UB2V1_HUMAN
Evidence for PS localization
Functions
Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate Lys-63-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UBE2N, catalyzes the viral RNA-dependent Lys-63-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (PubMed). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate Lys-63-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in UB2V1_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 24.1935 | 4 | no |
| GO:0017076 | purine nucleotide binding | 24.1935 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 24.1935 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 24.1935 | 4 | no |
| GO:0046872 | metal ion binding | 22.5806 | 4 | no |
| GO:0019901 | protein kinase binding | 20.9677 | 5 | no |
| GO:0005524 | ATP binding | 20.9677 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 20.9677 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 20.9677 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in UB2V1_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 70.9677 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 69.3548 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 69.3548 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 67.7419 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 64.5161 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 56.4516 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 54.8387 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 54.8387 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 53.2258 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 50.0000 | 5 | yes |
| GO:0010646 | regulation of cell communication | 48.3871 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 46.7742 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 45.1613 | 5 | yes |
| GO:0043412 | macromolecule modification | 43.5484 | 4 | yes |
| GO:0036211 | protein modification process | 41.9355 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 41.9355 | 6 | yes |
| GO:0010468 | regulation of gene expression | 38.7097 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 38.7097 | 6 | yes |
| GO:0051128 | regulation of cellular component organization | 38.7097 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 35.4839 | 5 | yes |
| GO:0051049 | regulation of transport | 35.4839 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 33.8710 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 33.8710 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 33.8710 | 5 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 32.2581 | 5 | yes |
| GO:0031401 | positive regulation of protein modification process | 32.2581 | 7 | yes |
| GO:0008104 | protein localization | 32.2581 | 4 | no |
| GO:0010941 | regulation of cell death | 32.2581 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 32.2581 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 32.2581 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 32.2581 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 32.2581 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 32.2581 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 30.6452 | 6 | yes |
| GO:0048584 | positive regulation of response to stimulus | 30.6452 | 4 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 30.6452 | 5 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 30.6452 | 5 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 30.6452 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 30.6452 | 6 | yes |
| GO:0010647 | positive regulation of cell communication | 29.0323 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 29.0323 | 4 | yes |
| GO:0006996 | organelle organization | 29.0323 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 29.0323 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 27.4194 | 5 | yes |
| GO:0032446 | protein modification by small protein conjugation | 27.4194 | 6 | yes |
| GO:0016567 | protein ubiquitination | 25.8065 | 7 | yes |
| GO:0080134 | regulation of response to stress | 25.8065 | 4 | yes |
| GO:0009057 | macromolecule catabolic process | 25.8065 | 4 | no |
| GO:0009894 | regulation of catabolic process | 25.8065 | 4 | no |
| GO:0051338 | regulation of transferase activity | 25.8065 | 4 | no |
| GO:0060341 | regulation of cellular localization | 24.1935 | 4 | no |
| GO:0051050 | positive regulation of transport | 24.1935 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 24.1935 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 24.1935 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 24.1935 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 24.1935 | 5 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 22.5806 | 6 | yes |
| GO:0032880 | regulation of protein localization | 22.5806 | 5 | no |
| GO:0071702 | organic substance transport | 22.5806 | 4 | no |
| GO:0071705 | nitrogen compound transport | 22.5806 | 4 | no |
| GO:0022607 | cellular component assembly | 22.5806 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 22.5806 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.5806 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 22.5806 | 6 | no |
| GO:0006508 | proteolysis | 22.5806 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 20.9677 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.9677 | 6 | yes |
| GO:0080135 | regulation of cellular response to stress | 20.9677 | 4 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 20.9677 | 6 | yes |
| GO:0015031 | protein transport | 20.9677 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.9677 | 5 | no |
| GO:0071310 | cellular response to organic substance | 20.9677 | 4 | no |
| GO:0030162 | regulation of proteolysis | 20.9677 | 6 | no |
| GO:0043066 | negative regulation of apoptotic process | 20.9677 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 20.9677 | 6 | no |
| GO:0060548 | negative regulation of cell death | 20.9677 | 5 | no |
| GO:0019941 | modification-dependent protein catabolic process | 20.9677 | 6 | no |
| GO:0043632 | modification-dependent macromolecule catabolic process | 20.9677 | 5 | no |
| GO:0044265 | cellular macromolecule catabolic process | 20.9677 | 4 | no |
| GO:0051603 | proteolysis involved in protein catabolic process | 20.9677 | 5 | no |
| GO:0043549 | regulation of kinase activity | 20.9677 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 19.3548 | 6 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 19.3548 | 6 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 17.7419 | 7 | yes |
| GO:0090304 | nucleic acid metabolic process | 17.7419 | 4 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 17.7419 | 7 | yes |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 17.7419 | 8 | yes |
| GO:0006974 | cellular response to DNA damage stimulus | 16.1290 | 4 | yes |
| GO:0031396 | regulation of protein ubiquitination | 16.1290 | 8 | yes |
| GO:1903320 | regulation of protein modification by small protein conjugation or removal | 16.1290 | 7 | yes |
| GO:0031398 | positive regulation of protein ubiquitination | 14.5161 | 9 | yes |
| GO:1903322 | positive regulation of protein modification by small protein conjugation or removal | 14.5161 | 8 | yes |
| GO:0000209 | protein polyubiquitination | 12.9032 | 8 | yes |
| GO:0006259 | DNA metabolic process | 11.2903 | 4 | yes |
| GO:0006281 | DNA repair | 11.2903 | 5 | yes |
| GO:0043122 | regulation of I-kappaB kinase/NF-kappaB signaling | 11.2903 | 6 | yes |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 9.6774 | 7 | yes |
| GO:0051052 | regulation of DNA metabolic process | 9.6774 | 5 | yes |
| GO:0051091 | positive regulation of DNA-binding transcription factor activity | 9.6774 | 4 | yes |
| GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 9.6774 | 5 | yes |
| GO:0070534 | protein K63-linked ubiquitination | 9.6774 | 9 | yes |
| GO:1902914 | regulation of protein polyubiquitination | 9.6774 | 9 | yes |
| GO:1902916 | positive regulation of protein polyubiquitination | 8.0645 | 10 | yes |
| GO:2001020 | regulation of response to DNA damage stimulus | 8.0645 | 5 | yes |
| GO:0006282 | regulation of DNA repair | 6.4516 | 6 | yes |
| GO:0006301 | postreplication repair | 6.4516 | 6 | yes |
| GO:1900044 | regulation of protein K63-linked ubiquitination | 6.4516 | 10 | yes |
| GO:1902523 | positive regulation of protein K63-linked ubiquitination | 6.4516 | 11 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in UB2V1_HUMAN |
|---|---|---|---|---|
| DOID:0050686 | organ system cancer | 3.2258 | 3 | no |
| DOID:0050700 | cardiomyopathy | 3.2258 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 3.2258 | 5 | no |
| DOID:114 | heart disease | 3.2258 | 3 | no |
| DOID:2843 | long QT syndrome | 3.2258 | 6 | no |
| DOID:1289 | neurodegenerative disease | 3.2258 | 4 | no |
| DOID:331 | central nervous system disease | 3.2258 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PRKN_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | Low throughput | no | yes |
| RHDF2_HUMAN | [view interactions] | Low throughput | no | yes |
| TRAF2_HUMAN | [view interactions] | Low throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BIRC2_HUMAN | [view interactions] | Low throughput | no | yes |
| PELI3_HUMAN | [view interactions] | Low throughput | no | yes |
| CIKS_HUMAN | [view interactions] | Low throughput | no | yes |
| RNF8_HUMAN | [view interactions] | Low throughput | no | yes |
| CHFR_HUMAN | [view interactions] | Low throughput | no | no |
| PSDE_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CHIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UB2V1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| TRAF6_HUMAN | [view interactions] | Low throughput | no | yes |
| CASP8_HUMAN | [view interactions] | Low throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | Low throughput | no | no |
| PELI1_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2E2_HUMAN | [view interactions] | High throughput | no | yes |
| TSN17_HUMAN | [view interactions] | High throughput | no | yes |
| PELI2_HUMAN | [view interactions] | High throughput | no | yes |
| RN122_HUMAN | [view interactions] | High throughput | no | yes |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2T_HUMAN | [view interactions] | High throughput | no | no |
| POLI_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL4_HUMAN | [view interactions] | High throughput | no | yes |
| CCD69_HUMAN | [view interactions] | High throughput | no | yes |
| HIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HGS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJB6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FKBP6_HUMAN | [view interactions] | High throughput | no | no |
| KRT36_HUMAN | [view interactions] | High throughput | no | no |
| HG2A_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
| GRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP85_HUMAN | [view interactions] | High throughput | no | no |
| DCNL2_HUMAN | [view interactions] | High throughput | no | yes |
| F184A_HUMAN | [view interactions] | High throughput | no | no |
| DEN6B_HUMAN | [view interactions] | High throughput | no | no |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| FAF2_HUMAN | [view interactions] | High throughput | no | yes |
| CREL1_HUMAN | [view interactions] | High throughput | no | yes |
| DCNL1_HUMAN | [view interactions] | High throughput | no | yes |
| CAR14_HUMAN | [view interactions] | High throughput | no | no |
| HOIL1_HUMAN | [view interactions] | High throughput | no | no |
| ASCC2_HUMAN | [view interactions] | High throughput | no | yes |
| ILRUN_HUMAN | [view interactions] | High throughput | no | yes |
| CUED1_HUMAN | [view interactions] | High throughput | no | yes |
| IMPCT_HUMAN | [view interactions] | High throughput | no | yes |
| APEX2_HUMAN | [view interactions] | High throughput | no | no |
| DP13A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GGA2_HUMAN | [view interactions] | High throughput | no | yes |
| HBS1L_HUMAN | [view interactions] | High throughput | no | yes |
| EPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AQP6_HUMAN | [view interactions] | High throughput | no | no |
| NTCP_HUMAN | [view interactions] | High throughput | no | no |
| ZNT4_HUMAN | [view interactions] | High throughput | no | no |
| F209A_HUMAN | [view interactions] | High throughput | no | no |
| SOAT_HUMAN | [view interactions] | High throughput | no | no |
| STOM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CR3L1_HUMAN | [view interactions] | High throughput | no | yes |
| PGRC2_HUMAN | [view interactions] | High throughput | no | yes |
| TM52B_HUMAN | [view interactions] | High throughput | no | no |
| TRFR_HUMAN | [view interactions] | High throughput | no | no |
| GP152_HUMAN | [view interactions] | High throughput | no | no |
| TMM31_HUMAN | [view interactions] | High throughput | no | no |
| VACHT_HUMAN | [view interactions] | High throughput | no | no |
| CNR2_HUMAN | [view interactions] | High throughput | no | yes |
| TMX2_HUMAN | [view interactions] | High throughput | no | yes |
| ZNRF2_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| MEX3C_HUMAN | [view interactions] | High throughput | no | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| NR3L1_HUMAN | [view interactions] | High throughput | no | no |
| HBB_HUMAN | [view interactions] | High throughput | no | no |
| MINP1_HUMAN | [view interactions] | High throughput | no | yes |
| ACHA4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HBA_HUMAN | [view interactions] | High throughput | no | no |
| UB2V2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2B_HUMAN | [view interactions] | High throughput | no | no |
| SAHH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP34_HUMAN | [view interactions] | High throughput | no | yes |
| UGDH_HUMAN | [view interactions] | High throughput | no | no |
| UBE2A_HUMAN | [view interactions] | High throughput | no | no |
| UCHL3_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN7_HUMAN | [view interactions] | High throughput | no | yes |
| UB2D2_HUMAN | [view interactions] | High throughput | no | yes |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| VATF_HUMAN | [view interactions] | High throughput | no | yes |
| ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
| UBE4B_HUMAN | [view interactions] | High throughput | no | yes |
| ZYX_HUMAN | [view interactions] | High throughput | no | no |
| POMP_HUMAN | [view interactions] | High throughput | no | yes |
| ULK4_HUMAN | [view interactions] | High throughput | no | yes |
| TTC9C_HUMAN | [view interactions] | High throughput | no | yes |
| VATB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSB1_HUMAN | [view interactions] | High throughput | no | yes |
| VATG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G6PD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LDHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433S_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGM2_HUMAN | [view interactions] | High throughput | no | no |
| TXND5_HUMAN | [view interactions] | High throughput | no | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHRD1_HUMAN | [view interactions] | High throughput | no | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAGL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBE2K_HUMAN | [view interactions] | High throughput | no | yes |
| GMPPB_HUMAN | [view interactions] | High throughput | no | yes |
| HINT1_HUMAN | [view interactions] | High throughput | no | yes |
| ITPA_HUMAN | [view interactions] | High throughput | no | yes |
| NDKB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| YKT6_HUMAN | [view interactions] | High throughput | no | yes |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2D1_HUMAN | [view interactions] | High throughput | no | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TECT3_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IQCB1_HUMAN | [view interactions] | High throughput | no | no |
| ELOC_HUMAN | [view interactions] | High throughput | no | no |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAX6_HUMAN | [view interactions] | High throughput | no | no |
| ERP44_HUMAN | [view interactions] | High throughput | no | yes |
| MUS81_HUMAN | [view interactions] | High throughput | no | no |
| PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P2RY6_HUMAN | [view interactions] | High throughput | no | no |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| EPB41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RNF37_HUMAN | [view interactions] | High throughput | no | no |
| TRI18_HUMAN | [view interactions] | High throughput | no | no |
| RNF14_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM8_HUMAN | [view interactions] | High throughput | no | yes |
| ZNRF1_HUMAN | [view interactions] | High throughput | no | yes |
| XIAP_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| DZIP3_HUMAN | [view interactions] | High throughput | no | yes |
| RNF5_HUMAN | [view interactions] | High throughput | no | yes |
| MKRN3_HUMAN | [view interactions] | High throughput | no | yes |
| ARI2_HUMAN | [view interactions] | High throughput | no | no |
| R144A_HUMAN | [view interactions] | High throughput | no | yes |
| RNF10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN111_HUMAN | [view interactions] | High throughput | no | yes |
| RN185_HUMAN | [view interactions] | High throughput | no | no |
| TRI39_HUMAN | [view interactions] | High throughput | no | no |
| TRIM5_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC8_HUMAN | [view interactions] | High throughput | no | no |
| DTX3_HUMAN | [view interactions] | High throughput | no | yes |
| F168A_HUMAN | [view interactions] | High throughput | no | yes |
| UBQL1_HUMAN | [view interactions] | High throughput | no | yes |
| CTG1B_HUMAN | [view interactions] | High throughput | no | no |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| DAZP2_HUMAN | [view interactions] | High throughput | no | no |
| XBP1_HUMAN | [view interactions] | High throughput | no | no |
| SHSA4_HUMAN | [view interactions] | High throughput | no | no |
| CRYAA_HUMAN | [view interactions] | High throughput | no | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| NMDE3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KLK6_HUMAN | [view interactions] | High throughput | no | no |
| RNF11_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| M3K1_HUMAN | [view interactions] | High throughput | no | yes |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2C_HUMAN | [view interactions] | High throughput | no | yes |
| RIOK3_HUMAN | [view interactions] | High throughput | no | yes |
| RNF13_HUMAN | [view interactions] | High throughput | no | yes |
| THA_HUMAN | [view interactions] | High throughput | no | yes |
| RO52_HUMAN | [view interactions] | High throughput | no | yes |
| RET2_HUMAN | [view interactions] | High throughput | no | no |
| TRI23_HUMAN | [view interactions] | High throughput | no | yes |
| UB2E1_HUMAN | [view interactions] | High throughput | no | yes |
| UB2D3_HUMAN | [view interactions] | High throughput | no | yes |
| NUDT6_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| CBLB_HUMAN | [view interactions] | High throughput | no | yes |
| UBE3A_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2S_HUMAN | [view interactions] | High throughput | no | no |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| INT3_HUMAN | [view interactions] | High throughput | no | yes |
| RFWD3_HUMAN | [view interactions] | High throughput | no | yes |
| MFSD6_HUMAN | [view interactions] | High throughput | no | yes |
| LRSM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UB2R2_HUMAN | [view interactions] | High throughput | no | no |
| SL9B2_HUMAN | [view interactions] | High throughput | no | yes |
| AN13D_HUMAN | [view interactions] | High throughput | no | yes |
| AN13A_HUMAN | [view interactions] | High throughput | no | yes |
| RN135_HUMAN | [view interactions] | High throughput | no | yes |
| DBF4B_HUMAN | [view interactions] | High throughput | no | yes |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| RN182_HUMAN | [view interactions] | High throughput | no | no |
| RNF34_HUMAN | [view interactions] | High throughput | no | no |
| TRI52_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC7_HUMAN | [view interactions] | High throughput | no | no |
| TRI11_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2O_HUMAN | [view interactions] | High throughput | no | yes |
| TLR7_HUMAN | [view interactions] | Computational | no | no |
| UB2Q2_HUMAN | [view interactions] | Computational | no | no |
| MP2K4_HUMAN | [view interactions] | Computational | no | yes |
| UB2D4_HUMAN | [view interactions] | Computational | no | yes |
| UBE2U_HUMAN | [view interactions] | Computational | no | no |
| UB2G2_HUMAN | [view interactions] | Computational | no | yes |
| UB2L3_HUMAN | [view interactions] | Computational | no | yes |
| TCAM1_HUMAN | [view interactions] | Computational | no | yes |
| UBE2F_HUMAN | [view interactions] | Computational | no | yes |
| UBA6_HUMAN | [view interactions] | Computational | no | no |
| MP2K3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TAB3_HUMAN | [view interactions] | Computational | no | yes |
| TLR4_HUMAN | [view interactions] | Computational | no | yes |
| CD14_HUMAN | [view interactions] | Computational | no | no |
| MP2K7_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UB2G1_HUMAN | [view interactions] | Computational | no | yes |
| BRE1B_HUMAN | [view interactions] | Computational | no | yes |
| MYD88_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| IRAK1_HUMAN | [view interactions] | Computational | no | yes |
| M3K7_HUMAN | [view interactions] | Computational | no | yes |
| UBE2H_HUMAN | [view interactions] | Computational | no | yes |
| TAB2_HUMAN | [view interactions] | Computational | no | yes |
| TAB1_HUMAN | [view interactions] | Computational | no | yes |
| UB2Q1_HUMAN | [view interactions] | Computational | no | no |
| MP2K6_HUMAN | [view interactions] | Computational | no | yes |
| UBB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RS27A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RL40_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UB2J2_HUMAN | [view interactions] | Computational | no | no |
| NEMO_HUMAN | [view interactions] | Computational | no | yes |
| ATG7_HUMAN | [view interactions] | Computational | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KPCT_HUMAN | [view interactions] | Computational | no | no |
| UB2L6_HUMAN | [view interactions] | Computational | no | no |
| RIPK1_HUMAN | [view interactions] | Computational | no | yes |
| UB2R1_HUMAN | [view interactions] | Computational | no | yes |
| IKKA_HUMAN | [view interactions] | Computational | no | yes |
| BRE1A_HUMAN | [view interactions] | Computational | no | yes |
| CAR11_HUMAN | [view interactions] | Computational | no | no |
| UB2E3_HUMAN | [view interactions] | Computational | no | yes |
| UBA5_HUMAN | [view interactions] | Computational | no | yes |
| LY96_HUMAN | [view interactions] | Computational | no | no |
| IKKB_HUMAN | [view interactions] | Computational | no | yes |
| UBA7_HUMAN | [view interactions] | Computational | no | yes |
| TLR3_HUMAN | [view interactions] | Computational | no | yes |
| UBA3_HUMAN | [view interactions] | Computational | no | yes |
| TCAM2_HUMAN | [view interactions] | Computational | no | no |
| PDPK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| UB2J1_HUMAN | [view interactions] | Computational | no | yes |
| UBE2Z_HUMAN | [view interactions] | Computational | no | yes |
| IRF7_HUMAN | [view interactions] | Computational | no | yes |