Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RNF34_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed). May mediate Lys-48-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed). Possibly involved in innate immunity, through Lys-48-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RNF34_HUMAN
GO:0000166 nucleotide binding 50.0000 4 no
GO:0005524 ATP binding 50.0000 5 no
GO:0017076 purine nucleotide binding 50.0000 5 no
GO:0030554 adenyl nucleotide binding 50.0000 6 no
GO:0032555 purine ribonucleotide binding 50.0000 4 no
GO:0032559 adenyl ribonucleotide binding 50.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 50.0000 4 no
GO:0043168 anion binding 50.0000 4 no
GO:0031625 ubiquitin protein ligase binding 41.6667 5 yes
GO:0043169 cation binding 41.6667 4 yes
GO:0044389 ubiquitin-like protein ligase binding 41.6667 4 yes
GO:0046872 metal ion binding 41.6667 5 yes
GO:0004842 ubiquitin-protein transferase activity 25.0000 4 yes
GO:0016755 aminoacyltransferase activity 25.0000 4 yes
GO:0003723 RNA binding 25.0000 4 no
GO:0035091 phosphatidylinositol binding 16.6667 4 yes
GO:0061630 ubiquitin protein ligase activity 16.6667 5 yes
GO:0061659 ubiquitin-like protein ligase activity 16.6667 4 yes
GO:1901981 phosphatidylinositol phosphate binding 16.6667 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RNF34_HUMAN
GO:0031323 regulation of cellular metabolic process 75.0000 4 yes
GO:0060255 regulation of macromolecule metabolic process 75.0000 4 yes
GO:0080090 regulation of primary metabolic process 75.0000 4 yes
GO:0048523 negative regulation of cellular process 66.6667 4 yes
GO:0002684 positive regulation of immune system process 58.3333 4 yes
GO:0010646 regulation of cell communication 58.3333 4 yes
GO:0036211 protein modification process 58.3333 4 yes
GO:0043412 macromolecule modification 58.3333 4 yes
GO:0051246 regulation of protein metabolic process 58.3333 5 yes
GO:0080134 regulation of response to stress 58.3333 4 yes
GO:0048522 positive regulation of cellular process 58.3333 4 no
GO:0009892 negative regulation of metabolic process 50.0000 4 yes
GO:0009966 regulation of signal transduction 50.0000 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 50.0000 5 yes
GO:0048584 positive regulation of response to stimulus 50.0000 4 yes
GO:1902531 regulation of intracellular signal transduction 50.0000 5 yes
GO:0009893 positive regulation of metabolic process 50.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 no
GO:0009889 regulation of biosynthetic process 50.0000 4 no
GO:0010468 regulation of gene expression 50.0000 6 no
GO:0010556 regulation of macromolecule biosynthetic process 50.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 50.0000 5 no
GO:0006915 apoptotic process 41.6667 4 yes
GO:0009057 macromolecule catabolic process 41.6667 4 yes
GO:0016567 protein ubiquitination 41.6667 8 yes
GO:0031347 regulation of defense response 41.6667 5 yes
GO:0032101 regulation of response to external stimulus 41.6667 4 yes
GO:0032446 protein modification by small protein conjugation 41.6667 7 yes
GO:0043687 post-translational protein modification 41.6667 5 yes
GO:0048585 negative regulation of response to stimulus 41.6667 4 yes
GO:0050776 regulation of immune response 41.6667 4 yes
GO:0070647 protein modification by small protein conjugation or removal 41.6667 6 yes
GO:0006996 organelle organization 41.6667 4 no
GO:0031399 regulation of protein modification process 41.6667 6 no
GO:0031401 positive regulation of protein modification process 41.6667 7 no
GO:0051247 positive regulation of protein metabolic process 41.6667 6 no
GO:0006355 regulation of DNA-templated transcription 41.6667 7 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 41.6667 5 no
GO:0051252 regulation of RNA metabolic process 41.6667 5 no
GO:0090304 nucleic acid metabolic process 41.6667 4 no
GO:2001141 regulation of RNA biosynthetic process 41.6667 6 no
GO:0000209 protein polyubiquitination 33.3333 9 yes
GO:0006508 proteolysis 33.3333 4 yes
GO:0006511 ubiquitin-dependent protein catabolic process 33.3333 7 yes
GO:0009968 negative regulation of signal transduction 33.3333 5 yes
GO:0010648 negative regulation of cell communication 33.3333 5 yes
GO:0019941 modification-dependent protein catabolic process 33.3333 6 yes
GO:0023057 negative regulation of signaling 33.3333 4 yes
GO:0030163 protein catabolic process 33.3333 4 yes
GO:0042981 regulation of apoptotic process 33.3333 5 yes
GO:0043066 negative regulation of apoptotic process 33.3333 6 yes
GO:0043067 regulation of programmed cell death 33.3333 4 yes
GO:0043069 negative regulation of programmed cell death 33.3333 5 yes
GO:0043632 modification-dependent macromolecule catabolic process 33.3333 5 yes
GO:0050778 positive regulation of immune response 33.3333 5 yes
GO:0051603 proteolysis involved in protein catabolic process 33.3333 5 yes
GO:1901565 organonitrogen compound catabolic process 33.3333 4 yes
GO:1902532 negative regulation of intracellular signal transduction 33.3333 6 yes
GO:0031325 positive regulation of cellular metabolic process 33.3333 5 no
GO:0051128 regulation of cellular component organization 33.3333 4 no
GO:0008104 protein localization 33.3333 4 no
GO:0009890 negative regulation of biosynthetic process 33.3333 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 33.3333 6 no
GO:0031324 negative regulation of cellular metabolic process 33.3333 5 no
GO:0031327 negative regulation of cellular biosynthetic process 33.3333 6 no
GO:0051240 positive regulation of multicellular organismal process 33.3333 4 no
GO:0002831 regulation of response to biotic stimulus 25.0000 4 yes
GO:0010466 negative regulation of peptidase activity 25.0000 6 yes
GO:0010498 proteasomal protein catabolic process 25.0000 5 yes
GO:0010951 negative regulation of endopeptidase activity 25.0000 7 yes
GO:0030162 regulation of proteolysis 25.0000 6 yes
GO:0031349 positive regulation of defense response 25.0000 5 yes
GO:0032103 positive regulation of response to external stimulus 25.0000 5 yes
GO:0043086 negative regulation of catalytic activity 25.0000 4 yes
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 25.0000 7 yes
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 25.0000 6 yes
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 25.0000 8 yes
GO:0045088 regulation of innate immune response 25.0000 5 yes
GO:0045861 negative regulation of proteolysis 25.0000 7 yes
GO:0051248 negative regulation of protein metabolic process 25.0000 6 yes
GO:0051336 regulation of hydrolase activity 25.0000 4 yes
GO:0051346 negative regulation of hydrolase activity 25.0000 5 yes
GO:0052547 regulation of peptidase activity 25.0000 5 yes
GO:0052548 regulation of endopeptidase activity 25.0000 6 yes
GO:2000116 regulation of cysteine-type endopeptidase activity 25.0000 7 yes
GO:2000117 negative regulation of cysteine-type endopeptidase activity 25.0000 8 yes
GO:0001932 regulation of protein phosphorylation 25.0000 7 no
GO:0006986 response to unfolded protein 25.0000 4 no
GO:0007346 regulation of mitotic cell cycle 25.0000 5 no
GO:0010564 regulation of cell cycle process 25.0000 5 no
GO:0019220 regulation of phosphate metabolic process 25.0000 6 no
GO:0042325 regulation of phosphorylation 25.0000 7 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0045787 positive regulation of cell cycle 25.0000 5 no
GO:0045931 positive regulation of mitotic cell cycle 25.0000 6 no
GO:0051174 regulation of phosphorus metabolic process 25.0000 5 no
GO:0051726 regulation of cell cycle 25.0000 4 no
GO:0090068 positive regulation of cell cycle process 25.0000 6 no
GO:1901987 regulation of cell cycle phase transition 25.0000 6 no
GO:1901989 positive regulation of cell cycle phase transition 25.0000 7 no
GO:1901990 regulation of mitotic cell cycle phase transition 25.0000 6 no
GO:1901992 positive regulation of mitotic cell cycle phase transition 25.0000 7 no
GO:0002694 regulation of leukocyte activation 25.0000 4 no
GO:0002696 positive regulation of leukocyte activation 25.0000 5 no
GO:0006259 DNA metabolic process 25.0000 5 no
GO:0031396 regulation of protein ubiquitination 25.0000 9 no
GO:0031398 positive regulation of protein ubiquitination 25.0000 10 no
GO:0034097 response to cytokine 25.0000 4 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0043122 regulation of canonical NF-kappaB signal transduction 25.0000 6 no
GO:0050865 regulation of cell activation 25.0000 4 no
GO:0050867 positive regulation of cell activation 25.0000 5 no
GO:0051249 regulation of lymphocyte activation 25.0000 5 no
GO:0051251 positive regulation of lymphocyte activation 25.0000 6 no
GO:1901873 regulation of post-translational protein modification 25.0000 7 no
GO:1901875 positive regulation of post-translational protein modification 25.0000 8 no
GO:1903320 regulation of protein modification by small protein conjugation or removal 25.0000 8 no
GO:1903322 positive regulation of protein modification by small protein conjugation or removal 25.0000 9 no
GO:0098657 import into cell 25.0000 4 no
GO:0015031 protein transport 25.0000 4 no
GO:0071702 organic substance transport 25.0000 4 no
GO:0071705 nitrogen compound transport 25.0000 4 no
GO:0051049 regulation of transport 25.0000 4 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:0006974 DNA damage response 25.0000 4 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0009967 positive regulation of signal transduction 25.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010647 positive regulation of cell communication 25.0000 5 no
GO:0023056 positive regulation of signaling 25.0000 4 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0051091 positive regulation of DNA-binding transcription factor activity 25.0000 4 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:0002221 pattern recognition receptor signaling pathway 16.6667 5 yes
GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 16.6667 4 yes
GO:0002758 innate immune response-activating signaling pathway 16.6667 4 yes
GO:0002833 positive regulation of response to biotic stimulus 16.6667 5 yes
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 16.6667 5 yes
GO:0045089 positive regulation of innate immune response 16.6667 6 yes
GO:0070417 cellular response to cold 16.6667 4 yes
GO:0070936 protein K48-linked ubiquitination 16.6667 10 yes
GO:1900117 regulation of execution phase of apoptosis 16.6667 4 yes
GO:1900118 negative regulation of execution phase of apoptosis 16.6667 5 yes
GO:1901796 regulation of signal transduction by p53 class mediator 16.6667 6 yes
GO:1901797 negative regulation of signal transduction by p53 class mediator 16.6667 7 yes
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 16.6667 7 yes
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 16.6667 8 yes
GO:2000374 regulation of oxygen metabolic process 16.6667 5 yes
GO:2001233 regulation of apoptotic signaling pathway 16.6667 5 yes
GO:2001234 negative regulation of apoptotic signaling pathway 16.6667 6 yes
GO:2001236 regulation of extrinsic apoptotic signaling pathway 16.6667 6 yes
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 16.6667 7 yes
GO:2001270 regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis 16.6667 9 yes
GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis 16.6667 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TAXB1_HUMAN [view interactions] Low throughput no yes
UB2D2_HUMAN [view interactions] Low throughput no yes
UB2E1_HUMAN [view interactions] Low throughput no yes
UB2D3_HUMAN [view interactions] Low throughput no yes
RNF34_HUMAN [view entry] [view interactions] Low throughput yes no
CASPA_HUMAN [view interactions] Low throughput no yes
CASP8_HUMAN [view interactions] Low throughput no yes
DNJA3_HUMAN [view entry] [view interactions] Low throughput yes yes
NOD1_HUMAN [view interactions] Low throughput no no
MAVS_HUMAN [view interactions] Low throughput no yes
P53_HUMAN [view interactions] Low throughput no no
PRGC1_HUMAN [view interactions] Low throughput no no
ANC2_HUMAN [view interactions] Low throughput no no
CDC20_HUMAN [view interactions] Low throughput no no
FZR1_HUMAN [view interactions] Low throughput no no
RIGI_HUMAN [view interactions] Low throughput no yes
CACO2_HUMAN [view interactions] Low throughput no yes
NEMO_HUMAN [view interactions] Low throughput no yes
MKS1_HUMAN [view interactions] Low throughput no no
MSX2_HUMAN [view interactions] High throughput no no
A4_HUMAN [view entry] [view interactions] High throughput yes yes
DCA15_HUMAN [view interactions] High throughput no no
UBE2H_HUMAN [view interactions] High throughput no yes
UBE2F_HUMAN [view interactions] High throughput no yes
PHF7_HUMAN [view interactions] High throughput no no
TRI23_HUMAN [view interactions] High throughput no yes
APBP2_HUMAN [view interactions] High throughput no yes
CRYAA_HUMAN [view interactions] High throughput no no
NC2B_HUMAN [view interactions] High throughput no yes
GLE1_HUMAN [view interactions] High throughput no yes
KLK6_HUMAN [view interactions] High throughput no no
TF3C3_HUMAN [view interactions] High throughput no no
SPRE1_HUMAN [view interactions] High throughput no yes
ANXA1_HUMAN [view entry] [view interactions] High throughput yes no
SPT5H_HUMAN [view interactions] High throughput no yes
CHCH2_HUMAN [view interactions] High throughput no yes
MYCBP_HUMAN [view interactions] High throughput no yes
HSP72_HUMAN [view entry] [view interactions] High throughput yes no
SPT4H_HUMAN [view interactions] High throughput no no
UB2V1_HUMAN [view entry] [view interactions] High throughput yes no
UBA1_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2N_HUMAN [view entry] [view interactions] High throughput yes yes
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
CASP9_HUMAN [view interactions] High throughput no yes
RFFL_HUMAN [view interactions] High throughput no yes
U119A_HUMAN [view interactions] High throughput no no
U119B_HUMAN [view interactions] High throughput no yes
EFCB7_HUMAN [view interactions] High throughput no no
SPB13_HUMAN [view interactions] High throughput no no
KLH15_HUMAN [view interactions] High throughput no yes
MANS1_HUMAN [view interactions] High throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
TSR3_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
KCNE3_HUMAN [view interactions] High throughput no yes
DUS16_HUMAN [view interactions] High throughput no yes
DDX3Y_HUMAN [view interactions] High throughput no yes
HSP74_HUMAN [view entry] [view interactions] High throughput yes yes
OST4_HUMAN [view interactions] High throughput no no