] High throughput yes yes
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
UFO_HUMAN [view interactions] High throughput no no
DDR1_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
EPHA6_HUMAN [view interactions] High throughput no no
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
FGFR3_HUMAN [view interactions] High throughput no yes
VGFR1_HUMAN [view interactions] High throughput no no
VGFR3_HUMAN [view interactions] High throughput no yes
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
VGFR2_HUMAN [view interactions] High throughput no no
LMTK1_HUMAN [view interactions] High throughput no yes
LMTK2_HUMAN [view entry] [view interactions] High throughput yes yes
LMTK3_HUMAN [view entry] [view interactions] High throughput yes yes
MERTK_HUMAN [view interactions] High throughput no yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
ROR1_HUMAN [view interactions] High throughput no no
ROS1_HUMAN [view interactions] High throughput no no
TIE2_HUMAN [view interactions] High throughput no no
HOOK2_HUMAN [view interactions] High throughput no yes
IF2P_HUMAN [view interactions] High throughput no yes
CPNE3_HUMAN [view interactions] High throughput no yes
HPRT_HUMAN [view interactions] High throughput no yes
ANXA5_HUMAN [view entry] [view interactions] High throughput yes no
VIME_HUMAN [view entry] [view interactions] High throughput yes no
G6PI_HUMAN [view entry] [view interactions] High throughput yes yes
PYGL_HUMAN [view interactions] High throughput no yes
PLST_HUMAN [view interactions] High throughput no yes
PDIA3_HUMAN [view entry] [view interactions] High throughput yes yes
CBS_HUMAN [view interactions] High throughput no yes
ATP5E_HUMAN [view interactions] High throughput no no
VINC_HUMAN [view entry] [view interactions] High throughput yes no
HMGB1_HUMAN [view interactions] High throughput no yes
RU2B_HUMAN [view interactions] High throughput no yes
DNJC8_HUMAN [view interactions] High throughput no yes
CISY_HUMAN [view entry] [view interactions] High throughput yes yes
ZN207_HUMAN [view interactions] High throughput no yes
ML12B_HUMAN [view interactions] High throughput no no
KAPCA_HUMAN [view entry] [view interactions] High throughput yes yes
ZYX_HUMAN [view interactions] High throughput no no
ADRM1_HUMAN [view interactions] High throughput no yes
ARPC4_HUMAN [view entry] [view interactions] High throughput yes no
RM12_HUMAN [view interactions] High throughput no yes
IDHP_HUMAN [view entry] [view interactions] High throughput yes yes
GARS_HUMAN [view interactions] High throughput no yes
ECHM_HUMAN [view interactions] High throughput no yes
PA2G4_HUMAN [view interactions] High throughput no yes
SIAS_HUMAN [view interactions] High throughput no yes
PRP31_HUMAN [view interactions] High throughput no yes
EIF3M_HUMAN [view interactions] High throughput no yes
IPYR_HUMAN [view interactions] High throughput no yes
CYC_HUMAN [view entry] [view interactions] High throughput yes yes
AIMP1_HUMAN [view interactions] High throughput no yes
SF3A3_HUMAN [view interactions] High throughput no yes
TRAP1_HUMAN [view entry] [view interactions] High throughput yes yes
SF3A1_HUMAN [view interactions] High throughput no yes
CPSF6_HUMAN [view interactions] High throughput no yes
SND1_HUMAN [view entry] [view interactions] High throughput yes yes
CRNN_HUMAN [view interactions] High throughput no no
SRP68_HUMAN [view interactions] High throughput no yes
TRIM1_HUMAN [view interactions] High throughput no no
TRI50_HUMAN [view interactions] High throughput no no
TRI27_HUMAN [view interactions] High throughput no yes
TRI14_HUMAN [view interactions] High throughput no yes
TAXB1_HUMAN [view interactions] High throughput no yes
TLR4_HUMAN [view interactions] High throughput no yes
M3K7_HUMAN [view interactions] High throughput no yes
TNR5_HUMAN [view interactions] High throughput no no
NEMO_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
RD23A_HUMAN [view interactions] High throughput no yes
TFE2_HUMAN [view interactions] High throughput no no
CDK2_HUMAN [view interactions] High throughput no yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
RHNO1_HUMAN [view interactions] High throughput no no
EED_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
DERL1_HUMAN [view interactions] High throughput no yes
FACD2_HUMAN [view interactions] High throughput no no
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
U5S1_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
PIHD1_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
DZIP3_HUMAN [view interactions] High throughput no yes
PPT1_HUMAN [view interactions] High throughput no yes
SUZ12_HUMAN [view interactions] High throughput no no
BFAR_HUMAN [view interactions] High throughput no no
TCTP_HUMAN [view entry] [view interactions] High throughput yes yes
NR2C2_HUMAN [view interactions] High throughput no yes
MEX3C_HUMAN [view interactions] High throughput no yes
MRP6_HUMAN [view interactions] High throughput no no
LRRK2_HUMAN [view interactions] High throughput no yes
GLUT4_HUMAN [view interactions] High throughput no no
HELLS_HUMAN [view interactions] High throughput no yes
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4C_HUMAN [view interactions] High throughput no yes
STALP_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
KIF1C_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
PPIA_HUMAN [view entry] [view interactions] High throughput yes yes
DJC14_HUMAN [view interactions] High throughput no yes
APR_HUMAN [view interactions] High throughput no yes
FSCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CAV1_HUMAN [view interactions] High throughput no no
SAR1B_HUMAN [view interactions] High throughput no yes
FINC_HUMAN [view interactions] High throughput no yes
VCAM1_HUMAN [view interactions] High throughput no no
FEN1_HUMAN [view interactions] High throughput no yes
DLDH_HUMAN [view entry] [view interactions] High throughput yes yes
ATG12_HUMAN [view interactions] High throughput no yes
SODC_HUMAN [view interactions] High throughput no yes
RIT1_HUMAN [view interactions] High throughput no yes
PHOP1_HUMAN [view interactions] High throughput no no
HTRA4_HUMAN [view interactions] High throughput no no
RIPK4_HUMAN [view interactions] High throughput no no
MIB2_HUMAN [view interactions] High throughput no yes
NEK7_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
AATC_HUMAN [view entry] [view interactions] High throughput yes yes
LTK_HUMAN [view interactions] High throughput no no
VHL_HUMAN [view entry] [view interactions] High throughput yes yes
PINX1_HUMAN [view interactions] High throughput no yes
NDKB_HUMAN [view entry] [view interactions] High throughput yes yes
BARD1_HUMAN [view interactions] High throughput no yes
AAKB1_HUMAN [view interactions] High throughput no yes
MDM2_HUMAN [view interactions] High throughput no yes
IKKE_HUMAN [view interactions] High throughput no yes
SNW1_HUMAN [view interactions] High throughput no yes
CDC5L_HUMAN [view interactions] High throughput no yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
AMFR_HUMAN [view interactions] High throughput no yes
CNOT4_HUMAN [view interactions] High throughput no yes
CAPS2_HUMAN [view interactions] High throughput no no
DTX1_HUMAN [view interactions] High throughput no yes
MIB1_HUMAN [view entry] [view interactions] High throughput yes yes
RC3H1_HUMAN [view interactions] High throughput no yes
NEUL1_HUMAN [view entry] [view interactions] High throughput yes yes
NFX1_HUMAN [view interactions] High throughput no yes
PJA2_HUMAN [view entry] [view interactions] High throughput yes yes
RNF13_HUMAN [view interactions] High throughput no yes
GOLI_HUMAN [view interactions] High throughput no yes
TRI54_HUMAN [view interactions] High throughput no no
RFFL_HUMAN [view interactions] High throughput no yes
RN167_HUMAN [view interactions] High throughput no yes
SIAH2_HUMAN [view interactions] High throughput no no
UBE3A_HUMAN [view interactions] High throughput no yes
RN182_HUMAN [view interactions] High throughput no no
SH3R2_HUMAN [view interactions] High throughput no yes
RNF43_HUMAN [view interactions] High throughput no yes
TOPRS_HUMAN [view interactions] High throughput no yes
ZNRF3_HUMAN [view interactions] High throughput no no
ZNRF4_HUMAN [view interactions] High throughput no no
XIAP_HUMAN [view interactions] High throughput no yes
TRI18_HUMAN [view interactions] High throughput no no
SIAH1_HUMAN [view interactions] High throughput no yes
MKRN3_HUMAN [view interactions] High throughput no yes
HOIL1_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
VATH_HUMAN [view entry] [view interactions] High throughput yes yes
RC3H2_HUMAN [view interactions] High throughput no yes
VP33B_HUMAN [view interactions] High throughput no yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
MARH5_HUMAN [view interactions] High throughput no no
TXD17_HUMAN [view interactions] High throughput no yes
RN125_HUMAN [view interactions] High throughput no yes
SARDH_HUMAN [view interactions] High throughput no yes
RFWD3_HUMAN [view interactions] High throughput no yes
UFD1_HUMAN [view interactions] High throughput no no
VASP_HUMAN [view interactions] High throughput no yes
ARP2_HUMAN [view entry] [view interactions] High throughput yes yes
BIRC8_HUMAN [view interactions] High throughput no no
AT2B3_HUMAN [view entry] [view interactions] High throughput yes yes
MNS1_HUMAN [view interactions] High throughput no no
GNA1_HUMAN [view interactions] High throughput no no
SDCG8_HUMAN [view interactions] High throughput no yes
ACO13_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2F_HUMAN [view interactions] Computational no yes
TCAM1_HUMAN [view interactions] Computational no yes
XPC_HUMAN [view interactions] Computational no yes
TERA_HUMAN [view entry] [view interactions] Computational yes yes
MP2K3_HUMAN [view entry] [view interactions] Computational yes yes
TF2H4_HUMAN [view interactions] Computational no no
BRCC3_HUMAN [view interactions] Computational no no
TF2H1_HUMAN [view interactions] Computational no yes
PARP1_HUMAN [view entry] [view interactions] Computational yes yes
H2AX_HUMAN [view interactions] Computational no yes
UB2D4_HUMAN [view interactions] Computational no yes
UBE2U_HUMAN [view interactions] Computational no no
UB2Q2_HUMAN [view interactions] Computational no no
CHK2_HUMAN [view interactions] Computational no yes
TLR7_HUMAN [view interactions] Computational no no
SUMO3_HUMAN [view interactions] Computational no yes
TAB1_HUMAN [view interactions] Computational no yes
TAB2_HUMAN [view interactions] Computational no yes
MYD88_HUMAN [view entry] [view interactions] Computational yes yes
ERCC2_HUMAN [view interactions] Computational no yes
BRE1B_HUMAN [view interactions] Computational no yes
UBE2A_HUMAN [view interactions] Computational no no
TRAF5_HUMAN [view interactions] Computational no yes
CD14_HUMAN [view interactions] Computational no no
XPA_HUMAN [view interactions] Computational no yes
TAB3_HUMAN [view interactions] Computational no yes
UBE2B_HUMAN [view interactions] Computational no no
RAD50_HUMAN [view interactions] Computational no yes
CAR11_HUMAN [view interactions] Computational no no
RL40_HUMAN [view entry] [view interactions] Computational yes yes
UB2R1_HUMAN [view interactions] Computational no yes
UBE2S_HUMAN [view interactions] Computational no no
REV3L_HUMAN [view entry] [view interactions] Computational yes yes
UBE2O_HUMAN [view interactions] Computational no yes
UBC12_HUMAN [view entry] [view interactions] Computational yes yes
KAT5_HUMAN [view interactions] Computational no yes
RAD52_HUMAN [view interactions] Computational no no
IRF7_HUMAN [view interactions] Computational no yes
ERCC3_HUMAN [view interactions] Computational no yes
PDPK1_HUMAN [view entry] [view interactions] Computational yes yes
DDB2_HUMAN [view interactions] Computational no yes
UBE2C_HUMAN [view interactions] Computational no yes
RBX1_HUMAN [view entry] [view interactions] Computational yes no
TCAM2_HUMAN [view interactions] Computational no no
UBA3_HUMAN [view interactions] Computational no yes
PIAS4_HUMAN [view interactions] Computational no yes
IKKB_HUMAN [view interactions] Computational no yes
LY96_HUMAN [view interactions] Computational no no
UBA5_HUMAN [view interactions] Computational no yes
CETN2_HUMAN [view interactions] Computational no yes
TF2H3_HUMAN [view interactions] Computational no yes
UBA6_HUMAN [view interactions] Computational no no
CUL4A_HUMAN [view interactions] Computational no no
UB2G2_HUMAN [view interactions] Computational no yes
MP2K4_HUMAN [view interactions] Computational no yes
REV1_HUMAN [view interactions] Computational no yes
MDC1_HUMAN [view interactions] Computational no yes
RAD18_HUMAN [view interactions] Computational no yes
PPP5_HUMAN [view entry] [view interactions] Computational yes yes
UBE2H_HUMAN [view interactions] Computational no yes
IRAK1_HUMAN [view interactions] Computational no yes
CHD1L_HUMAN [view interactions] Computational no yes
RAD51_HUMAN [view interactions] Computational no yes
POLH_HUMAN [view interactions] Computational no yes
TF2H5_HUMAN [view interactions] Computational no no
SUMO2_HUMAN [view interactions] Computational no yes
UB2G1_HUMAN [view interactions] Computational no yes
MP2K7_HUMAN [view entry] [view interactions] Computational yes yes
TRAF3_HUMAN [view entry] [view interactions] Computational yes yes
TF2H2_HUMAN [view interactions] Computational no no
BRE1A_HUMAN [view interactions] Computational no yes
UB2E3_HUMAN [view interactions] Computational no yes
PARP2_HUMAN [view interactions] Computational no yes
KPCT_HUMAN [view interactions] Computational no no
UB2L6_HUMAN [view interactions] Computational no no
ATG7_HUMAN [view interactions] Computational no yes
ATM_HUMAN [view interactions] Computational no yes
MRE11_HUMAN [view interactions] Computational no yes
IKBA_HUMAN [view interactions] Computational no yes
UIMC1_HUMAN [view interactions] Computational no no
MP2K6_HUMAN [view interactions] Computational no yes
PCNA_HUMAN [view interactions] Computational no no
UB2Q1_HUMAN [view interactions] Computational no no
TP53B_HUMAN [view entry] [view interactions] Computational yes yes
UB2J2_HUMAN [view interactions] Computational no no
UBE2Z_HUMAN [view interactions] Computational no yes
UB2J1_HUMAN [view interactions] Computational no yes
UBC9_HUMAN [view interactions] Computational no yes
TLR3_HUMAN [view interactions] Computational no yes
DDB1_HUMAN [view interactions] Computational no yes
SUMO1_HUMAN [view interactions] Computational no yes
UBA7_HUMAN [view interactions] Computational no yes