RNF34_HUMAN
E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed). May mediate Lys-48-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed). Possibly involved in innate immunity, through Lys-48-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed). [View more on UniProt]
![](/static/images/legend1.gif)
Interacting region for partners were not defined.
![](/static/images/legend3.gif)
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in RNF34_HUMAN |
---|---|---|---|---|
GO:0000166 | nucleotide binding | 50.0000 | 4 | no |
GO:0005524 | ATP binding | 50.0000 | 5 | no |
GO:0017076 | purine nucleotide binding | 50.0000 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 50.0000 | 6 | no |
GO:0032555 | purine ribonucleotide binding | 50.0000 | 4 | no |
GO:0032559 | adenyl ribonucleotide binding | 50.0000 | 5 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 50.0000 | 4 | no |
GO:0043168 | anion binding | 50.0000 | 4 | no |
GO:0031625 | ubiquitin protein ligase binding | 41.6667 | 5 | yes |
GO:0043169 | cation binding | 41.6667 | 4 | yes |
GO:0044389 | ubiquitin-like protein ligase binding | 41.6667 | 4 | yes |
GO:0046872 | metal ion binding | 41.6667 | 5 | yes |
GO:0004842 | ubiquitin-protein transferase activity | 25.0000 | 4 | yes |
GO:0016755 | aminoacyltransferase activity | 25.0000 | 4 | yes |
GO:0003723 | RNA binding | 25.0000 | 4 | no |
GO:0035091 | phosphatidylinositol binding | 16.6667 | 4 | yes |
GO:0061630 | ubiquitin protein ligase activity | 16.6667 | 5 | yes |
GO:0061659 | ubiquitin-like protein ligase activity | 16.6667 | 4 | yes |
GO:1901981 | phosphatidylinositol phosphate binding | 16.6667 | 5 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in RNF34_HUMAN |
---|---|---|---|---|
GO:0031323 | regulation of cellular metabolic process | 75.0000 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 75.0000 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 75.0000 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 66.6667 | 4 | yes |
GO:0002684 | positive regulation of immune system process | 58.3333 | 4 | yes |
GO:0010646 | regulation of cell communication | 58.3333 | 4 | yes |
GO:0036211 | protein modification process | 58.3333 | 4 | yes |
GO:0043412 | macromolecule modification | 58.3333 | 4 | yes |
GO:0051246 | regulation of protein metabolic process | 58.3333 | 5 | yes |
GO:0080134 | regulation of response to stress | 58.3333 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 58.3333 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 50.0000 | 4 | yes |
GO:0009966 | regulation of signal transduction | 50.0000 | 4 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 50.0000 | 5 | yes |
GO:0048584 | positive regulation of response to stimulus | 50.0000 | 4 | yes |
GO:1902531 | regulation of intracellular signal transduction | 50.0000 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 50.0000 | 5 | no |
GO:0009889 | regulation of biosynthetic process | 50.0000 | 4 | no |
GO:0010468 | regulation of gene expression | 50.0000 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 50.0000 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 50.0000 | 5 | no |
GO:0006915 | apoptotic process | 41.6667 | 4 | yes |
GO:0009057 | macromolecule catabolic process | 41.6667 | 4 | yes |
GO:0016567 | protein ubiquitination | 41.6667 | 8 | yes |
GO:0031347 | regulation of defense response | 41.6667 | 5 | yes |
GO:0032101 | regulation of response to external stimulus | 41.6667 | 4 | yes |
GO:0032446 | protein modification by small protein conjugation | 41.6667 | 7 | yes |
GO:0043687 | post-translational protein modification | 41.6667 | 5 | yes |
GO:0048585 | negative regulation of response to stimulus | 41.6667 | 4 | yes |
GO:0050776 | regulation of immune response | 41.6667 | 4 | yes |
GO:0070647 | protein modification by small protein conjugation or removal | 41.6667 | 6 | yes |
GO:0006996 | organelle organization | 41.6667 | 4 | no |
GO:0031399 | regulation of protein modification process | 41.6667 | 6 | no |
GO:0031401 | positive regulation of protein modification process | 41.6667 | 7 | no |
GO:0051247 | positive regulation of protein metabolic process | 41.6667 | 6 | no |
GO:0006355 | regulation of DNA-templated transcription | 41.6667 | 7 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 41.6667 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 41.6667 | 5 | no |
GO:0090304 | nucleic acid metabolic process | 41.6667 | 4 | no |
GO:2001141 | regulation of RNA biosynthetic process | 41.6667 | 6 | no |
GO:0000209 | protein polyubiquitination | 33.3333 | 9 | yes |
GO:0006508 | proteolysis | 33.3333 | 4 | yes |
GO:0006511 | ubiquitin-dependent protein catabolic process | 33.3333 | 7 | yes |
GO:0009968 | negative regulation of signal transduction | 33.3333 | 5 | yes |
GO:0010648 | negative regulation of cell communication | 33.3333 | 5 | yes |
GO:0019941 | modification-dependent protein catabolic process | 33.3333 | 6 | yes |
GO:0023057 | negative regulation of signaling | 33.3333 | 4 | yes |
GO:0030163 | protein catabolic process | 33.3333 | 4 | yes |
GO:0042981 | regulation of apoptotic process | 33.3333 | 5 | yes |
GO:0043066 | negative regulation of apoptotic process | 33.3333 | 6 | yes |
GO:0043067 | regulation of programmed cell death | 33.3333 | 4 | yes |
GO:0043069 | negative regulation of programmed cell death | 33.3333 | 5 | yes |
GO:0043632 | modification-dependent macromolecule catabolic process | 33.3333 | 5 | yes |
GO:0050778 | positive regulation of immune response | 33.3333 | 5 | yes |
GO:0051603 | proteolysis involved in protein catabolic process | 33.3333 | 5 | yes |
GO:1901565 | organonitrogen compound catabolic process | 33.3333 | 4 | yes |
GO:1902532 | negative regulation of intracellular signal transduction | 33.3333 | 6 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
GO:0008104 | protein localization | 33.3333 | 4 | no |
GO:0009890 | negative regulation of biosynthetic process | 33.3333 | 5 | no |
GO:0010558 | negative regulation of macromolecule biosynthetic process | 33.3333 | 6 | no |
GO:0031324 | negative regulation of cellular metabolic process | 33.3333 | 5 | no |
GO:0031327 | negative regulation of cellular biosynthetic process | 33.3333 | 6 | no |
GO:0051240 | positive regulation of multicellular organismal process | 33.3333 | 4 | no |
GO:0002831 | regulation of response to biotic stimulus | 25.0000 | 4 | yes |
GO:0010466 | negative regulation of peptidase activity | 25.0000 | 6 | yes |
GO:0010498 | proteasomal protein catabolic process | 25.0000 | 5 | yes |
GO:0010951 | negative regulation of endopeptidase activity | 25.0000 | 7 | yes |
GO:0030162 | regulation of proteolysis | 25.0000 | 6 | yes |
GO:0031349 | positive regulation of defense response | 25.0000 | 5 | yes |
GO:0032103 | positive regulation of response to external stimulus | 25.0000 | 5 | yes |
GO:0043086 | negative regulation of catalytic activity | 25.0000 | 4 | yes |
GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 25.0000 | 7 | yes |
GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 25.0000 | 6 | yes |
GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 25.0000 | 8 | yes |
GO:0045088 | regulation of innate immune response | 25.0000 | 5 | yes |
GO:0045861 | negative regulation of proteolysis | 25.0000 | 7 | yes |
GO:0051248 | negative regulation of protein metabolic process | 25.0000 | 6 | yes |
GO:0051336 | regulation of hydrolase activity | 25.0000 | 4 | yes |
GO:0051346 | negative regulation of hydrolase activity | 25.0000 | 5 | yes |
GO:0052547 | regulation of peptidase activity | 25.0000 | 5 | yes |
GO:0052548 | regulation of endopeptidase activity | 25.0000 | 6 | yes |
GO:2000116 | regulation of cysteine-type endopeptidase activity | 25.0000 | 7 | yes |
GO:2000117 | negative regulation of cysteine-type endopeptidase activity | 25.0000 | 8 | yes |
GO:0001932 | regulation of protein phosphorylation | 25.0000 | 7 | no |
GO:0006986 | response to unfolded protein | 25.0000 | 4 | no |
GO:0007346 | regulation of mitotic cell cycle | 25.0000 | 5 | no |
GO:0010564 | regulation of cell cycle process | 25.0000 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 25.0000 | 6 | no |
GO:0042325 | regulation of phosphorylation | 25.0000 | 7 | no |
GO:0044087 | regulation of cellular component biogenesis | 25.0000 | 4 | no |
GO:0045787 | positive regulation of cell cycle | 25.0000 | 5 | no |
GO:0045931 | positive regulation of mitotic cell cycle | 25.0000 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 25.0000 | 5 | no |
GO:0051726 | regulation of cell cycle | 25.0000 | 4 | no |
GO:0090068 | positive regulation of cell cycle process | 25.0000 | 6 | no |
GO:1901987 | regulation of cell cycle phase transition | 25.0000 | 6 | no |
GO:1901989 | positive regulation of cell cycle phase transition | 25.0000 | 7 | no |
GO:1901990 | regulation of mitotic cell cycle phase transition | 25.0000 | 6 | no |
GO:1901992 | positive regulation of mitotic cell cycle phase transition | 25.0000 | 7 | no |
GO:0002694 | regulation of leukocyte activation | 25.0000 | 4 | no |
GO:0002696 | positive regulation of leukocyte activation | 25.0000 | 5 | no |
GO:0006259 | DNA metabolic process | 25.0000 | 5 | no |
GO:0031396 | regulation of protein ubiquitination | 25.0000 | 9 | no |
GO:0031398 | positive regulation of protein ubiquitination | 25.0000 | 10 | no |
GO:0034097 | response to cytokine | 25.0000 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 25.0000 | 4 | no |
GO:0043122 | regulation of canonical NF-kappaB signal transduction | 25.0000 | 6 | no |
GO:0050865 | regulation of cell activation | 25.0000 | 4 | no |
GO:0050867 | positive regulation of cell activation | 25.0000 | 5 | no |
GO:0051249 | regulation of lymphocyte activation | 25.0000 | 5 | no |
GO:0051251 | positive regulation of lymphocyte activation | 25.0000 | 6 | no |
GO:1901873 | regulation of post-translational protein modification | 25.0000 | 7 | no |
GO:1901875 | positive regulation of post-translational protein modification | 25.0000 | 8 | no |
GO:1903320 | regulation of protein modification by small protein conjugation or removal | 25.0000 | 8 | no |
GO:1903322 | positive regulation of protein modification by small protein conjugation or removal | 25.0000 | 9 | no |
GO:0098657 | import into cell | 25.0000 | 4 | no |
GO:0015031 | protein transport | 25.0000 | 4 | no |
GO:0071702 | organic substance transport | 25.0000 | 4 | no |
GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
GO:0051049 | regulation of transport | 25.0000 | 4 | no |
GO:0071310 | cellular response to organic substance | 25.0000 | 4 | no |
GO:0006974 | DNA damage response | 25.0000 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
GO:0009967 | positive regulation of signal transduction | 25.0000 | 5 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
GO:0051091 | positive regulation of DNA-binding transcription factor activity | 25.0000 | 4 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 25.0000 | 6 | no |
GO:0002221 | pattern recognition receptor signaling pathway | 16.6667 | 5 | yes |
GO:0002753 | cytoplasmic pattern recognition receptor signaling pathway | 16.6667 | 4 | yes |
GO:0002758 | innate immune response-activating signaling pathway | 16.6667 | 4 | yes |
GO:0002833 | positive regulation of response to biotic stimulus | 16.6667 | 5 | yes |
GO:0035872 | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | 16.6667 | 5 | yes |
GO:0045089 | positive regulation of innate immune response | 16.6667 | 6 | yes |
GO:0070417 | cellular response to cold | 16.6667 | 4 | yes |
GO:0070936 | protein K48-linked ubiquitination | 16.6667 | 10 | yes |
GO:1900117 | regulation of execution phase of apoptosis | 16.6667 | 4 | yes |
GO:1900118 | negative regulation of execution phase of apoptosis | 16.6667 | 5 | yes |
GO:1901796 | regulation of signal transduction by p53 class mediator | 16.6667 | 6 | yes |
GO:1901797 | negative regulation of signal transduction by p53 class mediator | 16.6667 | 7 | yes |
GO:1902041 | regulation of extrinsic apoptotic signaling pathway via death domain receptors | 16.6667 | 7 | yes |
GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | 16.6667 | 8 | yes |
GO:2000374 | regulation of oxygen metabolic process | 16.6667 | 5 | yes |
GO:2001233 | regulation of apoptotic signaling pathway | 16.6667 | 5 | yes |
GO:2001234 | negative regulation of apoptotic signaling pathway | 16.6667 | 6 | yes |
GO:2001236 | regulation of extrinsic apoptotic signaling pathway | 16.6667 | 6 | yes |
GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | 16.6667 | 7 | yes |
GO:2001270 | regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis | 16.6667 | 9 | yes |
GO:2001271 | negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis | 16.6667 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
TAXB1_HUMAN | [view interactions] | Low throughput | no | yes |
UB2D2_HUMAN | [view interactions] | Low throughput | no | yes |
UB2E1_HUMAN | [view interactions] | Low throughput | no | yes |
UB2D3_HUMAN | [view interactions] | Low throughput | no | yes |
RNF34_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CASPA_HUMAN | [view interactions] | Low throughput | no | yes |
CASP8_HUMAN | [view interactions] | Low throughput | no | yes |
DNJA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NOD1_HUMAN | [view interactions] | Low throughput | no | no |
MAVS_HUMAN | [view interactions] | Low throughput | no | yes |
P53_HUMAN | [view interactions] | Low throughput | no | no |
PRGC1_HUMAN | [view interactions] | Low throughput | no | no |
ANC2_HUMAN | [view interactions] | Low throughput | no | no |
CDC20_HUMAN | [view interactions] | Low throughput | no | no |
FZR1_HUMAN | [view interactions] | Low throughput | no | no |
RIGI_HUMAN | [view interactions] | Low throughput | no | yes |
CACO2_HUMAN | [view interactions] | Low throughput | no | yes |
NEMO_HUMAN | [view interactions] | Low throughput | no | yes |
MKS1_HUMAN | [view interactions] | Low throughput | no | no |
MSX2_HUMAN | [view interactions] | High throughput | no | no |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DCA15_HUMAN | [view interactions] | High throughput | no | no |
UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
UBE2F_HUMAN | [view interactions] | High throughput | no | yes |
PHF7_HUMAN | [view interactions] | High throughput | no | no |
TRI23_HUMAN | [view interactions] | High throughput | no | yes |
APBP2_HUMAN | [view interactions] | High throughput | no | yes |
CRYAA_HUMAN | [view interactions] | High throughput | no | no |
NC2B_HUMAN | [view interactions] | High throughput | no | yes |
GLE1_HUMAN | [view interactions] | High throughput | no | yes |
KLK6_HUMAN | [view interactions] | High throughput | no | no |
TF3C3_HUMAN | [view interactions] | High throughput | no | no |
SPRE1_HUMAN | [view interactions] | High throughput | no | yes |
ANXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SPT5H_HUMAN | [view interactions] | High throughput | no | yes |
CHCH2_HUMAN | [view interactions] | High throughput | no | yes |
MYCBP_HUMAN | [view interactions] | High throughput | no | yes |
HSP72_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SPT4H_HUMAN | [view interactions] | High throughput | no | no |
UB2V1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CASP9_HUMAN | [view interactions] | High throughput | no | yes |
RFFL_HUMAN | [view interactions] | High throughput | no | yes |
U119A_HUMAN | [view interactions] | High throughput | no | no |
U119B_HUMAN | [view interactions] | High throughput | no | yes |
EFCB7_HUMAN | [view interactions] | High throughput | no | no |
SPB13_HUMAN | [view interactions] | High throughput | no | no |
KLH15_HUMAN | [view interactions] | High throughput | no | yes |
MANS1_HUMAN | [view interactions] | High throughput | no | yes |
HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TSR3_HUMAN | [view interactions] | High throughput | no | yes |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
DUS16_HUMAN | [view interactions] | High throughput | no | yes |
DDX3Y_HUMAN | [view interactions] | High throughput | no | yes |
HSP74_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OST4_HUMAN | [view interactions] | High throughput | no | no |