CNR2_HUMAN
Evidence for PS localization
Functions
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CNR2_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 34.8837 | 4 | no |
| GO:0046872 | metal ion binding | 30.2326 | 5 | no |
| GO:0000166 | nucleotide binding | 30.2326 | 4 | no |
| GO:0043169 | cation binding | 30.2326 | 4 | no |
| GO:0017076 | purine nucleotide binding | 27.9070 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 27.9070 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.5814 | 4 | no |
| GO:0003723 | RNA binding | 23.2558 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 20.9302 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 20.9302 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 20.9302 | 6 | no |
| GO:0004930 | G protein-coupled receptor activity | 4.6512 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CNR2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 30.2326 | 4 | no |
| GO:0010646 | regulation of cell communication | 25.5814 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 25.5814 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 23.2558 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 20.9302 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 20.9302 | 5 | no |
| GO:0071702 | organic substance transport | 20.9302 | 4 | no |
| GO:0010243 | response to organonitrogen compound | 18.6047 | 4 | yes |
| GO:0033993 | response to lipid | 16.2791 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 16.2791 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 11.6279 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 11.6279 | 4 | yes |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 9.3023 | 4 | yes |
| GO:0002237 | response to molecule of bacterial origin | 6.9767 | 4 | yes |
| GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | 6.9767 | 5 | yes |
| GO:0032496 | response to lipopolysaccharide | 6.9767 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 6.9767 | 4 | yes |
| GO:0006954 | inflammatory response | 4.6512 | 4 | yes |
| GO:0010648 | negative regulation of cell communication | 4.6512 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 4.6512 | 4 | yes |
| GO:0060326 | cell chemotaxis | 4.6512 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SQSTM_HUMAN | [view interactions] | Low throughput | no | yes |
| GPR18_HUMAN | [view interactions] | Low throughput | no | no |
| CNR1_HUMAN | [view interactions] | Low throughput | no | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RELN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GNAI1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DHC24_HUMAN | [view interactions] | High throughput | no | yes |
| DHRS7_HUMAN | [view interactions] | High throughput | no | yes |
| GGT7_HUMAN | [view interactions] | High throughput | no | yes |
| HECD3_HUMAN | [view interactions] | High throughput | no | yes |
| K2013_HUMAN | [view interactions] | High throughput | no | yes |
| PLS1_HUMAN | [view interactions] | High throughput | no | no |
| CLGN_HUMAN | [view interactions] | High throughput | no | no |
| KDSR_HUMAN | [view interactions] | High throughput | no | yes |
| TMX3_HUMAN | [view interactions] | High throughput | no | yes |
| SGMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBR1_HUMAN | [view interactions] | High throughput | no | yes |
| FDFT_HUMAN | [view interactions] | High throughput | no | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| B4GA1_HUMAN | [view interactions] | High throughput | no | yes |
| SE1L1_HUMAN | [view interactions] | High throughput | no | yes |
| PTPRF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATE1_HUMAN | [view interactions] | High throughput | no | yes |
| CCD47_HUMAN | [view interactions] | High throughput | no | yes |
| SPTC1_HUMAN | [view interactions] | High throughput | no | yes |
| MBRL_HUMAN | [view interactions] | High throughput | no | yes |
| ZZEF1_HUMAN | [view interactions] | High throughput | no | no |
| RER1_HUMAN | [view interactions] | High throughput | no | yes |
| TMX1_HUMAN | [view interactions] | High throughput | no | no |
| PGRC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S39AE_HUMAN | [view interactions] | High throughput | no | yes |
| COQ8A_HUMAN | [view interactions] | High throughput | no | no |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PI4KA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRAF3_HUMAN | [view interactions] | High throughput | no | yes |
| HACL2_HUMAN | [view interactions] | High throughput | no | yes |
| TBL2_HUMAN | [view interactions] | High throughput | no | no |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
| SELT_HUMAN | [view interactions] | High throughput | no | yes |
| GDIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCN2_HUMAN | [view interactions] | High throughput | no | yes |
| TBA1C_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OST48_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VKOR1_HUMAN | [view interactions] | High throughput | no | yes |
| PLST_HUMAN | [view interactions] | High throughput | no | yes |
| PREB_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA1_HUMAN | [view interactions] | High throughput | no | yes |
| AL3A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX41_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 4F2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMED2_HUMAN | [view interactions] | High throughput | no | yes |
| ARF3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PGRC2_HUMAN | [view interactions] | High throughput | no | yes |
| AIFM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S10A8_HUMAN | [view interactions] | High throughput | no | no |
| TRAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUR2_HUMAN | [view interactions] | High throughput | no | yes |
| S27A2_HUMAN | [view interactions] | High throughput | no | no |
| C1TC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC22B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PDIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPB_HUMAN | [view interactions] | High throughput | no | yes |
| SSRD_HUMAN | [view interactions] | High throughput | no | yes |
| S61A1_HUMAN | [view interactions] | High throughput | no | no |
| PRDX3_HUMAN | [view interactions] | High throughput | no | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| EF1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DHB12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HACD3_HUMAN | [view interactions] | High throughput | no | yes |
| S25A3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S10A9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CMTD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| USP9X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HLAC_HUMAN | [view interactions] | High throughput | no | no |
| S39A2_HUMAN | [view interactions] | High throughput | no | yes |
| NRM_HUMAN | [view interactions] | High throughput | no | no |
| TM242_HUMAN | [view interactions] | High throughput | no | yes |
| TM203_HUMAN | [view interactions] | High throughput | no | no |
| YIPF1_HUMAN | [view interactions] | High throughput | no | no |
| COMT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADIPO_HUMAN | [view interactions] | High throughput | no | no |
| RFT1_HUMAN | [view interactions] | High throughput | no | yes |
| YIPF4_HUMAN | [view interactions] | High throughput | no | yes |
| MUC15_HUMAN | [view interactions] | High throughput | no | yes |
| TM86A_HUMAN | [view interactions] | High throughput | no | yes |
| SELK_HUMAN | [view interactions] | High throughput | no | yes |
| YIPF6_HUMAN | [view interactions] | High throughput | no | yes |
| CCL4_HUMAN | [view interactions] | High throughput | no | no |
| S35E4_HUMAN | [view interactions] | High throughput | no | no |
| TMPPE_HUMAN | [view interactions] | High throughput | no | yes |
| TMM19_HUMAN | [view interactions] | High throughput | no | yes |
| TSPO2_HUMAN | [view interactions] | High throughput | no | no |
| PLCD_HUMAN | [view interactions] | High throughput | no | yes |
| TMM60_HUMAN | [view interactions] | High throughput | no | no |
| ADA21_HUMAN | [view interactions] | High throughput | no | no |
| PSMD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXYD3_HUMAN | [view interactions] | High throughput | no | yes |
| UB2V1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |